Abstract:
:Crucial steps in the miniaturisation of biosensors are the conversion of a biological signal into an electrical current as well as the direct sampling of bodily fluids. Here we show that protein sensors in combination with a nanopore, acting as an electrical transducer, can accurately quantify metabolites in real time directly from nanoliter amounts of blood and other bodily fluids. Incorporation of the nanopore into portable electronic devices will allow developing sensitive, continuous, and non-invasive sensors for metabolites for point-of-care and home diagnostics.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Galenkamp NS,Soskine M,Hermans J,Wloka C,Maglia Gdoi
10.1038/s41467-018-06534-1subject
Has Abstractpub_date
2018-10-05 00:00:00pages
4085issue
1issn
2041-1723pii
10.1038/s41467-018-06534-1journal_volume
9pub_type
杂志文章abstract::Ligand-induced receptor dimerization has traditionally been viewed as the key event in transmembrane signalling by epidermal growth factor receptors (EGFRs). Here we show that the Caenorhabditis elegans EGFR orthologue LET-23 is constitutively dimeric, yet responds to its ligand LIN-3 without changing oligomerization ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8380
更新日期:2015-06-10 00:00:00
abstract::The performance of conjugated polymer devices is largely dictated by charge transport processes. However, it is difficult to obtain a clear relationship between conjugated polymer structures and charge transport properties, due to the complexity of the structure and the dispersive nature of charge transport in conjuga...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06846-2
更新日期:2018-10-17 00:00:00
abstract::Activation of autophagy and elevation of glutamine synthesis represent key adaptations to maintain amino acid balance during starvation. In this study, we investigate the role of autophagy and glutamine on the regulation of mTORC1, a critical kinase that regulates cell growth and proliferation. We report that suppleme...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00369-y
更新日期:2017-08-24 00:00:00
abstract::Adult neural stem cells reside in a specialized niche in the subventricular zone (SVZ). Throughout life they give rise to adult-born neurons in the olfactory bulb (OB), thus contributing to neural plasticity and pattern discrimination. Here, we show that the neurovascular protein EGFL7 is secreted by endothelial cells...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15922
更新日期:2017-06-28 00:00:00
abstract::Metastasis is the main cause of cancer-related death and thus understanding the molecular and cellular mechanisms underlying this process is critical. Here, our data demonstrate, contrary to established dogma, that loss of haematopoietic-derived focal adhesion kinase (FAK) is sufficient to enhance tumour metastasis. U...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6054
更新日期:2014-10-01 00:00:00
abstract::Glucagon promotes hepatic gluconeogenesis and maintains whole-body glucose levels during fasting. The regulatory factors that are involved in fasting glucagon response are not well understood. Here we report a role of p52, a key activator of the noncanonical nuclear factor-kappaB signaling, in hepatic glucagon respons...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12351-x
更新日期:2019-09-20 00:00:00
abstract::Transposable elements constitute a substantial portion of eukaryotic genomes and contribute to genomic variation, function, and evolution. Miniature inverted-repeat transposable elements (MITEs), as DNA transposons, are widely distributed in plant and animal genomes. Previous studies have suggested that retrotransposo...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14651
更新日期:2017-03-03 00:00:00
abstract::Sclerosing stromal tumor (SST) of the ovary is a rare type of sex cord-stromal tumor (SCST), whose genetic underpinning is currently unknown. Here, using whole-exome, targeted capture and RNA-sequencing, we report recurrent FHL2-GLI2 fusion genes in 65% (17/26) of SSTs and other GLI2 rearrangements in additional 15% (...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13806-x
更新日期:2020-01-02 00:00:00
abstract::Familial hemiplegic migraine is an episodic neurological disorder characterized by transient sensory and motor symptoms and signs. Mutations of the ion pump α2-Na/K ATPase cause familial hemiplegic migraine, but the mechanisms by which α2-Na/K ATPase mutations lead to the migraine phenotype remain incompletely underst...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19915-2
更新日期:2020-12-02 00:00:00
abstract::Janus, patchy, stripe-like, or random arrangements of molecules within the ligand shell of nanoparticles affect many properties. Among all existing ligand shell morphology characterization methods, the one based on mass spectroscopy is arguably the simplest. Its greatest limitation is that the results are qualitative....
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06939-y
更新日期:2018-10-26 00:00:00
abstract::Metastasis-associated recurrence is the major cause of poor prognosis in hepatocellular carcinoma (HCC), however, the underlying mechanisms remain largely elusive. In this study, we report that expression of choroideremia-like (CHML) is increased in HCC, associated with poor survival, early recurrence and more satelli...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10364-0
更新日期:2019-06-07 00:00:00
abstract::The atypical chemokine receptor 3 (ACKR3) plays a pivotal role in directing the migration of various cellular populations and its over-expression in tumors promotes cell proliferation and invasiveness. The intracellular signaling pathways transducing ACKR3-dependent effects remain poorly characterized, an issue we add...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18634-y
更新日期:2020-09-25 00:00:00
abstract::Singlet oxygen has won a great deal of attention to catalysis and biological studies due to its strong oxidizing properties. However, the photosensitizers which require for the generation of singlet oxygen remain inadequate because of their lack of long-wavelength absorption, weak hydrophilicity, and poor biocompatibi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05223-3
更新日期:2018-07-18 00:00:00
abstract::Duchenne muscular dystrophy (DMD) is characterized by muscle degeneration and progressive weakness. There is considerable inter-patient variability in disease onset and progression, which can confound the results of clinical trials. Here we show that a common null polymorphism (R577X) in ACTN3 results in significantly...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14143
更新日期:2017-01-31 00:00:00
abstract::Long-term stability remains a key issue impeding the commercialization of halide perovskite solar cells (HPVKSCs). The diffusion of molecules and ions causes irreversible degradation to photovoltaic device performance. Here, we demonstrate a facile strategy for producing highly stable HPVKSCs by using a thin but compa...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09167-0
更新日期:2019-03-11 00:00:00
abstract::The combined effects of anthropogenic and biological CO2 inputs may lead to more rapid acidification in coastal waters compared to the open ocean. It is less clear, however, how redox reactions would contribute to acidification. Here we report estuarine acidification dynamics based on oxygen, hydrogen sulfide (H2S), p...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00417-7
更新日期:2017-08-28 00:00:00
abstract::Magnetic reconnection is a fundamental process in magnetized plasma where magnetic energy is converted to plasma energy. Despite huge differences in the physical size of the reconnection layer, remarkably similar characteristics are observed in both laboratory and magnetosphere plasmas. Here we present the comparative...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07680-2
更新日期:2018-12-06 00:00:00
abstract::The striking diversity of bird beak shapes is an outcome of natural selection, yet the relative importance of the limitations imposed by the process of beak development on generating such variation is unclear. Untangling these factors requires mapping developmental mechanisms over a phylogeny far exceeding model syste...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4700
更新日期:2014-04-16 00:00:00
abstract::The Unc-51 like autophagy activating kinase 1 (ULK1) complex plays a central role in the initiation stage of autophagy. However, the function of ULK1 in the late stage of autophagy is unknown. Here, we report that ULK1, a central kinase of the ULK1 complex involved in autophagy initiation, promotes autophagosome-lysos...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05449-1
更新日期:2018-08-28 00:00:00
abstract::Human Ebp1 is a member of the proliferation-associated 2G4 (PA2G4) family and plays an important role in cancer regulation. Ebp1 shares the methionine aminopeptidase (MetAP) fold and binds to mature 80S ribosomes for translational control. Here, we present a cryo-EM single particle analysis reconstruction of Ebp1 boun...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14603-7
更新日期:2020-02-07 00:00:00
abstract::Inversions are one type of structural variants linked to phenotypic differences and adaptation in multiple organisms. However, there is still very little information about polymorphic inversions in the human genome due to the difficulty of their detection. Here, we develop a new high-throughput genotyping method based...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12173-x
更新日期:2019-09-17 00:00:00
abstract::Although, a number of pathogenic mutations have been found for Alzheimer's disease (AD), only one protective mutation has been identified so far in humans. Here we identify possible protective deletion mutations in the 3'-UTR of the amyloid precursor protein (App) gene in mice. We use an App knock-in mouse model carry...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04238-0
更新日期:2018-05-04 00:00:00
abstract::The control of matter motion at liquid-gas interfaces opens an opportunity to create two-dimensional materials with remotely tunable properties. In analogy with optical lattices used in ultra-cold atom physics, such materials can be created by a wave field capable of dynamically guiding matter into periodic spatial st...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14325
更新日期:2017-02-09 00:00:00
abstract::The word 'holography' means a drawing that contains all of the information for light-both amplitude and wavefront. However, because of the insufficient bandwidth of current electronics, the direct measurement of the wavefront of light has not yet been achieved. Though reference-field-assisted interferometric methods h...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13359
更新日期:2016-10-31 00:00:00
abstract::Building a population-specific catalogue of single nucleotide variants (SNVs), indels and structural variants (SVs) with frequencies, termed a national pan-genome, is critical for further advancing clinical and public health genetics in large cohorts. Here we report a Danish pan-genome obtained from sequencing 10 trio...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6969
更新日期:2015-01-19 00:00:00
abstract::Loss of appetite or anorexia associated with inflammation impairs quality of life and increases morbidity in many diseases. However, the exact neural mechanism that mediates inflammation-associated anorexia is still poorly understood. Here we identified a population of neurons, marked by the expression of protein kina...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10715-x
更新日期:2019-06-24 00:00:00
abstract::Although substantial progress has been made in cancer biology and treatment, clinical outcomes of bladder carcinoma (BC) patients are still not satisfactory. The tumor microenvironment (TME) is a potential target. Here, by single-cell RNA sequencing on 8 BC tumor samples and 3 para tumor samples, we identify 19 differ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18916-5
更新日期:2020-10-08 00:00:00
abstract::Iminium catalysis, involving the transformation of iminium ions to enamines, has been extensively studied in the context of a number of organic processes. However, the reverse of this process involving conversion of enamines to iminium species has not been realized. Here, we describe a new transformation-'oxidative en...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1214
更新日期:2011-01-01 00:00:00
abstract::Random numbers are commonly used in many different fields, ranging from simulations in fundamental science to security applications. In some critical cases, as Bell's tests and cryptography, the random numbers are required to be both private and to be provided at an ultra-fast rate. However, practical generators are u...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07585-0
更新日期:2018-12-18 00:00:00
abstract::Valosin-containing protein (VCP, also called p97) is an essential and highly conserved adenosine triphosphate-dependent chaperone implicated in a wide range of cellular processes in eukaryotes, and mild VCP mutations can cause severe neurodegenerative disease. Here we show that mammalian VCP is trimethylated on Lys315...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2041
更新日期:2012-01-01 00:00:00