Ligand regulation of a constitutively dimeric EGF receptor.

abstract：:Achieving and exceeding diversity of colloidal analogs of chemical elements and molecules as building blocks of matter has been the central goal and challenge of colloidal science ever since Einstein introduced the colloidal atom paradigm. Recent advances in colloids assembly have been achieved by exploiting the machi...

journal_title：Nature communications

authors： Senyuk B,Aplinc J,Ravnik M,Smalyukh II

更新日期：2019-04-23 00:00:00

abstract：:Discarding by fisheries is perceived as contrary to responsible harvesting. Legislation seeking to end the practice is being introduced in many jurisdictions. However, discarded fish are food for a range of scavenging species; so, ending discarding may have ecological consequences. Here we investigate the sensitivity ...

journal_title：Nature communications

authors： Heath MR,Cook RM,Cameron AI,Morris DJ,Speirs DC

更新日期：2014-05-13 00:00:00

abstract：:β-Diguetoxin-Dc1a (Dc1a) is a toxin from the desert bush spider Diguetia canities that incapacitates insects at concentrations that are non-toxic to mammals. Dc1a promotes opening of German cockroach voltage-gated sodium (Nav) channels (BgNav1), whereas human Nav channels are insensitive. Here, by transplanting common...

journal_title：Nature communications

authors： Bende NS,Dziemborowicz S,Mobli M,Herzig V,Gilchrist J,Wagner J,Nicholson GM,King GF,Bosmans F

更新日期：2014-07-11 00:00:00

abstract：:Creatine kinase (CK) and lactate dehydrogenase (LDH) are widely used markers of tissue damage. To search for sequence variants influencing serum levels of CK and LDH, 28.3 million sequence variants identified through whole-genome sequencing of 2,636 Icelanders were imputed into 63,159 and 98,585 people with CK and LDH...

journal_title：Nature communications

authors： Kristjansson RP,Oddsson A,Helgason H,Sveinbjornsson G,Arnadottir GA,Jensson BO,Jonasdottir A,Jonasdottir A,Bragi Walters G,Sulem G,Oskarsdottir A,Benonisdottir S,Davidsson OB,Masson G,Magnusson OT,Holm H,Sigurdardottir O

更新日期：2016-02-03 00:00:00

abstract：:Although influenza viruses lead to severe illness in high-risk populations, host genetic factors associated with severe disease are largely unknown. As the HLA-A*68:01 allele can be linked to severe pandemic 2009-H1N1 disease, we investigate a potential impairment of HLA-A*68:01-restricted CD8+ T cells to mount robust...

journal_title：Nature communications

authors： van de Sandt CE,Clemens EB,Grant EJ,Rowntree LC,Sant S,Halim H,Crowe J,Cheng AC,Kotsimbos TC,Richards M,Miller A,Tong SYC,Rossjohn J,Nguyen THO,Gras S,Chen W,Kedzierska K

更新日期：2019-12-06 00:00:00

abstract：:Preparation and characterization of polariton Bose-Einstein condensates in micro-cavities of high quality are at the frontier of contemporary solid state physics. Here, we report on three-dimensional polariton condensation and confinement in pseudo-spherical ZnO microcrystals. The boundary of micro-spherical ZnO resem...

journal_title：Nature communications

authors： Volkov VV,Oliver DJ,Perry CC

更新日期：2020-09-30 00:00:00

abstract：:Monolayer transition metal dichalcogenides integrated in optical microcavities host exciton-polaritons as a hallmark of the strong light-matter coupling regime. Analogous concepts for hybrid light-matter systems employing spatially indirect excitons with a permanent electric dipole moment in heterobilayer crystals pro...

journal_title：Nature communications

authors： Förg M,Colombier L,Patel RK,Lindlau J,Mohite AD,Yamaguchi H,Glazov MM,Hunger D,Högele A

更新日期：2019-08-16 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Barlow JT,Bogatyrev SR,Ismagilov RF

更新日期：2020-07-06 00:00:00

abstract：:Southern Africa is characterised by unusually elevated topography and abnormal heat flow. This can be explained by thermal perturbation of the mantle, but the origin of this is unclear. Geophysics has not detected a thermal anomaly in the upper mantle and there is no geochemical evidence of an asthenosphere mantle con...

journal_title：Nature communications

authors： Gilfillan SMV,Györe D,Flude S,Johnson G,Bond CE,Hicks N,Lister R,Jones DG,Kremer Y,Haszeldine RS,Stuart FM

更新日期：2019-11-05 00:00:00

abstract：:Charge acceleration during an intense light field application to solids attracts much attention as elementary processes in high-harmonic generation and photoelectron emission. For manipulating such attosecond dynamics of charge, carrier-envelope-phase (CEP: relative phase between carrier oscillation of light field and...

journal_title：Nature communications

authors： Kawakami Y,Amano T,Ohashi H,Itoh H,Nakamura Y,Kishida H,Sasaki T,Kawaguchi G,Yamamoto HM,Yamamoto K,Ishihara S,Yonemitsu K,Iwai S

更新日期：2020-08-18 00:00:00

abstract：:It is unclear whether the establishment of apical-basal cell polarity during the generation of epithelial lumens requires molecules acting at the plasma membrane/actin interface. Here, we show that the I-BAR-containing IRSp53 protein controls lumen formation and the positioning of the polarity determinants aPKC and po...

journal_title：Nature communications

authors： Bisi S,Marchesi S,Rizvi A,Carra D,Beznoussenko GV,Ferrara I,Deflorian G,Mironov A,Bertalot G,Pisati F,Oldani A,Cattaneo A,Saberamoli G,Pece S,Viale G,Bachi A,Tripodo C,Scita G,Disanza A

更新日期：2020-07-14 00:00:00

abstract：:Natural killer (NK) cells limit viral replication by direct recognition of infected cells, antibody-dependent cellular cytotoxicity (ADCC), and releasing cytokines. Although growing evidence supports NK cell antiviral immunity in HIV-1 infection, further knowledge of their response is necessary. Here we show that NK c...

journal_title：Nature communications

authors： Costanzo MC,Kim D,Creegan M,Lal KG,Ake JA,Currier JR,Streeck H,Robb ML,Michael NL,Bolton DL,Steers NJ,Eller MA

更新日期：2018-03-23 00:00:00

abstract：:As children grow, they gradually learn how to make decisions independently. However, decisions like choosing healthy but less-tasty foods can be challenging for children whose self-regulation and executive cognitive functions are still maturing. We propose a computational decision-making process in which children esti...

journal_title：Nature communications

authors： Lim SL,Cherry JB,Davis AM,Balakrishnan SN,Ha OR,Bruce JM,Bruce AS

更新日期：2016-05-24 00:00:00

abstract：:Topological defects in matter behave collectively to form highly non-trivial structures called topological textures that are characterised by conserved quantities such as the winding number. Here we show that an epitaxial ferroelectric square nanoplate of bismuth ferrite subjected to a large strain gradient (as much a...

journal_title：Nature communications

authors： Kim KE,Jeong S,Chu K,Lee JH,Kim GY,Xue F,Koo TY,Chen LQ,Choi SY,Ramesh R,Yang CH

更新日期：2018-01-26 00:00:00

abstract：:Parkinson's disease (PD) and Multiple System Atrophy (MSA) are clinically distinctive diseases that feature a common neuropathological hallmark of aggregated α-synuclein. Little is known about how differences in α-synuclein aggregate structure affect disease phenotype. Here, we amplified α-synuclein aggregates from PD...

journal_title：Nature communications

authors： Strohäker T,Jung BC,Liou SH,Fernandez CO,Riedel D,Becker S,Halliday GM,Bennati M,Kim WS,Lee SJ,Zweckstetter M

更新日期：2019-12-04 00:00:00

abstract：:Triacylglycerols are among the most attractive alternative raw materials for biofuel development. Current oil plant-based technologies are limited in terms of triacylglycerol production capacity and rate. These limitations may be circumvented by biotransformation of carbohydrates into lipids; however, our understandin...

journal_title：Nature communications

authors： Zhu Z,Zhang S,Liu H,Shen H,Lin X,Yang F,Zhou YJ,Jin G,Ye M,Zou H,Zhao ZK

更新日期：2012-01-01 00:00:00

abstract：:DNA-coated colloids hold great promise for self-assembly of programmed heterogeneous microstructures, provided they not only bind when cooled below their melting temperature, but also rearrange so that aggregated particles can anneal into the structure that minimizes the free energy. Unfortunately, DNA-coated colloids...

journal_title：Nature communications

authors： Wang Y,Wang Y,Zheng X,Ducrot É,Yodh JS,Weck M,Pine DJ

更新日期：2015-06-16 00:00:00

abstract：:Closed timelike curves are striking predictions of general relativity allowing for time-travel. They are afflicted by notorious causality issues (e.g. grandfather's paradox). Quantum models where a qubit travels back in time solve these problems, at the cost of violating quantum theory's linearity-leading e.g. to univ...

journal_title：Nature communications

authors： Marletto C,Vedral V,Virzì S,Rebufello E,Avella A,Piacentini F,Gramegna M,Degiovanni IP,Genovese M

更新日期：2019-01-14 00:00:00

abstract：:Single impurities with nonzero spin and multiple ground states offer a degree of freedom that can be utilized to store the quantum information. However, Fe(2+) dopant is known for having a single nondegenerate ground state in the bulk host semiconductors and thus is of little use for spintronic applications. Here we s...

journal_title：Nature communications

authors： Smoleński T,Kazimierczuk T,Kobak J,Goryca M,Golnik A,Kossacki P,Pacuski W

更新日期：2016-01-28 00:00:00

abstract：:The ever-increasing demand for flexible electronics calls for the development of low-voltage and high-mobility organic thin-film transistors (OTFTs) that can be integrated into emerging display and labeling technologies. Polymer dielectrics with comprehensive and balanced dielectric properties (i.e., a good balance be...

journal_title：Nature communications

authors： Ji D,Li T,Zou Y,Chu M,Zhou K,Liu J,Tian G,Zhang Z,Zhang X,Li L,Wu D,Dong H,Miao Q,Fuchs H,Hu W

更新日期：2018-06-14 00:00:00

abstract：:Organic conjugated polymers demonstrate great potential in transistors, solar cells and light-emitting diodes, whose performances are fundamentally governed by charge transport. However, the morphology-property relationships and the underpinning charge transport mechanisms remain unclear. Particularly, whether the non...

journal_title：Nature communications

authors： Wang J,Niu J,Shao B,Yang G,Lu C,Li M,Zhou Z,Chuai X,Chen J,Lu N,Huang B,Wang Y,Li L,Liu M

更新日期：2021-01-04 00:00:00

abstract：:Hydride transfers play a crucial role in a multitude of biological redox reactions and are mediated by flavin, deazaflavin or nicotinamide adenine dinucleotide cofactors at standard redox potentials ranging from 0 to -340 mV. 2-Naphthoyl-CoA reductase, a key enzyme of oxygen-independent bacterial naphthalene degradati...

journal_title：Nature communications

authors： Willistein M,Bechtel DF,Müller CS,Demmer U,Heimann L,Kayastha K,Schünemann V,Pierik AJ,Ullmann GM,Ermler U,Boll M

更新日期：2019-05-06 00:00:00

abstract：:Transcriptome-wide association studies integrate gene expression data with common risk variation to identify gene-trait associations. By incorporating epigenome data to estimate the functional importance of genetic variation on gene expression, we generate a small but significant improvement in the accuracy of transcr...

journal_title：Nature communications

authors： Zhang W,Voloudakis G,Rajagopal VM,Readhead B,Dudley JT,Schadt EE,Björkegren JLM,Kim Y,Fullard JF,Hoffman GE,Roussos P

更新日期：2019-08-23 00:00:00

abstract：:Turn-on fluorescence imaging is routinely studied; however, turn-on chemiluminescence has been rarely explored for in vivo imaging. Herein, we report the design and validation of chemiluminescence probe ADLumin-1 as a turn-on probe for amyloid beta (Aβ) species. Two-photon imaging indicates that ADLumin-1 can efficien...

journal_title：Nature communications

authors： Yang J,Yin W,Van R,Yin K,Wang P,Zheng C,Zhu B,Ran K,Zhang C,Kumar M,Shao Y,Ran C

更新日期：2020-08-13 00:00:00

abstract：:The practices of synthetic biology are being integrated into 'multiscale' designs enabling two-way communication across organic and inorganic information substrates in biological, digital and cyber-physical system integrations. Novel applications of 'bio-informational' engineering will arise in environmental monitorin...

journal_title：Nature communications

authors： Dixon TA,Williams TC,Pretorius IS

更新日期：2021-01-15 00:00:00

abstract：:The cytosolic antibody receptor TRIM21 possesses unique ubiquitination activity that drives broad-spectrum anti-pathogen targeting and underpins the protein depletion technology Trim-Away. This activity is dependent on formation of self-anchored, K63-linked ubiquitin chains by the heterodimeric E2 enzyme Ube2N/Ube2V2....

journal_title：Nature communications

authors： Kiss L,Zeng J,Dickson CF,Mallery DL,Yang JC,McLaughlin SH,Boland A,Neuhaus D,James LC

更新日期：2019-10-03 00:00:00

abstract：:N-Methyl-D-aspartate receptors (NMDARs) play critical roles in the central nervous system. Their heterotetrameric composition generates subtypes with distinct functional properties and spatio-temporal distribution in the brain, raising the possibility for subtype-specific targeting by pharmacological means for treatme...

journal_title：Nature communications

authors： Wang JX,Irvine MW,Burnell ES,Sapkota K,Thatcher RJ,Li M,Simorowski N,Volianskis A,Collingridge GL,Monaghan DT,Jane DE,Furukawa H

更新日期：2020-01-22 00:00:00

abstract：:The fields of soft polymers and macromolecular sciences have enjoyed a unique combination of metals and organic frameworks in the name of metallopolymers or organometallic polymers. When metallopolymers carry charged groups, they form a class of metal-containing polyelectrolytes or metallo-polyelectrolytes. This revie...

journal_title：Nature communications

authors： Zhu T,Sha Y,Yan J,Pageni P,Rahman MA,Yan Y,Tang C

更新日期：2018-10-18 00:00:00

abstract：:Topological insulators interacting with magnetic impurities have been reported to host several unconventional effects. These phenomena are described within the framework of gapping Dirac quasiparticles due to broken time-reversal symmetry. However, the overwhelming majority of studies demonstrate the presence of a fin...

journal_title：Nature communications

authors： Sessi P,Biswas RR,Bathon T,Storz O,Wilfert S,Barla A,Kokh KA,Tereshchenko OE,Fauth K,Bode M,Balatsky AV

更新日期：2016-06-27 00:00:00

abstract：:The demand for highly scalable, low-power devices for data storage and logic operations is strongly stimulating research into resistive switching as a novel concept for future non-volatile memory devices. To meet technological requirements, it is imperative to have a set of material design rules based on fundamental m...

journal_title：Nature communications

authors： Baeumer C,Schmitz C,Ramadan AH,Du H,Skaja K,Feyer V,Müller P,Arndt B,Jia CL,Mayer J,De Souza RA,Michael Schneider C,Waser R,Dittmann R

更新日期：2015-10-19 00:00:00