Copolymer dielectrics with balanced chain-packing density and surface polarity for high-performance flexible organic electronics.

abstract：:A major conundrum in climate science is how to account for dependence between climate models. This complicates interpretation of probabilistic projections derived from such models. Here we show that this problem can be addressed using a novel method to test multiple non-exclusive hypotheses, and to make predictions un...

journal_title：Nature communications

authors： Olson R,An SI,Fan Y,Chang W,Evans JP,Lee JY

更新日期：2019-07-09 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Hermoso-Mendizabal A,Hyafil A,Rueda-Orozco PE,Jaramillo S,Robbe D,de la Rocha J

更新日期：2020-07-07 00:00:00

abstract：:The use of hyperpolarized agents in magnetic resonance, such as (13)C-labelled compounds, enables powerful new imaging and detection modalities that stem from a 10,000-fold boost in signal. A major challenge for the future of the hyperpolarization technique is the inherently short spin-relaxation times, typically <60 ...

journal_title：Nature communications

authors： Rej E,Gaebel T,Boele T,Waddington DE,Reilly DJ

更新日期：2015-10-09 00:00:00

abstract：:Idiopathic scoliosis (IS) is a common paediatric musculoskeletal disease that displays a strong female bias. By performing a genome-wide association study (GWAS) of 3,102 individuals, we identify significant associations with 20p11.22 SNPs for females (P=6.89 × 10(-9)) but not males (P=0.71). This association with IS ...

journal_title：Nature communications

authors： Sharma S,Londono D,Eckalbar WL,Gao X,Zhang D,Mauldin K,Kou I,Takahashi A,Matsumoto M,Kamiya N,Murphy KK,Cornelia R,TSRHC Scoliosis Clinical Group.,Japan Scoliosis Clinical Research Group.,Herring JA,Burns D,Ahituv N,Ike

更新日期：2015-03-18 00:00:00

abstract：:The cellular and molecular basis of stromal cell recruitment, activation and crosstalk in carcinomas is poorly understood, limiting the development of targeted anti-stromal therapies. In mouse models of triple negative breast cancer (TNBC), Hedgehog ligand produced by neoplastic cells reprograms cancer-associated fibr...

journal_title：Nature communications

authors： Cazet AS,Hui MN,Elsworth BL,Wu SZ,Roden D,Chan CL,Skhinas JN,Collot R,Yang J,Harvey K,Johan MZ,Cooper C,Nair R,Herrmann D,McFarland A,Deng N,Ruiz-Borrego M,Rojo F,Trigo JM,Bezares S,Caballero R,Lim E,Timpson P

更新日期：2018-07-24 00:00:00

abstract：:Despite the global impact of macrophage activation in vascular disease, the underlying mechanisms remain obscure. Here we show, with global proteomic analysis of macrophage cell lines treated with either IFNγ or IL-4, that PARP9 and PARP14 regulate macrophage activation. In primary macrophages, PARP9 and PARP14 have o...

journal_title：Nature communications

authors： Iwata H,Goettsch C,Sharma A,Ricchiuto P,Goh WW,Halu A,Yamada I,Yoshida H,Hara T,Wei M,Inoue N,Fukuda D,Mojcher A,Mattson PC,Barabási AL,Boothby M,Aikawa E,Singh SA,Aikawa M

更新日期：2016-10-31 00:00:00

abstract：:Base editing tools with diversified editing scopes and minimized RNA off-target activities are required for broad applications. Nevertheless, current Streptococcus pyogenes Cas9 (SpCas9)-based adenine base editors (ABEs) with minimized RNA off-target activities display constrained editing scopes with efficient editing...

journal_title：Nature communications

authors： Li S,Yuan B,Cao J,Chen J,Chen J,Qiu J,Zhao XM,Wang X,Qiu Z,Cheng TL

更新日期：2020-11-17 00:00:00

abstract：:According to the clonal evolution model, tumour growth is driven by competing subclones in somatically evolving cancer cell populations, which gives rise to genetically heterogeneous tumours. Here we present a comparative targeted deep-sequencing approach combined with a customised statistical algorithm, called deepSN...

journal_title：Nature communications

authors： Gerstung M,Beisel C,Rechsteiner M,Wild P,Schraml P,Moch H,Beerenwinkel N

更新日期：2012-05-01 00:00:00

abstract：:Direct reprogramming of fibroblasts into cardiomyocytes by forced expression of cardiomyogenic factors, GMT (GATA4, Mef2C, Tbx5) or GHMT (GATA4, Hand2, Mef2C, Tbx5), has recently been demonstrated, suggesting a novel therapeutic strategy for cardiac repair. However, current approaches are inefficient. Here we demonstr...

journal_title：Nature communications

authors： Zhao Y,Londono P,Cao Y,Sharpe EJ,Proenza C,O'Rourke R,Jones KL,Jeong MY,Walker LA,Buttrick PM,McKinsey TA,Song K

更新日期：2015-09-10 00:00:00

abstract：:Exaggerated cranial structures such as crests and horns, hereafter referred to collectively as ornaments, are pervasive across animal species. These structures perform vital roles in visual communication and physical interactions within and between species. Yet the origin and influence of ornamentation on speciation a...

journal_title：Nature communications

authors： Gates TA,Organ C,Zanno LE

更新日期：2016-09-27 00:00:00

abstract：:Conventional interferometers usually utilize beam splitters for wave splitting and recombination. These interferometers are widely used for precision measurement. Their sensitivity for phase measurement is limited by the shot noise, which can be suppressed with squeezed states of light. Here we study a new type of int...

journal_title：Nature communications

authors： Hudelist F,Kong J,Liu C,Jing J,Ou ZY,Zhang W

更新日期：2014-01-01 00:00:00

abstract：:Type 2 diabetes (T2D) results from the combined effects of genetic and environmental factors on multiple tissues over time. Of the >100 variants associated with T2D and related traits in genome-wide association studies (GWAS), >90% occur in non-coding regions, suggesting a strong regulatory component to T2D risk. Here...

journal_title：Nature communications

authors： Scott LJ,Erdos MR,Huyghe JR,Welch RP,Beck AT,Wolford BN,Chines PS,Didion JP,Narisu N,Stringham HM,Taylor DL,Jackson AU,Vadlamudi S,Bonnycastle LL,Kinnunen L,Saramies J,Sundvall J,Albanus RD,Kiseleva A,Hensley J,Cr

更新日期：2016-06-29 00:00:00

abstract：:Trigonal tellurium (Te) is a chiral semiconductor that lacks both mirror and inversion symmetries, resulting in complex band structures with Weyl crossings and unique spin textures. Detailed time-resolved polarized reflectance spectroscopy is used to investigate its band structure and carrier dynamics. The polarized t...

journal_title：Nature communications

authors： Jnawali G,Xiang Y,Linser SM,Shojaei IA,Wang R,Qiu G,Lian C,Wong BM,Wu W,Ye PD,Leng Y,Jackson HE,Smith LM

更新日期：2020-08-10 00:00:00

abstract：:Plants can produce organs throughout their entire life from pluripotent stem cells located at their growing tip, the shoot apical meristem (SAM). At the time of flowering, the SAM of Arabidopsis thaliana switches fate and starts producing flowers instead of leaves. Correct timing of flowering in part determines reprod...

journal_title：Nature communications

authors： You Y,Sawikowska A,Neumann M,Posé D,Capovilla G,Langenecker T,Neher RA,Krajewski P,Schmid M

更新日期：2017-05-17 00:00:00

abstract：:Two-dimensional atomic crystals, such as two-dimensional oxides, have attracted much attention in energy storage because nearly all of the atoms can be exposed to the electrolyte and involved in redox reactions. However, current strategies are largely limited to intrinsically layered compounds. Here we report a genera...

journal_title：Nature communications

authors： Xiao X,Song H,Lin S,Zhou Y,Zhan X,Hu Z,Zhang Q,Sun J,Yang B,Li T,Jiao L,Zhou J,Tang J,Gogotsi Y

更新日期：2016-04-22 00:00:00

abstract：:Secondary multidrug transporters use ion concentration gradients to energize the removal from cells of various antibiotics. The Escherichia coli multidrug transporter MdfA exchanges a single proton with a single monovalent cationic drug molecule. This stoichiometry renders the efflux of divalent cationic drugs energet...

journal_title：Nature communications

authors： Fluman N,Adler J,Rotenberg SA,Brown MH,Bibi E

更新日期：2014-08-08 00:00:00

abstract：:Message RNA poly(A) tails are vital for their function and regulation. However, the full-length sequence of mRNA isoforms with their poly(A) tails remains undetermined. Here, we develop a method at single-cell level sensitivity that enables quantification of poly(A) tails along with the full-length cDNA while reading ...

journal_title：Nature communications

authors： Liu Y,Nie H,Liu H,Lu F

更新日期：2019-11-22 00:00:00

abstract：:All common genome-wide association (GWA) methods rely on population structure correction, to avoid false genotype-to-phenotype associations. However, population structure correction is a stringent penalization, which also impedes identification of real associations. Using recent statistical advances, we developed a ne...

journal_title：Nature communications

authors： Klasen JR,Barbez E,Meier L,Meinshausen N,Bühlmann P,Koornneef M,Busch W,Schneeberger K

更新日期：2016-11-10 00:00:00

abstract：:The superconducting state is formed by the condensation of Cooper pairs and protected by the superconducting gap. The pairing interaction between the two electrons of a Cooper pair determines the gap function. Thus, it is pivotal to detect the gap structure for understanding the mechanism of superconductivity. In cupr...

journal_title：Nature communications

authors： Gu Q,Wan S,Tang Q,Du Z,Yang H,Wang QH,Zhong R,Wen J,Gu GD,Wen HH

更新日期：2019-04-08 00:00:00

abstract：:Polymorphism is a remarkable concept in chemistry, materials science, computer science, and biology. Whether it is the ability of a material to exist in two or more crystal structures, a single interface connecting to two different entities, or alternative phenotypes of an organism, polymorphism determines function an...

journal_title：Nature communications

authors： Li L,Salamończyk M,Shadpour S,Zhu C,Jákli A,Hegmann T

更新日期：2018-02-19 00:00:00

abstract：:Patterns in biomass production are determined by resource input (productivity) and trophic transfer efficiency. At fixed resource input, variation in consumer biomass production has been related to food quality, metabolic type and diversity among species. In contrast, intraspecific variation in individual body size be...

journal_title：Nature communications

authors： Reichstein B,Persson L,De Roos AM

更新日期：2015-03-04 00:00:00

abstract：:Autoantibodies have been associated with autoimmune diseases. However, studies have identified autoantibodies in healthy donors (HD) who do not develop autoimmune disorders. Here we provide evidence of a network of immunoglobulin G (IgG) autoantibodies targeting G protein-coupled receptors (GPCR) in HD compared to pat...

journal_title：Nature communications

authors： Cabral-Marques O,Marques A,Giil LM,De Vito R,Rademacher J,Günther J,Lange T,Humrich JY,Klapa S,Schinke S,Schimke LF,Marschner G,Pitann S,Adler S,Dechend R,Müller DN,Braicu I,Sehouli J,Schulze-Forster K,Trippel T,S

更新日期：2018-12-06 00:00:00

abstract：:While engineering the phase and structure of electrocatalysts could regulate the performance of many typical electrochemical processes, its importance to the carbon dioxide electroreduction has been largely unexplored. Herein, a series of phase and structure engineered copper-tin dioxide catalysts have been created an...

journal_title：Nature communications

authors： Wang P,Qiao M,Shao Q,Pi Y,Zhu X,Li Y,Huang X

更新日期：2018-11-22 00:00:00

abstract：:Robust surveillance methods are needed for trachoma control and recrudescence monitoring, but existing methods have limitations. Here, we analyse data from nine trachoma-endemic populations and provide operational thresholds for interpretation of serological data in low-transmission and post-elimination settings. Anal...

journal_title：Nature communications

authors： Pinsent A,Solomon AW,Bailey RL,Bid R,Cama A,Dean D,Goodhew B,Gwyn SE,Jack KR,Kandel RP,Kama M,Massae P,Macleod C,Mabey DCW,Migchelsen S,Müller A,Sandi F,Sokana O,Taoaba R,Tekeraoi R,Martin DL,White MT

更新日期：2018-12-21 00:00:00

abstract：:Neurodegenerative diseases like Alzheimer's disease, Parkinson's disease and Huntington's disease manifest with the neuronal accumulation of toxic proteins. Since autophagy upregulation enhances the clearance of such proteins and ameliorates their toxicities in animal models, we and others have sought to re-position/r...

journal_title：Nature communications

authors： Siddiqi FH,Menzies FM,Lopez A,Stamatakou E,Karabiyik C,Ureshino R,Ricketts T,Jimenez-Sanchez M,Esteban MA,Lai L,Tortorella MD,Luo Z,Liu H,Metzakopian E,Fernandes HJR,Bassett A,Karran E,Miller BL,Fleming A,Rubinsztei

更新日期：2019-04-18 00:00:00

abstract：:Artificial molecules containing just one or two electrons provide a powerful platform for studies of orbital and spin quantum dynamics in nanoscale devices. A well-known example of these dynamics is tunnelling of electrons between two coupled quantum dots triggered by mi...

journal_title：Nature communications

authors： Schreiber LR,Braakman FR,Meunier T,Calado V,Danon J,Taylor JM,Wegscheider W,Vandersypen LM

更新日期：2011-11-22 00:00:00

abstract：:Electric gating can strongly modulate a wide variety of physical properties in semiconductors and insulators, such as significant changes of conductivity in silicon, appearance of superconductivity in SrTiO3, the paramagnet-ferromagnet transition in (In,Mn)As, and so on. The key to such modulation is charge accumulati...

journal_title：Nature communications

authors： Dushenko S,Hokazono M,Nakamura K,Ando Y,Shinjo T,Shiraishi M

更新日期：2018-08-07 00:00:00

abstract：:14-3-3 family proteins regulate multiple signalling pathways. Understanding biological functions of 14-3-3 proteins has been limited by the functional redundancy of conserved isotypes. Here we provide evidence that 14-3-3 proteins regulate two interacting components of Tor signalling in Drosophila, translationally con...

journal_title：Nature communications

authors： Le TP,Vuong LT,Kim AR,Hsu YC,Choi KW

更新日期：2016-05-06 00:00:00

abstract：:Soft particulate media include a wide range of systems involving athermal dissipative particles both in non-living and biological materials. Characterization of flows of particulate media is of great practical and theoretical importance. A fascinating feature of these systems is the existence of a critical rigidity tr...

journal_title：Nature communications

authors： Rahbari SHE,Saberi AA,Park H,Vollmer J

更新日期：2017-04-10 00:00:00

abstract：:In certain regions of the predominantly nitrogen limited ocean, microbes can become co-limited by phosphorus. Within such regions, a proportion of the dissolved organic phosphorus pool can be accessed by microbes employing a variety of alkaline phosphatase (APase) enzymes. In contrast to the PhoA family of APases that...

journal_title：Nature communications

authors： Browning TJ,Achterberg EP,Yong JC,Rapp I,Utermann C,Engel A,Moore CM

更新日期：2017-05-19 00:00:00