Hyperpolarized nanodiamond with long spin-relaxation times.

Abstract:

:The use of hyperpolarized agents in magnetic resonance, such as (13)C-labelled compounds, enables powerful new imaging and detection modalities that stem from a 10,000-fold boost in signal. A major challenge for the future of the hyperpolarization technique is the inherently short spin-relaxation times, typically <60 s for (13)C liquid-state compounds, which limit the time that the signal remains boosted. Here we demonstrate that 1.1% natural abundance (13)C spins in synthetic nanodiamond can be hyperpolarized at cryogenic and room temperature without the use of free radicals, and, owing to their solid-state environment, exhibit relaxation times exceeding 1 h. Combined with the already established applications of nanodiamonds in the life sciences as inexpensive fluorescent markers and non-cytotoxic substrates for gene and drug delivery, these results extend the theranostic capabilities of nanoscale diamonds into the domain of hyperpolarized magnetic resonance.

journal_name

Nat Commun

journal_title

Nature communications

authors

Rej E,Gaebel T,Boele T,Waddington DE,Reilly DJ

doi

10.1038/ncomms9459

subject

Has Abstract

pub_date

2015-10-09 00:00:00

pages

8459

issn

2041-1723

pii

ncomms9459

journal_volume

6

pub_type

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