当前位置： SCI文献检索 > Nature Communications期刊下所有文献 > Single-cell RNA sequencing highlights the role of inflammatory cancer-associated fibroblasts in bladder urothelial carcinoma.

Single-cell RNA sequencing highlights the role of inflammatory cancer-associated fibroblasts in bladder urothelial carcinoma.

Abstract：

:Although substantial progress has been made in cancer biology and treatment, clinical outcomes of bladder carcinoma (BC) patients are still not satisfactory. The tumor microenvironment (TME) is a potential target. Here, by single-cell RNA sequencing on 8 BC tumor samples and 3 para tumor samples, we identify 19 different cell types in the BC microenvironment, indicating high intra-tumoral heterogeneity. We find that tumor cells down regulated MHC-II molecules, suggesting that the downregulated immunogenicity of cancer cells may contribute to the formation of an immunosuppressive microenvironment. We also find that monocytes undergo M2 polarization in the tumor region and differentiate. Furthermore, the LAMP3 + DC subgroup may be able to recruit regulatory T cells, potentially taking part in the formation of an immunosuppressive TME. Through correlation analysis using public datasets containing over 3000 BC samples, we identify a role for inflammatory cancer-associated fibroblasts (iCAFs) in tumor progression, which is significantly related to poor prognosis. Additionally, we characterize a regulatory network depending on iCAFs. These results could help elucidate the protumor mechanisms of iCAFs. Our results provide deep insight into cancer immunology and provide an essential resource for drug discovery in the future.

journal_name

Nat Commun

journal_title

Nature communications

authors

Chen Z,Zhou L,Liu L,Hou Y,Xiong M,Yang Y,Hu J,Chen K

doi

10.1038/s41467-020-18916-5

subject

Has Abstract

pub_date

2020-10-08 00:00:00

pages

5077

issue

1

issn

2041-1723

pii

10.1038/s41467-020-18916-5

journal_volume

11

pub_type

杂志文章

相关文献

Nature Communications文献大全
  • Centromeric binding and activity of Protein Phosphatase 4.

    abstract：:The cell division cycle requires tight coupling between protein phosphorylation and dephosphorylation. However, understanding the cell cycle roles of multimeric protein phosphatases has been limited by the lack of knowledge of how their diverse regulatory subunits target highly conserved catalytic subunits to their si...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms6894

    authors： Lipinszki Z,Lefevre S,Savoian MS,Singleton MR,Glover DM,Przewloka MR

    更新日期：2015-01-06 00:00:00

  • A novel method to test non-exclusive hypotheses applied to Arctic ice projections from dependent models.

    abstract：:A major conundrum in climate science is how to account for dependence between climate models. This complicates interpretation of probabilistic projections derived from such models. Here we show that this problem can be addressed using a novel method to test multiple non-exclusive hypotheses, and to make predictions un...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-10561-x

    authors： Olson R,An SI,Fan Y,Chang W,Evans JP,Lee JY

    更新日期：2019-07-09 00:00:00

  • DNA barcoding reveals diverse growth kinetics of human breast tumour subclones in serially passaged xenografts.

    abstract：:Genomic and phenotypic analyses indicate extensive intra- as well as intertumoral heterogeneity in primary human malignant cell populations despite their clonal origin. Cellular DNA barcoding offers a powerful and unbiased alternative to track the number and size of multiple subclones within a single human tumour xeno...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms6871

    authors： Nguyen LV,Cox CL,Eirew P,Knapp DJ,Pellacani D,Kannan N,Carles A,Moksa M,Balani S,Shah S,Hirst M,Aparicio S,Eaves CJ

    更新日期：2014-12-23 00:00:00

  • Platelets reduce anoikis and promote metastasis by activating YAP1 signaling.

    abstract：:Thrombocytosis is present in more than 30% of patients with solid malignancies and correlates with worsened patient survival. Tumor cell interaction with various cellular components of the tumor microenvironment including platelets is crucial for tumor growth and metastasis. Although it is known that platelets can inf...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-00411-z

    authors： Haemmerle M,Taylor ML,Gutschner T,Pradeep S,Cho MS,Sheng J,Lyons YM,Nagaraja AS,Dood RL,Wen Y,Mangala LS,Hansen JM,Rupaimoole R,Gharpure KM,Rodriguez-Aguayo C,Yim SY,Lee JS,Ivan C,Hu W,Lopez-Berestein G,Wong ST,

    更新日期：2017-08-21 00:00:00

  • Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration.

    abstract：:Tissue injury and the healing response lead to the release of endogenous danger signals including Toll-like receptor (TLR) and interleukin-1 receptor, type 1 (IL-1R1) ligands, which modulate the immune microenvironment. Because TLRs and IL-1R1 have been shown to influence the repair process of various tissues, we expl...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms11051

    authors： Martino MM,Maruyama K,Kuhn GA,Satoh T,Takeuchi O,Müller R,Akira S

    更新日期：2016-03-22 00:00:00

  • Demonstration of a positron beam-driven hollow channel plasma wakefield accelerator.

    abstract：:Plasma wakefield accelerators have been used to accelerate electron and positron particle beams with gradients that are orders of magnitude larger than those achieved in conventional accelerators. In addition to being accelerated by the plasma wakefield, the beam particles also experience strong transverse forces that...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms11785

    authors： Gessner S,Adli E,Allen JM,An W,Clarke CI,Clayton CE,Corde S,Delahaye JP,Frederico J,Green SZ,Hast C,Hogan MJ,Joshi C,Lindstrøm CA,Lipkowitz N,Litos M,Lu W,Marsh KA,Mori WB,O'Shea B,Vafaei-Najafabadi N,Walz D,Y

    更新日期：2016-06-02 00:00:00

  • Continental shelves as a variable but increasing global sink for atmospheric carbon dioxide.

    abstract：:It has been speculated that the partial pressure of carbon dioxide (pCO2) in shelf waters may lag the rise in atmospheric CO2. Here, we show that this is the case across many shelf regions, implying a tendency for enhanced shelf uptake of atmospheric CO2. This result is based on analysis of long-term trends in the air...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-02738-z

    authors： Laruelle GG,Cai WJ,Hu X,Gruber N,Mackenzie FT,Regnier P

    更新日期：2018-01-31 00:00:00

  • CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity.

    abstract：:Adoptive immunotherapy using chimeric antigen receptor (CAR) expressing T cells targeting the CD19 B lineage receptor has demonstrated marked success in relapsed pre-B-cell acute lymphoblastic leukaemia (ALL). Persisting CAR-T cells generate sustained pressure against CD19 that may drive unique mechanisms of resistanc...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms12320

    authors： Jacoby E,Nguyen SM,Fountaine TJ,Welp K,Gryder B,Qin H,Yang Y,Chien CD,Seif AE,Lei H,Song YK,Khan J,Lee DW,Mackall CL,Gardner RA,Jensen MC,Shern JF,Fry TJ

    更新日期：2016-07-27 00:00:00

  • Dehydrative π-extension to nanographenes with zig-zag edges.

    abstract：:Zig-zag nanographenes are promising candidates for the applications in organic electronics due to the electronic properties induced by their periphery. However, the synthetic access to these compounds remains virtually unexplored. There is a lack in efficient and mild strategies origins in the reduced stability, incre...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-07095-z

    authors： Lungerich D,Papaianina O,Feofanov M,Liu J,Devarajulu M,Troyanov SI,Maier S,Amsharov K

    更新日期：2018-11-12 00:00:00

  • SMPDL3b modulates insulin receptor signaling in diabetic kidney disease.

    abstract：:Sphingomyelin phosphodiesterase acid-like 3b (SMPDL3b) is a lipid raft enzyme that regulates plasma membrane (PM) fluidity. Here we report that SMPDL3b excess, as observed in podocytes in diabetic kidney disease (DKD), impairs insulin receptor isoform B-dependent pro-survival insulin signaling by interfering with insu...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-10584-4

    authors： Mitrofanova A,Mallela SK,Ducasa GM,Yoo TH,Rosenfeld-Gur E,Zelnik ID,Molina J,Varona Santos J,Ge M,Sloan A,Kim JJ,Pedigo C,Bryn J,Volosenco I,Faul C,Zeidan YH,Garcia Hernandez C,Mendez AJ,Leibiger I,Burke GW,Futerm

    更新日期：2019-06-19 00:00:00

  • A shift in glutamine nitrogen metabolism contributes to the malignant progression of cancer.

    abstract：:Glucose metabolism is remodeled in cancer, but the global pattern of cancer-specific metabolic changes remains unclear. Here we show, using the comprehensive measurement of metabolic enzymes by large-scale targeted proteomics, that the metabolism both carbon and nitrogen is altered during the malignant progression of ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-15136-9

    authors： Kodama M,Oshikawa K,Shimizu H,Yoshioka S,Takahashi M,Izumi Y,Bamba T,Tateishi C,Tomonaga T,Matsumoto M,Nakayama KI

    更新日期：2020-03-17 00:00:00

  • Truly work-like work extraction via a single-shot analysis.

    abstract：:The work content of non-equilibrium systems in relation to a heat bath is often analysed in terms of expectation values of an underlying random work variable. However, when optimizing the expectation value of the extracted work, the resulting extraction process is subject to intrinsic fluctuations, uniquely determined...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms2712

    authors： Aberg J

    更新日期：2013-01-01 00:00:00

  • TruePrime is a novel method for whole-genome amplification from single cells based on TthPrimPol.

    abstract：:Sequencing of a single-cell genome requires DNA amplification, a process prone to introducing bias and errors into the amplified genome. Here we introduce a novel multiple displacement amplification (MDA) method based on the unique DNA primase features of Thermus thermophilus (Tth) PrimPol. TthPrimPol displays a poten...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms13296

    authors： Picher ÁJ,Budeus B,Wafzig O,Krüger C,García-Gómez S,Martínez-Jiménez MI,Díaz-Talavera A,Weber D,Blanco L,Schneider A

    更新日期：2016-11-29 00:00:00

  • In situ conversion of defective Treg into SuperTreg cells to treat advanced IPEX-like disorders in mice.

    abstract：:Mutations disrupting regulatory T (Treg) cell function can cause IPEX and IPEX-related disorders, but whether established disease can be reversed by correcting these mutations is unclear. Treg-specific deletion of the chromatin remodeling factor Brg1 impairs Treg cell activation and causes fatal autoimmunity in mice. ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-15836-2

    authors： Li Y,Chen Y,Mao S,Kaundal R,Jing Z,Chen Q,Wang X,Xia J,Liu D,Sun J,Wang H,Chi T

    更新日期：2020-06-03 00:00:00

  • A number-based inventory of size-resolved black carbon particle emissions by global civil aviation.

    abstract：:With the rapidly growing global air traffic, the impacts of the black carbon (BC) in the aviation exhaust on climate, environment and public health are likely rising. The particle number and size distribution are crucial metrics for toxicological analysis and aerosol-cloud interactions. Here, a size-resolved BC partic...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-08491-9

    authors： Zhang X,Chen X,Wang J

    更新日期：2019-02-01 00:00:00

  • Predictors of responses to immune checkpoint blockade in advanced melanoma.

    abstract：:Immune checkpoint blockers (ICB) have become pivotal therapies in the clinical armamentarium against metastatic melanoma (MMel). Given the frequency of immune related adverse events and increasing use of ICB, predictors of response to CTLA-4 and/or PD-1 blockade represent unmet clinical needs. Using a systems biology-...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-00608-2

    authors： Jacquelot N,Roberti MP,Enot DP,Rusakiewicz S,Ternès N,Jegou S,Woods DM,Sodré AL,Hansen M,Meirow Y,Sade-Feldman M,Burra A,Kwek SS,Flament C,Messaoudene M,Duong CPM,Chen L,Kwon BS,Anderson AC,Kuchroo VK,Weide B,Au

    更新日期：2017-09-19 00:00:00

  • O-GlcNAcylation of PGK1 coordinates glycolysis and TCA cycle to promote tumor growth.

    abstract：:Many cancer cells display enhanced glycolysis and suppressed mitochondrial metabolism. This phenomenon, known as the Warburg effect, is critical for tumor development. However, how cancer cells coordinate glucose metabolism through glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle is largely unknown. We ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-13601-8

    authors： Nie H,Ju H,Fan J,Shi X,Cheng Y,Cang X,Zheng Z,Duan X,Yi W

    更新日期：2020-01-07 00:00:00

  • Monolayer surface chemistry enables 2-colour single molecule localisation microscopy of adhesive ligands and adhesion proteins.

    abstract：:Nanofabricated and nanopatterned surfaces have revealed the sensitivity of cell adhesion to nanoscale variations in the spacing of adhesive ligands such as the tripeptide arginine-glycine-aspartic acid (RGD). To date, surface characterisation and cell adhesion are often examined in two separate experiments so that the...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-05837-7

    authors： Lu X,Nicovich PR,Zhao M,Nieves DJ,Mollazade M,Vivekchand SRC,Gaus K,Gooding JJ

    更新日期：2018-08-20 00:00:00

  • Therapeutic faecal microbiota transplantation controls intestinal inflammation through IL10 secretion by immune cells.

    abstract：:Alteration of the gut microbiota has been associated with different gastrointestinal disorders. Normobiosis restoration by faecal microbiota transplantation (FMT) is considered a promising therapeutic approach, even if the mechanisms underlying its efficacy are at present largely unknown. Here we sought to elucidate t...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-07359-8

    authors： Burrello C,Garavaglia F,Cribiù FM,Ercoli G,Lopez G,Troisi J,Colucci A,Guglietta S,Carloni S,Guglielmetti S,Taverniti V,Nizzoli G,Bosari S,Caprioli F,Rescigno M,Facciotti F

    更新日期：2018-12-05 00:00:00

  • Free choice shapes normalized value signals in medial orbitofrontal cortex.

    abstract：:Normalization is a common cortical computation widely observed in sensory perception, but its importance in perception of reward value and decision making remains largely unknown. We examined (1) whether normalized value signals occur in the orbitofrontal cortex (OFC) and (2) whether changes in behavioral task context...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-02614-w

    authors： Yamada H,Louie K,Tymula A,Glimcher PW

    更新日期：2018-01-11 00:00:00

  • Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci.

    abstract：:Hedgehog (Hh) signalling regulates embryonic development and adult tissue homoeostasis. Mutations of its pathway components including Suppressor of Fused (Sufu) and Gli/Ci predispose to cancers and congenital anomalies. The Sufu-Gli protein complex occupies a central position in the vertebrate Hh signalling pathway, e...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms3608

    authors： Zhang Y,Fu L,Qi X,Zhang Z,Xia Y,Jia J,Jiang J,Zhao Y,Wu G

    更新日期：2013-01-01 00:00:00

  • A chromosome-scale assembly of the sorghum genome using nanopore sequencing and optical mapping.

    abstract：:Long-read sequencing technologies have greatly facilitated assemblies of large eukaryotic genomes. In this paper, Oxford Nanopore sequences generated on a MinION sequencer are combined with Bionano Genomics Direct Label and Stain (DLS) optical maps to generate a chromosome-scale de novo assembly of the repeat-rich Sor...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-07271-1

    authors： Deschamps S,Zhang Y,Llaca V,Ye L,Sanyal A,King M,May G,Lin H

    更新日期：2018-11-19 00:00:00

  • Addendum: Precise tuning of gene expression levels in mammalian cells.

    abstract：:Following re-sequencing of the miSFIT constructs used in the paper, two of the construct variants inserted into the 3'UTR of PD-1, namely '12C' and '17A, 18G', have been found to contain additional insertions not present in the other construct variants. The data points corresponding to these constructs in Figs. 2c, f ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-10615-0

    authors： Michaels YS,Barnkob MB,Barbosa H,Baeumler TA,Thompson MK,Andre V,Colin-York H,Fritzsche M,Gileadi U,Sheppard HM,Knapp DJHF,Milne TA,Cerundolo V,Fulga TA

    更新日期：2019-06-10 00:00:00

  • Publisher Correction: A square-root topological insulator with non-quantized indices realized with photonic Aharonov-Bohm cages.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Nature communications

    pub_type： 已发布勘误

    doi：10.1038/s41467-020-15252-6

    authors： Kremer M,Petrides I,Meyer E,Heinrich M,Zilberberg O,Szameit A

    更新日期：2020-04-08 00:00:00

  • Genome-wide association study identifies variation at 6q25.1 associated with survival in multiple myeloma.

    abstract：:Survival following a diagnosis of multiple myeloma (MM) varies between patients and some of these differences may be a consequence of inherited genetic variation. In this study, to identify genetic markers associated with MM overall survival (MM-OS), we conduct a meta-analysis of four patient series of European ancest...

    journal_title：Nature communications

    pub_type： 杂志文章,meta分析

    doi：10.1038/ncomms10290

    authors： Johnson DC,Weinhold N,Mitchell JS,Chen B,Kaiser M,Begum DB,Hillengass J,Bertsch U,Gregory WA,Cairns D,Jackson GH,Försti A,Nickel J,Hoffmann P,Nöethen MM,Stephens OW,Barlogie B,Davis FE,Hemminki K,Goldschmidt H,Hou

    更新日期：2016-01-08 00:00:00

  • Arabidopsis uses two gluconeogenic gateways for organic acids to fuel seedling establishment.

    abstract：:Gluconeogenesis is a fundamental metabolic process that allows organisms to make sugars from non-carbohydrate stores such as lipids and protein. In eukaryotes only one gluconeogenic route has been described from organic acid intermediates and this relies on the enzyme phosphoenolpyruvate carboxykinase (PCK). Here we s...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms7659

    authors： Eastmond PJ,Astley HM,Parsley K,Aubry S,Williams BP,Menard GN,Craddock CP,Nunes-Nesi A,Fernie AR,Hibberd JM

    更新日期：2015-04-10 00:00:00

  • Bacterial outer membrane proteins assemble via asymmetric interactions with the BamA β-barrel.

    abstract：:The integration of β-barrel proteins into the bacterial outer membrane (OM) is catalysed by the β-barrel assembly machinery (BAM). The central BAM subunit (BamA) itself contains a β-barrel domain that is essential for OM protein biogenesis, but its mechanism of action is unknown. To elucidate its function, here we dev...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-11230-9

    authors： Doyle MT,Bernstein HD

    更新日期：2019-07-26 00:00:00

  • Dawn-dusk asymmetry in the Kelvin-Helmholtz instability at Mercury.

    abstract：:The NASA MErcury Surface, Space ENvironment, GEochemistry and Ranging (MESSENGER) spacecraft entered orbital phase around Mercury on 18 March 2011. A surprising consistent feature in the data returned is large-scale vortices that form exclusively on the dusk side of the magnetosphere. Here we present global kinetic hy...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms2676

    authors： Paral J,Rankin R

    更新日期：2013-01-01 00:00:00

  • Marangoni-driven flower-like patterning of an evaporating drop spreading on a liquid substrate.

    abstract：:Drop motility at liquid surfaces is attracting growing interest because of its potential applications in microfluidics and artificial cell design. Here we report the unique highly ordered pattern that sets in when a millimeter-size drop of dichloromethane spreads on an aqueous substrate under the influence of surface ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-03201-3

    authors： Wodlei F,Sebilleau J,Magnaudet J,Pimienta V

    更新日期：2018-02-26 00:00:00

  • Elevated levels of TRF2 induce telomeric ultrafine anaphase bridges and rapid telomere deletions.

    abstract：:The shelterin protein TRF2 is essential for chromosome-end protection. Depletion of TRF2 causes chromosome end-to-end fusions, initiating genomic instability that can be cancer promoting. Paradoxically, significant increased levels of TRF2 are observed in a subset of human cancers. Experimental overexpression of TRF2 ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms10132

    authors： Nera B,Huang HS,Lai T,Xu L

    更新日期：2015-12-07 00:00:00