Identification of recurrent FHL2-GLI2 oncogenic fusion in sclerosing stromal tumors of the ovary.

abstract：:Mutations disrupting regulatory T (Treg) cell function can cause IPEX and IPEX-related disorders, but whether established disease can be reversed by correcting these mutations is unclear. Treg-specific deletion of the chromatin remodeling factor Brg1 impairs Treg cell activation and causes fatal autoimmunity in mice. ...

journal_title：Nature communications

authors： Li Y,Chen Y,Mao S,Kaundal R,Jing Z,Chen Q,Wang X,Xia J,Liu D,Sun J,Wang H,Chi T

更新日期：2020-06-03 00:00:00

abstract：:Multifactorial mechanisms underlying late-onset Alzheimer's disease (LOAD) are poorly characterized from an integrative perspective. Here spatiotemporal alterations in brain amyloid-β deposition, metabolism, vascular, functional activity at rest, structural properties, cognitive integrity and peripheral proteins level...

journal_title：Nature communications

authors： Iturria-Medina Y,Sotero RC,Toussaint PJ,Mateos-Pérez JM,Evans AC,Alzheimer’s Disease Neuroimaging Initiative.

更新日期：2016-06-21 00:00:00

abstract：:Gemcitabine is the first-line treatment for locally advanced and metastatic gallbladder cancer (GBC), but poor gemcitabine response is universal. Here, we utilize a genome-wide CRISPR screen to identify that loss of ELP5 reduces the gemcitabine-induced apoptosis in GBC cells in a P53-dependent manner through the Elong...

journal_title：Nature communications

authors： Xu S,Zhan M,Jiang C,He M,Yang L,Shen H,Huang S,Huang X,Lin R,Shi Y,Liu Q,Chen W,Mohan M,Wang J

更新日期：2019-12-02 00:00:00

abstract：:Myoblast fusion (MF) is required for muscle growth and repair, and its alteration contributes to muscle diseases. The mechanisms governing this process are incompletely understood, and no epigenetic regulator has been previously described. Ash1L is an epigenetic activator belonging to the Trithorax group of proteins a...

journal_title：Nature communications

authors： Castiglioni I,Caccia R,Garcia-Manteiga JM,Ferri G,Caretti G,Molineris I,Nishioka K,Gabellini D

更新日期：2018-11-28 00:00:00

abstract：:Gamma-ray 'glows' are long duration (seconds to tens of minutes) X-ray and gamma-ray emission coming from thunderclouds. Measurements suggest the presence of relativistic runaway electron avalanches (RREA), the same process underlying terrestrial gamma-ray flashes. Here we demonstrate that glows are relatively a commo...

journal_title：Nature communications

authors： Kelley NA,Smith DM,Dwyer JR,Splitt M,Lazarus S,Martinez-McKinney F,Hazelton B,Grefenstette B,Lowell A,Rassoul HK

更新日期：2015-08-12 00:00:00

abstract：:Remarkable breakthroughs have established the functionality of graphene and carbon nanotube transistors as replacements to silicon in conventional computing structures, and numerous spintronic logic gates have been presented. However, an efficient cascaded logic structure that exploits electron spin has not yet been d...

journal_title：Nature communications

authors： Friedman JS,Girdhar A,Gelfand RM,Memik G,Mohseni H,Taflove A,Wessels BW,Leburton JP,Sahakian AV

更新日期：2017-06-05 00:00:00

abstract：:Acid-sensing ion channel 3 (ASIC3) is involved in acid nociception, but its possible role in neurosensory mechanotransduction is disputed. We report here the generation of Asic3-knockout/eGFPf-knockin mice and subsequent characterization of heterogeneous expression of ASIC3 in the dorsal root ganglion (DRG). ASIC3 is ...

journal_title：Nature communications

authors： Lin SH,Cheng YR,Banks RW,Min MY,Bewick GS,Chen CC

更新日期：2016-05-10 00:00:00

abstract：:The coupling of ordered electronic phases with lattice, spin, and orbital degrees of freedom are of central interest in strongly correlated systems. Their interplay has been intensively studied from femtosecond to picosecond time scales, while their dynamics beyond nanoseconds are usually assumed to follow lattice coo...

journal_title：Nature communications

authors： Zhu Y,Hoffman J,Rowland CE,Park H,Walko DA,Freeland JW,Ryan PJ,Schaller RD,Bhattacharya A,Wen H

更新日期：2018-05-04 00:00:00

abstract：:Recent advances in nonlinear optics have revolutionized integrated photonics, providing on-chip solutions to a wide range of new applications. Currently, state of the art integrated nonlinear photonic devices are mainly based on dielectric material platforms, such as Si3N4 and SiO2. While semiconductor materials featu...

journal_title：Nature communications

authors： Chang L,Xie W,Shu H,Yang QF,Shen B,Boes A,Peters JD,Jin W,Xiang C,Liu S,Moille G,Yu SP,Wang X,Srinivasan K,Papp SB,Vahala K,Bowers JE

更新日期：2020-03-12 00:00:00

abstract：:Thousands of tons of isotopic mixtures are processed annually for heavy-water production and tritium decontamination. The existing technologies remain extremely energy intensive and require large capital investments. New approaches are needed to reduce the industry's footprint. Recently, micrometre-size crystals of gr...

journal_title：Nature communications

authors： Lozada-Hidalgo M,Zhang S,Hu S,Esfandiar A,Grigorieva IV,Geim AK

更新日期：2017-05-09 00:00:00

abstract：:Profiling immunoglobulin (Ig) receptor repertoires with specialized assays can be cost-ineffective and time-consuming. Here we report ImReP, a computational method for rapid and accurate profiling of the Ig repertoire, including the complementary-determining region 3 (CDR3), using regular RNA sequencing data such as t...

journal_title：Nature communications

authors： Mandric I,Rotman J,Yang HT,Strauli N,Montoya DJ,Van Der Wey W,Ronas JR,Statz B,Yao D,Petrova V,Zelikovsky A,Spreafico R,Shifman S,Zaitlen N,Rossetti M,Ansel KM,Eskin E,Mangul S

更新日期：2020-06-19 00:00:00

abstract：:Nature has developed striking light-powered proteins such as bacteriorhodopsin, which can convert light energy into conformational changes for biological functions. Such natural machines are a great source of inspiration for creation of their synthetic analogues. However, synthetic molecular machines typically operate...

journal_title：Nature communications

authors： Kuzyk A,Yang Y,Duan X,Stoll S,Govorov AO,Sugiyama H,Endo M,Liu N

更新日期：2016-02-02 00:00:00

abstract：:Because monoclonal antibodies (mAbs) have exceptional specificity and favorable pharmacology, substantial efforts have been made to functionalize them, either with potent cytotoxins, biologics, radionuclides, or fluorescent groups for therapeutic benefit and/or use as theranostic agents. To exploit our recently discov...

journal_title：Nature communications

authors： Bzymek KP,Puckett JW,Zer C,Xie J,Ma Y,King JD,Goodstein LH,Avery KN,Colcher D,Singh G,Horne DA,Williams JC

更新日期：2018-04-20 00:00:00

abstract：:The molecular mechanisms underlying vascular inflammation and associated inflammatory vascular diseases are not well defined. Here we show that endothelial intracellular adenosine and its key regulator adenosine kinase (ADK) play important roles in vascular inflammation. Pro-inflammatory stimuli lead to endothelial in...

journal_title：Nature communications

authors： Xu Y,Wang Y,Yan S,Yang Q,Zhou Y,Zeng X,Liu Z,An X,Toque HA,Dong Z,Jiang X,Fulton DJ,Weintraub NL,Li Q,Bagi Z,Hong M,Boison D,Wu C,Huo Y

更新日期：2017-10-16 00:00:00

abstract：:Mass extinctions have profoundly impacted the evolution of life through not only reducing taxonomic diversity but also reshaping ecosystems and biogeographic patterns. In particular, they are considered to have driven increased biogeographic cosmopolitanism, but quantitative tests of this hypothesis are rare and have ...

journal_title：Nature communications

authors： Button DJ,Lloyd GT,Ezcurra MD,Butler RJ

更新日期：2017-10-10 00:00:00

abstract：:Thalamic inputs of cells in sensory cortices are outnumbered by local connections. Thus, it was suggested that robust sensory response in layer 4 emerges due to synchronized thalamic activity. To investigate the role of both inputs in the generation of correlated cortical activities, we isolated the thalamic excitator...

journal_title：Nature communications

authors： Cohen-Kashi Malina K,Mohar B,Rappaport AN,Lampl I

更新日期：2016-09-12 00:00:00

abstract：:The number of viruses circulating in small isolated human populations may be reduced by viral extinctions and rare introductions. Here we used viral metagenomics to characterize the eukaryotic virome in feces from healthy children from a large urban center and from three Amerindian villages with minimal outside contac...

journal_title：Nature communications

authors： Siqueira JD,Dominguez-Bello MG,Contreras M,Lander O,Caballero-Arias H,Xutao D,Noya-Alarcon O,Delwart E

更新日期：2018-10-15 00:00:00

abstract：:Clock genes are expressed throughout the body, although how they oscillate in unrestrained animals is not known. Here, we show an in vivo imaging technique that enables long-term simultaneous imaging of multiple tissues. We use dual-focal 3D tracking and signal-intensity calibration to follow gene expression in a targ...

journal_title：Nature communications

authors： Hamada T,Sutherland K,Ishikawa M,Miyamoto N,Honma S,Shirato H,Honma K

更新日期：2016-06-10 00:00:00

abstract：:Recent years have witnessed the growing interest in the remote functionalization of alkenes for it offers a strategy to activate the challenging C-H bonds distant from the initiation point via alkene isomerization/functionalization. However, the catalytic enantioselective isomerization/functionalization with one singl...

journal_title：Nature communications

authors： Chen X,Cheng Z,Guo J,Lu Z

更新日期：2018-09-26 00:00:00

abstract：:Haematopoietic stem cells (HSCs) are produced during embryogenesis from the floor of the dorsal aorta. The localization of HSCs is dependent on the presence of instructive signals on the ventral side of the vessel. The nature of the extrinsic molecular signals that control the aortic haematopoietic niche is currently ...

journal_title：Nature communications

authors： Pouget C,Peterkin T,Simões FC,Lee Y,Traver D,Patient R

更新日期：2014-11-27 00:00:00

abstract：:Cas9/gRNA-mediated gene-drive systems have advanced development of genetic technologies for controlling vector-borne pathogen transmission. These technologies include population suppression approaches, genetic analogs of insecticidal techniques that reduce the number of insect vectors, and population modification (rep...

journal_title：Nature communications

authors： Adolfi A,Gantz VM,Jasinskiene N,Lee HF,Hwang K,Terradas G,Bulger EA,Ramaiah A,Bennett JB,Emerson JJ,Marshall JM,Bier E,James AA

更新日期：2020-11-03 00:00:00

abstract：:Identifying a bona fide population of cardiac stem cells (CSCs) is a critical step for developing cell-based therapies for heart failure patients. Previously, cardiac c-kit(+) cells were reported to be CSCs with a potential to become myocardial, endothelial and smooth muscle cells in vitro and after cardiac injury. He...

journal_title：Nature communications

authors： Sultana N,Zhang L,Yan J,Chen J,Cai W,Razzaque S,Jeong D,Sheng W,Bu L,Xu M,Huang GY,Hajjar RJ,Zhou B,Moon A,Cai CL

更新日期：2015-10-30 00:00:00

abstract：:Rapid and accurate clinical diagnosis remains challenging. A component of diagnosis tool development is the design of effective classification models with Mass spectrometry (MS) data. Some Machine Learning approaches have been investigated but these models require time-consuming preprocessing steps to remove artifacts...

journal_title：Nature communications

authors： Seddiki K,Saudemont P,Precioso F,Ogrinc N,Wisztorski M,Salzet M,Fournier I,Droit A

更新日期：2020-11-05 00:00:00

abstract：:The allotetraploid plant Nicotiana tabacum (common tobacco) is a major crop species and a model organism, for which only very fragmented genomic sequences are currently available. Here we report high-quality draft genomes for three main tobacco varieties. These genomes show both the low divergence of tobacco from its ...

journal_title：Nature communications

authors： Sierro N,Battey JN,Ouadi S,Bakaher N,Bovet L,Willig A,Goepfert S,Peitsch MC,Ivanov NV

更新日期：2014-05-08 00:00:00

abstract：:Phonons are the main source of relaxation in molecular nanomagnets, and different mechanisms have been proposed in order to explain the wealth of experimental findings. However, very limited experimental investigations on phonons in these systems have been performed so far, yielding no information about their dispersi...

journal_title：Nature communications

authors： Garlatti E,Tesi L,Lunghi A,Atzori M,Voneshen DJ,Santini P,Sanvito S,Guidi T,Sessoli R,Carretta S

更新日期：2020-04-09 00:00:00

abstract：:Memory consolidation requires a timely controlled interplay between the hippocampus, a brain region important for memory formation, and the cortex, a region recruited for memory storage. Here we show that memory consolidation is associated with specific epigenetic modifications on histone proteins that have a distinct...

journal_title：Nature communications

authors： Gräff J,Woldemichael BT,Berchtold D,Dewarrat G,Mansuy IM

更新日期：2012-01-01 00:00:00

abstract：:The development of intelligent materials, in particular those showing the highly sensitive mechanoresponsive luminescence (MRL), is desirable but challenging. Here we report a design strategy for constructing high performance On-Off MRL materials by introducing nitrophenyl groups to molecules with aggregation-induced ...

journal_title：Nature communications

authors： Zhao W,He Z,Peng Q,Lam JWY,Ma H,Qiu Z,Chen Y,Zhao Z,Shuai Z,Dong Y,Tang BZ

更新日期：2018-08-02 00:00:00

abstract：:Respiratory syncytial virus (RSV) causes acute lower respiratory tract infections and is the leading cause of infant hospitalizations. Recently, a promising vaccine antigen based on the RSV fusion protein (RSV F) stabilized in the native prefusion conformation has been described. Here we report alternative strategies ...

journal_title：Nature communications

authors： Krarup A,Truan D,Furmanova-Hollenstein P,Bogaert L,Bouchier P,Bisschop IJM,Widjojoatmodjo MN,Zahn R,Schuitemaker H,McLellan JS,Langedijk JPM

更新日期：2015-09-03 00:00:00

abstract：:Causal reasoning can shed new light on the major challenges in machine learning for medical imaging: scarcity of high-quality annotated data and mismatch between the development dataset and the target environment. A causal perspective on these issues allows decisions about data collection, annotation, preprocessing, a...

journal_title：Nature communications

authors： Castro DC,Walker I,Glocker B

更新日期：2020-07-22 00:00:00

abstract：:Target-centric drug development strategies prioritize single-target potency in vitro and do not account for connectivity and multi-target effects within a signal transduction network. Here, we present a systems biology approach that combines transcriptomic and structural analyses with live-cell imaging to predict smal...

journal_title：Nature communications

authors： Pabon NA,Zhang Q,Cruz JA,Schipper DL,Camacho CJ,Lee REC

更新日期：2019-02-26 00:00:00