In vivo imaging of clock gene expression in multiple tissues of freely moving mice.

abstract：:As energy efficiency becomes a paramount issue in this day and age, reversible computing may serve as a critical step towards energy conservation in information technology. The inputs of reversible computing elements define the outputs and vice versa. Some reversible gates such as the Fredkin gate are also universal; ...

journal_title：Nature communications

authors： Cohen E,Dolev S,Rosenblit M

更新日期：2016-04-26 00:00:00

abstract：:Research results on the effects of land cover change on water resources vary greatly and the topic remains controversial. Here we use published data worldwide to examine the validity of Fuh's equation, which relates annual water yield (R) to a wetness index (precipitation/potential evapotranspiration; P/PET) and water...

journal_title：Nature communications

authors： Zhou G,Wei X,Chen X,Zhou P,Liu X,Xiao Y,Sun G,Scott DF,Zhou S,Han L,Su Y

更新日期：2015-01-09 00:00:00

abstract：:Continuous cycles of nucleocytoplasmic transport require disassembly of transport receptor/Ran-GTP complexes in the cytoplasm. A basic disassembly mechanism in all eukaryotes depends on soluble RanGAP and RanBP1. In vertebrates, a significant fraction of RanGAP1 stably interacts with the nucleoporin RanBP2 at a bindin...

journal_title：Nature communications

authors： Ritterhoff T,Das H,Hofhaus G,Schröder RR,Flotho A,Melchior F

更新日期：2016-05-10 00:00:00

abstract：:Precise rare-cell technologies require the blood to be processed immediately or be stabilized with fixatives. Such restrictions limit the translation of circulating tumor cell (CTC)-based liquid biopsy assays that provide accurate molecular data in guiding clinical decisions. Here we describe a method to preserve whol...

journal_title：Nature communications

authors： Wong KHK,Tessier SN,Miyamoto DT,Miller KL,Bookstaver LD,Carey TR,Stannard CJ,Thapar V,Tai EC,Vo KD,Emmons ES,Pleskow HM,Sandlin RD,Sequist LV,Ting DT,Haber DA,Maheswaran S,Stott SL,Toner M

更新日期：2017-11-23 00:00:00

abstract：:A disturbance of reactive oxygen species (ROS) homeostasis may cause the pathogenesis of many diseases. Inspired by natural photosynthesis, this work proposes a photo-driven H2-evolving liposomal nanoplatform (Lip NP) that comprises an upconversion nanoparticle (UCNP) that is conjugated with gold nanoparticles (AuNPs)...

journal_title：Nature communications

authors： Wan WL,Tian B,Lin YJ,Korupalli C,Lu MY,Cui Q,Wan D,Chang Y,Sung HW

更新日期：2020-01-27 00:00:00

abstract：:Astrocytes are implicated in modulation of neuronal excitability and synaptic function, but it remains unknown if these glial cells can directly control activities of motor circuits to influence complex behaviors in vivo. This study focused on the vital respiratory rhythm-generating circuits of the preBötzinger comple...

journal_title：Nature communications

authors： Sheikhbahaei S,Turovsky EA,Hosford PS,Hadjihambi A,Theparambil SM,Liu B,Marina N,Teschemacher AG,Kasparov S,Smith JC,Gourine AV

更新日期：2018-01-25 00:00:00

abstract：:The ontogeny of haematopoietic niches in vertebrates is essentially unknown. Here we show that the stromal cells of the caudal haematopoietic tissue (CHT), the first niche where definitive haematopoietic stem/progenitor cells (HSPCs) home in zebrafish development, derive from the caudal somites through an epithelial-m...

journal_title：Nature communications

authors： Murayama E,Sarris M,Redd M,Le Guyader D,Vivier C,Horsley W,Trede N,Herbomel P

更新日期：2015-09-28 00:00:00

abstract：:Forests impact regional hydrology and climate directly by regulating water and heat fluxes. Indirect effects through cloud formation and precipitation can be important in facilitating continental-scale moisture recycling but are poorly understood at regional scales. In particular, the impact of temperate forest on clo...

journal_title：Nature communications

authors： Teuling AJ,Taylor CM,Meirink JF,Melsen LA,Miralles DG,van Heerwaarden CC,Vautard R,Stegehuis AI,Nabuurs GJ,de Arellano JV

更新日期：2017-01-11 00:00:00

abstract：:Domain walls can be driven by current at very high speeds in nanowires formed from ultra-thin, perpendicularly magnetized cobalt layers and cobalt/nickel multilayers deposited on platinum underlayers due to a chiral spin torque. An important feature of this torque is a magnetic chiral exchange field that each domain w...

journal_title：Nature communications

authors： Ryu KS,Yang SH,Thomas L,Parkin SS

更新日期：2014-05-23 00:00:00

abstract：:The contrast and sensitivity of in vivo fluorescence imaging has been revolutionized by molecular fluorophores operating in the second near-infrared window (NIR-II; 1000-1700 nm), but an ongoing challenge is the solvatochromism-caused quenching in aqueous solution for the long-wavelength absorbing fluorophores. Herein...

journal_title：Nature communications

authors： Wang S,Fan Y,Li D,Sun C,Lei Z,Lu L,Wang T,Zhang F

更新日期：2019-03-05 00:00:00

abstract：:Emerging evidence has revealed that Nestin not only serves as a biomarker for multipotent stem cells, but also regulates cell proliferation and invasion in various tumors. However, the mechanistic contributions of Nestin to cancer pathogenesis are still unknown. In the present study, previously thought to reside exclu...

journal_title：Nature communications

authors： Zhang Y,Wang J,Huang W,Cai J,Ba J,Wang Y,Ke Q,Huang Y,Liu X,Qiu Y,Lu Q,Sui X,Shi Y,Wang T,Shen H,Guan Y,Zhou Y,Chen Y,Wang M,Xiang AP

更新日期：2018-09-06 00:00:00

abstract：:Nascent polypeptides can induce ribosome stalling, regulating downstream genes. Stalling of ErmBL peptide translation in the presence of the macrolide antibiotic erythromycin leads to resistance in Streptococcus sanguis. To reveal this stalling mechanism we obtained 3.6-Å-resolution cryo-EM structures of ErmBL-stalled...

journal_title：Nature communications

authors： Arenz S,Bock LV,Graf M,Innis CA,Beckmann R,Grubmüller H,Vaiana AC,Wilson DN

更新日期：2016-07-06 00:00:00

abstract：:Amazon forests have experienced frequent and severe droughts in the past two decades. However, little is known about the large-scale legacy of droughts on carbon stocks and dynamics of forests. Using systematic sampling of forest structure measured by LiDAR waveforms from 2003 to 2008, here we show a significant loss ...

journal_title：Nature communications

authors： Yang Y,Saatchi SS,Xu L,Yu Y,Choi S,Phillips N,Kennedy R,Keller M,Knyazikhin Y,Myneni RB

更新日期：2018-08-09 00:00:00

abstract：:The maturation of HIV-1 viral particles is essential for viral infectivity. During maturation, many copies of the capsid protein (CA) self-assemble into a capsid shell to enclose the viral RNA. The mechanistic details of the initiation and early stages of capsid assembly remain to be delineated. We present coarse-grai...

journal_title：Nature communications

authors： Grime JMA,Dama JF,Ganser-Pornillos BK,Woodward CL,Jensen GJ,Yeager M,Voth GA

更新日期：2016-05-13 00:00:00

abstract：:The development of integrated photonics and lab-on-a-chip platforms for environmental and biomedical diagnostics demands ultraviolet electroluminescent materials with high mechanical, chemical and environmental stability and almost complete compatibility with existing silicon technology. Here we report the realization...

journal_title：Nature communications

authors： Brovelli S,Chiodini N,Lorenzi R,Lauria A,Romagnoli M,Paleari A

更新日期：2012-02-21 00:00:00

abstract：:MicroRNAs play important roles in regulating tumour development, progression and metastasis. Here we show that one of the miR-200 family members, miR-141, is under-expressed in several prostate cancer (PCa) stem/progenitor cell populations in both xenograft and primary patient tumours. Enforced expression of miR-141 i...

journal_title：Nature communications

authors： Liu C,Liu R,Zhang D,Deng Q,Liu B,Chao HP,Rycaj K,Takata Y,Lin K,Lu Y,Zhong Y,Krolewski J,Shen J,Tang DG

更新日期：2017-01-23 00:00:00

abstract：:The Middle Eocene Climatic Optimum (MECO) represents a ~500-kyr period of global warming ~40 million years ago and is associated with a rise in atmospheric CO2 concentrations, but the cause of this CO2 rise remains enigmatic. Here we show, based on osmium isotope ratios (187Os/188Os) of marine sediments and published ...

journal_title：Nature communications

authors： van der Ploeg R,Selby D,Cramwinckel MJ,Li Y,Bohaty SM,Middelburg JJ,Sluijs A

更新日期：2018-07-23 00:00:00

abstract：:In the originally published version of this Article, financial support was not fully acknowledged. The PDF and HTML versions of the Article have now been corrected to include support from National Institute of General Medical Sciences, National Institutes of Health grant R01GM124072. ...

journal_title：Nature communications

authors： Lorent JH,Diaz-Rohrer B,Lin X,Spring K,Gorfe AA,Levental KR,Levental I

更新日期：2018-05-01 00:00:00

abstract：:ARID1A, a component of the SWI/SNF chromatin remodeling complex, is a tumor suppressor with a high frequency of inactivating mutations in many cancers. Therefore, ARID1A deficiency has been exploited therapeutically for treating cancer. Here we show that ARID1A has a synthetic lethal interaction with aurora kinase A (...

journal_title：Nature communications

authors： Wu C,Lyu J,Yang EJ,Liu Y,Zhang B,Shim JS

更新日期：2018-08-10 00:00:00

abstract：:Herein, we report on a significant discovery, namely, the quantitative discharging of reduced graphite forms, such as graphite intercalation compounds, graphenide dispersions and graphenides deposited on surfaces with the simple solvent benzonitrile. Because of its comparatively low reduction potential, benzonitrile i...

journal_title：Nature communications

authors： Vecera P,Holzwarth J,Edelthalhammer KF,Mundloch U,Peterlik H,Hauke F,Hirsch A

更新日期：2016-08-10 00:00:00

abstract：:The role of the histamine H3 receptor (H3R) in cerebral ischaemia/reperfusion (I/R) injury remains unknown. Here we show that H3R expression is upregulated after I/R in two mouse models. H3R antagonists and H3R knockout attenuate I/R injury, which is reversed by an H3R-selective agonist. Interestingly, H1R and H2R ant...

journal_title：Nature communications

authors： Yan H,Zhang X,Hu W,Ma J,Hou W,Zhang X,Wang X,Gao J,Shen Y,Lv J,Ohtsu H,Han F,Wang G,Chen Z

更新日期：2014-02-25 00:00:00

abstract：:Strategies to harness photosynthesis from living organisms to generate electrical power have long been considered, yet efficiency remains low. Here, we aimed to reroute photosynthetic electron flow in photosynthetic organisms without compromising their phototrophic properties. We show that 2,6-dimethyl-p-benzoquinone ...

journal_title：Nature communications

authors： Fu HY,Picot D,Choquet Y,Longatte G,Sayegh A,Delacotte J,Guille-Collignon M,Lemaître F,Rappaport F,Wollman FA

更新日期：2017-05-03 00:00:00

abstract：:Metastasis is the main cause of cancer-related death and thus understanding the molecular and cellular mechanisms underlying this process is critical. Here, our data demonstrate, contrary to established dogma, that loss of haematopoietic-derived focal adhesion kinase (FAK) is sufficient to enhance tumour metastasis. U...

journal_title：Nature communications

authors： Batista S,Maniati E,Reynolds LE,Tavora B,Lees DM,Fernandez I,Elia G,Casanovas O,Lo Celso C,Hagemann T,Hodivala-Dilke K

更新日期：2014-10-01 00:00:00

abstract：:Late-onset Alzheimer's disease (AD) can, in part, be considered a metabolic disease. Besides age, female sex and APOE ε4 genotype represent strong risk factors for AD that also give rise to large metabolic differences. We systematically investigated group-specific metabolic alterations by conducting stratified associa...

journal_title：Nature communications

authors： Arnold M,Nho K,Kueider-Paisley A,Massaro T,Huynh K,Brauner B,MahmoudianDehkordi S,Louie G,Moseley MA,Thompson JW,John-Williams LS,Tenenbaum JD,Blach C,Chang R,Brinton RD,Baillie R,Han X,Trojanowski JQ,Shaw LM,Martin

更新日期：2020-03-02 00:00:00

abstract：:Ferroelectrics based on proton tautomerism are promising in low-field and above-room-temperature operations. Here seven organic ferroelectric crystals are examined to search for efficient switching of strong spontaneous polarization on proton tautomerism. Solution-grown crystals exhibit strong pinning of ferroelectric...

journal_title：Nature communications

authors： Horiuchi S,Kobayashi K,Kumai R,Ishibashi S

更新日期：2017-02-16 00:00:00

abstract：:Bipolar spindle assembly is a critical control point for initiation of mitosis through nucleation and organization of spindle microtubules and is regulated by kinesin-like proteins. In fission yeast, the kinesin-14 Pkl1 binds the γ-tubulin ring complex (γ-TuRC) microtubule-organizing centre at spindle poles and can al...

journal_title：Nature communications

authors： Olmsted ZT,Colliver AG,Riehlman TD,Paluh JL

更新日期：2014-10-28 00:00:00

abstract：:Paternal epigenetic inheritance is gaining attention for its growing medical relevance. However, the form in which paternal epigenetic information is transmitted to offspring and how it influences offspring development remain poorly understood. Here we show that in C. elegans, sperm-inherited chromatin states transmit...

journal_title：Nature communications

authors： Kaneshiro KR,Rechtsteiner A,Strome S

更新日期：2019-03-20 00:00:00

abstract：:Whispering-gallery-mode resonators have been extensively used in conjunction with different materials for the development of a variety of photonic devices. Among the latter, hybrid structures, consisting of dielectric microspheres and colloidal core/shell semiconductor nanocrystals as gain media, have attracted intere...

journal_title：Nature communications

authors： Grivas C,Li C,Andreakou P,Wang P,Ding M,Brambilla G,Manna L,Lagoudakis P

更新日期：2013-01-01 00:00:00

abstract：:We show how the kinetics of a fast and irreversible chemical reaction in a nanocrystalline material at high temperature can be studied using nanosecond electron pulses in an electron microscope. Infrared laser pulses first heat a nanocrystalline oxide layer on a carbon film, then single nanosecond electron pulses allo...

journal_title：Nature communications

authors： Sinha SK,Khammari A,Picher M,Roulland F,Viart N,LaGrange T,Banhart F

更新日期：2019-08-13 00:00:00

abstract：:Bioluminescent organisms are likely to have an evolutionary drive towards high radiance. As such, bio-optimized materials derived from them hold great promise for photonic applications. Here, we show that biologically produced fluorescent proteins retain their high brightness even at the maximum density in solid state...

journal_title：Nature communications

authors： Gather MC,Yun SH

更新日期：2014-12-08 00:00:00