Proton tautomerism for strong polarization switching.

abstract：:Despite their energy-efficient merits as promising light-weight structural materials, magnesium (Mg) based alloys suffer from inadequate corrosion resistance. One primary reason is that the native surface film on Mg formed in air mainly consists of Mg(OH)2 and MgO, which is porous and unprotective, especially in humid...

journal_title：Nature communications

authors： Wang Y,Liu B,Zhao X,Zhang X,Miao Y,Yang N,Yang B,Zhang L,Kuang W,Li J,Ma E,Shan Z

更新日期：2018-10-03 00:00:00

abstract：:To understand functional consequences of genetic and transcriptional aberrations in prostate cancer, the proteomic changes during disease formation and progression need to be revealed. Here we report high-throughput mass spectrometry on clinical tissue samples of benign prostatic hyperplasia (BPH), untreated primary p...

journal_title：Nature communications

authors： Latonen L,Afyounian E,Jylhä A,Nättinen J,Aapola U,Annala M,Kivinummi KK,Tammela TTL,Beuerman RW,Uusitalo H,Nykter M,Visakorpi T

更新日期：2018-03-21 00:00:00

abstract：:The manipulation of crystal orientation from the thermodynamic equilibrium states is desired in layered hybrid perovskite films to direct charge transport and enhance the perovskite devices performance. Here we report a templated growth mechanism of layered perovskites from 3D-like perovskites which can be a general d...

journal_title：Nature communications

authors： Wang J,Luo S,Lin Y,Chen Y,Deng Y,Li Z,Meng K,Chen G,Huang T,Xiao S,Huang H,Zhou C,Ding L,He J,Huang J,Yuan Y

更新日期：2020-01-29 00:00:00

abstract：:Recently, it has been shown that animals such as jumping spiders, birds, and butterflies have evolved ultra-black coloration comparable to the blackest synthetic materials. Of these, certain papilionid butterflies have reflectances approaching 0.2%, resulting from a polydisperse honeycomb structure. It is unknown if o...

journal_title：Nature communications

authors： Davis AL,Nijhout HF,Johnsen S

更新日期：2020-03-10 00:00:00

abstract：:Hexanucleotide repeat expansion in C9ORF72 is the most frequent cause of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here we demonstrate that the repeat-associated non-AUG (RAN) translation of (GGGGCC) n -containing RNAs into poly-dipeptides can initiate in vivo without a 5'-cap. The pr...

journal_title：Nature communications

authors： Cheng W,Wang S,Mestre AA,Fu C,Makarem A,Xian F,Hayes LR,Lopez-Gonzalez R,Drenner K,Jiang J,Cleveland DW,Sun S

更新日期：2018-01-04 00:00:00

abstract：:To fully exploit the microbial genome resources, a high-throughput experimental platform is needed to associate genes with phenotypes at the genome level. We present here a novel method that enables investigation of the cellular consequences of repressing individual transcripts based on the CRISPR interference (CRISPR...

journal_title：Nature communications

authors： Wang T,Guan C,Guo J,Liu B,Wu Y,Xie Z,Zhang C,Xing XH

更新日期：2018-06-26 00:00:00

abstract：:The removal of dying neurons by microglia has a key role during both development and in several diseases. To date, little is known about the cellular and molecular processes underlying neuronal engulfment in the brain. Here we took a live imaging approach to quantify neuronal cell death progression in embryonic zebraf...

journal_title：Nature communications

authors： Mazaheri F,Breus O,Durdu S,Haas P,Wittbrodt J,Gilmour D,Peri F

更新日期：2014-06-05 00:00:00

abstract：:Selector devices are indispensable components of large-scale nonvolatile memory and neuromorphic array systems. Besides the conventional silicon transistor, two-terminal ovonic threshold switching device with much higher scalability is currently the most industrially favored selector technology. However, current ovoni...

journal_title：Nature communications

authors： Jia S,Li H,Gotoh T,Longeaud C,Zhang B,Lyu J,Lv S,Zhu M,Song Z,Liu Q,Robertson J,Liu M

更新日期：2020-09-15 00:00:00

abstract：:CD11b(+)Gr-1(+) myeloid-derived suppressor cells (MDSCs) expand in the spleen during cancer and promote progression through suppression of cytotoxic T cells. An anti-inflammatory reflex arc involving the vagus nerve and memory T cells is necessary for resolution of acute inflammation. Failure of this neural circuit co...

journal_title：Nature communications

authors： Dubeykovskaya Z,Si Y,Chen X,Worthley DL,Renz BW,Urbanska AM,Hayakawa Y,Xu T,Westphalen CB,Dubeykovskiy A,Chen D,Friedman RA,Asfaha S,Nagar K,Tailor Y,Muthupalani S,Fox JG,Kitajewski J,Wang TC

更新日期：2016-02-04 00:00:00

abstract：:Signalling pathways that control endothelial cell (EC) permeability, leukocyte adhesion and inflammation are pivotal for atherosclerosis initiation and progression. Here we demonstrate that the Sterile-20-like mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4), which has been implicated in inflammation, ...

journal_title：Nature communications

authors： Roth Flach RJ,Skoura A,Matevossian A,Danai LV,Zheng W,Cortes C,Bhattacharya SK,Aouadi M,Hagan N,Yawe JC,Vangala P,Menendez LG,Cooper MP,Fitzgibbons TP,Buckbinder L,Czech MP

更新日期：2015-12-21 00:00:00

abstract：:Vascularization and efficient perfusion are long-standing challenges in cardiac tissue engineering. Here we report engineered perfusable microvascular constructs, wherein human embryonic stem cell-derived endothelial cells (hESC-ECs) are seeded both into patterned microchannels and the surrounding collagen matrix. In ...

journal_title：Nature communications

authors： Redd MA,Zeinstra N,Qin W,Wei W,Martinson A,Wang Y,Wang RK,Murry CE,Zheng Y

更新日期：2019-02-04 00:00:00

abstract：:Patterns in biomass production are determined by resource input (productivity) and trophic transfer efficiency. At fixed resource input, variation in consumer biomass production has been related to food quality, metabolic type and diversity among species. In contrast, intraspecific variation in individual body size be...

journal_title：Nature communications

authors： Reichstein B,Persson L,De Roos AM

更新日期：2015-03-04 00:00:00

abstract：:Large-scale genetic and genomic data are increasingly available and the major bottleneck in their analysis is a lack of sufficiently scalable computational tools. To address this problem in the context of complex traits analysis, we present DISSECT. DISSECT is a new and freely available software that is able to exploi...

journal_title：Nature communications

authors： Canela-Xandri O,Law A,Gray A,Woolliams JA,Tenesa A

更新日期：2015-12-11 00:00:00

abstract：:The Great Hungarian Plain was a crossroads of cultural transformations that have shaped European prehistory. Here we analyse a 5,000-year transect of human genomes, sampled from petrous bones giving consistently excellent endogenous DNA yields, from 13 Hungarian Neolithic, Copper, Bronze and Iron Age burials including...

journal_title：Nature communications

authors： Gamba C,Jones ER,Teasdale MD,McLaughlin RL,Gonzalez-Fortes G,Mattiangeli V,Domboróczki L,Kővári I,Pap I,Anders A,Whittle A,Dani J,Raczky P,Higham TF,Hofreiter M,Bradley DG,Pinhasi R

更新日期：2014-10-21 00:00:00

abstract：:Low-light-level imaging techniques have application in many diverse fields, ranging from biological sciences to security. A high-quality digital camera based on a multi-megapixel array will typically record an image by collecting of order 10(5) photons per pixel, but by how much could this photon flux be reduced? In t...

journal_title：Nature communications

authors： Morris PA,Aspden RS,Bell JE,Boyd RW,Padgett MJ

更新日期：2015-01-05 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Wang X,Cao L,Fox AD,Fuller R,Griffin L,Mitchell C,Zhao Y,Moon OK,Cabot D,Xu Z,Batbayar N,Kölzsch A,van der Jeugd HP,Madsen J,Chen L,Nathan R

更新日期：2019-07-22 00:00:00

abstract：:By providing broad resistance to environmental biocides, transporters from the small multidrug resistance (SMR) family drive the spread of multidrug resistance cassettes among bacterial populations. A fundamental understanding of substrate selectivity by SMR transporters is needed to identify the types of selective pr...

journal_title：Nature communications

authors： Kermani AA,Macdonald CB,Burata OE,Ben Koff B,Koide A,Denbaum E,Koide S,Stockbridge RB

更新日期：2020-11-27 00:00:00

abstract：:Chromatin looping allows enhancer-bound regulatory factors to influence transcription. Large domains, referred to as topologically associated domains, participate in genome organization. However, the mechanisms underlining interactions within these domains, which control gene expression, are not fully understood. Here...

journal_title：Nature communications

authors： Magli A,Baik J,Pota P,Cordero CO,Kwak IY,Garry DJ,Love PE,Dynlacht BD,Perlingeiro RCR

更新日期：2019-05-24 00:00:00

abstract：:The reversible modification of cysteine residues by thioester formation with palmitate (S-palmitoylation) is an abundant lipid post-translational modification (PTM) in mammalian systems. S-palmitoylation has been observed on mitochondrial proteins, providing an intriguing potential connection between metabolic lipids ...

journal_title：Nature communications

authors： Kathayat RS,Cao Y,Elvira PD,Sandoz PA,Zaballa ME,Springer MZ,Drake LE,Macleod KF,van der Goot FG,Dickinson BC

更新日期：2018-01-23 00:00:00

abstract：:Previous studies have revealed that nucleosomes impede elongation of RNA polymerase II (RNAPII). Recent observations suggest a role for ATP-dependent chromatin remodellers in modulating this process, but direct in vivo evidence for this is unknown. Here using fission yeast, we identify Fun30Fft3 as a chromatin remodel...

journal_title：Nature communications

authors： Lee J,Choi ES,Seo HD,Kang K,Gilmore JM,Florens L,Washburn MP,Choe J,Workman JL,Lee D

更新日期：2017-02-20 00:00:00

abstract：:Cholesterol is a key component of cell membranes with a proven modulatory role on the function and ligand-binding properties of G-protein-coupled receptors (GPCRs). Crystal structures of prototypical GPCRs such as the adenosine A2A receptor (A2AR) have confirmed that cholesterol finds stable binding sites at the recep...

journal_title：Nature communications

authors： Guixà-González R,Albasanz JL,Rodriguez-Espigares I,Pastor M,Sanz F,Martí-Solano M,Manna M,Martinez-Seara H,Hildebrand PW,Martín M,Selent J

更新日期：2017-02-21 00:00:00

abstract：:One-fourth of Plasmodium falciparum proteins have asparagine repeats that increase the propensity for aggregation, especially at elevated temperatures that occur routinely in malaria-infected patients. Here we report that a Plasmodium Asn repeat-containing protein (PFI1155w) formed aggregates in mammalian cells at feb...

journal_title：Nature communications

authors： Muralidharan V,Oksman A,Pal P,Lindquist S,Goldberg DE

更新日期：2012-01-01 00:00:00

abstract：:Adeno-associated virus (AAV) capsid engineering is an emerging approach to advance gene therapy. However, a systematic analysis on how each capsid amino acid contributes to multiple functions remains challenging. Here we show proof-of-principle and successful application of a novel approach, termed AAV Barcode-Seq, th...

journal_title：Nature communications

authors： Adachi K,Enoki T,Kawano Y,Veraz M,Nakai H

更新日期：2014-01-01 00:00:00

abstract：:Superionic ice is a special group of ice phases at high temperature and pressure, which may exist in ice-rich planets and exoplanets. In superionic ice liquid hydrogen coexists with a crystalline oxygen sublattice. At high pressures, the properties of superionic ice are largely unknown. Here we report evidence that fr...

journal_title：Nature communications

authors： Sun J,Clark BK,Torquato S,Car R

更新日期：2015-08-28 00:00:00

abstract：:Although fibroblast heterogeneity is recognized in primary tumors, both its characterization in and its impact on metastases remain unknown. Here, combining flow cytometry, immunohistochemistry and RNA-sequencing on breast cancer samples, we identify four Cancer-Associated Fibroblast (CAF) subpopulations in metastatic...

journal_title：Nature communications

authors： Pelon F,Bourachot B,Kieffer Y,Magagna I,Mermet-Meillon F,Bonnet I,Costa A,Givel AM,Attieh Y,Barbazan J,Bonneau C,Fuhrmann L,Descroix S,Vignjevic D,Silberzan P,Parrini MC,Vincent-Salomon A,Mechta-Grigoriou F

更新日期：2020-01-21 00:00:00

abstract：:Underlying cellular responses is a transcriptional regulatory network (TRN) that modulates gene expression. A useful description of the TRN would decompose the transcriptome into targeted effects of individual transcriptional regulators. Here, we apply unsupervised machine learning to a diverse compendium of over 250 ...

journal_title：Nature communications

authors： Sastry AV,Gao Y,Szubin R,Hefner Y,Xu S,Kim D,Choudhary KS,Yang L,King ZA,Palsson BO

更新日期：2019-12-04 00:00:00

abstract：:Perovskite solar cells have received worldwide interests due to swiftly improved efficiency but the poor stability of the perovskite component hampers the device fabrication under normal condition. Herein, we develop a reliable nonstoichiometric acid-base reaction route to stable perovskite films by intermediate chemi...

journal_title：Nature communications

authors： Long M,Zhang T,Chai Y,Ng CF,Mak TC,Xu J,Yan K

更新日期：2016-11-15 00:00:00

abstract：:Two-dimensional layered transition-metal dichalcogenides have attracted considerable interest for their unique layer-number-dependent properties. In particular, vertical integration of these two-dimensional crystals to form van der Waals heterostructures can open up a new dimension for the design of functional electro...

journal_title：Nature communications

authors： Yu WJ,Vu QA,Oh H,Nam HG,Zhou H,Cha S,Kim JY,Carvalho A,Jeong M,Choi H,Castro Neto AH,Lee YH,Duan X

更新日期：2016-11-09 00:00:00

abstract：:Standard optical tweezers rely on optical forces arising when a focused laser beam interacts with a microscopic particle: scattering forces, pushing the particle along the beam direction, and gradient forces, attracting it towards the high-intensity focal spot. Importantly, the incoming laser beam is not affected by t...

journal_title：Nature communications

authors： Kalantarifard F,Elahi P,Makey G,Maragò OM,Ilday FÖ,Volpe G

更新日期：2019-06-18 00:00:00

abstract：:Surface charge density is the key factor for developing high performance triboelectric nanogenerators (TENG). The previously invented charge excitation TENG provides a most efficient way to achieve maximum charge output of a TENG device. Herein, criteria to quantitatively evaluate the contact efficiency and air breakd...

journal_title：Nature communications

authors： Liu Y,Liu W,Wang Z,He W,Tang Q,Xi Y,Wang X,Guo H,Hu C

更新日期：2020-03-27 00:00:00