Abstract：
:Chromatin looping allows enhancer-bound regulatory factors to influence transcription. Large domains, referred to as topologically associated domains, participate in genome organization. However, the mechanisms underlining interactions within these domains, which control gene expression, are not fully understood. Here we report that activation of embryonic myogenesis is associated with establishment of long-range chromatin interactions centered on Pax3-bound loci. Using mass spectrometry and genomic studies, we identify the ubiquitously expressed LIM-domain binding protein 1 (Ldb1) as the mediator of looping interactions at a subset of Pax3 binding sites. Ldb1 is recruited to Pax3-bound elements independently of CTCF-Cohesin, and is necessary for efficient deposition of H3K4me1 at these sites and chromatin looping. When Ldb1 is deleted in Pax3-expressing cells in vivo, specification of migratory myogenic progenitors is severely impaired. These results highlight Ldb1 requirement for Pax3 myogenic activity and demonstrate how transcription factors can promote formation of sub-topologically associated domain interactions involved in lineage specification.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Magli A,Baik J,Pota P,Cordero CO,Kwak IY,Garry DJ,Love PE,Dynlacht BD,Perlingeiro RCRdoi
10.1038/s41467-019-10318-6subject
Has Abstractpub_date
2019-05-24 00:00:00pages
2316issue
1issn
2041-1723pii
10.1038/s41467-019-10318-6journal_volume
10pub_type
杂志文章abstract：:High-performance piezoelectrics are lead-based solid solutions that exhibit a so-called morphotropic phase boundary, which separates two competing phases as a function of chemical composition; as a consequence, an intermediate low-symmetry phase with a strong piezoelectric effect arises. In search for environmentally ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms4172
更新日期：2014-01-01 00:00:00
abstract：:Health risk factors such as body mass index (BMI) and serum cholesterol are associated with many common diseases. It often remains unclear whether the risk factors are cause or consequence of disease, or whether the associations are the result of confounding. We develop and apply a method (called GSMR) that performs a...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-02317-2
更新日期：2018-01-15 00:00:00
abstract：:Osteoporosis is a devastating disease with an essential genetic component. GWAS have discovered genetic signals robustly associated with bone mineral density (BMD), but not the precise localization of effector genes. Here, we carry out physical and direct variant to gene mapping in human mesenchymal progenitor cell-de...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-09302-x
更新日期：2019-03-19 00:00:00
abstract：:In contrast to processive molecular motors, skeletal myosins form a large motor ensemble for contraction of muscles against high loads. Despite numerous information on the molecular properties of skeletal myosin, its ensemble effects on collective force generation have not been rigorously clarified. Here we show 4 nm ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms16036
更新日期：2017-07-06 00:00:00
abstract：:The poverty of disease resistance gene reservoirs limits the breeding of crops for durable resistance against evolutionary dynamic pathogens. Zymoseptoria tritici which causes Septoria tritici blotch (STB), represents one of the most genetically diverse and devastating wheat pathogens worldwide. No fully virulent Z. t...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-20685-0
更新日期：2021-01-19 00:00:00
abstract：:Architectural proteins have an important role in shaping the genome and act as global regulators of gene expression. How these proteins jointly modulate genome plasticity is largely unknown. In archaea, one of the most abundant proteins, Alba, is considered to have a key role in organizing the genome. Here we characte...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms2330
更新日期：2012-01-01 00:00:00
abstract：:Here, to overcome many limitations accompanying current available methods to detect protein-protein interactions (PPIs), we develop a live cell method called Split Intein-Mediated Protein Ligation (SIMPL). In this approach, bait and prey proteins are respectively fused to an intein N-terminal fragment (IN) and C-termi...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-16299-1
更新日期：2020-05-15 00:00:00
abstract：:Inferring neural mechanisms from functional magnetic resonance imaging (fMRI) is challenging because the fMRI signal integrates over millions of neurons. One approach is to compare computational models that map neural activity to fMRI responses, to see which best predicts fMRI data. We use this approach to compare fou...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-05957-0
更新日期：2018-09-21 00:00:00
abstract：:Translatome reprogramming is a primary determinant of protein levels during stimuli adaptation. This raises the question: what are the translatome remodelers that reprogram protein output to activate biochemical adaptations. Here, we identify a translational pathway that represses metabolism to safeguard genome integr...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-19602-2
更新日期：2020-11-13 00:00:00
abstract：:Toward the development of surface-sensitive analytical techniques for biosensors and diagnostic biochip assays, a local integration of low-concentration target materials into the sensing region of interest is essential to improve the sensitivity and reliability of the devices. As a result, the dynamic process of sorti...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-16630-w
更新日期：2020-06-04 00:00:00
abstract：:The androgen receptor (AR) plays a central role in establishing an oncogenic cascade that drives prostate cancer progression. Some prostate cancers escape androgen dependence and are often associated with an aggressive phenotype. The oestrogen receptor alpha (ERα) is expressed in prostate cancers, independent of AR st...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms6383
更新日期：2014-11-21 00:00:00
abstract：:Graphene flakes with giant shape anisotropy are extensively used to establish connectedness electrical percolation in various heterogeneous systems. However, the percolation behaviour of graphene flakes has been recently predicted to be far more complicated than generally anticipated on the basis of excluded volume ar...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms9700
更新日期：2015-11-16 00:00:00
abstract：:Understanding how immune challenges elicit different responses is critical for diagnosing and deciphering immune regulation. Using a modular strategy to interpret the complex transcriptional host response in mouse models of infection and inflammation, we show a breadth of immune responses in the lung. Lung immune sign...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-10601-6
更新日期：2019-06-28 00:00:00
abstract：:By providing broad resistance to environmental biocides, transporters from the small multidrug resistance (SMR) family drive the spread of multidrug resistance cassettes among bacterial populations. A fundamental understanding of substrate selectivity by SMR transporters is needed to identify the types of selective pr...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-19820-8
更新日期：2020-11-27 00:00:00
abstract：:Genomic imprinting is a phenomenon that restricts transcription to predominantly one parental allele. How this transcriptional duality is regulated is poorly understood. Here we perform an RNA interference screen for epigenetic factors involved in paternal allelic silencing at the Kcnq1ot1 imprinted domain in mouse ex...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-05208-2
更新日期：2018-07-18 00:00:00
abstract：:Bulk photovoltaic effect (BPVE), featuring polarization-dependent uniform photoresponse at zero external bias, holds potential for exceeding the Shockley-Queisser limit in the efficiency of existing opto-electronic devices. However, the implementation of BPVE has been limited to the naturally existing materials with b...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-20115-1
更新日期：2020-12-17 00:00:00
abstract：:Two-component signal transduction systems consist of pairs of histidine kinases and response regulators, which mediate adaptive responses to environmental cues. Most activated response regulators regulate transcription by binding tightly to promoter DNA via a phosphorylation-triggered inactive-to-active transition. Th...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms4282
更新日期：2014-01-01 00:00:00
abstract：:G-protein-coupled receptor (GPCR) expression is extensively studied in bulk cDNA, but heterogeneity and functional patterning of GPCR expression in individual vascular cells is poorly understood. Here, we perform a microfluidic-based single-cell GPCR expression analysis in primary smooth muscle cells (SMC) and endothe...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms15700
更新日期：2017-06-16 00:00:00
abstract：:Pseudo-topotactic conversion of carbon nanotubes into one-dimensional carbon nanowires is a challenging but feasible path to obtain desired diameters and morphologies. Here, a previously predicted but experimentally unobserved carbon allotrope, T-carbon, has been produced from pseudo-topotactic conversion of a multi-w...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-00817-9
更新日期：2017-09-25 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Nature communications
pub_type： 已发布勘误
doi：10.1038/s41467-019-10951-1
更新日期：2019-07-01 00:00:00
abstract：:Sunlight is the ultimate driver of biosynthesis but photochemical steps late in biosynthetic pathways are very rare. They appear to play a role in the formation of certain furanocembranoids isolated from Caribbean corals. One of these compounds, intricarene, has been suspected to arise from an intramolecular 1,3-dipol...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms6597
更新日期：2014-12-03 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Nature communications
pub_type： 已发布勘误
doi：10.1038/s41467-019-11219-4
更新日期：2019-07-10 00:00:00
abstract：:Many voltage-gated potassium channels open in response to membrane depolarization and then inactivate within milliseconds. Neurons use these channels to tune their excitability. In Shaker K(+) channels, inactivation is caused by the cytoplasmic amino terminus, termed the inactivation gate. Despite having four such gat...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms5050
更新日期：2014-06-09 00:00:00
abstract：:Essential components of animal behaviour are modulated by dopaminergic (DA) and noradrenergic circuitry. In this study, we reveal at cellular resolution the complete set of projections ('projectome') of every single type of DA and noradrenergio neurons in the central nervous system of zebrafish larvae. The most extens...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms1171
更新日期：2011-01-25 00:00:00
abstract：:Diatomic nitrogen is an archetypal molecular system known for its exceptional stability and complex behavior at high pressures and temperatures, including rich solid polymorphism, formation of energetic states, and an insulator-to-metal transformation coupled to a change in chemical bonding. However, the thermobaric c...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-05011-z
更新日期：2018-07-06 00:00:00
abstract：:The energy band alignment in solar cell devices is critically important because it largely governs elementary photovoltaic processes, such as the generation, separation, transport, recombination and collection of charge carriers. Despite the expenditure of considerable effort, the measurement of energy band depth prof...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms8745
更新日期：2015-07-13 00:00:00
abstract：:Age, as a threshold of floral competence acquisition, prevents precocious flowering when there is insufficient biomass, and ensures flowering independent of environmental conditions; however, the underlying regulatory mechanisms are largely unknown. In this study, silencing the expression of a nuclear factor gene, CmN...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-00812-0
更新日期：2017-10-10 00:00:00
abstract：:Here, we introduce a novel concept for the fabrication of colored materials with significantly reduced dye leaching through covalent immobilization of the desired dye using plasma-generated surface radicals. This plasma dye coating (PDC) procedure immobilizes a pre-adsorbed layer of a dye functionalized with a radical...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-03583-4
更新日期：2018-03-16 00:00:00
abstract：:Submarine channels are ubiquitous on the seafloor and their inception and evolution is a result of dynamic interaction between turbidity currents and the evolving seafloor. However, the morphodynamic links between channel inception and flow dynamics have not yet been monitored in experiments and only in one instance o...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms10886
更新日期：2016-03-21 00:00:00
abstract：:The efficiencies of green and red perovskite light-emitting diodes (PeLEDs) have been increased close to their theoretical upper limit, while the efficiency of blue PeLEDs is lagging far behind. Here we report enhancing the efficiency of sky-blue PeLEDs by overcoming a major hurdle of low photoluminescence quantum eff...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-13580-w
更新日期：2019-12-10 00:00:00
