Pooled CRISPR interference screening enables genome-scale functional genomics study in bacteria with superior performance.

abstract：:Light propagating in tissue attains a spectrum that varies with location due to wavelength-dependent fluence attenuation, an effect that causes spectral corruption. Spectral corruption has limited the quantification accuracy of optical and optoacoustic spectroscopic methods, and impeded the goal of imaging blood oxyge...

journal_title：Nature communications

authors： Tzoumas S,Nunes A,Olefir I,Stangl S,Symvoulidis P,Glasl S,Bayer C,Multhoff G,Ntziachristos V

更新日期：2016-06-30 00:00:00

abstract：:Formation of domain walls in ferroelectrics is not energetically favourable in low-dimensional systems. Instead, vortex-type structures are formed that are driven by depolarization fields occurring in such systems. Consequently, polarization vortices have only been experimentally found in systems in which these fields...

journal_title：Nature communications

authors： Peters JJP,Apachitei G,Beanland R,Alexe M,Sanchez AM

更新日期：2016-11-16 00:00:00

abstract：:Understanding the role of intermolecular interaction on through-space charge transfer characteristics in π-stacked molecular systems is central to the rational design of electronic materials. However, a quantitative study of charge transfer in such systems is often difficult because of poor control over molecular morp...

journal_title：Nature communications

authors： Batra A,Kladnik G,Vázquez H,Meisner JS,Floreano L,Nuckolls C,Cvetko D,Morgante A,Venkataraman L

更新日期：2012-01-01 00:00:00

abstract：:Chiral metal complexes show promise as asymmetric catalysts and optical materials. Chiral-at-metal complexes composed of achiral ligands have expanded the versatility and applicability of chiral metal complexes, especially for octahedral and half-sandwich complexes. However, Werner-type tetrahedral complexes with a st...

journal_title：Nature communications

authors： Endo K,Liu Y,Ube H,Nagata K,Shionoya M

更新日期：2020-12-09 00:00:00

abstract：:Caffeine is a major component of xanthine alkaloids and commonly consumed in many popular beverages. Due to its occasional side effects, reduction of caffeine in a natural way is of great importance and economic significance. Recent studies reveal that caffeine can be converted into non-stimulatory theacrine in the ra...

journal_title：Nature communications

authors： Zhang YH,Li YF,Wang Y,Tan L,Cao ZQ,Xie C,Xie G,Gong HB,Sun WY,Ouyang SH,Duan WJ,Lu X,Ding K,Kurihara H,Hu D,Zhang ZM,Abe I,He RR

更新日期：2020-03-19 00:00:00

abstract：:Hyperpolarization via dynamic nuclear polarization (DNP) is pivotal for boosting magnetic resonance imaging (MRI) sensitivity and dissolution DNP can be used to perform in vivo real-time 13C MRI. The type of applications is however limited by the relatively fast decay time of the hyperpolarized spin state together wit...

journal_title：Nature communications

authors： Capozzi A,Cheng T,Boero G,Roussel C,Comment A

更新日期：2017-06-01 00:00:00

abstract：:Energy affects every single individual and entity in the world. Therefore, it is crucial to precisely quantify the "price of energy" and study how it evolves through time, through major political and social events, and through changes in energy and monetary policies. Here, we develop a predictive framework, an index t...

journal_title：Nature communications

authors： Baratsas SG,Niziolek AM,Onel O,Matthews LR,Floudas CA,Hallermann DR,Sorescu SM,Pistikopoulos EN

更新日期：2021-01-04 00:00:00

abstract：:Sirtuins regulate numerous important biological processes in mammals, including various age-associated pathophysiologies. However, whether sirtuins are critical to control ageing and longevity in mammals has been controversial. Recent studies have demonstrated critical roles of sirtuins in the brain, especially the hy...

journal_title：Nature communications

authors： Satoh A,Imai S

更新日期：2014-06-26 00:00:00

abstract：:The outcome of molecule-surface collisions can be modified by pre-aligning the molecule; however, experiments accomplishing this are rare because of the difficulty of preparing molecules in aligned quantum states. Here we present a general solution to this problem based on magnetic manipulation of the rotational magne...

journal_title：Nature communications

authors： Godsi O,Corem G,Alkoby Y,Cantin JT,Krems RV,Somers MF,Meyer J,Kroes GJ,Maniv T,Alexandrowicz G

更新日期：2017-05-08 00:00:00

abstract：:Deep subwavelength integration of high-definition plasmonic nanostructures is of key importance in the development of future optical nanocircuitry for high-speed communication, quantum computation and lab-on-a-chip applications. To date, the experimental realization of proposed extended plasmonic networks consisting o...

journal_title：Nature communications

authors： Huang JS,Callegari V,Geisler P,Brüning C,Kern J,Prangsma JC,Wu X,Feichtner T,Ziegler J,Weinmann P,Kamp M,Forchel A,Biagioni P,Sennhauser U,Hecht B

更新日期：2010-01-01 00:00:00

abstract：:Chemoproteomics is a key technology to characterize the mode of action of drugs, as it directly identifies the protein targets of bioactive compounds and aids in the development of optimized small-molecule compounds. Current approaches cannot identify the protein targets of a compound and also detect the interaction s...

journal_title：Nature communications

authors： Piazza I,Beaton N,Bruderer R,Knobloch T,Barbisan C,Chandat L,Sudau A,Siepe I,Rinner O,de Souza N,Picotti P,Reiter L

更新日期：2020-08-21 00:00:00

abstract：:The quantum noise of the vacuum limits the achievable sensitivity of quantum sensors. In non-classical measurement schemes the noise can be reduced to overcome this limitation. However, schemes based on squeezed or Schrödinger cat states require alignment of the relative phase between the measured interaction and the ...

journal_title：Nature communications

authors： Wolf F,Shi C,Heip JC,Gessner M,Pezzè L,Smerzi A,Schulte M,Hammerer K,Schmidt PO

更新日期：2019-07-02 00:00:00

abstract：:Mammals have nine different homologues (ALKBH1-9) of the Escherichia coli DNA repair demethylase AlkB. ALKBH2 is a genuine DNA repair enzyme, but the in vivo function of the other ALKBH proteins has remained elusive. It was recently shown that ALKBH8 contains an additional transfer RNA (tRNA) methyltransferase domain,...

journal_title：Nature communications

authors： van den Born E,Vågbø CB,Songe-Møller L,Leihne V,Lien GF,Leszczynska G,Malkiewicz A,Krokan HE,Kirpekar F,Klungland A,Falnes PØ

更新日期：2011-02-01 00:00:00

abstract：:Since the observation of the first brown dwarf in 1995, numerous studies have led to a better understanding of the structures of these objects. Here we present a method for studying material resistivity in warm dense plasmas in the laboratory, which we relate to the microphysics of brown dwarfs through viscosity and e...

journal_title：Nature communications

authors： Booth N,Robinson AP,Hakel P,Clarke RJ,Dance RJ,Doria D,Gizzi LA,Gregori G,Koester P,Labate L,Levato T,Li B,Makita M,Mancini RC,Pasley J,Rajeev PP,Riley D,Wagenaars E,Waugh JN,Woolsey NC

更新日期：2015-11-06 00:00:00

abstract：:In weakly spin-orbit coupled materials, the spin-selective nature of recombination can give rise to large magnetic-field effects, e.g. on the electro-luminescence of molecular semiconductors. Although silicon has weak spin-orbit coupling, observing spin-dependent recombination through magneto-electroluminescence is ch...

journal_title：Nature communications

authors： Chiodi F,Bayliss SL,Barast L,Débarre D,Bouchiat H,Friend RH,Chepelianskii AD

更新日期：2018-01-26 00:00:00

abstract：:Pancreatic cancer is the fourth leading cause of cancer-related deaths in Japan. To identify risk loci, we perform a meta-analysis of three genome-wide association studies comprising 2,039 pancreatic cancer patients and 32,592 controls in the Japanese population. Here, we identify 3 (13q12.2, 13q22.1, and 16p12.3) gen...

journal_title：Nature communications

authors： Lin Y,Nakatochi M,Hosono Y,Ito H,Kamatani Y,Inoko A,Sakamoto H,Kinoshita F,Kobayashi Y,Ishii H,Ozaka M,Sasaki T,Matsuyama M,Sasahira N,Morimoto M,Kobayashi S,Fukushima T,Ueno M,Ohkawa S,Egawa N,Kuruma S,Mori M,

更新日期：2020-06-24 00:00:00

abstract：:Post-transcriptional regulation of cellular mRNA is essential for protein synthesis. Here we describe the importance of mRNA translational repression and mRNA subcellular location for protein expression during B lymphocyte activation and the DNA damage response. Cytoplasmic RNA granules are formed upon cell activation...

journal_title：Nature communications

authors： Díaz-Muñoz MD,Kiselev VY,Le Novère N,Curk T,Ule J,Turner M

更新日期：2017-09-13 00:00:00

abstract：:Tropical south-western Pacific temperatures are of vital importance to the Great Barrier Reef (GBR), but the role of sea surface temperatures (SSTs) in the growth of the GBR since the Last Glacial Maximum remains largely unknown. Here we present records of Sr/Ca and δ(18)O for Last Glacial Maximum and deglacial corals...

journal_title：Nature communications

authors： Felis T,McGregor HV,Linsley BK,Tudhope AW,Gagan MK,Suzuki A,Inoue M,Thomas AL,Esat TM,Thompson WG,Tiwari M,Potts DC,Mudelsee M,Yokoyama Y,Webster JM

更新日期：2014-06-17 00:00:00

abstract：:In nature, protein subunits on the capsids of many icosahedral viruses form rotational patterns, and mathematicians also incorporate asymmetric patterns into faces of polyhedra. Chemists have constructed molecular polyhedra with vacant or highly symmetric faces, but very little is known about constructing polyhedra wi...

journal_title：Nature communications

authors： Wang X,Wang Y,Yang H,Fang H,Chen R,Sun Y,Zheng N,Tan K,Lu X,Tian Z,Cao X

更新日期：2016-08-24 00:00:00

abstract：:The phosphorylation of eIF4E1 at serine 209 by MNK1 or MNK2 has been shown to initiate oncogenic mRNA translation, a process that favours cancer development and maintenance. Here, we interrogate the MNK-eIF4E axis in diffuse large B-cell lymphoma (DLBCL) and show a distinct distribution of MNK1 and MNK2 in germinal ce...

journal_title：Nature communications

authors： Landon AL,Muniandy PA,Shetty AC,Lehrmann E,Volpon L,Houng S,Zhang Y,Dai B,Peroutka R,Mazan-Mamczarz K,Steinhardt J,Mahurkar A,Becker KG,Borden KL,Gartenhaus RB

更新日期：2014-11-18 00:00:00

abstract：:The modern understanding of sleep is based on the classification of sleep into stages defined by their electroencephalography (EEG) signatures, but the underlying brain dynamics remain unclear. Here we aimed to move significantly beyond the current state-of-the-art description of sleep, and in particular to characteri...

journal_title：Nature communications

authors： Stevner ABA,Vidaurre D,Cabral J,Rapuano K,Nielsen SFV,Tagliazucchi E,Laufs H,Vuust P,Deco G,Woolrich MW,Van Someren E,Kringelbach ML

更新日期：2019-03-04 00:00:00

abstract：:Unlike microevolutionary processes, little is known about the genetic basis of macroevolutionary processes. One of these magnificent examples is the transition from non-avian dinosaurs to birds that has created numerous evolutionary innovations such as self-powered flight and its associated wings with flight feathers....

journal_title：Nature communications

authors： Seki R,Li C,Fang Q,Hayashi S,Egawa S,Hu J,Xu L,Pan H,Kondo M,Sato T,Matsubara H,Kamiyama N,Kitajima K,Saito D,Liu Y,Gilbert MT,Zhou Q,Xu X,Shiroishi T,Irie N,Tamura K,Zhang G

更新日期：2017-02-06 00:00:00

abstract：:TFIIS-like transcript cleavage factors enhance the processivity and fidelity of archaeal and eukaryotic RNA polymerases. Sulfolobus solfataricus TFS1 functions as a bona fide cleavage factor, while the paralogous TFS4 evolved into a potent RNA polymerase inhibitor. TFS4 destabilises the TBP-TFB-RNAP pre-initiation com...

journal_title：Nature communications

authors： Fouqueau T,Blombach F,Hartman R,Cheung ACM,Young MJ,Werner F

更新日期：2017-12-04 00:00:00

abstract：:Chains of quantum dots coupled to superconductors are promising for the realization of the Kitaev model of a topological superconductor. While individual superconducting quantum dots have been explored, control of longer chains requires understanding of interdot coupling. Here, double quantum dots are defined by gate ...

journal_title：Nature communications

authors： Su Z,Tacla AB,Hocevar M,Car D,Plissard SR,Bakkers EPAM,Daley AJ,Pekker D,Frolov SM

更新日期：2017-09-19 00:00:00

abstract：:Overcoming the restricted axonal regenerative ability that limits functional repair following a central nervous system injury remains a challenge. Here we report a regenerative paradigm that we call enriched conditioning, which combines environmental enrichment (EE) followed by a conditioning sciatic nerve axotomy tha...

journal_title：Nature communications

authors： De Virgiliis F,Hutson TH,Palmisano I,Amachree S,Miao J,Zhou L,Todorova R,Thompson R,Danzi MC,Lemmon VP,Bixby JL,Wittig I,Shah AM,Di Giovanni S

更新日期：2020-12-21 00:00:00

abstract：:Layered materials embrace rich intercalation reactions to accommodate high concentrations of foreign species within their structures, and find many applications spanning from energy storage, ion exchange to secondary batteries. Light alkali metals are generally most easily intercalated due to their light mass, high ch...

journal_title：Nature communications

authors： Yajima T,Koshiko M,Zhang Y,Oguchi T,Yu W,Kato D,Kobayashi Y,Orikasa Y,Yamamoto T,Uchimoto Y,Green MA,Kageyama H

更新日期：2016-12-14 00:00:00

abstract：:Seismological findings show a complex scenario of plume upwellings from a deep thermo-chemical anomaly (superplume) beneath the East African Rift System (EARS). It is unclear if these geophysical observations represent a true picture of the superplume and its influence on magmatism along the EARS. Thus, it is essentia...

journal_title：Nature communications

authors： O'Connor JM,Jokat W,Regelous M,Kuiper KF,Miggins DP,Koppers AAP

更新日期：2019-12-02 00:00:00

abstract：:Rabies is a viral zoonosis transmitted by vampire bats across Latin America. Substantial public health and agricultural burdens remain, despite decades of bats culls and livestock vaccinations. Virally vectored vaccines that spread autonomously through bat populations are a theoretically appealing solution to managing...

journal_title：Nature communications

authors： Griffiths ME,Bergner LM,Broos A,Meza DK,Filipe ADS,Davison A,Tello C,Becker DJ,Streicker DG

更新日期：2020-11-23 00:00:00

abstract：:Two-dimensional materials provide extraordinary opportunities for exploring phenomena arising in atomically thin crystals. Beginning with the first isolation of graphene, mechanical exfoliation has been a key to provide high-quality two-dimensional materials, but despite improvements it is still limited in yield, late...

journal_title：Nature communications

authors： Huang Y,Pan YH,Yang R,Bao LH,Meng L,Luo HL,Cai YQ,Liu GD,Zhao WJ,Zhou Z,Wu LM,Zhu ZL,Huang M,Liu LW,Liu L,Cheng P,Wu KH,Tian SB,Gu CZ,Shi YG,Guo YF,Cheng ZG,Hu JP,Zhao L,Yang GH,Sutter E,Sutter P,Wan

更新日期：2020-05-15 00:00:00

abstract：:The challenge of monitoring in planta dynamic changes of NADP(H) and NAD(H) redox states at the subcellular level is considered a major obstacle in plant bioenergetics studies. Here, we introduced two circularly permuted yellow fluorescent protein sensors, iNAP and SoNar, into Arabidopsis thaliana to monitor the dynam...

journal_title：Nature communications

authors： Lim SL,Voon CP,Guan X,Yang Y,Gardeström P,Lim BL

更新日期：2020-06-26 00:00:00