Systemic regulation of mammalian ageing and longevity by brain sirtuins.

Abstract:

:Sirtuins regulate numerous important biological processes in mammals, including various age-associated pathophysiologies. However, whether sirtuins are critical to control ageing and longevity in mammals has been controversial. Recent studies have demonstrated critical roles of sirtuins in the brain, especially the hypothalamus, in governing multiple physiological functions. These data provide strong evidence that brain sirtuins regulate mammalian ageing and longevity at the organismal level.

journal_name

Nat Commun

journal_title

Nature communications

authors

Satoh A,Imai S

doi

10.1038/ncomms5211

subject

Has Abstract

pub_date

2014-06-26 00:00:00

pages

4211

issn

2041-1723

pii

ncomms5211

journal_volume

5

pub_type

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