Abstract:
:Sirtuins regulate numerous important biological processes in mammals, including various age-associated pathophysiologies. However, whether sirtuins are critical to control ageing and longevity in mammals has been controversial. Recent studies have demonstrated critical roles of sirtuins in the brain, especially the hypothalamus, in governing multiple physiological functions. These data provide strong evidence that brain sirtuins regulate mammalian ageing and longevity at the organismal level.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Satoh A,Imai Sdoi
10.1038/ncomms5211subject
Has Abstractpub_date
2014-06-26 00:00:00pages
4211issn
2041-1723pii
ncomms5211journal_volume
5pub_type
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