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Anti-quenching NIR-II molecular fluorophores for in vivo high-contrast imaging and pH sensing.

Abstract：

:The contrast and sensitivity of in vivo fluorescence imaging has been revolutionized by molecular fluorophores operating in the second near-infrared window (NIR-II; 1000-1700 nm), but an ongoing challenge is the solvatochromism-caused quenching in aqueous solution for the long-wavelength absorbing fluorophores. Herein, we develop a series of anti-quenching pentamethine cyanine fluorophores that significantly overcome the severe solvatochromism, thus affording stable absorption/emission beyond 1000 nm with up to ~ 44-fold enhanced brightness and superior photostability in aqueous solution. These advantages allow for deep optical penetration (8 mm) as well as high-contrast and highly-stable lymphatic imaging superior to clinical-approved indocyanine green. Additionally, these fluorophores exhibit pH-responsive fluorescence, allowing for noninvasive ratiometric fluorescence imaging and quantification of gastric pH in vivo. The results demonstrate reliable accuracy in tissue as deep as 4 mm, comparable to standard pH electrode method. This work unlocks the potential of anti-quenching pentamethine cyanines for NIR-II biological applications.

journal_name

Nat Commun

journal_title

Nature communications

authors

Wang S,Fan Y,Li D,Sun C,Lei Z,Lu L,Wang T,Zhang F

doi

10.1038/s41467-019-09043-x

subject

Has Abstract

pub_date

2019-03-05 00:00:00

pages

1058

issue

1

issn

2041-1723

pii

10.1038/s41467-019-09043-x

journal_volume

10

pub_type

杂志文章

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