Abstract：
:Connection of tubules into larger networks is the key process for the development of circulatory systems. In Drosophila development, tip cells of the tracheal system lead the migration of each branch and connect tubules by adhering to each other and simultaneously changing into a torus-shape. We show that as adhesion sites form between fusion cells, myosin and microtubules form polarized bundles that connect the new adhesion site to the cells' microtubule-organizing centres, and that E-cadherin and retrograde recycling endosomes are preferentially deposited at the new adhesion site. We demonstrate that microtubules help balancing tip cell contraction, which is driven by myosin, and is required for adhesion and tube fusion. We also show that retrograde recycling and directed secretion of a specific matrix protein into the fusion-cell interface promote fusion. We propose that microtubule bundles connecting these cell-cell interfaces coordinate cell contractility and apical secretion to facilitate tube fusion.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Kato K,Dong B,Wada H,Tanaka-Matakatsu M,Yagi Y,Hayashi Sdoi
10.1038/ncomms11141subject
Has Abstractpub_date
2016-04-12 00:00:00pages
11141issn
2041-1723pii
ncomms11141journal_volume
7pub_type
杂志文章abstract：:Leaves lose approximately 400 H2O molecules for every 1 CO2 gained during photosynthesis. Most long-distance water transport in plants, or xylem sap flow, serves to replace this water to prevent desiccation. Theory predicts that the largest vessels contribute disproportionately to overall sap flow because flow in pipe...
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abstract：:Sponges (phylum Porifera) are early-diverging metazoa renowned for establishing complex microbial symbioses. Here we present a global Porifera microbiome survey, set out to establish the ecological and evolutionary drivers of these host-microbe interactions. We show that sponges are a reservoir of exceptional microbia...
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abstract：:Temperature measurement is critical for many technological applications and scientific experiments, and different types of thermometers have been developed to detect temperature at macroscopic length scales. However, quantitative measurement of the temperature of nanostructures remains a challenge. Here, we show a new...
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pub_type： 杂志文章
doi：10.1038/ncomms5986
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abstract：:The ciliary kinase NEK8 plays a critical role in situs determination and cystic kidney disease, yet its exact function remains unknown. In this study, we identify ANKS6 as a target and activator of NEK8. ANKS6 requires NEK8 for localizing to the ciliary inversin compartment (IC) and activates NEK8 by binding to its ki...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms7023
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abstract：:Suspension-feeding fishes such as goldfish and whale sharks retain prey without clogging their oral filters, whereas clogging is a major expense in industrial crossflow filtration of beer, dairy foods and biotechnology products. Fishes' abilities to retain particles that are smaller than the pore size of the gill-rake...
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doi：10.1038/ncomms11092
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abstract：:Nanophotonics is becoming invaluable for an expanding range of applications, from controlling the spontaneous emission rate and the directionality of quantum emitters, to reducing material requirements of solar cells by an order of magnitude. These effects are highly dependent on the near field of the nanostructure, w...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms13950
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abstract：:Zeolite catalysis is determined by a combination of pore architecture and Brønsted acidity. As Brønsted acid sites are formed by the substitution of AlO4 for SiO4 tetrahedra, it is of utmost importance to have information on the number as well as the location and neighbouring sites of framework aluminium. Unfortunatel...
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journal_title：Nature communications
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abstract：:Sustainable food production in the context of climate change necessitates diversification of agriculture and a more efficient utilization of plant genetic resources. Fonio millet (Digitaria exilis) is an orphan African cereal crop with a great potential for dryland agriculture. Here, we establish high-quality genomic ...
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journal_title：Nature communications
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doi：10.1038/s41467-019-12331-1
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abstract：:The yeast Rab5 homologue, Vps21p, is known to be involved both in the vacuolar protein sorting (VPS) pathway from the trans-Golgi network to the vacuole, and in the endocytic pathway from the plasma membrane to the vacuole. However, the intracellular location at which these two pathways converge remains unclear. In ad...
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abstract：:We currently have limited knowledge of the involvement of long non-coding RNAs (lncRNAs) in normal cellular processes and pathologies. Here, we identify and characterize SNHG5 as a stable cytoplasmic lncRNA with up-regulated expression in colorectal cancer. Depletion of SNHG5 induces cell cycle arrest and apoptosis in...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms13875
更新日期：2016-12-22 00:00:00
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journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-10543-z
更新日期：2019-06-13 00:00:00
abstract：:Hybrid halide perovskite solar cells were first demonstrated in 2009 with cell efficiency quickly soaring from below 10% to more than 23% in a few years. Halide perovskites have the desirable processing simplicity but are very fragile when exposed to water and heat. This fragility represents a great challenge for the ...
journal_title：Nature communications
pub_type： 杂志文章,评审
doi：10.1038/s41467-018-07382-9
更新日期：2018-11-28 00:00:00
abstract：:Ataxia telangiectasia is caused by mutations in ATM and represents a paradigm for cancer predisposition and neurodegenerative syndromes linked to deficiencies in the DNA-damage response. The role of ATM as a key regulator of signalling following DNA double-strand breaks (DSBs) has been dissected in extraordinary detai...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms4347
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abstract：:Efficient organic light-emitting diodes have been developed using emitters containing rare metals, such as platinum and iridium complexes. However, there is an urgent need to develop emitters composed of more abundant materials. Here we show a thermally activated delayed fluorescence material for organic light-emittin...
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pub_type： 杂志文章
doi：10.1038/ncomms9476
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journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-20157-5
更新日期：2020-12-18 00:00:00
abstract：:Oligodendrocytes (OLs) are the myelin-forming cells of the central nervous system. They are derived from differentiation of oligodendrocyte progenitors through a process requiring cell cycle exit and histone modifications. Here we identify the histone arginine methyl-transferase PRMT5, a molecule catalyzing symmetric ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-04863-9
更新日期：2018-07-19 00:00:00
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pub_type： 杂志文章
doi：10.1038/s41467-020-15411-9
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pub_type： 杂志文章
doi：10.1038/ncomms6629
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pub_type： 杂志文章
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更新日期：2014-12-08 00:00:00
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更新日期：2020-07-06 00:00:00
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pub_type： 杂志文章
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更新日期：2020-04-28 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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