Fonio millet genome unlocks African orphan crop diversity for agriculture in a changing climate.

abstract：:Many applications proposed for graphene require multiple sheets be assembled into a monolithic structure. The ability to maintain structural integrity upon large deformation is essential to ensure a macroscopic material which functions reliably. However, it has remained a great challenge to achieve high elasticity in ...

journal_title：Nature communications

authors： Qiu L,Liu JZ,Chang SL,Wu Y,Li D

更新日期：2012-01-01 00:00:00

abstract：:Type 2 diabetes mellitus (T2DM) is characterized by defects in both insulin sensitivity and glucose-stimulated insulin secretion (GSIS) and is often accompanied by obesity. In this study, we show that disruption of thioredoxin binding protein-2 (TBP-2, also called Txnip) in obese mice (ob/ob) dramatically improves hyp...

journal_title：Nature communications

authors： Yoshihara E,Fujimoto S,Inagaki N,Okawa K,Masaki S,Yodoi J,Masutani H

更新日期：2010-11-23 00:00:00

abstract：:Environmental challenges to plants typically entail retardation of vegetative growth and delay or cessation of flowering. Here we report a link between the flowering time regulator, GIGANTEA (GI), and adaptation to salt stress that is mechanistically based on GI degradation under saline conditions, thus retarding flow...

journal_title：Nature communications

authors： Kim WY,Ali Z,Park HJ,Park SJ,Cha JY,Perez-Hormaeche J,Quintero FJ,Shin G,Kim MR,Qiang Z,Ning L,Park HC,Lee SY,Bressan RA,Pardo JM,Bohnert HJ,Yun DJ

更新日期：2013-01-01 00:00:00

abstract：:Methane cold seep systems typically exhibit extensive buildups of authigenic carbonate minerals, resulting from local increases in alkalinity driven by methane oxidation. Here, we demonstrate that modern seep authigenic carbonates exhibit anomalously low clumped isotope values (Δ47), as much as ∼0.2‰ lower than expect...

journal_title：Nature communications

authors： Loyd SJ,Sample J,Tripati RE,Defliese WF,Brooks K,Hovland M,Torres M,Marlow J,Hancock LG,Martin R,Lyons T,Tripati AE

更新日期：2016-07-22 00:00:00

abstract：:The role of microglia in spinal cord injury (SCI) remains poorly understood and is often confused with the response of macrophages. Here, we use specific transgenic mouse lines and depleting agents to understand the response of microglia after SCI. We find that microglia are highly dynamic and proliferate extensively ...

journal_title：Nature communications

authors： Bellver-Landete V,Bretheau F,Mailhot B,Vallières N,Lessard M,Janelle ME,Vernoux N,Tremblay MÈ,Fuehrmann T,Shoichet MS,Lacroix S

更新日期：2019-01-31 00:00:00

abstract：:Chronic cranial window (CCW) is an essential tool in enabling longitudinal imaging and manipulation of various brain activities in live animals. However, an active CCW capable of sensing the concealed in vivo environment while simultaneously providing longitudinal optical access to the brain is not currently available...

journal_title：Nature communications

authors： Li H,Dong B,Zhang X,Shu X,Chen X,Hai R,Czaplewski DA,Zhang HF,Sun C

更新日期：2019-09-19 00:00:00

abstract：:Cancer is caused by the accumulation of multiple genetic mutations, but their cooperative effects are poorly understood. Using a genome-wide analysis of all the somatic mutations in colorectal cancer patients in a large-scale molecular interaction network, here we find that a giant cluster of mutation-propagating modu...

journal_title：Nature communications

authors： Shin D,Lee J,Gong JR,Cho KH

更新日期：2017-11-02 00:00:00

abstract：:Seismological findings show a complex scenario of plume upwellings from a deep thermo-chemical anomaly (superplume) beneath the East African Rift System (EARS). It is unclear if these geophysical observations represent a true picture of the superplume and its influence on magmatism along the EARS. Thus, it is essentia...

journal_title：Nature communications

authors： O'Connor JM,Jokat W,Regelous M,Kuiper KF,Miggins DP,Koppers AAP

更新日期：2019-12-02 00:00:00

abstract：:It is evident that epigenetic factors, especially DNA methylation, have essential roles in obesity development. Here, using pig as a model, we investigate the systematic association between DNA methylation and obesity. We sample eight variant adipose and two distinct ske...

journal_title：Nature communications

authors： Li M,Wu H,Luo Z,Xia Y,Guan J,Wang T,Gu Y,Chen L,Zhang K,Ma J,Liu Y,Zhong Z,Nie J,Zhou S,Mu Z,Wang X,Qu J,Jing L,Wang H,Huang S,Yi N,Wang Z,Xi D,Wang J,Yin G,Wang L,Li N,Jiang Z,Lang Q,Xiao H,Ji

更新日期：2012-05-22 00:00:00

abstract：:Many glasses exhibit fractional power law (FPL) between the mean atomic volume va and the first diffraction peak position q1, i.e. [Formula: see text] with d ≃ 2.5 deviating from the space dimension D = 3, under compression or composition change. What structural change causes such FPL and whether the FPL and d are uni...

journal_title：Nature communications

authors： Zhang H,Qiao K,Han Y

更新日期：2020-04-24 00:00:00

abstract：:Large-scale, unbiased proteomics studies are constrained by the complexity of the plasma proteome. Here we report a highly parallel protein quantitation platform integrating nanoparticle (NP) protein coronas with liquid chromatography-mass spectrometry for efficient proteomic profiling. A protein corona is a protein l...

journal_title：Nature communications

authors： Blume JE,Manning WC,Troiano G,Hornburg D,Figa M,Hesterberg L,Platt TL,Zhao X,Cuaresma RA,Everley PA,Ko M,Liou H,Mahoney M,Ferdosi S,Elgierari EM,Stolarczyk C,Tangeysh B,Xia H,Benz R,Siddiqui A,Carr SA,Ma P,Lan

更新日期：2020-07-22 00:00:00

abstract：:Genome editing critically relies on selective recognition of target sites. However, despite recent progress, the underlying search mechanism of genome-editing proteins is not fully understood in the context of cellular chromatin environments. Here, we use single-molecule imaging in live cells to directly study the beh...

journal_title：Nature communications

authors： Jain S,Shukla S,Yang C,Zhang M,Fatma Z,Lingamaneni M,Abesteh S,Lane ST,Xiong X,Wang Y,Schroeder CM,Selvin PR,Zhao H

更新日期：2021-01-27 00:00:00

abstract：:Netrins, a family of laminin-related molecules, have been proposed to act as guidance cues either during nervous system development or the establishment of the vascular system. This was clearly demonstrated for netrin-1 via its interaction with the receptors DCC and UNC5s. However, mainly based on shared homologies wi...

journal_title：Nature communications

authors： Reuten R,Patel TR,McDougall M,Rama N,Nikodemus D,Gibert B,Delcros JG,Prein C,Meier M,Metzger S,Zhou Z,Kaltenberg J,McKee KK,Bald T,Tüting T,Zigrino P,Djonov V,Bloch W,Clausen-Schaumann H,Poschl E,Yurchenco PD,Eh

更新日期：2016-11-30 00:00:00

abstract：:Current-induced magnetic domain wall (DW) motion is an important operating principle of spintronic devices. Injected current generates spin torques (STs) on the DWs in two ways. One is the spin transfer from magnetic domains to the walls by the current flowing in the magnet. Current flow in attached heavy metals also ...

journal_title：Nature communications

authors： Moon KW,Kim C,Yoon J,Choi JW,Kim DO,Song KM,Kim D,Chun BS,Hwang C

更新日期：2018-09-17 00:00:00

abstract：:Long-read sequencing technologies have greatly facilitated assemblies of large eukaryotic genomes. In this paper, Oxford Nanopore sequences generated on a MinION sequencer are combined with Bionano Genomics Direct Label and Stain (DLS) optical maps to generate a chromosome-scale de novo assembly of the repeat-rich Sor...

journal_title：Nature communications

authors： Deschamps S,Zhang Y,Llaca V,Ye L,Sanyal A,King M,May G,Lin H

更新日期：2018-11-19 00:00:00

abstract：:Proper regulation of energy storage in adipose tissue is crucial for maintaining insulin sensitivity and molecules contributing to this process have not been fully revealed. Here we show that type II transmembrane protein tenomodulin (TNMD) is upregulated in adipose tissue of insulin-resistant versus insulin-sensitive...

journal_title：Nature communications

authors： Senol-Cosar O,Flach RJ,DiStefano M,Chawla A,Nicoloro S,Straubhaar J,Hardy OT,Noh HL,Kim JK,Wabitsch M,Scherer PE,Czech MP

更新日期：2016-02-16 00:00:00

abstract：:Following microbial pathogen invasion, one of the main challenges for the host is to rapidly control pathogen spreading to avoid vital tissue damage. Here we report that an effector CD8(+) T-cell population that expresses the marker NK1.1 undergoes delayed contraction and sustains early anti-microbial protection. NK1....

journal_title：Nature communications

authors： Ruiz AL,Soudja SM,Deceneux C,Lauvau G,Marie JC

更新日期：2014-10-06 00:00:00

abstract：:Ions are ubiquitous biological regulators playing a key role for vital processes in animals and plants. The combined detection of ion concentration and real-time monitoring of small variations with respect to the resting conditions is a multiscale functionality providing important information on health states. This mu...

journal_title：Nature communications

authors： Romele P,Gkoupidenis P,Koutsouras DA,Lieberth K,Kovács-Vajna ZM,Blom PWM,Torricelli F

更新日期：2020-07-27 00:00:00

abstract：:Hepatitis B virus causes chronic infections in 250 million people worldwide. Chronic hepatitis B virus carriers are at risk of developing fibrosis, cirrhosis, and hepatocellular carcinoma. A prophylactic vaccine exists and currently available antivirals can suppress but rarely cure chronic infections. The study of hep...

journal_title：Nature communications

authors： Winer BY,Huang TS,Pludwinski E,Heller B,Wojcik F,Lipkowitz GE,Parekh A,Cho C,Shrirao A,Muir TW,Novik E,Ploss A

更新日期：2017-07-25 00:00:00

abstract：:Understanding marine environmental change and associated biological turnover across the Palaeocene-Eocene Thermal Maximum (PETM; ~56 Ma)-the most pronounced Cenozoic short-term global warming event-is important because of the potential role of the ocean in atmospheric CO2 drawdown, yet proxies for tracing marine produ...

journal_title：Nature communications

authors： Chang L,Harrison RJ,Zeng F,Berndt TA,Roberts AP,Heslop D,Zhao X

更新日期：2018-10-01 00:00:00

abstract：:The Unc-51 like autophagy activating kinase 1 (ULK1) complex plays a central role in the initiation stage of autophagy. However, the function of ULK1 in the late stage of autophagy is unknown. Here, we report that ULK1, a central kinase of the ULK1 complex involved in autophagy initiation, promotes autophagosome-lysos...

journal_title：Nature communications

authors： Wang C,Wang H,Zhang D,Luo W,Liu R,Xu D,Diao L,Liao L,Liu Z

更新日期：2018-08-28 00:00:00

abstract：:Electrospun nanofibres are promising in biomedical applications to replicate features of the natural extracellular matrix (ECM). However, nearly all electrospun scaffolds are either non-degradable or degrade hydrolytically, whereas natural ECM degrades proteolytically, often through matrix metalloproteinases. Here we ...

journal_title：Nature communications

authors： Wade RJ,Bassin EJ,Rodell CB,Burdick JA

更新日期：2015-03-23 00:00:00

abstract：:Scleractinian corals' microbial symbionts influence host health, yet how coral microbiomes assembled over evolution is not well understood. We survey bacterial and archaeal communities in phylogenetically diverse Australian corals representing more than 425 million years of diversification. We show that coral microbio...

journal_title：Nature communications

authors： Pollock FJ,McMinds R,Smith S,Bourne DG,Willis BL,Medina M,Thurber RV,Zaneveld JR

更新日期：2018-11-22 00:00:00

abstract：:Modern ultrafast metrology relies on the postulate that the pulse to be measured is fully coherent, that is, that it can be completely described by its spectrum and spectral phase. However, synthesizing fully coherent pulses is not always possible in practice, especially in the domain of emerging ultrashort X-ray sour...

journal_title：Nature communications

authors： Bourassin-Bouchet C,Couprie ME

更新日期：2015-03-06 00:00:00

abstract：:Supported gold (Au) nanocatalysts have attracted extensive interests in the past decades because of their unique catalytic properties for a number of key chemical reactions, especially in (selective) oxidations. The activation of O2 on Au nanocatalysts is crucial and remains a challenge because only small Au nanoparti...

journal_title：Nature communications

authors： Zhang Y,Zhang J,Zhang B,Si R,Han B,Hong F,Niu Y,Sun L,Li L,Qiao B,Sun K,Huang J,Haruta M

更新日期：2020-01-28 00:00:00

abstract：:Ever since the discovery of dye self-assemblies in nature, there have been tremendous efforts to exploit biomimetic supramolecular assemblies for tailored artificial photon processing materials. This feature necessarily has resulted in an increasing demand for understanding exciton dynamics in the dye self-assemblies....

journal_title：Nature communications

authors： Sung J,Kim P,Fimmel B,Würthner F,Kim D

更新日期：2015-10-23 00:00:00

abstract：:Making decisions based on choice-outcome history is a crucial, adaptive ability in life. However, the neural circuit mechanisms underlying history-dependent decision-making are poorly understood. In particular, history-related signals have been found in many brain areas during various decision-making tasks, but the ca...

journal_title：Nature communications

authors： Hwang EJ,Dahlen JE,Mukundan M,Komiyama T

更新日期：2017-11-01 00:00:00

abstract：:The cell cytosol is crowded with high concentrations of many different biomacromolecules, which is difficult to mimic in bottom-up synthetic cell research and limits the functionality of existing protocellular platforms. There is thus a clear need for a general, biocompatible, and accessible tool to more accurately em...

journal_title：Nature communications

authors： Altenburg WJ,Yewdall NA,Vervoort DFM,van Stevendaal MHME,Mason AF,van Hest JCM

更新日期：2020-12-08 00:00:00

abstract：:Approximately 30% of ERα breast cancer patients relapse with metastatic disease following adjuvant endocrine therapies. The connection between acquisition of drug resistance and invasive potential is poorly understood. In this study, we demonstrate that the type II keratin topological associating domain undergoes epig...

journal_title：Nature communications

authors： Perone Y,Farrugia AJ,Rodríguez-Meira A,Győrffy B,Ion C,Uggetti A,Chronopoulos A,Marrazzo P,Faronato M,Shousha S,Davies C,Steel JH,Patel N,Del Rio Hernandez A,Coombes C,Pruneri G,Lim A,Calvo F,Magnani L

更新日期：2019-05-09 00:00:00

abstract：:The flexibility in structural design of organic semiconductors endows organic solar cells (OSCs) not only great function-tunabilities, but also high potential toward practical application. In this work, simple non-fused-ring electron acceptors are developed through two-step synthesis from single aromatic units for con...

journal_title：Nature communications

authors： Yu ZP,Liu ZX,Chen FX,Qin R,Lau TK,Yin JL,Kong X,Lu X,Shi M,Li CZ,Chen H

更新日期：2019-05-14 00:00:00