Abstract:
:Leaves lose approximately 400 H2O molecules for every 1 CO2 gained during photosynthesis. Most long-distance water transport in plants, or xylem sap flow, serves to replace this water to prevent desiccation. Theory predicts that the largest vessels contribute disproportionately to overall sap flow because flow in pipe-like systems scales with the fourth power of radius. Here, we confront these theoretical flow predictions for a vessel network reconstructed from X-ray μCT imagery with in vivo flow MRI observations from the same sample of a first-year grapevine stem. Theoretical flow rate predictions based on vessel diameters are not supported. The heterogeneity of the vessel network gives rise to transverse pressure gradients that redirect flow from wide to narrow vessels, reducing the contribution of wide vessels to sap flow by 15% of the total. Our results call for an update of the current working model of the xylem to account for its heterogeneity.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Bouda M,Windt CW,McElrone AJ,Brodersen CRdoi
10.1038/s41467-019-13673-6subject
Has Abstractpub_date
2019-12-10 00:00:00pages
5645issue
1issn
2041-1723pii
10.1038/s41467-019-13673-6journal_volume
10pub_type
杂志文章abstract::Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus. Our understanding of PEL is poor and therefore treatment strategies are lacking. To address this need, we conducted genome-wide CRISPR/Cas9 knockout screens in eight PEL cell lines. Integration with data from unrelated cancers identi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05506-9
更新日期:2018-08-15 00:00:00
abstract::Mechanically flexible mobile phones have been long anticipated due to the rapid development of thin-film electronics in the last couple of decades. However, to date, no such phone has been developed, largely due to a lack of flexible electronic components that are fast enough for the required wireless communications, ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8561
更新日期:2015-07-03 00:00:00
abstract::Ultrasound sensors have wide applications across science and technology. However, improved sensitivity is required for both miniaturisation and increased spatial resolution. Here, we introduce cavity optomechanical ultrasound sensing, where dual optical and mechanical resonances enhance the ultrasound signal. We achie...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-08038-4
更新日期:2019-01-10 00:00:00
abstract::Electrocatalysts for oxygen reduction are a critical component that may dramatically enhance the performance of fuel cells and metal-air batteries, which may provide the power for future electric vehicles. Here we report a novel bio-inspired composite electrocatalyst, iron phthalocyanine with an axial ligand anchored ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3076
更新日期:2013-01-01 00:00:00
abstract::Graphene nanopores are potential successors to biological and silicon-based nanopores. For sensing applications, it is however crucial to understand and block the strong nonspecific hydrophobic interactions between DNA and graphene. Here we demonstrate a novel scheme to prevent DNA-graphene interactions, based on a ta...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3619
更新日期:2013-01-01 00:00:00
abstract::CD11b(+)Gr-1(+) myeloid-derived suppressor cells (MDSCs) expand in the spleen during cancer and promote progression through suppression of cytotoxic T cells. An anti-inflammatory reflex arc involving the vagus nerve and memory T cells is necessary for resolution of acute inflammation. Failure of this neural circuit co...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10517
更新日期:2016-02-04 00:00:00
abstract::To prevent new infections with human immunodeficiency virus type 1 (HIV-1) in sub-Saharan Africa, UNAIDS recommends targeting interventions to populations that are at high risk of acquiring and passing on the virus. Yet it is often unclear who and where these 'source' populations are. Here we demonstrate how viral dee...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09139-4
更新日期:2019-03-29 00:00:00
abstract::Accurate pathogenicity prediction of missense variants is critically important in genetic studies and clinical diagnosis. Previously published prediction methods have facilitated the interpretation of missense variants but have limited performance. Here, we describe MVP (Missense Variant Pathogenicity prediction), a n...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20847-0
更新日期:2021-01-21 00:00:00
abstract::In adult skin epidermis and the epithelium lining the esophagus cells are constantly shed from the tissue surface and replaced by cell division. Tracking genetically labelled cells in transgenic mice has given insight into cell behavior, but conflicting models appear consistent with the results. Here, we use an additi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15258-0
更新日期:2020-03-18 00:00:00
abstract::Solitary, persistent wave packets called solitons hold potential to transfer information and energy across a wide range of spatial and temporal scales in physical, chemical, and biological systems. Mechanical solitons characteristically emerge either as a single wave packet or uncorrelated propagating topological enti...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13546-y
更新日期:2019-12-06 00:00:00
abstract::Bioorthogonal chemistry introduces affinity-labels into biomolecules with minimal disruption to the original system and is widely applicable in a range of contexts. In proteomics, immobilized metal affinity chromatography (IMAC) enables enrichment of phosphopeptides with extreme sensitivity and selectivity. Here, we a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17010-0
更新日期:2020-06-26 00:00:00
abstract::Nanoparticles hosted in conductive matrices are ubiquitous in electrochemical energy storage, catalysis and energetic devices. However, agglomeration and surface oxidation remain as two major challenges towards their ultimate utility, especially for highly reactive materials. Here we report uniformly distributed nanop...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12332
更新日期:2016-08-12 00:00:00
abstract::Membranes with nano-apertures are versatile templates that possess a wide range of electronic, optical and biomedical applications. However, such membranes have been limited to silicon-based inorganic materials to utilize standard semiconductor processes. Here we report a new type of flexible and free-standing polymer...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4137
更新日期:2014-01-01 00:00:00
abstract::Two voltage-gated calcium channel subtypes-CaV1.2 and CaV1.3-underlie the major L-type Ca(2+) currents in the mammalian central nervous system. Owing to their high sequence homology, the two channel subtypes share similar pharmacological properties, and at high doses classic calcium channel blockers, such as dihydropy...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5481
更新日期:2014-07-24 00:00:00
abstract::CD1 proteins are expressed on dendritic cells, where they display lipid antigens to T-cell receptors (TCRs). Here we describe T-cell autoreactivity towards ubiquitous human membrane phospholipids presented by CD1b. These T-cells discriminate between two major types of lipids, sphingolipids and phospholipids, but were ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07898-0
更新日期:2019-01-04 00:00:00
abstract::Researchers strive to produce nanoparticles with complexity in composition and structure. Although traditional spherical, cylindrical and membranous, or planar, nanostructures are ubiquitous, scientists seek more complicated geometries for potential functionality. Here we report the simple solution construction of mul...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3297
更新日期:2013-01-01 00:00:00
abstract::Chronic nonalcoholic steatohepatitis (NASH) is a metabolic disorder that often leads to liver fibrosis, a condition with limited therapy options. Adiponectin is an adipocytokine that regulates glucose and lipid metabolism via binding to its receptors AdipoR1 and AdipoR2, and AdipoRs signaling is reported to enhance fa...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19668-y
更新日期:2020-11-16 00:00:00
abstract::Rather than targeting tumour cells directly, elements of the tumour microenvironment can be modulated to sensitize tumours to the effects of therapy. Here we report a unique mechanism by which ectopic microRNA-103 can manipulate tumour-associated endothelial cells to enhance tumour cell death. Using gain-and-loss of f...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13597
更新日期:2016-11-25 00:00:00
abstract::Treatments that stimulate neuronal excitability enhance motor performance after stroke. cAMP-response-element binding protein (CREB) is a transcription factor that plays a key role in neuronal excitability. Increasing the levels of CREB with a viral vector in a small pool of motor neurons enhances motor recovery after...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04445-9
更新日期:2018-06-08 00:00:00
abstract::Nonreciprocal microwave devices are ubiquitous in radar and radio communication and indispensable in the readout chains of superconducting quantum circuits. Since they commonly rely on ferrite materials requiring large magnetic fields that make them bulky and lossy, there has been significant interest in magnetic-fiel...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00447-1
更新日期:2017-09-19 00:00:00
abstract::Despite significant advances in the fabrication and applications of graphene-like materials, it remains a challenge to prepare single-layered metallic materials, which have great potential applications in physics, chemistry and material science. Here we report the fabrication of poly(vinylpyrrolidone)-supported single...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4093
更新日期:2014-01-01 00:00:00
abstract::Histone deacetylase inhibitors (HDACi) are approved for treating certain haematological malignancies, however, recent evidence also illustrates they are modulators of the immune system. In experimental models, HDACi are particularly potent against malignancies originating from the B-lymphocyte lineage. Here we examine...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7838
更新日期:2015-04-27 00:00:00
abstract::The liver integrates multiple metabolic pathways to warrant systemic energy homeostasis. An excessive lipogenic flux due to chronic dietary stimulation contributes to the development of hepatic steatosis, dyslipidemia and hyperglycemia. Here we show that the oxidoreductase retinol saturase (RetSat) is involved in the ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00430-w
更新日期:2017-08-30 00:00:00
abstract::The downstream consequences of inflammation in the adult mammalian heart are formation of a non-functional scar, pathological remodelling and heart failure. In zebrafish, hydrogen peroxide released from a wound is the initial instructive chemotactic cue for the infiltration of inflammatory cells, however, the identity...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3081
更新日期:2013-01-01 00:00:00
abstract::Developing earth-abundant, active and stable electrocatalysts which operate in the same electrolyte for water splitting, including oxygen evolution reaction and hydrogen evolution reaction, is important for many renewable energy conversion processes. Here we demonstrate the improvement of catalytic activity when trans...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8261
更新日期:2015-06-23 00:00:00
abstract::No method exists to measure large-scale translation of genes in uncultured organisms in microbiomes. To overcome this limitation, we develop MetaRibo-Seq, a method for simultaneous ribosome profiling of tens to hundreds of organisms in microbiome samples. MetaRibo-Seq was benchmarked against gold-standard Ribo-Seq in ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17081-z
更新日期:2020-06-29 00:00:00
abstract::Chiral magnets are an emerging class of topological matter harboring localized and topologically protected vortex-like magnetic textures called skyrmions, which are currently under intense scrutiny as an entity for information storage and processing. Here, on the level of micromagnetics we rigorously show that chiral ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00313-0
更新日期:2017-08-21 00:00:00
abstract::Tumour cells secrete exosomes that are involved in the remodelling of the tumour-stromal environment and promoting malignancy. The mechanisms governing tumour exosome release, however, remain incompletely understood. Here we show that tumour cell exosomes secretion is controlled by pyruvate kinase type M2 (PKM2), whic...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14041
更新日期:2017-01-09 00:00:00
abstract::The efficiencies of perovskite solar cells (PSCs) are now reaching such consistently high levels that scalable manufacturing at low cost is becoming critical. However, this remains challenging due to the expensive hole-transporting materials usually employed, and difficulties associated with the scalable deposition of...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04028-8
更新日期:2018-04-24 00:00:00
abstract::Specialized cells in the medial entorhinal cortex (mEC), such as speed cells, head direction (HD) cells, and grid cells, are thought to support spatial navigation. To determine whether these computations are dependent on local circuits, we record neuronal activity in mEC layers II and III and optogenetically perturb l...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06104-5
更新日期:2018-09-12 00:00:00