Abstract:
:Graphene nanopores are potential successors to biological and silicon-based nanopores. For sensing applications, it is however crucial to understand and block the strong nonspecific hydrophobic interactions between DNA and graphene. Here we demonstrate a novel scheme to prevent DNA-graphene interactions, based on a tailored self-assembled monolayer. For bare graphene, we encounter a paradox: whereas contaminated graphene nanopores facilitated DNA translocation well, clean crystalline graphene pores very quickly exhibit clogging of the pore. We attribute this to strong interactions between DNA nucleotides and graphene, yielding sticking and irreversible pore closure. We develop a general strategy to noncovalently tailor the hydrophobic surface of graphene by designing a dedicated self-assembled monolayer of pyrene ethylene glycol, which renders the surface hydrophilic. We demonstrate that this prevents DNA to adsorb on graphene and show that single-stranded DNA can now be detected in graphene nanopores with excellent nanopore durability and reproducibility.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Schneider GF,Xu Q,Hage S,Luik S,Spoor JN,Malladi S,Zandbergen H,Dekker Cdoi
10.1038/ncomms3619subject
Has Abstractpub_date
2013-01-01 00:00:00pages
2619issn
2041-1723pii
ncomms3619journal_volume
4pub_type
杂志文章abstract::The Non-Proliferation Treaty and other non-proliferation agreements are in place worldwide to ensure that nuclear material and facilities are used only for peaceful purposes. Antineutrino detectors, sensitive to reactor power and fuel changes, can complement the tools already at the disposal of international agencies ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11434-z
更新日期:2019-08-06 00:00:00
abstract::The cost of whole-genome bisulfite sequencing (WGBS) remains a bottleneck for many studies and it is therefore imperative to extract as much information as possible from a given dataset. This is particularly important because even at the recommend 30X coverage for reference methylomes, up to 50% of high-resolution fea...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11306
更新日期:2016-06-27 00:00:00
abstract::Homologous recombination-based gene targeting is a powerful tool for precise genome modification and has been widely used in organisms ranging from yeast to higher organisms such as Drosophila and mouse. However, gene targeting in higher plants, including the most widely used model plant Arabidopsis thaliana, remains ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04416-0
更新日期:2018-05-17 00:00:00
abstract::The integration of β-barrel proteins into the bacterial outer membrane (OM) is catalysed by the β-barrel assembly machinery (BAM). The central BAM subunit (BamA) itself contains a β-barrel domain that is essential for OM protein biogenesis, but its mechanism of action is unknown. To elucidate its function, here we dev...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11230-9
更新日期:2019-07-26 00:00:00
abstract::Topologically protected pseudospin transport, analogous to the quantum spin Hall effect, cannot be strictly implemented for photons and in general bosons because of the lack of symmetry-protected pseudospins. Here we show that the required protection can be provided by the real-space topological excitation of an inter...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06520-7
更新日期:2018-09-28 00:00:00
abstract::Although soluble inhibitors are frequently used to block cell binding to the extracellular matrix (ECM), mechanical stretching of a protein fibre alone can physically destroy a cell-binding site. Here, we show using binding assays and steered molecular dynamics that mechanical tension along fibronectin (Fn) fibres cau...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1135
更新日期:2010-01-01 00:00:00
abstract::The amazing structural variety of cells is matched only by their functional diversity, and reflects the complex interplay between biochemical and mechanical regulation. How both regulatory layers generate specifically shaped cellular domains is not fully understood. Here, we report how cell growth domains are shaped i...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9400
更新日期:2015-10-12 00:00:00
abstract::The bundle of stereocilia on inner ear hair cells responds to subnanometer deflections produced by sound or head movement. Stereocilia are interconnected by a variety of links and also carry an electron-dense surface coat. The coat may contribute to stereocilia adhesion or protect from stereocilia fusion, but its mole...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11712-w
更新日期:2019-08-23 00:00:00
abstract::Subduction zone magmas are more oxidised on eruption than those at mid-ocean ridges. This is attributed either to oxidising components, derived from subducted lithosphere (slab) and added to the mantle wedge, or to oxidation processes occurring during magma ascent via differentiation. Here we provide direct evidence f...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05804-2
更新日期:2018-08-29 00:00:00
abstract::Plasmodium parasites possess a translocon that exports parasite proteins into the infected erythrocyte. Although the translocon components are also expressed during the mosquito and liver stage of infection, their function remains unexplored. Here, using a combination of genetic and chemical assays, we show that the t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19492-4
更新日期:2020-11-06 00:00:00
abstract::The molecular pathogenesis of salivary gland acinic cell carcinoma (AciCC) is poorly understood. The secretory Ca-binding phosphoprotein (SCPP) gene cluster at 4q13 encodes structurally related phosphoproteins of which some are specifically expressed at high levels in the salivary glands and constitute major component...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-08069-x
更新日期:2019-01-21 00:00:00
abstract::Elevated glucose consumption is fundamental to cancer, but selectively targeting this pathway is challenging. We develop a high-throughput assay for measuring glucose consumption and use it to screen non-small-cell lung cancer cell lines against bioactive small molecules. We identify Milciclib that blocks glucose cons...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13334-8
更新日期:2019-11-29 00:00:00
abstract::The welding and sintering of nanomaterials is relevant, for example, to form electrical contacts between metallic particles in printed electronic devices. Usually the welding of nanoparticles is achieved at high temperatures. Here we find that merging of two different metals, silver and gold nanoparticles, occurs on c...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3994
更新日期:2014-01-01 00:00:00
abstract::The complexity embedded in condensed matter fertilizes the discovery of new states of matter, enriched by ingredients like frustration. Illustrating examples in magnetic systems are Kitaev spin liquids, skyrmions phases, or spin ices. These unconventional ground states support exotic excitations, for example the magne...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00277-1
更新日期:2017-08-08 00:00:00
abstract::Blood brain barrier (BBB) breakdown is not only a consequence of but also contributes to many neurological disorders, including stroke and Alzheimer's disease. How the basement membrane (BM) contributes to the normal functioning of the BBB remains elusive. Here we use conditional knockout mice and an acute adenovirus-...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4413
更新日期:2014-03-03 00:00:00
abstract::The number of viruses circulating in small isolated human populations may be reduced by viral extinctions and rare introductions. Here we used viral metagenomics to characterize the eukaryotic virome in feces from healthy children from a large urban center and from three Amerindian villages with minimal outside contac...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06502-9
更新日期:2018-10-15 00:00:00
abstract::Alkenes are fundamental functionalities in nature and highly useful intermediates in organic synthesis, medicinal chemistry and material sciences. Transition-metal-catalyzed Heck couplings with organic halides as electrophiles have been established as a powerful protocol for the synthesis of this valuable building blo...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08631-1
更新日期:2019-02-12 00:00:00
abstract::Novel atherosclerosis models are needed to guide clinical therapy. Here, we report an in vitro model of early atherosclerosis by fabricating and perfusing multi-layer arteriole-scale human tissue-engineered blood vessels (TEBVs) by plastic compression. TEBVs maintain mechanical strength, vasoactivity, and nitric oxide...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19197-8
更新日期:2020-10-27 00:00:00
abstract:: ...
journal_title:Nature communications
pub_type: 社论
doi:10.1038/s41467-018-07733-6
更新日期:2018-12-10 00:00:00
abstract::NaK and other non-selective channels are able to conduct both sodium (Na+) and potassium (K+) with equally high efficiency. In contrast to previous crystallographic results, we show that the selectivity filter (SF) of NaK in native-like lipid membranes adopts two distinct conformations that are stabilized by either Na...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03179-y
更新日期:2018-02-19 00:00:00
abstract::We propose the concept of universal fiducials based on a set of pre-made semi-synthetic antibodies (sABs) generated by customized phage display selections against the fusion protein BRIL, an engineered variant of apocytochrome b562a. These sABs can bind to BRIL fused either into the loops or termini of different GPCRs...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15363-0
更新日期:2020-03-27 00:00:00
abstract::Diamond photonics is an ever-growing field of research driven by the prospects of harnessing diamond and its colour centres as suitable hardware for solid-state quantum applications. The last two decades have seen the field shaped by the nitrogen-vacancy (NV) centre with both breakthrough fundamental physics demonstra...
journal_title:Nature communications
pub_type: 杂志文章,评审
doi:10.1038/s41467-019-13332-w
更新日期:2019-12-09 00:00:00
abstract::Geminiviruses are major plant pathogens that threaten food security globally. They have a unique architecture built from two incomplete icosahedral particles, fused to form a geminate capsid. However, despite their importance to agricultural economies and fundamental biological interest, the details of how this is rea...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04793-6
更新日期:2018-06-18 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-020-15800-0
更新日期:2020-04-20 00:00:00
abstract::The study of the high pressure phase diagram of hydrogen has continued with renewed effort for about one century as it remains a fundamental challenge for experimental and theoretical techniques. Here we employ an efficient molecular dynamics based on the quantum Monte Carlo method, which can describe accurately the e...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4487
更新日期:2014-03-19 00:00:00
abstract::Geranyl-CoA carboxylase (GCC) is essential for the growth of Pseudomonas organisms with geranic acid as the sole carbon source. GCC has the same domain organization and shares strong sequence conservation with the related biotin-dependent carboxylases 3-methylcrotonyl-CoA carboxylase (MCC) and propionyl-CoA carboxylas...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9986
更新日期:2015-11-23 00:00:00
abstract::The three-dimensional architecture of the genome affects genomic functions. Multiple genome architectures at different length scales, including chromatin loops, domains, compartments, and lamina- and nucleolus-associated regions, have been discovered. However, how these structures are arranged in the same cell and how...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16732-5
更新日期:2020-06-09 00:00:00
abstract::Mass extinctions have profoundly impacted the evolution of life through not only reducing taxonomic diversity but also reshaping ecosystems and biogeographic patterns. In particular, they are considered to have driven increased biogeographic cosmopolitanism, but quantitative tests of this hypothesis are rare and have ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00827-7
更新日期:2017-10-10 00:00:00
abstract::Traditionally, molecular assembly pathways for viruses are inferred from high resolution structures of purified stable intermediates, low resolution images of cell sections and genetic approaches. Here, we directly visualise an unsuspected 'single shelled' intermediate for a mammalian orthoreovirus in cryo-preserved i...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18243-9
更新日期:2020-09-07 00:00:00
abstract::Human glioblastoma is the most frequent and aggressive form of brain tumour in the adult population. Proteolytic turnover of tumour suppressors by the ubiquitin-proteasome system is a mechanism that tumour cells can adopt to sustain their growth and invasiveness. However, the identity of ubiquitin-proteasome targets a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2791
更新日期:2013-01-01 00:00:00