Directing cell therapy to anatomic target sites in vivo with magnetic resonance targeting.

abstract：:Inflammation is recognized as one of the drivers of cancer. Yet, the individual immune components that possess pro- and anti-tumorigenic functions in individual cancers remain largely unknown. NKG2D is a potent activating immunoreceptor that has emerged as an important player in inflammatory disorders besides its well...

journal_title：Nature communications

authors： Sheppard S,Guedes J,Mroz A,Zavitsanou AM,Kudo H,Rothery SM,Angelopoulos P,Goldin R,Guerra N

更新日期：2017-01-27 00:00:00

abstract：:The mobility of drops on surfaces is important in many biological and industrial processes, but the phenomena governing their adhesion, which is dictated by the morphology of the three-phase contact line, remain unclear. Here we describe a technique for measuring the dynamic behaviour of the three-phase contact line a...

journal_title：Nature communications

authors： Paxson AT,Varanasi KK

更新日期：2013-01-01 00:00:00

abstract：:Plasma accelerators driven by particle beams are a very promising future accelerator technology as they can sustain high accelerating fields over long distances with high energy efficiency. They rely on the excitation of a plasma wave in the wake of a drive beam. To generate the plasma, a neutral gas can be field-ioni...

journal_title：Nature communications

authors： Corde S,Adli E,Allen JM,An W,Clarke CI,Clausse B,Clayton CE,Delahaye JP,Frederico J,Gessner S,Green SZ,Hogan MJ,Joshi C,Litos M,Lu W,Marsh KA,Mori WB,Vafaei-Najafabadi N,Walz D,Yakimenko V

更新日期：2016-06-17 00:00:00

abstract：:Vegetation impacts on ecosystem functioning are mediated by mycorrhizas, plant-fungal associations formed by most plant species. Ecosystems dominated by distinct mycorrhizal types differ strongly in their biogeochemistry. Quantitative analyses of mycorrhizal impacts on ecosystem functioning are hindered by the scarcit...

journal_title：Nature communications

authors： Soudzilovskaia NA,van Bodegom PM,Terrer C,Zelfde MV,McCallum I,Luke McCormack M,Fisher JB,Brundrett MC,de Sá NC,Tedersoo L

更新日期：2019-11-07 00:00:00

abstract：:Longevity is influenced by genetic and environmental factors, but the underlying mechanisms remain elusive. Here, we functionally characterise a Drosophila small nucleolar RNA (snoRNA), named jouvence whose loss of function reduces lifespan. The genomic region of jouvence rescues the longevity in mutant, while its ove...

journal_title：Nature communications

authors： Soulé S,Mellottée L,Arab A,Chen C,Martin JR

更新日期：2020-02-20 00:00:00

abstract：:The microbial communities living in the human intestine can have profound impact on our well-being and health. However, we have limited understanding of the mechanisms that control this complex ecosystem. Here, based on a deep phylogenetic analysis of the intestinal microbiota in a thousand western adults, we identify...

journal_title：Nature communications

authors： Lahti L,Salojärvi J,Salonen A,Scheffer M,de Vos WM

更新日期：2014-07-08 00:00:00

abstract：:Tumour-associated macrophages (TAMs) play an important role in tumour progression, which is facilitated by their ability to respond to environmental cues. Here we report, using murine models of breast cancer, that TAMs expressing fibroblast activation protein alpha (FAP) and haem oxygenase-1 (HO-1), which are also fou...

journal_title：Nature communications

authors： Muliaditan T,Caron J,Okesola M,Opzoomer JW,Kosti P,Georgouli M,Gordon P,Lall S,Kuzeva DM,Pedro L,Shields JD,Gillett CE,Diebold SS,Sanz-Moreno V,Ng T,Hoste E,Arnold JN

更新日期：2018-07-27 00:00:00

abstract：:Elevated plasma cholesterol and type 2 diabetes (T2D) are associated with coronary artery disease (CAD). Individuals treated with cholesterol-lowering statins have increased T2D risk, while individuals with hypercholesterolemia have reduced T2D risk. We explore the relationship between lipid and glucose control by con...

journal_title：Nature communications

authors： Cohain AT,Barrington WT,Jordan DM,Beckmann ND,Argmann CA,Houten SM,Charney AW,Ermel R,Sukhavasi K,Franzen O,Koplev S,Whatling C,Belbin GM,Yang J,Hao K,Kenny EE,Tu Z,Zhu J,Gan LM,Do R,Giannarelli C,Kovacic JC,R

更新日期：2021-01-22 00:00:00

abstract：:6-Phosphogluconate dehydrogenase (6PGD) is a key enzyme that converts 6-phosphogluconate into ribulose-5-phosphate with NADP+ as cofactor in the pentose phosphate pathway (PPP). 6PGD is commonly upregulated and plays important roles in many human cancers, while the mechanism underlying such roles of 6PGD remains elusi...

journal_title：Nature communications

authors： Liu R,Li W,Tao B,Wang X,Yang Z,Zhang Y,Wang C,Liu R,Gao H,Liang J,Yang W

更新日期：2019-03-01 00:00:00

abstract：:Glioblastoma (GBM) is the most common primary adult brain tumor. Despite extensive efforts, the median survival for GBM patients is approximately 14 months. GBM therapy could benefit greatly from patient-specific targeted therapies that maximize treatment efficacy. Here we report a platform termed SynergySeq to identi...

journal_title：Nature communications

authors： Stathias V,Jermakowicz AM,Maloof ME,Forlin M,Walters W,Suter RK,Durante MA,Williams SL,Harbour JW,Volmar CH,Lyons NJ,Wahlestedt C,Graham RM,Ivan ME,Komotar RJ,Sarkaria JN,Subramanian A,Golub TR,Schürer SC,Ayad NG

更新日期：2018-12-14 00:00:00

abstract：:Most estimates of the burden of malaria are based on its direct impacts; however, its true burden is likely to be greater because of its wider effects on overall health. Here we estimate the indirect impact of malaria on children's health in a case-control study, using the sickle cell trait (HbAS), a condition associa...

journal_title：Nature communications

authors： Uyoga S,Macharia AW,Ndila CM,Nyutu G,Shebe M,Awuondo KO,Mturi N,Peshu N,Tsofa B,Scott JAG,Maitland K,Williams TN

更新日期：2019-02-20 00:00:00

abstract：:Sequencing of a single-cell genome requires DNA amplification, a process prone to introducing bias and errors into the amplified genome. Here we introduce a novel multiple displacement amplification (MDA) method based on the unique DNA primase features of Thermus thermophilus (Tth) PrimPol. TthPrimPol displays a poten...

journal_title：Nature communications

authors： Picher ÁJ,Budeus B,Wafzig O,Krüger C,García-Gómez S,Martínez-Jiménez MI,Díaz-Talavera A,Weber D,Blanco L,Schneider A

更新日期：2016-11-29 00:00:00

abstract：:The original version of this Article contained an error in Eq. 1. The arrows between the symbols "T" and "B", and "B" and "T", were written "↔" but should have been "→", and incorrectly read: IEBIC=IEBAC+ISEE+I(e↔h)+IEBICT↔B+IESEEB↔T The correct from of the Eq. 1 is as follows:IEBIC=IEBAC+ISEE+I(e↔h)+IEBICT→B+IESEEB→T...

journal_title：Nature communications

authors： Hoskins BD,Adam GC,Strelcov E,Zhitenev N,Kolmakov A,Strukov DB,McClelland JJ

更新日期：2018-01-24 00:00:00

abstract：:Supercooled liquids exhibit spatial heterogeneity in the dynamics of their fluctuating atomic arrangements. The length and time scales of the heterogeneous dynamics are central to the glass transition and influence nucleation and growth of crystals from the liquid. Here, we report direct experimental visualization of ...

journal_title：Nature communications

authors： Zhang P,Maldonis JJ,Liu Z,Schroers J,Voyles PM

更新日期：2018-03-19 00:00:00

abstract：:Device performance and in particular device stability for blue perovskite light-emitting diodes (PeLEDs) remain considerable challenges for the whole community. In this manuscript, we conceive an approach by tuning the 'A-site' cation composition of perovskites to develop blue-emitters. We herein report a Rubidium-Ces...

journal_title：Nature communications

authors： Jiang Y,Qin C,Cui M,He T,Liu K,Huang Y,Luo M,Zhang L,Xu H,Li S,Wei J,Liu Z,Wang H,Kim GH,Yuan M,Chen J

更新日期：2019-04-23 00:00:00

abstract：:During centriole duplication, a single daughter centriole is formed next to the mother centriole. The molecular mechanism that determines a single duplication site remains a long-standing question. Here, we show that intrinsic self-organization of Plk4 is implicated in symmetry breaking in the process of centriole dup...

journal_title：Nature communications

authors： Yamamoto S,Kitagawa D

更新日期：2019-04-18 00:00:00

abstract：:Epithelial barrier function is maintained by coordination of cell proliferation and cell loss, whereas barrier dysfunction can lead to disease and organismal death. JNK signalling is a conserved stress signalling pathway activated by bacterial infection and tissue damage, often leading to apoptotic cell death and comp...

journal_title：Nature communications

authors： Zhou J,Edgar BA,Boutros M

更新日期：2017-03-08 00:00:00

abstract：:The metazoan TREX complex is recruited to mRNA during nuclear RNA processing and functions in exporting mRNA to the cytoplasm. Nxf1 is an mRNA export receptor, which binds processed mRNA and transports it through the nuclear pore complex. At present, the relationship between TREX and Nxf1 is not understood. Here we sh...

journal_title：Nature communications

authors： Viphakone N,Hautbergue GM,Walsh M,Chang CT,Holland A,Folco EG,Reed R,Wilson SA

更新日期：2012-01-01 00:00:00

abstract：:Contextual influences on choice are ubiquitous in ecological settings. Current evidence suggests that subjective values are normalized with respect to the distribution of potentially available rewards. However, how this context-sensitivity is realised in the brain remains unknown. To address this, here we examine func...

journal_title：Nature communications

authors： Rigoli F,Friston KJ,Dolan RJ

更新日期：2016-08-18 00:00:00

abstract：:Imaging the atomic structure of a single biomolecule is an important challenge in the physical biosciences. Whilst existing techniques all rely on averaging over large ensembles of molecules, the single-molecule realm remains unsolved. Here we present a protocol for 3D magnetic resonance imaging of a single molecule u...

journal_title：Nature communications

authors： Perunicic VS,Hill CD,Hall LT,Hollenberg LC

更新日期：2016-10-11 00:00:00

abstract：:Macrophages play crucial roles in host defence and tissue homoeostasis, processes in which both environmental stimuli and intracellularly generated metabolites influence activation of macrophages. Activated macrophages are classified into M1 and M2 macrophages. It remains unclear how intracellular nutrition sufficienc...

journal_title：Nature communications

authors： Kimura T,Nada S,Takegahara N,Okuno T,Nojima S,Kang S,Ito D,Morimoto K,Hosokawa T,Hayama Y,Mitsui Y,Sakurai N,Sarashina-Kida H,Nishide M,Maeda Y,Takamatsu H,Okuzaki D,Yamada M,Okada M,Kumanogoh A

更新日期：2016-10-12 00:00:00

abstract：:Photocatalysis has not found widespread industrial adoption, in spite of decades of active research, because the challenges associated with catalyst illumination and turnover outweigh the touted advantages of replacing heat with light. A demonstration that light can control product selectivity in complex chemical reac...

journal_title：Nature communications

authors： Zhang X,Li X,Zhang D,Su NQ,Yang W,Everitt HO,Liu J

更新日期：2017-02-23 00:00:00

abstract：:Organic conjugated polymers demonstrate great potential in transistors, solar cells and light-emitting diodes, whose performances are fundamentally governed by charge transport. However, the morphology-property relationships and the underpinning charge transport mechanisms remain unclear. Particularly, whether the non...

journal_title：Nature communications

authors： Wang J,Niu J,Shao B,Yang G,Lu C,Li M,Zhou Z,Chuai X,Chen J,Lu N,Huang B,Wang Y,Li L,Liu M

更新日期：2021-01-04 00:00:00

abstract：:Transcription errors occur in all living cells; however, it is unknown how these errors affect cellular health. To answer this question, we monitor yeast cells that are genetically engineered to display error-prone transcription. We discover that these cells suffer from a profound loss in proteostasis, which sensitize...

journal_title：Nature communications

authors： Vermulst M,Denney AS,Lang MJ,Hung CW,Moore S,Moseley MA,Thompson JW,Madden V,Gauer J,Wolfe KJ,Summers DW,Schleit J,Sutphin GL,Haroon S,Holczbauer A,Caine J,Jorgenson J,Cyr D,Kaeberlein M,Strathern JN,Duncan MC,E

更新日期：2015-08-25 00:00:00

abstract：:It is unclear why atmospheric oxygen remained trapped at low levels for more than 1.5 billion years following the Paleoproterozoic Great Oxidation Event. Here, we use models for erosion, weathering and biogeochemical cycling to show that this can be explained by the tectonic recycling of previously accumulated sedimen...

journal_title：Nature communications

authors： Daines SJ,Mills BJ,Lenton TM

更新日期：2017-02-02 00:00:00

abstract：:In the Drosophila antenna, different subtypes of olfactory receptor neurons (ORNs) housed in the same sensory hair (sensillum) can inhibit each other non-synaptically. However, the mechanisms underlying this underexplored form of lateral inhibition remain unclear. Here we use recordings from pairs of sensilla impaled ...

journal_title：Nature communications

authors： Zhang Y,Tsang TK,Bushong EA,Chu LA,Chiang AS,Ellisman MH,Reingruber J,Su CY

更新日期：2019-04-05 00:00:00

abstract：:Inelastic collisions involving molecular species are key to energy transfer in gaseous environments. They are commonly governed by an energy gap law, which dictates that transitions are dominated by those between initial and final states with roughly the same ro-vibrational energy. Transitions involving rotational ine...

journal_title：Nature communications

authors： Yang D,Huang J,Hu X,Guo H,Xie D

更新日期：2019-10-11 00:00:00

abstract：:Recently, broken symmetry effect induced edge states in two-dimensional electronic systems have attracted great attention. However, whether edge states may exist in strongly correlated oxides is not yet known. In this work, using perovskite manganites as prototype systems, we demonstrate that edge states do exist in s...

journal_title：Nature communications

authors： Du K,Zhang K,Dong S,Wei W,Shao J,Niu J,Chen J,Zhu Y,Lin H,Yin X,Liou SH,Yin L,Shen J

更新日期：2015-02-04 00:00:00

abstract：:Congenital Zika syndrome (CZS) causes early brain development impairment by affecting neural progenitor cells (NPCs). Here, we analyze NPCs from three pairs of dizygotic twins discordant for CZS. We compare by RNA-Seq the NPCs derived from CZS-affected and CZS-unaffected twins. Prior to Zika virus (ZIKV) infection the...

journal_title：Nature communications

authors： Caires-Júnior LC,Goulart E,Melo US,Araujo BHS,Alvizi L,Soares-Schanoski A,de Oliveira DF,Kobayashi GS,Griesi-Oliveira K,Musso CM,Amaral MS,daSilva LF,Astray RM,Suárez-Patiño SF,Ventini DC,Gomes da Silva S,Yamamoto GL,Ez

更新日期：2018-02-02 00:00:00

abstract：:Epigenetic regulation plays an important role in governing stem cell fate and tumorigenesis. Lost expression of a key DNA demethylation enzyme TET2 is associated with human cancers and has been linked to stem cell traits in vitro; however, whether and how TET2 regulates mammary stem cell fate and mammary tumorigenesis...

journal_title：Nature communications

authors： Kim MR,Wu MJ,Zhang Y,Yang JY,Chang CJ

更新日期：2020-09-15 00:00:00