Coarse-grained simulation reveals key features of HIV-1 capsid self-assembly.

abstract：:Pachytene piRNAs are the most abundant piRNAs in mammalian adult testes. They are generated from long precursor transcripts by the primary piRNA biogenesis pathway but the factors involved in pachytene piRNA precursors processing are poorly understood. Here we show that the Tudor domain-containing 5 (TDRD5) protein is...

journal_title：Nature communications

authors： Ding D,Liu J,Midic U,Wu Y,Dong K,Melnick A,Latham KE,Chen C

更新日期：2018-01-09 00:00:00

abstract：:O-GlcNAcylation has been implicated in the tumorigenesis of various tissue origins, but its function in liver tumorigenesis is not clear. Here, we demonstrate that O-GlcNAcylation can enhance the expression, stability and function of Yes-associated protein (YAP), the downstream transcriptional regulator of the Hippo p...

journal_title：Nature communications

authors： Zhang X,Qiao Y,Wu Q,Chen Y,Zou S,Liu X,Zhu G,Zhao Y,Chen Y,Yu Y,Pan Q,Wang J,Sun F

更新日期：2017-05-05 00:00:00

abstract：:Plasma membrane Ca2+-ATPases (PMCAs) are key regulators of global Ca2+ homeostasis and local intracellular Ca2+ dynamics. Recently, Neuroplastin (NPTN) and basigin were identified as previously unrecognized obligatory subunits of PMCAs that dramatically increase the efficiency of PMCA-mediated Ca2+ clearance. Here, we...

journal_title：Nature communications

authors： Gong D,Chi X,Ren K,Huang G,Zhou G,Yan N,Lei J,Zhou Q

更新日期：2018-09-06 00:00:00

abstract：:Metals and polymers are dissimilar materials in terms of their physicochemical properties, but complementary in terms of functionality. As a result, metal-organic structures can introduce a wealth of novel applications in small-scale robotics. However, current fabrication techniques are unable to process three-dimensi...

journal_title：Nature communications

authors： Alcântara CCJ,Landers FC,Kim S,De Marco C,Ahmed D,Nelson BJ,Pané S

更新日期：2020-11-24 00:00:00

abstract：:The friction between two adjacent tectonic plates under shear loading may dictate seismic activities. To advance the understanding of mechanisms underlying fault strength, we investigate the frictional characteristics of calcite in an aqueous environment. By conducting single-asperity friction experiments using an ato...

journal_title：Nature communications

authors： Diao Y,Espinosa-Marzal RM

更新日期：2018-06-13 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： López-Barneo J,Simon MC

更新日期：2020-02-25 00:00:00

abstract：:The cost, size and availability of electron accelerators are dominated by the achievable accelerating gradient. Conventional high-brightness radio-frequency accelerating structures operate with 30-50 MeV m(-1) gradients. Electron accelerators driven with optical or infrared sources have demonstrated accelerating gradi...

journal_title：Nature communications

authors： Nanni EA,Huang WR,Hong KH,Ravi K,Fallahi A,Moriena G,Miller RJ,Kärtner FX

更新日期：2015-10-06 00:00:00

abstract：:Use of aromatase inhibitors (AIs), exemestane, letrozole and anastrozole, for breast cancer therapy is associated with severe pain symptoms, the underlying mechanism of which is unknown. The electrophilic nature of AIs suggests that they may target the transient receptor potential ankyrin 1 (TRPA1) channel, a major pa...

journal_title：Nature communications

authors： Fusi C,Materazzi S,Benemei S,Coppi E,Trevisan G,Marone IM,Minocci D,De Logu F,Tuccinardi T,Di Tommaso MR,Susini T,Moneti G,Pieraccini G,Geppetti P,Nassini R

更新日期：2014-12-08 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Ma X,Liang H,Cui X,Liu Y,Lu H,Ning W,Poon NY,Ho B,Zhou K

更新日期：2019-08-21 00:00:00

abstract：:We establish a powerful poly(4-styrenesulfonate) (PSS)-treated strategy for sulfur vacancy healing in monolayer MoS2 to precisely and steadily tune its electronic state. The self-healing mechanism, in which the sulfur vacancies are healed spontaneously by the sulfur adatom clusters on the MoS2 surface through a PSS-in...

journal_title：Nature communications

authors： Zhang X,Liao Q,Liu S,Kang Z,Zhang Z,Du J,Li F,Zhang S,Xiao J,Liu B,Ou Y,Liu X,Gu L,Zhang Y

更新日期：2017-06-22 00:00:00

abstract：:A platform for highly parallel direct sequencing of native RNA strands was recently described by Oxford Nanopore Technologies, but despite initial efforts it remains crucial to further investigate the technology for quantification of complex transcriptomes. Here we undertake native RNA sequencing of polyA + RNA from t...

journal_title：Nature communications

authors： Soneson C,Yao Y,Bratus-Neuenschwander A,Patrignani A,Robinson MD,Hussain S

更新日期：2019-07-31 00:00:00

abstract：:Incited by public fascination and engineering application, water-skipping of rigid stones and spheres has received considerable study. While these objects can be coaxed to ricochet, elastic spheres demonstrate superior water-skipping ability, but little is known about the effect of large material compliance on water i...

journal_title：Nature communications

authors： Belden J,Hurd RC,Jandron MA,Bower AF,Truscott TT

更新日期：2016-02-04 00:00:00

abstract：:Integrin αVβ8, which like αVβ6 functions to activate TGF-βs, is atypical. Its β8 subunit binds to a distinctive cytoskeleton adaptor and does not exhibit large changes in conformation upon binding to ligand. Here, crystal structures, hydrogen-deuterium exchange dynamics, and affinity measurements on mutants are used t...

journal_title：Nature communications

authors： Wang J,Su Y,Iacob RE,Engen JR,Springer TA

更新日期：2019-12-02 00:00:00

abstract：:The study of the high pressure phase diagram of hydrogen has continued with renewed effort for about one century as it remains a fundamental challenge for experimental and theoretical techniques. Here we employ an efficient molecular dynamics based on the quantum Monte Carlo method, which can describe accurately the e...

journal_title：Nature communications

authors： Mazzola G,Yunoki S,Sorella S

更新日期：2014-03-19 00:00:00

abstract：:Iron sequestration by host proteins contributes to the defence against bacterial pathogens, which need iron for their metabolism and virulence. A Pseudomonas aeruginosa mutant lacking all three known iron acquisition systems retains the ability to grow in media containing iron chelators, suggesting the presence of add...

journal_title：Nature communications

authors： Lin J,Zhang W,Cheng J,Yang X,Zhu K,Wang Y,Wei G,Qian PY,Luo ZQ,Shen X

更新日期：2017-03-28 00:00:00

abstract：:Collisions between the DNA replication machinery and co-transcriptional R-loops can impede DNA synthesis and are a major source of genomic instability in cancer cells. How cancer cells deal with R-loops to proliferate is poorly understood. Here we show that the ATP-dependent chromatin remodelling INO80 complex promote...

journal_title：Nature communications

authors： Prendergast L,McClurg UL,Hristova R,Berlinguer-Palmini R,Greener S,Veitch K,Hernandez I,Pasero P,Rico D,Higgins JMG,Gospodinov A,Papamichos-Chronakis M

更新日期：2020-09-10 00:00:00

abstract：:Sign epistasis is a central evolutionary constraint, but its causal factors remain difficult to predict. Here we use the notion of parameterised optima to explain epistasis within a signalling cascade, and test these predictions in Escherichia coli. We show that sign epistasis arises from the benefit of tuning phenoty...

journal_title：Nature communications

authors： Nghe P,Kogenaru M,Tans SJ

更新日期：2018-04-13 00:00:00

abstract：:Innovations in soft material synthesis and fabrication technologies have led to the development of integrated soft electronic devices. Such soft devices offer opportunities to interact with biological cells, mimicking their soft environment. However, existing fabrication technologies cannot create the submicron-scale,...

journal_title：Nature communications

authors： Kim MG,Brown DK,Brand O

更新日期：2020-02-21 00:00:00

abstract：:Hypertensive disorders in pregnancy (HDPs) are leading perinatal diseases. Using a national cohort of 2,043,182 pregnant women in China, we evaluated the association between ambient temperatures and HDP subgroups, including preeclampsia or eclampsia, gestational hypertension, and superimposed preeclampsia. Under extre...

journal_title：Nature communications

authors： Xiong T,Chen P,Mu Y,Li X,Di B,Li J,Qu Y,Tang J,Liang J,Mu D

更新日期：2020-06-10 00:00:00

abstract：:Synthetic polymers are indispensable in many different applications, but there is a growing need for green processes and natural surfactants for emulsion polymerization. The use of solid particles to stabilize Pickering emulsions is a particularly attractive avenue, but oxygen sensitivity has remained a formidable cha...

journal_title：Nature communications

authors： Moreno A,Sipponen MH

更新日期：2020-11-05 00:00:00

abstract：:TH17 cells exemplify environmental immune adaptation: they can acquire both a pathogenic and an anti-inflammatory fate. However, it is not known whether the anti-inflammatory fate is merely a vestigial trait, or whether it serves to preserve the integrity of the host tissues. Here we show that the capacity of TH17 cel...

journal_title：Nature communications

authors： Xu H,Agalioti T,Zhao J,Steglich B,Wahib R,Vesely MCA,Bielecki P,Bailis W,Jackson R,Perez D,Izbicki J,Licona-Limón P,Kaartinen V,Geginat J,Esplugues E,Tolosa E,Huber S,Flavell RA,Gagliani N

更新日期：2020-07-03 00:00:00

abstract：:The Clp protease complex degrades a multitude of substrates, which are engaged by a AAA+ chaperone such as ClpX and subsequently digested by the dynamic, barrel-shaped ClpP protease. Acyldepsipeptides (ADEPs) are natural product-derived antibiotics that activate ClpP for chaperone-independent protein digestion. Here w...

journal_title：Nature communications

authors： Gersch M,Famulla K,Dahmen M,Göbl C,Malik I,Richter K,Korotkov VS,Sass P,Rübsamen-Schaeff H,Madl T,Brötz-Oesterhelt H,Sieber SA

更新日期：2015-02-19 00:00:00

abstract：:Major depressive disorder is associated with abnormalities in the brain and the immune system. Chronic stress in animals showed that epigenetic and inflammatory mechanisms play important roles in mediating resilience and susceptibility to depression. Here, through a high-throughput screening, we identify two phytochem...

journal_title：Nature communications

authors： Wang J,Hodes GE,Zhang H,Zhang S,Zhao W,Golden SA,Bi W,Menard C,Kana V,Leboeuf M,Xie M,Bregman D,Pfau ML,Flanigan ME,Esteban-Fernández A,Yemul S,Sharma A,Ho L,Dixon R,Merad M,Han MH,Russo SJ,Pasinetti GM

更新日期：2018-02-02 00:00:00

abstract：:Cells couple growth with division and regulate size in response to nutrient availability. In rod-shaped fission yeast, cell-size control occurs at mitotic commitment. An important regulator is the DYRK-family kinase Pom1, which forms gradients from cell poles and inhibits the mitotic activator Cdr2, itself localized a...

journal_title：Nature communications

authors： Kelkar M,Martin SG

更新日期：2015-10-07 00:00:00

abstract：:The efficient selection and isolation of individual cells of interest from a mixed population is desired in many biomedical and clinical applications. Here we show the concept of using photoswitchable semiconducting polymer dots (Pdots) as an optical 'painting' tool, which enables the selection of certain adherent cel...

journal_title：Nature communications

authors： Kuo CT,Thompson AM,Gallina ME,Ye F,Johnson ES,Sun W,Zhao M,Yu J,Wu IC,Fujimoto B,DuFort CC,Carlson MA,Hingorani SR,Paguirigan AL,Radich JP,Chiu DT

更新日期：2016-04-27 00:00:00

abstract：:Continuous cycles of nucleocytoplasmic transport require disassembly of transport receptor/Ran-GTP complexes in the cytoplasm. A basic disassembly mechanism in all eukaryotes depends on soluble RanGAP and RanBP1. In vertebrates, a significant fraction of RanGAP1 stably interacts with the nucleoporin RanBP2 at a bindin...

journal_title：Nature communications

authors： Ritterhoff T,Das H,Hofhaus G,Schröder RR,Flotho A,Melchior F

更新日期：2016-05-10 00:00:00

abstract：:Regional differences in health-related phenotypes have been detected between and within countries. In Scotland, regions differ for a variety of health-related traits and display differences in mean lifespan of up to 7.5 years. Both genetics and lifestyle differences are potential causes of this variation. Using data o...

journal_title：Nature communications

authors： Amador C,Xia C,Nagy R,Campbell A,Porteous D,Smith BH,Hastie N,Vitart V,Hayward C,Navarro P,Haley CS

更新日期：2017-10-06 00:00:00

abstract：:Untethered small actuators have various applications in multiple fields. However, existing small-scale actuators are very limited in their intractability with their surroundings, respond to only a single type of stimulus and are unable to achieve programmable structural changes under different stimuli. Here, we presen...

journal_title：Nature communications

authors： Dong Y,Wang J,Guo X,Yang S,Ozen MO,Chen P,Liu X,Du W,Xiao F,Demirci U,Liu BF

更新日期：2019-09-09 00:00:00

abstract：:High-aspect ratio nanostructures such as nanowires and nanotubes are a powerful new tool for accessing the cell interior for delivery and sensing. Controlling and optimizing cellular access is a critical challenge for this new technology, yet even the most basic aspect of this process, whether these structures directl...

journal_title：Nature communications

authors： Xu AM,Aalipour A,Leal-Ortiz S,Mekhdjian AH,Xie X,Dunn AR,Garner CC,Melosh NA

更新日期：2014-04-07 00:00:00

abstract：:Broomcorn millet (Panicum miliaceum L.) is the most water-efficient cereal and one of the earliest domesticated plants. Here we report its high-quality, chromosome-scale genome assembly using a combination of short-read sequencing, single-molecule real-time sequencing, Hi-C, and a high-density genetic map. Phylogeneti...

journal_title：Nature communications

authors： Zou C,Li L,Miki D,Li D,Tang Q,Xiao L,Rajput S,Deng P,Peng L,Jia W,Huang R,Zhang M,Sun Y,Hu J,Fu X,Schnable PS,Chang Y,Li F,Zhang H,Feng B,Zhu X,Liu R,Schnable JC,Zhu JK,Zhang H

更新日期：2019-01-25 00:00:00