Abstract:
:O-GlcNAcylation has been implicated in the tumorigenesis of various tissue origins, but its function in liver tumorigenesis is not clear. Here, we demonstrate that O-GlcNAcylation can enhance the expression, stability and function of Yes-associated protein (YAP), the downstream transcriptional regulator of the Hippo pathway and a potent oncogenic factor in liver cancer. O-GlcNAcylation induces transformative phenotypes of liver cancer cells in a YAP-dependent manner. An O-GlcNAc site of YAP was identified at Thr241, and mutating this site decreased the O-GlcNAcylation, stability, and pro-tumorigenic capacities of YAP, while increasing YAP phosphorylation. Importantly, we found via in vitro cell-based and in vivo mouse model experiments that O-GlcNAcylation of YAP was required for high-glucose-induced liver tumorigenesis. Interestingly, a positive feedback between YAP and global cellular O-GlcNAcylation is also uncovered. We conclude that YAP O-GlcNAcylation is a potential therapeutic intervention point for treating liver cancer associated with high blood glucose levels and possibly diabetes.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Zhang X,Qiao Y,Wu Q,Chen Y,Zou S,Liu X,Zhu G,Zhao Y,Chen Y,Yu Y,Pan Q,Wang J,Sun Fdoi
10.1038/ncomms15280subject
Has Abstractpub_date
2017-05-05 00:00:00pages
15280issn
2041-1723pii
ncomms15280journal_volume
8pub_type
杂志文章abstract::Plasmacytoid dendritic cells (pDC) are type I interferon-producing cells with critical functions in a number of human illnesses; however, their molecular regulation is incompletely understood. Here we show the role of Src family kinases (SFK) in mouse and human pDCs. pDCs express Fyn and Lyn and their activating resid...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14830
更新日期:2017-04-03 00:00:00
abstract::Writing artificial logic and dynamic function into complex cellular background to achieve desired phenotypes or improved outputs calls for the development of new genetic tools as well as their innovative use. In this study, we present a sensor-regulator and RNAi-based bifunctional dynamic control network that can prov...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05466-0
更新日期:2018-08-02 00:00:00
abstract::Viscous electron fluids have emerged recently as a new paradigm of strongly-correlated electron transport in solids. Here we report on a direct observation of the transition to this long-sought-for state of matter in a high-mobility electron system in graphene. Unexpectedly, the electron flow is found to be interactio...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07004-4
更新日期:2018-10-31 00:00:00
abstract::The sudden deterioration of patients with novel coronavirus disease 2019 (COVID-19) into critical illness is of major concern. It is imperative to identify these patients early. We show that a deep learning-based survival model can predict the risk of COVID-19 patients developing critical illness based on clinical cha...
journal_title:Nature communications
pub_type: 杂志文章,多中心研究
doi:10.1038/s41467-020-17280-8
更新日期:2020-07-15 00:00:00
abstract::Increasing incidence of inflammatory bowel disorders demands a better understanding of the molecular mechanisms underlying its multifactorial aetiology. Here we demonstrate that mice deficient for REGγ, a proteasome activator, show significantly attenuated intestinal inflammation and colitis-associated cancer in dextr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10761
更新日期:2016-02-22 00:00:00
abstract::The microbial communities living in the human intestine can have profound impact on our well-being and health. However, we have limited understanding of the mechanisms that control this complex ecosystem. Here, based on a deep phylogenetic analysis of the intestinal microbiota in a thousand western adults, we identify...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5344
更新日期:2014-07-08 00:00:00
abstract::Chromatin looping allows enhancer-bound regulatory factors to influence transcription. Large domains, referred to as topologically associated domains, participate in genome organization. However, the mechanisms underlining interactions within these domains, which control gene expression, are not fully understood. Here...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10318-6
更新日期:2019-05-24 00:00:00
abstract::Steels belong to one of the best established materials, however, the mechanisms of various phase transformations down to the nano length scale are still not fully clear. In this work, high-resolution transmission electron microscopy is combined with atomistic simulations to study the nanoscale carbide precipitation in...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06474-w
更新日期:2018-10-01 00:00:00
abstract::Genetic screens are powerful tools to identify the genes required for a given biological process. However, for technical reasons, comprehensive screens have been restricted to very few model organisms. Therefore, although deep sequencing is revealing the genes of ever more insect species, the functional studies predom...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8822
更新日期:2015-07-28 00:00:00
abstract::The interoceanic transfer of seawater between the Indian Ocean and the Atlantic, 'Agulhas leakage', forms a choke point for the overturning circulation in the global ocean. Here, by combining output from a series of high-resolution ocean and climate models with in situ and satellite observations, we construct a time s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10082
更新日期:2015-12-10 00:00:00
abstract::Multiple myeloma (MM) progression and myeloma-associated bone disease (MBD) are highly dependent on bone marrow mesenchymal stromal cells (MSCs). MM-MSCs exhibit abnormal transcriptomes, suggesting the involvement of epigenetic mechanisms governing their tumor-promoting functions and prolonged osteoblast suppression. ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20715-x
更新日期:2021-01-18 00:00:00
abstract::Fibroblastic reticular cells (FRCs) are immunologically specialized myofibroblasts of lymphoid organ, and FRC maturation is essential for structural and functional properties of lymph nodes (LNs). Here we show that YAP and TAZ (YAP/TAZ), the final effectors of Hippo signaling, regulate FRC commitment and maturation. S...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14293-1
更新日期:2020-01-24 00:00:00
abstract::The Earth's biggest magmatic events are believed to originate from massive melting when hot mantle plumes rising from the lowermost mantle reach the base of the lithosphere. Classical models predict large plume heads that cause kilometre-scale surface uplift, and narrow (100 km radius) plume tails that remain in the m...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7960
更新日期:2015-04-24 00:00:00
abstract::Heterogeneous catalysis is an enabling technology that utilises transition metal nanoparticles (NPs) supported on oxides to promote chemical reactions. Structural mismatch at the NP-support interface generates lattice strain that could affect catalytic properties. However, detailed knowledge about strain in supported ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05055-1
更新日期:2018-07-13 00:00:00
abstract::Reduced-dimensional perovskites are attractive light-emitting materials due to their efficient luminescence, color purity, tunable bandgap, and structural diversity. A major limitation in perovskite light-emitting diodes is their limited operational stability. Here we demonstrate that rapid photodegradation arises fro...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13944-2
更新日期:2020-01-10 00:00:00
abstract::Dynamics are fundamental to the functions of biomolecules and can occur on a wide range of time and length scales. Here we develop and apply high-speed AFM height spectroscopy (HS-AFM-HS), a technique whereby we monitor the sensing of a HS-AFM tip at a fixed position to directly detect the motions of unlabeled molecul...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07512-3
更新日期:2018-11-26 00:00:00
abstract::Application of coherent light-matter interactions has recently been extended to the ultrafast control of magnetization. An important but unrealized technique is the manipulation of magnetization vector motion to make it follow an arbitrarily designed multidimensional trajectory. Here we demonstrate a full manipulation...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1366
更新日期:2011-06-21 00:00:00
abstract::Trypanosoma brucei is a protozoan parasite that evades its host's adaptive immune response by repeatedly replacing its dense variant surface glycoprotein (VSG) coat from its large genomic VSG repertoire. While the mechanisms regulating VSG gene expression and diversification have been examined extensively, the dynamic...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00959-w
更新日期:2017-10-10 00:00:00
abstract::To date, the vast preponderance of somatic variants observed in the cancer genome have been rare variants, and it is common in practice to encounter in a new tumor variants that have not been observed previously. Here we focus on probability estimation for encountering such hitherto unseen variants. We draw upon stati...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13402-z
更新日期:2019-12-03 00:00:00
abstract::The ubiquitin proteasome system (UPS) has emerged as a drug target for diverse diseases characterized by altered proteostasis, but pharmacological agents that enhance UPS activity have been challenging to establish. Here we report the Deg-On system, a genetic inverter that translates proteasomal degradation of the tra...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4612
更新日期:2014-04-08 00:00:00
abstract::Fire emissions generate air pollutants ozone (O3) and aerosols that influence the land carbon cycle. Surface O3 damages vegetation photosynthesis through stomatal uptake, while aerosols influence photosynthesis by increasing diffuse radiation. Here we combine several state-of-the-art models and multiple measurement da...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07921-4
更新日期:2018-12-21 00:00:00
abstract::Effective prevention strategies will be essential in reducing disease burden due to bacterial infections. Here we harness the specificity and rapid-acting properties of bacteriophages as a potential prophylaxis therapy for cholera, a severely dehydrating disease caused by Vibrio cholerae. To this end, we test a cockta...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14187
更新日期:2017-02-01 00:00:00
abstract::Cryptosporidiosis in an enteric infection caused by Cryptosporidium parasites and is a major cause of acute infant diarrhea in the developing world. A major bottleneck to research progress is the lack of methods to cryopreserve Cryptosporidium oocysts, thus requiring routine propagation in laboratory animals. Here, we...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05240-2
更新日期:2018-07-23 00:00:00
abstract::Semiconducting two-dimensional transition metal dichalcogenides are emerging as top candidates for post-silicon electronics. While most of them exhibit isotropic behaviour, lowering the lattice symmetry could induce anisotropic properties, which are both scientifically interesting and potentially useful. Here we prese...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7991
更新日期:2015-05-07 00:00:00
abstract::There is increasing evidence from genome-wide association studies for a strong inherited genetic basis of susceptibility to acute lymphoblastic leukaemia (ALL) in children, yet the effects of protein-coding variants on ALL risk have not been systematically evaluated. Here we show a missense variant in CDKN2A associate...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8553
更新日期:2015-06-24 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-020-15793-w
更新日期:2020-04-28 00:00:00
abstract::Monitoring the Earth's stress state plays a role in our understanding of an earthquake's mechanism and in the distribution of hazards. Crustal deformation due to the July 2019 earthquake sequence in Ridgecrest (California) that culminated in a preceding quake of magnitude (M) 6.4 and a subsequent M7.1 quake caused str...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16867-5
更新日期:2020-06-17 00:00:00
abstract::Age, as a threshold of floral competence acquisition, prevents precocious flowering when there is insufficient biomass, and ensures flowering independent of environmental conditions; however, the underlying regulatory mechanisms are largely unknown. In this study, silencing the expression of a nuclear factor gene, CmN...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00812-0
更新日期:2017-10-10 00:00:00
abstract::The process of crystallization is difficult to observe for transported, out-of-equilibrium systems, as the continuous energy injection increases activity and competes with ordering. In emerging fields such as microfluidics and active matter, the formation of long-range order is often frustrated by the presence of hydr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10255-4
更新日期:2019-06-04 00:00:00
abstract::Surface-supported isolated atoms in single-atom catalysts (SACs) are usually stabilized by diverse defects. The fabrication of high-metal-loading and thermally stable SACs remains a formidable challenge due to the difficulty of creating high densities of underpinning stable defects. Here we report that isolated Pt ato...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-08136-3
更新日期:2019-01-16 00:00:00