Abstract:
:Use of aromatase inhibitors (AIs), exemestane, letrozole and anastrozole, for breast cancer therapy is associated with severe pain symptoms, the underlying mechanism of which is unknown. The electrophilic nature of AIs suggests that they may target the transient receptor potential ankyrin 1 (TRPA1) channel, a major pathway in pain transmission and neurogenic inflammation. AIs evoke TRPA1-mediated calcium response and current in rodent nociceptors and human cells expressing the recombinant channel. In mice, AIs produce acute nociception, which is exaggerated by pre-exposure to proalgesic stimuli, and, by releasing sensory neuropeptides, neurogenic inflammation in peripheral tissues. AIs also evoke mechanical allodynia and decreased grip strength, which do not undergo desensitization on prolonged AI administration. These effects are markedly attenuated by TRPA1 pharmacological blockade or in TRPA1-deficient mice. TRPA1 is a major mediator of the proinflammatory/proalgesic actions of AIs, thus suggesting TRPA1 antagonists for the treatment of pain symptoms associated with AI use.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Fusi C,Materazzi S,Benemei S,Coppi E,Trevisan G,Marone IM,Minocci D,De Logu F,Tuccinardi T,Di Tommaso MR,Susini T,Moneti G,Pieraccini G,Geppetti P,Nassini Rdoi
10.1038/ncomms6736subject
Has Abstractpub_date
2014-12-08 00:00:00pages
5736issn
2041-1723pii
ncomms6736journal_volume
5pub_type
杂志文章abstract::Inorganic perovskites such as CsPbX3 (X=Cl, Br, I) have attracted attention due to their excellent thermal stability and high photoluminescence quantum efficiency. However, the electroluminescence quantum efficiency of their light-emitting diodes was <1%. We posited that this low efficiency was a result of high leakag...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15640
更新日期:2017-06-07 00:00:00
abstract::Phase transitions in amorphous alloys under pressure are an important fundamental problem. Here we report on a first-principles study that reproduces the recently discovered pressure-induced crystallization of amorphous Ce100-xAlx (x<25) alloys and reveals an atomistic transformation mechanism. Contrary to common beli...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7493
更新日期:2015-03-09 00:00:00
abstract::The magnetic excitations in the cuprate superconductors might be essential for an understanding of high-temperature superconductivity. In these cuprate superconductors the magnetic excitation spectrum resembles an hour-glass and certain resonant magnetic excitations within are believed to be connected to the pairing m...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6731
更新日期:2014-12-23 00:00:00
abstract::In vivo liposomes, like other types of nanoparticles, acquire a totally new 'biological identity' due to the formation of a biomolecular coating known as the protein corona that depends on and modifies the liposomes' synthetic identity. The liposome-protein corona is a dynamic interface that regulates the interaction ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11642-7
更新日期:2019-08-15 00:00:00
abstract::Polymers bearing dynamic covalent bonds may exhibit dynamic properties, such as self-healing, shape memory and environmental adaptation. However, most dynamic covalent chemistries developed so far require either catalyst or change of environmental conditions to facilitate bond reversion and dynamic property change in ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4218
更新日期:2014-01-01 00:00:00
abstract::Botulinum neurotoxins are known to have seven serotypes (BoNT/A-G). Here we report a new BoNT serotype, tentatively named BoNT/X, which has the lowest sequence identity with other BoNTs and is not recognized by antisera against known BoNTs. Similar to BoNT/B/D/F/G, BoNT/X cleaves vesicle-associated membrane proteins (...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14130
更新日期:2017-08-03 00:00:00
abstract::CDKL5 deficiency disorder (CDD) is characterized by epilepsy, intellectual disability, and autistic features, and CDKL5-deficient mice exhibit a constellation of behavioral phenotypes reminiscent of the human disorder. We previously found that CDKL5 dysfunction in forebrain glutamatergic neurons results in deficits in...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10689-w
更新日期:2019-06-14 00:00:00
abstract::Calcareous microplankton shells form the dominant components of ancient and modern pelagic sea-floor carbonates and are widely used in palaeoenvironmental reconstructions. The efficacy of these applications, however, is dependent upon minimal geochemical alteration during diagenesis, but these modifying processes are ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3052
更新日期:2013-01-01 00:00:00
abstract::Laboratory spectroscopy of atomic hydrogen in a magnetic flux density of 10(5) T (1 gigagauss), the maximum observed on high-field magnetic white dwarfs, is impossible because practically available fields are about a thousand times less. In this regime, the cyclotron and binding energies become equal. Here we demonstr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2466
更新日期:2013-01-01 00:00:00
abstract::The integration of β-barrel proteins into the bacterial outer membrane (OM) is catalysed by the β-barrel assembly machinery (BAM). The central BAM subunit (BamA) itself contains a β-barrel domain that is essential for OM protein biogenesis, but its mechanism of action is unknown. To elucidate its function, here we dev...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11230-9
更新日期:2019-07-26 00:00:00
abstract::Scalable, integrative methods to understand mechanisms that link genetic variants with phenotypes are needed. Here we derive a mathematical expression to compute PrediXcan (a gene mapping approach) results using summary data (S-PrediXcan) and show its accuracy and general robustness to misspecified reference sets. We ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03621-1
更新日期:2018-05-08 00:00:00
abstract::Foldamers provide an attractive medium to test the mechanisms by which biological macromolecules fold into complex three-dimensional structures, and ultimately to design novel protein-like architectures with properties unprecedented in nature. Here, we describe a large cage-like structure formed from an amphiphilic ar...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4581
更新日期:2014-04-07 00:00:00
abstract::The evolutionary progression from primary to metastatic prostate cancer is largely uncharted, and the implications for liquid biopsy are unexplored. We infer detailed reconstructions of tumor phylogenies in ten prostate cancer patients with fatal disease, and investigate them in conjunction with histopathology and tum...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18843-5
更新日期:2020-10-08 00:00:00
abstract::Stimuli-responsive behaviors of flexible metal-organic frameworks (MOFs) make these materials promising in a wide variety of applications such as gas separation, drug delivery, and molecular sensing. Considerable efforts have been made over the last decade to understand the structural changes of flexible MOFs in respo...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08939-y
更新日期:2019-03-01 00:00:00
abstract::Energy affects every single individual and entity in the world. Therefore, it is crucial to precisely quantify the "price of energy" and study how it evolves through time, through major political and social events, and through changes in energy and monetary policies. Here, we develop a predictive framework, an index t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20203-2
更新日期:2021-01-04 00:00:00
abstract::While intron retention (IR) is considered a widely conserved and distinct mechanism of gene expression control, its regulation is poorly understood. Here we show that DNA methylation directly regulates IR. We also find reduced occupancy of MeCP2 near the splice junctions of retained introns, mirroring the reduced DNA ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15134
更新日期:2017-05-08 00:00:00
abstract::Single-crystal cathode materials for lithium-ion batteries have attracted increasing interest in providing greater capacity retention than their polycrystalline counterparts. However, after being cycled at high voltages, these single-crystal materials exhibit severe structural instability and capacity fade. Understand...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16824-2
更新日期:2020-06-16 00:00:00
abstract::To learn, obtain reward and survive, humans and other animals must monitor, approach and act on objects that are associated with variable or unknown rewards. However, the neuronal mechanisms that mediate behaviours aimed at uncertain objects are poorly understood. Here we demonstrate that a set of neurons in an intern...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12735
更新日期:2016-09-14 00:00:00
abstract::Breast cancer metastasis involves lymphatic dissemination in addition to hematogenous spreading. Although stromal lymphatic vessels (LVs) serve as initial metastatic routes, roles of organ-residing LVs are underinvestigated. Here we show that lymphatic endothelial cells (LECs), a component of LVs within pre-metastatic...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5715
更新日期:2014-09-02 00:00:00
abstract::Woody (lignocellulosic) plant biomass is an abundant renewable feedstock, rich in polysaccharides that are bound into an insoluble fiber composite with lignin. Marine crustacean woodborers of the genus Limnoria are among the few animals that can survive on a diet of this recalcitrant material without relying on gut re...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07575-2
更新日期:2018-12-03 00:00:00
abstract::Type I interferons (IFN) are being rediscovered as potent anti-tumoral agents. Activation of the STimulator of INterferon Genes (STING) by DMXAA (5,6-dimethylxanthenone-4-acetic acid) can induce strong production of IFNα/β and rejection of transplanted primary tumors. In the present study, we address whether targeting...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11998-w
更新日期:2019-09-11 00:00:00
abstract::Innate immune chemoreceptors of the formyl peptide receptor (Fpr) family are expressed by vomeronasal sensory neurons (VSNs) in the accessory olfactory system. Their biological function and coding mechanisms remain unknown. We show that mouse Fpr3 (Fpr-rs1) recognizes the core peptide motif f-MKKFRW that is predominan...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12842-x
更新日期:2019-10-25 00:00:00
abstract::Global fish production (capture and aquaculture) has increased quickly, which has altered global flows of phosphorus (P). Here we show that in 2016, [Formula: see text] Tg P yr-1 (mean and interquartile range) was applied in aquaculture to increase fish production; while [Formula: see text] Tg P yr-1 was removed from ...
journal_title:Nature communications
pub_type: 历史文章,杂志文章
doi:10.1038/s41467-019-14242-7
更新日期:2020-01-17 00:00:00
abstract::The poverty of disease resistance gene reservoirs limits the breeding of crops for durable resistance against evolutionary dynamic pathogens. Zymoseptoria tritici which causes Septoria tritici blotch (STB), represents one of the most genetically diverse and devastating wheat pathogens worldwide. No fully virulent Z. t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20685-0
更新日期:2021-01-19 00:00:00
abstract::Human land use may detrimentally affect biodiversity, yet long-term stability of species communities is vital for maintaining ecosystem functioning. Community stability can be achieved by higher species diversity (portfolio effect), higher asynchrony across species (insurance hypothesis) and higher abundance of popula...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10697
更新日期:2016-02-12 00:00:00
abstract::Biodegradable polyesters with various tacticities have been synthesized by means of stereoselective ring-opening polymerization of racemic lactide and β-lactones but with limited side-chain groups. However, stereoselective synthesis of functional polyesters remains challenging from O-carboxyanhydrides that have abunda...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03879-5
更新日期:2018-04-19 00:00:00
abstract::Olfactory and metabolic dysfunctions are intertwined phenomena associated with obesity and neurodegenerative diseases; yet how mechanistically olfaction regulates metabolic homeostasis remains unclear. Specificity of olfactory perception integrates diverse environmental odors and olfactory neurons expressing different...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15296-8
更新日期:2020-03-19 00:00:00
abstract::Variability in dense shelf water formation can potentially impact Antarctic Bottom Water (AABW) production, a vital component of the global climate system. In East Antarctica, the George V Land polynya system (142-150°E) is structured by the local 'icescape', promoting sea ice formation that is driven by the offshore ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1820
更新日期:2012-05-08 00:00:00
abstract::How rapidly natural selection sorts genome-wide standing genetic variation during adaptation remains largely unstudied experimentally. Here, we present a genomic release-recapture experiment using paired threespine stickleback fish populations adapted to selectively different lake and stream habitats. First, we use po...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15657-3
更新日期:2020-04-21 00:00:00
abstract::The diversity reflected by >100 different neural cell types fundamentally contributes to brain function and a central idea is that neuronal identity can be inferred from genetic information. Recent large-scale transcriptomic assays seem to confirm this hypothesis, but a lack of morphological information has limited th...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20328-4
更新日期:2021-01-04 00:00:00