Abstract:
:In the originally published version of this Article, financial support was not fully acknowledged. The PDF and HTML versions of the Article have now been corrected to include support from National Institute of General Medical Sciences, National Institutes of Health grant R01GM124072.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Lorent JH,Diaz-Rohrer B,Lin X,Spring K,Gorfe AA,Levental KR,Levental Idoi
10.1038/s41467-018-04164-1subject
Has Abstractpub_date
2018-05-01 00:00:00pages
1805issue
1issn
2041-1723pii
10.1038/s41467-018-04164-1journal_volume
9pub_type
杂志文章,已发布勘误abstract::Interfacial issues commonly exist in solid-state batteries, and the microstructural complexity combines with the chemical heterogeneity to govern the local interfacial chemistry. The conventional wisdom suggests that "point-to-point" ion diffusion at the interface determines the ion transport kinetics. Here, we show t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19528-9
更新日期:2020-11-11 00:00:00
abstract::Controlling nanocarrier interactions with the immune system requires a thorough understanding of the surface properties that modulate protein adsorption in biological fluids, since the resulting protein corona redefines cellular interactions with nanocarrier surfaces. Albumin is initially one of the dominant proteins ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20886-7
更新日期:2021-01-28 00:00:00
abstract::Nanoscale dimensions in materials lead to unique electronic and structural properties with applications ranging from site-specific drug delivery to anodes for lithium-ion batteries. These functional properties often involve large-amplitude strains and structural modifications, and thus require an understanding of the ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7577
更新日期:2015-03-12 00:00:00
abstract::Germline removal provokes longevity in several species and shifts resources towards survival and repair. Several Caenorhabditis elegans transcription factors regulate longevity arising from germline removal; yet, how they work together is unknown. Here we identify a Myc-like HLH transcription factor network comprised ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10944
更新日期:2016-03-22 00:00:00
abstract::Transition metal-catalyzed C-H activation and radical reactions are two versatile strategies to construct diverse organic skeletons. Here we show the construction of a class of flavylium fluorophores via the merge of radical chemistry and C-H activation starting from (hetero)aryl ketones and alkynes. This protocol is ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13611-6
更新日期:2019-12-11 00:00:00
abstract::The importance of metabolism in macrophage function has been reported, but the in vivo relevance of the in vitro observations is still unclear. Here we show that macrophage metabolites are defined in a specific tissue context, and these metabolites are crucially linked to tissue-resident macrophage functions. We find ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02092-0
更新日期:2017-12-12 00:00:00
abstract::Most motile bacteria navigate within gradients of external chemical stimuli by regulating the length of randomly oriented swimming episodes. Magnetotactic bacteria are characterized by chains of intracellular ferromagnetic nanoparticles and their ability to sense the geomagnetic field, which is believed to facilitate ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6398
更新日期:2014-11-14 00:00:00
abstract::Many-body entanglement is at the heart of the Kondo effect, which has its hallmark in quantum dots as a zero-bias conductance peak at low temperatures. It signals the emergence of a conducting singlet state formed by a localized dot degree of freedom and conduction electrons. Carbon nanotubes offer the possibility to ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12442
更新日期:2016-08-16 00:00:00
abstract::Obesity develops when energy intake exceeds energy expenditure. Promoting brown adipose tissue formation and function increases energy expenditure and hence may counteract obesity. Berberine (BBR) is a compound derived from the Chinese medicinal plant Coptis chinensis. Here we show that BBR increases energy expenditur...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6493
更新日期:2014-11-25 00:00:00
abstract::The interoceanic transfer of seawater between the Indian Ocean and the Atlantic, 'Agulhas leakage', forms a choke point for the overturning circulation in the global ocean. Here, by combining output from a series of high-resolution ocean and climate models with in situ and satellite observations, we construct a time s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10082
更新日期:2015-12-10 00:00:00
abstract::A synthetic biology method based on heterologous biosynthesis coupled with genome mining is a promising approach for increasing the opportunities to rationally access natural product with novel structures and biological activities through total biosynthesis and combinatorial biosynthesis. Here, we demonstrate the adva...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15664-4
更新日期:2020-04-14 00:00:00
abstract::The expression and stabilization of recombinant proteins is fundamental to basic and applied biology. Here we have engineered a thermostable protein nanoparticle (tES) to improve both expression and stabilization of recombinant proteins using this technology. tES provides steric accommodation and charge complementatio...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01585-2
更新日期:2017-11-13 00:00:00
abstract::Schizophrenia and bipolar disorder are major psychiatric disorders with high heritability and overlapping genetic variance. Here we perform a genome-wide association study in an ethnically homogeneous cohort of 904 schizophrenia cases and 1,640 controls drawn from the Ashkenazi Jewish population. We identify a novel g...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3739
更新日期:2013-01-01 00:00:00
abstract::Superchiral light, generated by the interference of two counter-propagating circularly polarized light (CPL) with same frequency, opposite handedness and different intensity, exhibits enhanced dissymmetry in its interaction with chiral molecules, and has the potential for ultrasensitive detection and characterization ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07533-y
更新日期:2018-11-30 00:00:00
abstract::Metal-organic frameworks (MOFs) are well known for their tunable structure and porosity. Many studies have shown they are promising for various important applications, for which their performance can be further enhanced by encapsulating functional species, such as luminescent guest molecules, within the frameworks. Al...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3717
更新日期:2013-01-01 00:00:00
abstract::Magnetic reconnection (MR) is a fundamental plasma process associated with conversion of the magnetic field energy into kinetic plasma energy, which is invoked to explain many non-thermal signatures in astrophysical events. Here we demonstrate that ultrafast relativistic MR in a magnetically dominated regime can be tr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04065-3
更新日期:2018-04-23 00:00:00
abstract::Plasmodium vivax is the leading cause of human malaria in Asia and Latin America but is absent from most of central Africa due to the near fixation of a mutation that inhibits the expression of its receptor, the Duffy antigen, on human erythrocytes. The emergence of this protective allele is not understood because P. ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4346
更新日期:2014-01-01 00:00:00
abstract::Polyborylated organic compounds have been emerging as versatile building blocks in chemical synthesis. Here we report a selective cobalt-catalyzed deoxygenative 1,1,3-triborylation reaction of allylic ethers with pinacolborane to prepare 1,1,3-triborylalkane compounds. With naturally abundant and/or synthetic cinnamic...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19039-7
更新日期:2020-10-15 00:00:00
abstract::For COVID-19, it is vital to understand if quarantines shorter than 14 days can be equally effective with judiciously deployed testing. Here, we develop a mathematical model that quantifies the probability of post-quarantine transmission incorporating testing into travel quarantine, quarantine of traced contacts with ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20742-8
更新日期:2021-01-07 00:00:00
abstract::Remyelination occurs after spinal cord injury (SCI) but its functional relevance is unclear. We assessed the necessity of myelin regulatory factor (Myrf) in remyelination after contusive SCI by deleting the gene from platelet-derived growth factor receptor alpha positive (PDGFRα-positive) oligodendrocyte progenitor ce...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05473-1
更新日期:2018-08-03 00:00:00
abstract::Microglia and peripheral monocytes contribute to hypersensitivity in rodent models of neuropathic pain. However, the precise respective function of microglia and peripheral monocytes has not been investigated in these models. To address this question, here we combined transgenic mice and pharmacological tools to speci...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12029
更新日期:2016-06-28 00:00:00
abstract::Mechanically flexible mobile phones have been long anticipated due to the rapid development of thin-film electronics in the last couple of decades. However, to date, no such phone has been developed, largely due to a lack of flexible electronic components that are fast enough for the required wireless communications, ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8561
更新日期:2015-07-03 00:00:00
abstract::Intracellular traffic between compartments of the secretory and endocytic pathways is mediated by vesicle-based carriers. The proteomes of carriers destined for many organelles are ill-defined because the vesicular intermediates are transient, low-abundance and difficult to purify. Here, we combine vesicle relocalisat...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19840-4
更新日期:2020-11-25 00:00:00
abstract::Genome stability relies on proper coordination of mitosis and cytokinesis, where dynamic microtubules capture and faithfully segregate chromosomes into daughter cells. With a high-content RNAi imaging screen targeting more than 2,000 human lncRNAs, we identify numerous lncRNAs involved in key steps of cell division su...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14978-7
更新日期:2020-04-15 00:00:00
abstract::Mitochondria are essential cellular organelles for generation of energy and their dysfunction may cause diabetes, Parkinson's disease and multi-systemic failure marked by failure to thrive, gastrointestinal problems, lactic acidosis and early lethality. Disease-associated mitochondrial mutations often affect component...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3886
更新日期:2013-01-01 00:00:00
abstract::Different symmetry breaking ways determine various magnetization switching modes driven by spin-orbit torques (SOT). For instance, an applied or effective field parallel to applied current is indispensable to switch magnetization with perpendicular anisotropy by SOT. Besides of this mode, here we experimentally demons...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-08181-y
更新日期:2019-01-16 00:00:00
abstract::Genomic evolution, transmission and pathogenesis of Streptococcus pneumoniae, an opportunistic human-adapted pathogen, is driven principally by nasopharyngeal carriage. However, little is known about genomic changes during natural colonisation. Here, we use whole-genome sequencing to investigate within-host microevolu...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17327-w
更新日期:2020-07-10 00:00:00
abstract::Australopithecus sediba has been hypothesized to be a close relative of the genus Homo. Here we show that MH1, the type specimen of A. sediba, was not optimized to produce high molar bite force and appears to have been limited in its ability to consume foods that were mechanically challenging to eat. Dental microwear ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10596
更新日期:2016-02-08 00:00:00
abstract::Organic-inorganic hybrid perovskites are promising candidates for the next-generation solar cells. Many efforts have been made to study their structures in the search for a better mechanistic understanding to guide the materials optimization. Here, we investigate the structure instability of the single-crystalline CH3...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07177-y
更新日期:2018-11-15 00:00:00
abstract::The 26S proteasome is the primary machinery that degrades ubiquitin (Ub)-conjugated proteins, including many proteotoxic proteins implicated in neurodegeneraton. It has been suggested that the elevation of proteasomal activity is tolerable to cells and may be beneficial to prevent the accumulation of protein aggregate...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6633
更新日期:2014-12-05 00:00:00