Abstract:
:Multifactorial mechanisms underlying late-onset Alzheimer's disease (LOAD) are poorly characterized from an integrative perspective. Here spatiotemporal alterations in brain amyloid-β deposition, metabolism, vascular, functional activity at rest, structural properties, cognitive integrity and peripheral proteins levels are characterized in relation to LOAD progression. We analyse over 7,700 brain images and tens of plasma and cerebrospinal fluid biomarkers from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Through a multifactorial data-driven analysis, we obtain dynamic LOAD-abnormality indices for all biomarkers, and a tentative temporal ordering of disease progression. Imaging results suggest that intra-brain vascular dysregulation is an early pathological event during disease development. Cognitive decline is noticeable from initial LOAD stages, suggesting early memory deficit associated with the primary disease factors. High abnormality levels are also observed for specific proteins associated with the vascular system's integrity. Although still subjected to the sensitivity of the algorithms and biomarkers employed, our results might contribute to the development of preventive therapeutic interventions.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Iturria-Medina Y,Sotero RC,Toussaint PJ,Mateos-Pérez JM,Evans AC,Alzheimer’s Disease Neuroimaging Initiative.doi
10.1038/ncomms11934subject
Has Abstractpub_date
2016-06-21 00:00:00pages
11934issn
2041-1723pii
ncomms11934journal_volume
7pub_type
杂志文章abstract::Human mesenchymal stromal cells (hMSCs) are a promising source for engineered cell-based therapies in which genetic engineering could enhance therapeutic efficacy and install novel cellular functions. Here, we describe an optimized Cas9-AAV6-based genome editing tool platform for site-specific mutagenesis and integrat...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16065-3
更新日期:2020-05-18 00:00:00
abstract::Compounds with incommensurate structural modulations have been extensively studied in last several decades. However, the relationship between structurally incommensurate/commensurate phases and associated electronic states remains enigmatic. Here we report the coexisting of complex incommensurate structures and highly...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6358
更新日期:2014-11-07 00:00:00
abstract::With its light weight, low cost and high efficiency even at low operation frequency, the triboelectric nanogenerator is considered a potential solution for self-powered sensor networks and large-scale renewable blue energy. As an energy harvester, its output power density and efficiency are dictated by the triboelectr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00131-4
更新日期:2017-07-20 00:00:00
abstract::The CRISPR/Cas9 system is a powerful tool for studying gene function. Here, we describe a method that allows temporal control of CRISPR/Cas9 activity based on conditional Cas9 destabilization. We demonstrate that fusing an FKBP12-derived destabilizing domain to Cas9 (DD-Cas9) enables conditional Cas9 expression and te...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14370
更新日期:2017-02-22 00:00:00
abstract::Acid-sensing ion channel 3 (ASIC3) is involved in acid nociception, but its possible role in neurosensory mechanotransduction is disputed. We report here the generation of Asic3-knockout/eGFPf-knockin mice and subsequent characterization of heterogeneous expression of ASIC3 in the dorsal root ganglion (DRG). ASIC3 is ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11460
更新日期:2016-05-10 00:00:00
abstract::In human cancers, oncogenic mutations commonly occur in the RAS genes KRAS, NRAS, or HRAS, but there are no clinical RAS inhibitors. Mutations are more prevalent in KRAS, possibly suggesting a unique oncogenic activity mediated by KRAS-specific interaction partners, which might be targeted. Here, we determine the spec...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05692-6
更新日期:2018-09-07 00:00:00
abstract::Detecting the metallic Dirac electronic states on the surface of Topological Insulators (TIs) is critical for the study of important surface quantum properties (SQPs), such as Majorana zero modes, where simultaneous probing of the bulk and edge electron states is required. However, there is a particular shortage of ex...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14838-4
更新日期:2020-03-09 00:00:00
abstract::Preparation and characterization of polariton Bose-Einstein condensates in micro-cavities of high quality are at the frontier of contemporary solid state physics. Here, we report on three-dimensional polariton condensation and confinement in pseudo-spherical ZnO microcrystals. The boundary of micro-spherical ZnO resem...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18666-4
更新日期:2020-09-30 00:00:00
abstract::Large Igneous Provinces (LIPs) are associated with the largest climate perturbations in Earth's history. The North Atlantic Igneous Province (NAIP) and Paleocene-Eocene Thermal Maximum (PETM) constitute an exemplar of this association. As yet we have no means to reconstruct the pacing of LIP greenhouse gas emissions f...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12957-1
更新日期:2019-12-05 00:00:00
abstract::Adult neural stem cells reside in a specialized niche in the subventricular zone (SVZ). Throughout life they give rise to adult-born neurons in the olfactory bulb (OB), thus contributing to neural plasticity and pattern discrimination. Here, we show that the neurovascular protein EGFL7 is secreted by endothelial cells...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15922
更新日期:2017-06-28 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 已发布勘误
doi:10.1038/s41467-019-13138-w
更新日期:2019-11-22 00:00:00
abstract::Understanding and predicting radiation damage evolution in complex materials is crucial for developing next-generation nuclear energy sources. Here, using a combination of ion beam irradiation, transmission electron microscopy and X-ray diffraction, we show that, contrary to the behaviour observed in pyrochlores, the ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9750
更新日期:2015-10-29 00:00:00
abstract::The cellular mechanisms driving cardiac tissue formation remain poorly understood, largely due to the structural and functional complexity of the heart. It is unclear whether newly generated myocytes originate from cardiac stem/progenitor cells or from pre-existing cardiomyocytes that re-enter the cell cycle. Here, we...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-02891-z
更新日期:2018-02-21 00:00:00
abstract::Considerable interest has been devoted to converting mechanical energy into electricity using polymer nanofibres. In particular, piezoelectric nanofibres produced by electrospinning have shown remarkable mechanical energy-to-electricity conversion ability. However, there is little data for the acoustic-to-electric con...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11108
更新日期:2016-03-23 00:00:00
abstract::Practice improves perception and enhances neural representations of trained visual stimuli, a phenomenon known as visual perceptual learning (VPL). While attention to task-relevant stimuli plays an important role in such learning, Pavlovian stimulus-reinforcer associations are sufficient to drive VPL, even subconsciou...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11527-9
更新日期:2019-08-09 00:00:00
abstract::The sensitivity of quantum magnetometer is challenged by control errors and, especially in the solid state, by their short coherence times. Refocusing techniques can overcome these limitations and improve the sensitivity to periodic fields, but they come at the cost of reduced bandwidth and cannot be applied to sense ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2375
更新日期:2013-01-01 00:00:00
abstract::Multipotent mesenchymal stromal cells (MSCs) are required for skeletal formation, maintenance, and repair throughout life; however, current models posit that postnatally arising long-lived adult MSCs replace transient embryonic progenitor populations. We previously reported exclusive expression and function of the emb...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11100-4
更新日期:2019-07-18 00:00:00
abstract::Circuit reactivations involve a stereotyped sequence of neuronal firing and have been behaviourally linked to memory consolidation. Here we use multiphoton imaging and patch-clamp recording, and observe sparse and stereotyped circuit reactivations that correspond to UP states within active neurons. To evaluate the eff...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3574
更新日期:2013-01-01 00:00:00
abstract::The presence and absence of RNA modifications regulates RNA metabolism by modulating the binding of writer, reader, and eraser proteins. For 5-methylcytosine (m5C) however, it is largely unknown how it recruits or repels RNA-binding proteins. Here, we decipher the consequences of m5C deposition into the abundant non-c...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10020-7
更新日期:2019-06-11 00:00:00
abstract::Foxg constitutes a regulatory loop with Fgf8 and plays an important role in the development of anterior placodes and the telencephalon in vertebrate embryos. Ascidians, which belong to Tunicata, the sister group of vertebrates, develop a primitive placode-like structure at the anterior boundary of the neural plate, bu...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12839-6
更新日期:2019-10-29 00:00:00
abstract::Exosomes are nanometer-sized lipid vesicles present in liquid biopsies and used as biomarkers for several diseases including cancer, Alzheimer's, and central nervous system diseases. Purification and subsequent size and surface characterization are essential to exosome-based diagnostics. Sample purification is, howeve...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15889-3
更新日期:2020-05-11 00:00:00
abstract::Monolayer chalcogenide semiconductors with both luminescent and ferromagnetic properties are dreamed for simultaneous polarization and detection of the valley degree of freedom in valleytronics. However, a conventional chalcogenide monolayer lacks these coexisting properties due to their mutually exclusive origins. He...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09531-0
更新日期:2019-04-05 00:00:00
abstract::Semiconductor nanowires offer the opportunity to incorporate novel structures and functionality into electronic and optoelectronic devices. A clear understanding of the nanowire growth mechanism is essential for well-controlled growth of structures with desired properties, but the understanding is currently limited by...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12437-6
更新日期:2019-10-08 00:00:00
abstract::Manipulating symmetry environments of metal ions to control functional properties is a fundamental concept of chemistry. For example, lattice strain enables control of symmetry in solids through a change in the nuclear positions surrounding a metal centre. Light-matter interactions can also induce strain but providing...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18869-9
更新日期:2020-10-14 00:00:00
abstract::Human activity has caused dramatic population declines in many wild species. The resulting bottlenecks have a profound impact on the genetic makeup of a species with unknown consequences for health. A key genetic factor for species survival is the evolution of deleterious mutation load, but how bottleneck strength and...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14803-1
更新日期:2020-02-21 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 已发布勘误
doi:10.1038/s41467-019-12107-7
更新日期:2019-09-05 00:00:00
abstract::Glacier retreat is a worldwide phenomenon with important consequences for the hydrological cycle and downstream ecosystem structure and functioning. To determine the effects of glacier retreat on aquatic communities, we conducted a 4-year flow manipulation in a tropical glacier-fed stream. Compared with an adjacent re...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12025
更新日期:2016-06-24 00:00:00
abstract::Momentum and spin represent fundamental dynamic properties of quantum particles and fields. In particular, propagating optical waves (photons) carry momentum and longitudinal spin determined by the wave vector and circular polarization, respectively. Here we show that exactly the opposite can be the case for evanescen...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4300
更新日期:2014-03-06 00:00:00
abstract::Sedimentary rocks are the archives of environmental conditions and ancient planetary surface processes that led to their formation. Reconstructions of Earth's past surface behaviour from the physical sedimentary record remain controversial, however, in part because we lack a quantitative framework to deconvolve intern...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4298
更新日期:2014-02-28 00:00:00
abstract::Although research on human-mediated exchanges of species has substantially intensified during the last centuries, we know surprisingly little about temporal dynamics of alien species accumulations across regions and taxa. Using a novel database of 45,813 first records of 16,926 established alien species, we show that ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14435
更新日期:2017-02-15 00:00:00