Abstract:
:Identifying a bona fide population of cardiac stem cells (CSCs) is a critical step for developing cell-based therapies for heart failure patients. Previously, cardiac c-kit(+) cells were reported to be CSCs with a potential to become myocardial, endothelial and smooth muscle cells in vitro and after cardiac injury. Here we provide further insights into the nature of cardiac c-kit(+) cells. By targeting the c-kit locus with multiple reporter genes in mice, we find that c-kit expression rarely co-localizes with the expression of the cardiac progenitor and myogenic marker Nkx2.5, or that of the myocardial marker, cardiac troponin T (cTnT). Instead, c-kit predominantly labels a cardiac endothelial cell population in developing and adult hearts. After acute cardiac injury, c-kit(+) cells retain their endothelial identity and do not become myogenic progenitors or cardiomyocytes. Thus, our work strongly suggests that c-kit(+) cells in the murine heart are endothelial cells and not CSCs.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Sultana N,Zhang L,Yan J,Chen J,Cai W,Razzaque S,Jeong D,Sheng W,Bu L,Xu M,Huang GY,Hajjar RJ,Zhou B,Moon A,Cai CLdoi
10.1038/ncomms9701subject
Has Abstractpub_date
2015-10-30 00:00:00pages
8701issn
2041-1723pii
ncomms9701journal_volume
6pub_type
杂志文章abstract::Heterostructures formed by stacking layered materials require atomically clean interfaces. However, contaminants are usually trapped between the layers, aggregating into randomly located blisters, incompatible with scalable fabrication processes. Here we report a process to remove blisters from fully formed heterostru...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07558-3
更新日期:2018-12-19 00:00:00
abstract::Human land use may detrimentally affect biodiversity, yet long-term stability of species communities is vital for maintaining ecosystem functioning. Community stability can be achieved by higher species diversity (portfolio effect), higher asynchrony across species (insurance hypothesis) and higher abundance of popula...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10697
更新日期:2016-02-12 00:00:00
abstract::The insulator-metal transition (IMT) of vanadium dioxide (VO2) has remained a long-standing challenge in correlated electron physics since its discovery five decades ago. Most interpretations of experimental observations have implicitly assumed a homogeneous material response. Here we reveal inhomogeneous behaviour of...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7849
更新日期:2015-04-21 00:00:00
abstract::The original version of this Article contained errors in the units of concentration of three reagents listed in the Methods. These errors have all been corrected in both the PDF and HTML versions of the Article. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-017-02128-5
更新日期:2017-12-12 00:00:00
abstract::Understanding the biomolecular interactions between graphene and human immune cells is a prerequisite for its utilization as a diagnostic or therapeutic tool. To characterize the complex interactions between graphene and immune cells, we propose an integrative analytical pipeline encompassing the evaluation of molecul...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01015-3
更新日期:2017-10-24 00:00:00
abstract::Properties of human brain tissue change across the lifespan. Here we model these changes in the living human brain by combining quantitative magnetic resonance imaging (MRI) measurements of R1 (1/T1) with diffusion MRI and tractography (N=102, ages 7-85). The amount of R1 change during development differs between whit...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5932
更新日期:2014-09-17 00:00:00
abstract::For the state-of-the-art quantum dot light-emitting diodes, while the ZnO nanoparticle layers can provide effective electron injections into quantum dots layers, the hole transporting materials usually cannot guarantee sufficient hole injection owing to the deep valence band of quantum dots. Developing proper hole tra...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04986-z
更新日期:2018-07-04 00:00:00
abstract::Bloch electrons lacking inversion symmetry exhibit orbital magnetic moments owing to the rotation around their center of mass; this moment induces a valley splitting in a magnetic field. For the graphene/h-BN moiré superlattice, inversion symmetry is broken by the h-BN. The superlattice potential generates a series of...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19043-x
更新日期:2020-10-23 00:00:00
abstract::This corrects the article DOI: 10.1038/ncomms14454. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/ncomms16007
更新日期:2017-06-23 00:00:00
abstract::Thin films comprising semiconductor nanocrystals are emerging for applications in electronic and optoelectronic devices including light emitting diodes and solar cells. Achieving high charge carrier mobility in these films requires the identification and elimination of electronic traps on the nanocrystal surfaces. Her...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6822
更新日期:2014-12-19 00:00:00
abstract::Although the amyloid β-protein (Aβ) is believed to play an initiating role in Alzheimer's disease (AD), the molecular characteristics of the key pathogenic Aβ forms are not well understood. As a result, it has proved difficult to identify optimal agents that target disease-relevant forms of Aβ. Here, we combined the u...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05068-w
更新日期:2018-07-11 00:00:00
abstract::Bulk photovoltaic effect (BPVE), featuring polarization-dependent uniform photoresponse at zero external bias, holds potential for exceeding the Shockley-Queisser limit in the efficiency of existing opto-electronic devices. However, the implementation of BPVE has been limited to the naturally existing materials with b...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20115-1
更新日期:2020-12-17 00:00:00
abstract::Tpt1 is an essential agent of fungal tRNA splicing that removes the 2'-PO4 at the splice junction generated by fungal tRNA ligase. Tpt1 catalyzes a unique two-step reaction whereby the 2'-PO4 attacks NAD+ to form an RNA-2'-phospho-ADP-ribosyl intermediate that undergoes transesterification to yield 2'-OH RNA and ADP-r...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-08211-9
更新日期:2019-01-15 00:00:00
abstract::Separation of C2H4 from C2H4/C2H2/C2H6 mixture with high working capacity is still a challenging task. Herein, we deliberately design a Th-metal-organic framework (MOF) for highly efficient separation of C2H4 from a binary C2H6/C2H4 and ternary C2H4/C2H2/C2H6 mixture. The synthesized MOF Azole-Th-1 shows a UiO-66-type...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16960-9
更新日期:2020-06-22 00:00:00
abstract::Cancer is caused by the accumulation of multiple genetic mutations, but their cooperative effects are poorly understood. Using a genome-wide analysis of all the somatic mutations in colorectal cancer patients in a large-scale molecular interaction network, here we find that a giant cluster of mutation-propagating modu...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01171-6
更新日期:2017-11-02 00:00:00
abstract::In nature, protein subunits on the capsids of many icosahedral viruses form rotational patterns, and mathematicians also incorporate asymmetric patterns into faces of polyhedra. Chemists have constructed molecular polyhedra with vacant or highly symmetric faces, but very little is known about constructing polyhedra wi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12469
更新日期:2016-08-24 00:00:00
abstract::Organic light-emitting diodes utilizing thermally activated delayed fluorescence is a potential solution for achieving stable blue devices. Sky-blue devices (CIEy < 0.4) with high stability and high external quantum efficiency (>15%) at 1000 cd m-2 based on either delayed fluorescence or phosphorescence are still limi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07482-6
更新日期:2018-11-28 00:00:00
abstract::Van der Waals materials and their heterostructures offer a versatile platform for studying a variety of quantum transport phenomena due to their unique crystalline properties and the exceptional ability in tuning their electronic spectrum. However, most experiments are limited to devices that have lateral dimensions o...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11379-3
更新日期:2019-07-26 00:00:00
abstract::Insulin-like growth factors (IGFs) induce proliferation of various cell types and play important roles in somatic growth and cancer development. Phosphorylation of insulin receptor substrate (IRS)-1/2 by IGF-I receptor tyrosine kinase is essential for IGF action. Here we identify Nedd4 as an IRS-2 ubiquitin ligase. Ne...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7780
更新日期:2015-04-16 00:00:00
abstract::Quantum Hall edge channels offer an efficient and controllable platform to study quantum transport in one dimension. Such channels are a prospective tool for the efficient transfer of quantum information at the nanoscale, and play a vital role in exposing intriguing physics. Electric current along the edge carries ene...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11888-1
更新日期:2019-09-02 00:00:00
abstract::Conventional lithium-ion batteries embrace graphite anodes which operate at potential as low as metallic lithium, subjected to poor rate capability and safety issues. Among possible alternatives, oxides based on titanium redox couple, such as spinel Li4Ti5O12, have received renewed attention. Here we further expand th...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17233-1
更新日期:2020-07-13 00:00:00
abstract::Magnetic reconnection is a fundamental process in magnetized plasma where magnetic energy is converted to plasma energy. Despite huge differences in the physical size of the reconnection layer, remarkably similar characteristics are observed in both laboratory and magnetosphere plasmas. Here we present the comparative...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07680-2
更新日期:2018-12-06 00:00:00
abstract::The causes of impaired skeletal muscle mass and strength during aging are well-studied in healthy populations. Less is known on pathological age-related muscle wasting and weakness termed sarcopenia, which directly impacts physical autonomy and survival. Here, we compare genome-wide transcriptional changes of sarcopen...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13694-1
更新日期:2019-12-20 00:00:00
abstract::Ganglioside GM3, a host-derived glycosphingolipid incorporated in the membrane of human immunodeficiency virus-1 (HIV-1) viral particles, mediates interactions between HIV-1 and Siglec1/CD169, a protein expressed on dendritic cells (DCs). Such interactions, which seem to be independent of viral envelope glycoprotein g...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5136
更新日期:2014-06-20 00:00:00
abstract::Prostate development depends on balanced cell proliferation and differentiation, and acetylated KLF5 is known to alter epithelial proliferation. It remains elusive whether post-translational modifications of transcription factors can differentially determine adult stem/progenitor cell fate. Here we report that, in hum...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14737-8
更新日期:2020-02-21 00:00:00
abstract::Vertebrates exhibit specific requirements for replicative H3 and non-replicative H3.3 variants during development. To disentangle whether this involves distinct modes of deposition or unique functions once incorporated into chromatin, we combined studies in Xenopus early development with chromatin assays. Here we inve...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15084-4
更新日期:2020-03-09 00:00:00
abstract::Three-dimensional graphene network is a promising structure for improving both the mechanical properties and functional capabilities of reinforced polymer and ceramic matrix composites. However, direct application in a metal matrix remains difficult due to the reason that wetting is usually unfavorable in the carbon/m...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16490-4
更新日期:2020-06-02 00:00:00
abstract::Ubiquitylation of histone H2B at lysine residue 120 (H2BK120ub) is a prominent histone posttranslational modification (PTM) associated with the actively transcribed genome. Although H2BK120ub triggers several critical downstream histone modification pathways and changes in chromatin structure, less is known about the ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03895-5
更新日期:2018-04-11 00:00:00
abstract::One-fourth of Plasmodium falciparum proteins have asparagine repeats that increase the propensity for aggregation, especially at elevated temperatures that occur routinely in malaria-infected patients. Here we report that a Plasmodium Asn repeat-containing protein (PFI1155w) formed aggregates in mammalian cells at feb...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2306
更新日期:2012-01-01 00:00:00
abstract::Despite significant advances in the fabrication and applications of graphene-like materials, it remains a challenge to prepare single-layered metallic materials, which have great potential applications in physics, chemistry and material science. Here we report the fabrication of poly(vinylpyrrolidone)-supported single...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4093
更新日期:2014-01-01 00:00:00