Scalable and efficient separation of hydrogen isotopes using graphene-based electrochemical pumping.


:Thousands of tons of isotopic mixtures are processed annually for heavy-water production and tritium decontamination. The existing technologies remain extremely energy intensive and require large capital investments. New approaches are needed to reduce the industry's footprint. Recently, micrometre-size crystals of graphene are shown to act as efficient sieves for hydrogen isotopes pumped through graphene electrochemically. Here we report a fully-scalable approach, using graphene obtained by chemical vapour deposition, which allows a proton-deuteron separation factor of around 8, despite cracks and imperfections. The energy consumption is projected to be orders of magnitude smaller with respect to existing technologies. A membrane based on 30 m2 of graphene, a readily accessible amount, could provide a heavy-water output comparable to that of modern plants. Even higher efficiency is expected for tritium separation. With no fundamental obstacles for scaling up, the technology's simplicity, efficiency and green credentials call for consideration by the nuclear and related industries.


Nat Commun


Nature communications


Lozada-Hidalgo M,Zhang S,Hu S,Esfandiar A,Grigorieva IV,Geim AK




Has Abstract


2017-05-09 00:00:00










  • Fishing for newly synthesized proteins with phosphonate-handles.

    abstract::Bioorthogonal chemistry introduces affinity-labels into biomolecules with minimal disruption to the original system and is widely applicable in a range of contexts. In proteomics, immobilized metal affinity chromatography (IMAC) enables enrichment of phosphopeptides with extreme sensitivity and selectivity. Here, we a...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Kleinpenning F,Steigenberger B,Wu W,Heck AJR

    更新日期:2020-06-26 00:00:00

  • PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity.

    abstract::Allergic asthma is a leading chronic disease associated with airway hyperreactivity (AHR). Type-2 innate lymphoid cells (ILC2s) are a potent source of T-helper 2 (Th2) cytokines that promote AHR and lung inflammation. As the programmed cell death protein-1 (PD-1) inhibitory axis regulates a variety of immune responses...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Helou DG,Shafiei-Jahani P,Lo R,Howard E,Hurrell BP,Galle-Treger L,Painter JD,Lewis G,Soroosh P,Sharpe AH,Akbari O

    更新日期:2020-08-10 00:00:00

  • Partially coherent radar unties range resolution from bandwidth limitations.

    abstract::It is widely believed that range resolution, the ability to distinguish between two closely situated targets, depends inversely on the bandwidth of the transmitted radar signal. Here we demonstrate a different type of ranging system, which possesses superior range resolution that is almost completely free of bandwidth...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Komissarov R,Kozlov V,Filonov D,Ginzburg P

    更新日期:2019-03-29 00:00:00

  • Synthesis of molecular metallic barium superhydride: pseudocubic BaH12.

    abstract::Following the discovery of high-temperature superconductivity in the La-H system, we studied the formation of new chemical compounds in the barium-hydrogen system at pressures from 75 to 173 GPa. Using in situ generation of hydrogen from NH3BH3, we synthesized previously unknown superhydride BaH12 with a pseudocubic (...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Chen W,Semenok DV,Kvashnin AG,Huang X,Kruglov IA,Galasso M,Song H,Duan D,Goncharov AF,Prakapenka VB,Oganov AR,Cui T

    更新日期:2021-01-11 00:00:00

  • Functional dissociation in sweet taste receptor neurons between and within taste organs of Drosophila.

    abstract::Finding food sources is essential for survival. Insects detect nutrients with external taste receptor neurons. Drosophila possesses multiple taste organs that are distributed throughout its body. However, the role of different taste organs in feeding remains poorly understood. By blocking subsets of sweet taste recept...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Thoma V,Knapek S,Arai S,Hartl M,Kohsaka H,Sirigrivatanawong P,Abe A,Hashimoto K,Tanimoto H

    更新日期:2016-02-19 00:00:00

  • Protein kinase C-alpha suppresses autophagy and induces neural tube defects via miR-129-2 in diabetic pregnancy.

    abstract::Gene deletion-induced autophagy deficiency leads to neural tube defects (NTDs), similar to those in diabetic pregnancy. Here we report the key autophagy regulators modulated by diabetes in the murine developing neuroepithelium. Diabetes predominantly leads to exencephaly, induces neuroepithelial cell apoptosis and sup...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Wang F,Xu C,Reece EA,Li X,Wu Y,Harman C,Yu J,Dong D,Wang C,Yang P,Zhong J,Yang P

    更新日期:2017-05-05 00:00:00

  • High-performance p-channel transistors with transparent Zn doped-CuI.

    abstract::'Ideal' transparent p-type semiconductors are required for the integration of high-performance thin-film transistors (TFTs) and circuits. Although CuI has recently attracted attention owing to its excellent opto-electrical properties, solution processability, and low-temperature synthesis, the uncontrolled copper vaca...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Liu A,Zhu H,Park WT,Kim SJ,Kim H,Kim MG,Noh YY

    更新日期:2020-08-27 00:00:00

  • Break-induced replication promotes formation of lethal joint molecules dissolved by Srs2.

    abstract::Break-induced replication (BIR) is a DNA double-strand break repair pathway that leads to genomic instabilities similar to those observed in cancer. BIR proceeds by a migrating bubble where asynchrony between leading and lagging strand synthesis leads to accumulation of long single-stranded DNA (ssDNA). It remains unk...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Elango R,Sheng Z,Jackson J,DeCata J,Ibrahim Y,Pham NT,Liang DH,Sakofsky CJ,Vindigni A,Lobachev KS,Ira G,Malkova A

    更新日期:2017-11-27 00:00:00

  • A novel method to test non-exclusive hypotheses applied to Arctic ice projections from dependent models.

    abstract::A major conundrum in climate science is how to account for dependence between climate models. This complicates interpretation of probabilistic projections derived from such models. Here we show that this problem can be addressed using a novel method to test multiple non-exclusive hypotheses, and to make predictions un...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Olson R,An SI,Fan Y,Chang W,Evans JP,Lee JY

    更新日期:2019-07-09 00:00:00

  • Drawing a high-resolution functional map of adeno-associated virus capsid by massively parallel sequencing.

    abstract::Adeno-associated virus (AAV) capsid engineering is an emerging approach to advance gene therapy. However, a systematic analysis on how each capsid amino acid contributes to multiple functions remains challenging. Here we show proof-of-principle and successful application of a novel approach, termed AAV Barcode-Seq, th...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Adachi K,Enoki T,Kawano Y,Veraz M,Nakai H

    更新日期:2014-01-01 00:00:00

  • Cytomembrane nanovaccines show therapeutic effects by mimicking tumor cells and antigen presenting cells.

    abstract::Most cancer vaccines are unsuccessful in eliciting clinically relevant effects. Without using exogenous antigens and adoptive cells, we show a concept of utilizing biologically reprogrammed cytomembranes of the fused cells (FCs) derived from dendritic cells (DCs) and cancer cells as tumor vaccines. The fusion of immun...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Liu WL,Zou MZ,Liu T,Zeng JY,Li X,Yu WY,Li CX,Ye JJ,Song W,Feng J,Zhang XZ

    更新日期:2019-07-19 00:00:00

  • Sub-microWatt threshold nanoisland lasers.

    abstract::Ultralow threshold nanolasers have been sought after as power efficient light sources in photonic integrated circuits. Here a single-cell nanobeam laser with a nanoisland quantum well is proposed and demonstrated. Continuous operation at 1.5 μm is achieved at room temperature with an ultralow lasing threshold of 210 n...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Jang H,Karnadi I,Pramudita P,Song JH,Kim KS,Lee YH

    更新日期:2015-09-22 00:00:00

  • Benchmarking monolayer MoS2 and WS2 field-effect transistors.

    abstract::Here we benchmark device-to-device variation in field-effect transistors (FETs) based on monolayer MoS2 and WS2 films grown using metal-organic chemical vapor deposition process. Our study involves 230 MoS2 FETs and 160 WS2 FETs with channel lengths ranging from 5 μm down to 100 nm. We use statistical measures to eval...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Sebastian A,Pendurthi R,Choudhury TH,Redwing JM,Das S

    更新日期:2021-01-29 00:00:00

  • Selective photocatalytic conversion of methane into carbon monoxide over zinc-heteropolyacid-titania nanocomposites.

    abstract::Chemical utilization of vast fossil and renewable feedstocks of methane remains one of the most important challenges of modern chemistry. Herein, we report direct and selective methane photocatalytic oxidation at ambient conditions into carbon monoxide, which is an important chemical intermediate and a platform molecu...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Yu X,De Waele V,Löfberg A,Ordomsky V,Khodakov AY

    更新日期:2019-02-11 00:00:00

  • Publisher Correction: MethCORR modelling of methylomes from formalin-fixed paraffin-embedded tissue enables characterization and prognostication of colorectal cancer.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Nature communications

    pub_type: 杂志文章,已发布勘误


    authors: Mattesen TB,Rasmussen MH,Sandoval J,Ongen H,Árnadóttir SS,Gladov J,Martinez-Cardus A,de Moura MC,Madsen AH,Laurberg S,Dermitzakis ET,Esteller M,Andersen CL,Bramsen JB

    更新日期:2020-06-03 00:00:00

  • Determining the location and nearest neighbours of aluminium in zeolites with atom probe tomography.

    abstract::Zeolite catalysis is determined by a combination of pore architecture and Brønsted acidity. As Brønsted acid sites are formed by the substitution of AlO4 for SiO4 tetrahedra, it is of utmost importance to have information on the number as well as the location and neighbouring sites of framework aluminium. Unfortunatel...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Perea DE,Arslan I,Liu J,Ristanović Z,Kovarik L,Arey BW,Lercher JA,Bare SR,Weckhuysen BM

    更新日期:2015-07-02 00:00:00

  • Characterizing rare and low-frequency height-associated variants in the Japanese population.

    abstract::Human height is a representative phenotype to elucidate genetic architecture. However, the majority of large studies have been performed in European population. To investigate the rare and low-frequency variants associated with height, we construct a reference panel (N = 3,541) for genotype imputation by integrating t...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Akiyama M,Ishigaki K,Sakaue S,Momozawa Y,Horikoshi M,Hirata M,Matsuda K,Ikegawa S,Takahashi A,Kanai M,Suzuki S,Matsui D,Naito M,Yamaji T,Iwasaki M,Sawada N,Tanno K,Sasaki M,Hozawa A,Minegishi N,Wakai K,Tsugane S

    更新日期:2019-09-27 00:00:00

  • MUC1-C regulates lineage plasticity driving progression to neuroendocrine prostate cancer.

    abstract::Neuroendocrine prostate cancer (NEPC) is an aggressive malignancy with no effective targeted therapies. The oncogenic MUC1-C protein is overexpressed in castration-resistant prostate cancer (CRPC) and NEPC, but its specific role is unknown. Here, we demonstrate that upregulation of MUC1-C in androgen-dependent PC cell...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Yasumizu Y,Rajabi H,Jin C,Hata T,Pitroda S,Long MD,Hagiwara M,Li W,Hu Q,Liu S,Yamashita N,Fushimi A,Kui L,Samur M,Yamamoto M,Zhang Y,Zhang N,Hong D,Maeda T,Kosaka T,Wong KK,Oya M,Kufe D

    更新日期:2020-01-17 00:00:00

  • SMPDL3b modulates insulin receptor signaling in diabetic kidney disease.

    abstract::Sphingomyelin phosphodiesterase acid-like 3b (SMPDL3b) is a lipid raft enzyme that regulates plasma membrane (PM) fluidity. Here we report that SMPDL3b excess, as observed in podocytes in diabetic kidney disease (DKD), impairs insulin receptor isoform B-dependent pro-survival insulin signaling by interfering with insu...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Mitrofanova A,Mallela SK,Ducasa GM,Yoo TH,Rosenfeld-Gur E,Zelnik ID,Molina J,Varona Santos J,Ge M,Sloan A,Kim JJ,Pedigo C,Bryn J,Volosenco I,Faul C,Zeidan YH,Garcia Hernandez C,Mendez AJ,Leibiger I,Burke GW,Futerm

    更新日期:2019-06-19 00:00:00

  • Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors.

    abstract::The liver parenchyma is composed of hepatocytes and bile duct epithelial cells (BECs). Controversy exists regarding the cellular origin of human liver parenchymal tissue generation during embryonic development, homeostasis or repair. Here we report the existence of a hepatobiliary hybrid progenitor (HHyP) population i...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Segal JM,Kent D,Wesche DJ,Ng SS,Serra M,Oulès B,Kar G,Emerton G,Blackford SJI,Darmanis S,Miquel R,Luong TV,Yamamoto R,Bonham A,Jassem W,Heaton N,Vigilante A,King A,Sancho R,Teichmann S,Quake SR,Nakauchi H,Rash

    更新日期:2019-07-26 00:00:00

  • Andreev molecules in semiconductor nanowire double quantum dots.

    abstract::Chains of quantum dots coupled to superconductors are promising for the realization of the Kitaev model of a topological superconductor. While individual superconducting quantum dots have been explored, control of longer chains requires understanding of interdot coupling. Here, double quantum dots are defined by gate ...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Su Z,Tacla AB,Hocevar M,Car D,Plissard SR,Bakkers EPAM,Daley AJ,Pekker D,Frolov SM

    更新日期:2017-09-19 00:00:00

  • Magnon dark modes and gradient memory.

    abstract::Extensive efforts have been expended in developing hybrid quantum systems to overcome the short coherence time of superconducting circuits by introducing the naturally long-lived spin degree of freedom. Among all the possible materials, single-crystal yttrium iron garnet has shown up recently as a promising candidate ...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Zhang X,Zou CL,Zhu N,Marquardt F,Jiang L,Tang HX

    更新日期:2015-11-16 00:00:00

  • Targeting VEGF-A in myeloid cells enhances natural killer cell responses to chemotherapy and ameliorates cachexia.

    abstract::Chemotherapy remains a mainstay of cancer treatment but its use is often limited by the development of adverse reactions. Severe loss of body weight (cachexia) is a frequent cause of death in cancer patients and is exacerbated by chemotherapy. We show that genetic inactivation of vascular endothelial growth factor (VE...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Klose R,Krzywinska E,Castells M,Gotthardt D,Putz EM,Kantari-Mimoun C,Chikdene N,Meinecke AK,Schrödter K,Helfrich I,Fandrey J,Sexl V,Stockmann C

    更新日期:2016-08-19 00:00:00

  • Spin-orbit interaction of light induced by transverse spin angular momentum engineering.

    abstract::The investigations on optical angular momenta and their interactions have broadened our knowledge of light's behavior at sub-wavelength scales. Recent studies further unveil the extraordinary characteristics of transverse spin angular momentum in confined light fields and orbital angular momentum in optical vortices. ...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Shao Z,Zhu J,Chen Y,Zhang Y,Yu S

    更新日期:2018-03-02 00:00:00

  • Femtosecond electron imaging of defect-modulated phonon dynamics.

    abstract::Precise manipulation and control of coherent lattice oscillations via nanostructuring and phonon-wave interference has the potential to significantly impact a broad array of technologies and research areas. Resolving the dynamics of individual phonons in defect-laden materials presents an enormous challenge, however, ...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Cremons DR,Plemmons DA,Flannigan DJ

    更新日期:2016-04-15 00:00:00

  • High rate and stable cycling of lithium metal anode.

    abstract::Lithium metal is an ideal battery anode. However, dendrite growth and limited Coulombic efficiency during cycling have prevented its practical application in rechargeable batteries. Herein, we report that the use of highly concentrated electrolytes composed of ether solvents and the lithium bis(fluorosulfonyl)imide sa...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Qian J,Henderson WA,Xu W,Bhattacharya P,Engelhard M,Borodin O,Zhang JG

    更新日期:2015-02-20 00:00:00

  • Rhythmic glucose metabolism regulates the redox circadian clockwork in human red blood cells.

    abstract::Circadian clocks coordinate mammalian behavior and physiology enabling organisms to anticipate 24-hour cycles. Transcription-translation feedback loops are thought to drive these clocks in most of mammalian cells. However, red blood cells (RBCs), which do not contain a nucleus, and cannot perform transcription or tran...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Ch R,Rey G,Ray S,Jha PK,Driscoll PC,Dos Santos MS,Malik DM,Lach R,Weljie AM,MacRae JI,Valekunja UK,Reddy AB

    更新日期:2021-01-15 00:00:00

  • Casimir forces on a silicon micromechanical chip.

    abstract::Quantum fluctuations give rise to van der Waals and Casimir forces that dominate the interaction between electrically neutral objects at sub-micron separations. Under the trend of miniaturization, such quantum electrodynamical effects are expected to play an important role in micro- and nano-mechanical devices. Nevert...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Zou J,Marcet Z,Rodriguez AW,Reid MT,McCauley AP,Kravchenko II,Lu T,Bao Y,Johnson SG,Chan HB

    更新日期:2013-01-01 00:00:00

  • Origin and structure of polar domains in doped molecular crystals.

    abstract::Doping is a primary tool for the modification of the properties of materials. Occlusion of guest molecules in crystals generally reduces their symmetry by the creation of polar domains, which engender polarization and pyroelectricity in the doped crystals. Here we describe a molecular-level determination of the struct...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Meirzadeh E,Azuri I,Qi Y,Ehre D,Rappe AM,Lahav M,Kronik L,Lubomirsky I

    更新日期:2016-11-08 00:00:00

  • Automated quantification of bioluminescence images.

    abstract::We developed a computer-aided analysis tool for quantitatively determining bioluminescent reporter distributions inside small animals. The core innovations are a body-fitting animal shuttle and a statistical mouse atlas, both of which are spatially aligned and scaled according to the animal's weight, and hence provide...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Klose AD,Paragas N

    更新日期:2018-10-15 00:00:00