Spin-orbit torque-assisted switching in magnetic insulator thin films with perpendicular magnetic anisotropy.

abstract：:CEP63 is a centrosomal protein that facilitates centriole duplication and is regulated by the DNA damage response. Mutations in CEP63 cause Seckel syndrome, a human disease characterized by microcephaly and dwarfism. Here we demonstrate that Cep63-deficient mice recapitulate Seckel syndrome pathology. The attrition of...

journal_title：Nature communications

authors： Marjanović M,Sánchez-Huertas C,Terré B,Gómez R,Scheel JF,Pacheco S,Knobel PA,Martínez-Marchal A,Aivio S,Palenzuela L,Wolfrum U,McKinnon PJ,Suja JA,Roig I,Costanzo V,Lüders J,Stracker TH

更新日期：2015-07-09 00:00:00

abstract：:Ferroelectrics based on proton tautomerism are promising in low-field and above-room-temperature operations. Here seven organic ferroelectric crystals are examined to search for efficient switching of strong spontaneous polarization on proton tautomerism. Solution-grown crystals exhibit strong pinning of ferroelectric...

journal_title：Nature communications

authors： Horiuchi S,Kobayashi K,Kumai R,Ishibashi S

更新日期：2017-02-16 00:00:00

abstract：:The Clp protease complex degrades a multitude of substrates, which are engaged by a AAA+ chaperone such as ClpX and subsequently digested by the dynamic, barrel-shaped ClpP protease. Acyldepsipeptides (ADEPs) are natural product-derived antibiotics that activate ClpP for chaperone-independent protein digestion. Here w...

journal_title：Nature communications

authors： Gersch M,Famulla K,Dahmen M,Göbl C,Malik I,Richter K,Korotkov VS,Sass P,Rübsamen-Schaeff H,Madl T,Brötz-Oesterhelt H,Sieber SA

更新日期：2015-02-19 00:00:00

abstract：:Kidney organogenesis requires the tight control of proliferation, differentiation and apoptosis of renal progenitor cells. How the balance between these cellular decisions is achieved remains elusive. The Wilms' tumour suppressor Wt1 is required for progenitor survival, but the molecular cause for renal agenesis in mu...

journal_title：Nature communications

authors： Motamedi FJ,Badro DA,Clarkson M,Lecca MR,Bradford ST,Buske FA,Saar K,Hübner N,Brändli AW,Schedl A

更新日期：2014-07-17 00:00:00

abstract：:Recent studies suggest that gut microbiomes of urban-industrialized societies are different from those of traditional peoples. Here we examine the relationship between lifeways and gut microbiota through taxonomic and functional potential characterization of faecal samples from hunter-gatherer and traditional agricult...

journal_title：Nature communications

authors： Obregon-Tito AJ,Tito RY,Metcalf J,Sankaranarayanan K,Clemente JC,Ursell LK,Zech Xu Z,Van Treuren W,Knight R,Gaffney PM,Spicer P,Lawson P,Marin-Reyes L,Trujillo-Villarroel O,Foster M,Guija-Poma E,Troncoso-Corzo L,Warinne

更新日期：2015-03-25 00:00:00

abstract：:Mutations in the gene coding for membrane-bound fatty aldehyde dehydrogenase (FALDH) lead to toxic accumulation of lipid species and development of the Sjögren-Larsson Syndrome (SLS), a rare disorder characterized by skin defects and mental retardation. Here, we present the crystallographic structure of human FALDH, t...

journal_title：Nature communications

authors： Keller MA,Zander U,Fuchs JE,Kreutz C,Watschinger K,Mueller T,Golderer G,Liedl KR,Ralser M,Kräutler B,Werner ER,Marquez JA

更新日期：2014-07-22 00:00:00

abstract：:Circular RNAs (circRNAs) have recently gained substantial attention in the cancer research field where most, including the putative oncogene ciRS-7 (CDR1as), have been proposed to function as competitive endogenous RNAs (ceRNAs) by sponging specific microRNAs. Here, we report the first spatially resolved cellular expr...

journal_title：Nature communications

authors： Kristensen LS,Ebbesen KK,Sokol M,Jakobsen T,Korsgaard U,Eriksen AC,Hansen TB,Kjems J,Hager H

更新日期：2020-09-11 00:00:00

abstract：:Artemisinin and its derivatives (collectively referred to as ARTs) rapidly reduce the parasite burden in Plasmodium falciparum infections, and antimalarial control is highly dependent on ART combination therapies (ACTs). Decreased sensitivity to ARTs is emerging, making it critically important to understand the mechan...

journal_title：Nature communications

authors： Bridgford JL,Xie SC,Cobbold SA,Pasaje CFA,Herrmann S,Yang T,Gillett DL,Dick LR,Ralph SA,Dogovski C,Spillman NJ,Tilley L

更新日期：2018-09-18 00:00:00

abstract：:Structural DNA nanotechnology seeks to build synthetic molecular machinery from DNA. DNA nanomachines are artificially designed assemblies that switch between defined conformations in response to an external cue. Though it has proved possible to create DNA machines and rudimentary walkers, the function of such autonom...

journal_title：Nature communications

authors： Surana S,Bhat JM,Koushika SP,Krishnan Y

更新日期：2011-06-07 00:00:00

abstract：:The coupled translocation of transfer RNA and messenger RNA through the ribosome entails large-scale structural rearrangements, including step-wise movements of the tRNAs. Recent structural work has visualized intermediates of translocation induced by elongation factor G (EF-G) with tRNAs trapped in chimeric states wi...

journal_title：Nature communications

authors： Adio S,Senyushkina T,Peske F,Fischer N,Wintermeyer W,Rodnina MV

更新日期：2015-06-15 00:00:00

abstract：:It is unclear why atmospheric oxygen remained trapped at low levels for more than 1.5 billion years following the Paleoproterozoic Great Oxidation Event. Here, we use models for erosion, weathering and biogeochemical cycling to show that this can be explained by the tectonic recycling of previously accumulated sedimen...

journal_title：Nature communications

authors： Daines SJ,Mills BJ,Lenton TM

更新日期：2017-02-02 00:00:00

abstract：:Current mitigation efforts and existing future commitments are inadequate to accomplish the Paris Agreement temperature goals. In light of this, research and debate are intensifying on the possibilities of additionally employing proposed climate geoengineering technologies, either through atmospheric carbon dioxide re...

journal_title：Nature communications

authors： Lawrence MG,Schäfer S,Muri H,Scott V,Oschlies A,Vaughan NE,Boucher O,Schmidt H,Haywood J,Scheffran J

更新日期：2018-09-13 00:00:00

abstract：:The serotonin transporter (SERT), a member of the neurotransmitter:sodium symporter family, is responsible for termination of serotonergic signaling by re-uptake of serotonin (5-HT) into the presynaptic neuron. Its key role in synaptic transmission makes it a major drug target, e.g. for the treatment of depression, an...

journal_title：Nature communications

authors： Möller IR,Slivacka M,Nielsen AK,Rasmussen SGF,Gether U,Loland CJ,Rand KD

更新日期：2019-04-11 00:00:00

abstract：:Alcohol consumption is a consistent protective factor for the development of autoimmune diseases such as rheumatoid arthritis (RA). The underlying mechanism for this tolerance-inducing effect of alcohol, however, is unknown. Here we show that alcohol and its metabolite acetate alter the functional state of T follicula...

journal_title：Nature communications

authors： Azizov V,Dietel K,Steffen F,Dürholz K,Meidenbauer J,Lucas S,Frech M,Omata Y,Tajik N,Knipfer L,Kolenbrander A,Seubert S,Lapuente D,Sokolova MV,Hofmann J,Tenbusch M,Ramming A,Steffen U,Nimmerjahn F,Linker R,Wirtz S

更新日期：2020-04-24 00:00:00

abstract：:Loss of gut mucosal integrity and an aberrant gut microbiota are proposed mechanisms contributing to chronic inflammation and increased morbidity and mortality during antiretroviral-treated HIV disease. Sexual practice has recently been uncovered as a major source of microbiota variation, potentially confounding prior...

journal_title：Nature communications

authors： Vujkovic-Cvijin I,Sortino O,Verheij E,Sklar J,Wit FW,Kootstra NA,Sellers B,Brenchley JM,Ananworanich J,Loeff MSV,Belkaid Y,Reiss P,Sereti I

更新日期：2020-05-15 00:00:00

abstract：:Long-range chromosomal interactions bring distal regulatory elements and promoters together to regulate gene expression in biological processes. By performing promoter capture Hi-C (PCHi-C) on human embryonic stem cell-derived cardiomyocytes (hESC-CMs), we show that such promoter interactions are a key mechanism by wh...

journal_title：Nature communications

authors： Choy MK,Javierre BM,Williams SG,Baross SL,Liu Y,Wingett SW,Akbarov A,Wallace C,Freire-Pritchett P,Rugg-Gunn PJ,Spivakov M,Fraser P,Keavney BD

更新日期：2018-06-28 00:00:00

abstract：:Human type 1 insulin-like growth factor receptor is a homodimeric receptor tyrosine kinase that signals into pathways directing normal cellular growth, differentiation and proliferation, with aberrant signalling implicated in cancer. Insulin-like growth factor binding is understood to relax conformational restraints w...

journal_title：Nature communications

authors： Xu Y,Kong GK,Menting JG,Margetts MB,Delaine CA,Jenkin LM,Kiselyov VV,De Meyts P,Forbes BE,Lawrence MC

更新日期：2018-02-26 00:00:00

abstract：:Constitutive activation of Wnt/β-catenin inhibits oligodendrocyte myelination. Tcf7l2/Tcf4, a β-catenin transcriptional partner, is required for oligodendrocyte differentiation. How Tcf7l2 modifies β-catenin signalling and controls myelination remains elusive. Here we define a stage-specific Tcf7l2-regulated transcrip...

journal_title：Nature communications

authors： Zhao C,Deng Y,Liu L,Yu K,Zhang L,Wang H,He X,Wang J,Lu C,Wu LN,Weng Q,Mao M,Li J,van Es JH,Xin M,Parry L,Goldman SA,Clevers H,Lu QR

更新日期：2016-03-09 00:00:00

abstract：:The developing CA3 hippocampus is comprised by highly connected hub neurons that are particularly effective in achieving network synchronization. Functional hub neurons were shown to be exclusively GABAergic, suggesting that the contribution of glutamatergic neurons to physiological synchronization processes at early ...

journal_title：Nature communications

authors： Marissal T,Bonifazi P,Picardo MA,Nardou R,Petit LF,Baude A,Fishell GJ,Ben-Ari Y,Cossart R

更新日期：2012-01-01 00:00:00

abstract：:In the original version of this Article, an incorrect sample size was provided for the number of relict species (443 instead of 442) and the number of relict forests (423 instead of 422). These errors have been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Tang CQ,Matsui T,Ohashi H,Dong YF,Momohara A,Herrando-Moraira S,Qian S,Yang Y,Ohsawa M,Luu HT,Grote PJ,Krestov PV,LePage B,Werger M,Robertson K,Hobohm C,Wang CY,Peng MC,Chen X,Wang HC,Su WH,Zhou R,Li S,He LY

更新日期：2018-12-04 00:00:00

abstract：:Phosphorylation is a major post-translational mechanism of regulation that frequently targets disordered protein domains, but it remains unclear how phosphorylation modulates disordered states of proteins. Here we determine the kinetics and energetics of a disordered protein domain the kinase-inducible domain (KID) of...

journal_title：Nature communications

authors： Stanley N,Esteban-Martín S,De Fabritiis G

更新日期：2014-10-28 00:00:00

abstract：:Measuring the pace at which speciation and extinction occur is fundamental to understanding the origin and evolution of biodiversity. Both the fossil record and molecular phylogenies of living species can provide independent estimates of speciation and extinction rates, but often produce strikingly divergent results. ...

journal_title：Nature communications

authors： Silvestro D,Warnock RCM,Gavryushkina A,Stadler T

更新日期：2018-12-07 00:00:00

abstract：:Replication-Factor-C (RFC) and RFC-like complexes (RLCs) mediate chromatin engagement of the proliferating cell nuclear antigen (PCNA). It remains controversial how RFC and RLCs cooperate to regulate PCNA loading and unloading. Here, we show the distinct PCNA loading or unloading activity of each clamp loader. ATAD5-R...

journal_title：Nature communications

authors： Kang MS,Ryu E,Lee SW,Park J,Ha NY,Ra JS,Kim YJ,Kim J,Abdel-Rahman M,Park SH,Lee KY,Kim H,Kang S,Myung K

更新日期：2019-06-03 00:00:00

abstract：:Melanoma cells use different migratory strategies to exit the primary tumor mass and invade surrounding and subsequently distant tissues. We reported previously that ADAR1 expression is downregulated in metastatic melanoma, thereby facilitating proliferation. Here we show that ADAR1 silencing enhances melanoma cell in...

journal_title：Nature communications

authors： Nemlich Y,Baruch EN,Besser MJ,Shoshan E,Bar-Eli M,Anafi L,Barshack I,Schachter J,Ortenberg R,Markel G

更新日期：2018-05-31 00:00:00

abstract：:In retinitis pigmentosa, loss of cone photoreceptors leads to blindness, and preservation of cone function is a major therapeutic goal. However, cone loss is thought to occur as a secondary event resulting from degeneration of rod photoreceptors. Here we report a genome editing approach in which adeno-associated virus...

journal_title：Nature communications

authors： Yu W,Mookherjee S,Chaitankar V,Hiriyanna S,Kim JW,Brooks M,Ataeijannati Y,Sun X,Dong L,Li T,Swaroop A,Wu Z

更新日期：2017-03-14 00:00:00

abstract：:How do descending inputs from the brain control leg motor circuits to change how an animal walks? Conceptually, descending neurons are thought to function either as command-type neurons, in which a single type of descending neuron exerts a high-level control to elicit a coordinated change in motor output, or through a...

journal_title：Nature communications

authors： Feng K,Sen R,Minegishi R,Dübbert M,Bockemühl T,Büschges A,Dickson BJ

更新日期：2020-12-02 00:00:00

abstract：:To know the properties of a particle or a wave, one should measure how its energy changes with its momentum. The relation between them is called the dispersion relation, which encodes essential information of the kinetics. In a magnet, the wave motion of atomic spins serves as an elementary excitation, called a spin w...

journal_title：Nature communications

authors： Hashimoto Y,Daimon S,Iguchi R,Oikawa Y,Shen K,Sato K,Bossini D,Tabuchi Y,Satoh T,Hillebrands B,Bauer GEW,Johansen TH,Kirilyuk A,Rasing T,Saitoh E

更新日期：2017-06-12 00:00:00

abstract：:Metastasis-associated recurrence is the major cause of poor prognosis in hepatocellular carcinoma (HCC), however, the underlying mechanisms remain largely elusive. In this study, we report that expression of choroideremia-like (CHML) is increased in HCC, associated with poor survival, early recurrence and more satelli...

journal_title：Nature communications

authors： Chen TW,Yin FF,Yuan YM,Guan DX,Zhang E,Zhang FK,Jiang H,Ma N,Wang JJ,Ni QZ,Qiu L,Feng J,Zhang XL,Bao Y,Wang K,Cheng SQ,Wang XF,Wang X,Li JJ,Xie D

更新日期：2019-06-07 00:00:00

abstract：:Optimising the supported modes of atom or ion dispersal onto substrates, to synchronously integrate high reactivity and robust stability in catalytic conversion, is an important yet challenging area of research. Here, theoretical calculations first show that three-coordinated copper (Cu) sites have higher activity tha...

journal_title：Nature communications

authors： Huang C,Dong J,Sun W,Xue Z,Ma J,Zheng L,Liu C,Li X,Zhou K,Qiao X,Song Q,Ma W,Zhang L,Lin Z,Wang T

更新日期：2019-06-25 00:00:00

abstract：:Large igneous province subduction is a rare process on Earth. A modern example is the subduction of the oceanic Hikurangi Plateau beneath the southern Kermadec arc, offshore New Zealand. This segment of the arc has the largest total lava volume erupted and the highest volcano density of the entire Kermadec arc. Here w...

journal_title：Nature communications

authors： Timm C,Davy B,Haase K,Hoernle KA,Graham IJ,de Ronde CE,Woodhead J,Bassett D,Hauff F,Mortimer N,Seebeck HC,Wysoczanski RJ,Caratori-Tontini F,Gamble JA

更新日期：2014-09-17 00:00:00