Geologically-inspired strong bulk ceramics made with water at room temperature.

abstract：:Understanding lithospheric plate motions is of paramount importance to geodynamicists. Much effort is going into kinematic reconstructions featuring progressively finer temporal resolution. However, the challenge of precisely identifying ocean-floor magnetic lineations, and uncertainties in geomagnetic reversal timesc...

journal_title：Nature communications

authors： Iaffaldano G,Bodin T,Sambridge M

更新日期：2012-01-01 00:00:00

abstract：:WNTs are lipid-modified proteins that control multiple functions in development and disease via short- and long-range signaling. However, it is unclear how these hydrophobic molecules spread over long distances in the mammalian brain. Here we show that WNT5A is produced by the choroid plexus (ChP) of the developing hi...

journal_title：Nature communications

authors： Kaiser K,Gyllborg D,Procházka J,Salašová A,Kompaníková P,Molina FL,Laguna-Goya R,Radaszkiewicz T,Harnoš J,Procházková M,Potěšil D,Barker RA,Casado ÁG,Zdráhal Z,Sedláček R,Arenas E,Villaescusa JC,Bryja V

更新日期：2019-04-02 00:00:00

abstract：:Copper resistance is a key virulence trait of the uropathogen Proteus mirabilis. Here we show that P. mirabilis ScsC (PmScsC) contributes to this defence mechanism by enabling swarming in the presence of copper. We also demonstrate that PmScsC is a thioredoxin-like disulfide isomerase but, unlike other characterized p...

journal_title：Nature communications

authors： Furlong EJ,Lo AW,Kurth F,Premkumar L,Totsika M,Achard MES,Halili MA,Heras B,Whitten AE,Choudhury HG,Schembri MA,Martin JL

更新日期：2017-07-19 00:00:00

abstract：:Anthropogenic mercury (Hg(0)) emissions oxidize to gaseous Hg(II) compounds, before deposition to Earth surface ecosystems. Atmospheric reduction of Hg(II) competes with deposition, thereby modifying the magnitude and pattern of Hg deposition. Global Hg models have postulated that Hg(II) reduction in the atmosphere oc...

journal_title：Nature communications

authors： Saiz-Lopez A,Sitkiewicz SP,Roca-Sanjuán D,Oliva-Enrich JM,Dávalos JZ,Notario R,Jiskra M,Xu Y,Wang F,Thackray CP,Sunderland EM,Jacob DJ,Travnikov O,Cuevas CA,Acuña AU,Rivero D,Plane JMC,Kinnison DE,Sonke JE

更新日期：2018-11-15 00:00:00

abstract：:The functional role of adult neurogenesis in the hippocampus remains the subject of intense speculation. One recent hypothesis is that adult-born neurons contribute to the endocrine and behavioural outputs of the stress response. Here we show a genetic model system to ablate neurogenesis by inducibly deleting Tbr2 gen...

journal_title：Nature communications

authors： Tsai CY,Tsai CY,Arnold SJ,Huang GJ

更新日期：2015-09-29 00:00:00

abstract：:The Mott metal-insulator transition-a manifestation of Coulomb interactions among electrons-is known as a discontinuous transition. Recent theoretical studies, however, suggest that the transition is continuous if the Mott insulator carries a spin liquid with a spinon Fermi surface. Here, we demonstrate the case of a ...

journal_title：Nature communications

authors： Furukawa T,Kobashi K,Kurosaki Y,Miyagawa K,Kanoda K

更新日期：2018-01-22 00:00:00

abstract：:Azobenzene, a versatile and polymorphic molecule, has been extensively and successfully used for photoswitching applications. The debate over its photoisomerization mechanism leveraged on the computational scrutiny with ever-increasing levels of theory. However, the most resolved absorption spectrum for the transition...

journal_title：Nature communications

authors： Tan EM,Amirjalayer S,Smolarek S,Vdovin A,Zerbetto F,Buma WJ

更新日期：2015-01-06 00:00:00

abstract：:Macrophages serve multiple functions including immune regulation, morphogenesis, tissue homeostasis and healing reactions. The current paradigm holds that mammary gland macrophages first arise postnatally during the prepubertal period from the bone marrow-derived monocytes. Here we delineate the origins of tissue-resi...

journal_title：Nature communications

authors： Jäppinen N,Félix I,Lokka E,Tyystjärvi S,Pynttäri A,Lahtela T,Gerke H,Elima K,Rantakari P,Salmi M

更新日期：2019-01-17 00:00:00

abstract：:The most frequent genetic alterations across multiple human cancers are mutations in TP53 and the activation of the PI3K/AKT pathway, two events crucial for cancer progression. Mutations in TP53 lead to the inhibition of the tumour and metastasis suppressor TAp63, a p53 family member. By performing a mouse-human cross...

journal_title：Nature communications

authors： Napoli M,Li X,Ackerman HD,Deshpande AA,Barannikov I,Pisegna MA,Bedrosian I,Mitsch J,Quinlan P,Thompson A,Rajapakshe K,Coarfa C,Gunaratne PH,Marchion DC,Magliocco AM,Tsai KY,Flores ER

更新日期：2020-10-14 00:00:00

abstract：:Antarctic Bottom Water (AABW) is a critical component of the global climate system, occupying the abyssal layer of the World Ocean and driving the lower limb of the global meridional overturning circulation. Around East Antarctica, the dense shelf water (DSW) precursor to AABW is predominantly formed by enhanced sea i...

journal_title：Nature communications

authors： Kusahara K,Hasumi H,Williams GD

更新日期：2011-01-18 00:00:00

abstract：:Gut microbiota composition influences the clinical benefit of immune checkpoints in patients with advanced cancer but mechanisms underlying this relationship remain unclear. Molecular mechanism whereby gut microbiota influences immune responses is mainly assigned to gut microbial metabolites. Short-chain fatty acids (...

journal_title：Nature communications

authors： Coutzac C,Jouniaux JM,Paci A,Schmidt J,Mallardo D,Seck A,Asvatourian V,Cassard L,Saulnier P,Lacroix L,Woerther PL,Vozy A,Naigeon M,Nebot-Bral L,Desbois M,Simeone E,Mateus C,Boselli L,Grivel J,Soularue E,Lepage P,

更新日期：2020-05-01 00:00:00

abstract：:Haematopoietic stem cells (HSCs) are produced during embryogenesis from the floor of the dorsal aorta. The localization of HSCs is dependent on the presence of instructive signals on the ventral side of the vessel. The nature of the extrinsic molecular signals that control the aortic haematopoietic niche is currently ...

journal_title：Nature communications

authors： Pouget C,Peterkin T,Simões FC,Lee Y,Traver D,Patient R

更新日期：2014-11-27 00:00:00

abstract：:To colonise their host, pathogens must counter local environmental and immunological challenges. Here, we reveal that the fungal pathogen Candida albicans exploits diverse host-associated signals to promote immune evasion by masking of a major pathogen-associated molecular pattern (PAMP), β-glucan. Certain nutrients, ...

journal_title：Nature communications

authors： Pradhan A,Avelar GM,Bain JM,Childers D,Pelletier C,Larcombe DE,Shekhova E,Netea MG,Brown GD,Erwig L,Gow NAR,Brown AJP

更新日期：2019-11-22 00:00:00

abstract：:Granule cells are the dominant cell type of the olfactory bulb inhibiting mitral and tufted cells via dendrodendritic synapses; yet the factors regulating the strength of their inhibitory output, and, therefore, their impact on odour discrimination, remain unknown. Here we show that GABAAR β3-subunits are distributed ...

journal_title：Nature communications

authors： Nunes D,Kuner T

更新日期：2015-11-23 00:00:00

abstract：:Ruddlesden-Popper halide perovskites are 2D solution-processed quantum wells with a general formula A2A'n-1M n X3n+1, where optoelectronic properties can be tuned by varying the perovskite layer thickness (n-value), and have recently emerged as efficient semiconductors with technologically relevant stability. However,...

journal_title：Nature communications

authors： Blancon JC,Stier AV,Tsai H,Nie W,Stoumpos CC,Traoré B,Pedesseau L,Kepenekian M,Katsutani F,Noe GT,Kono J,Tretiak S,Crooker SA,Katan C,Kanatzidis MG,Crochet JJ,Even J,Mohite AD

更新日期：2018-06-08 00:00:00

abstract：:Chronic inflammation has been proposed as having a prominent role in the construction of social inequalities in health. Disentangling the effects of early life and adulthood social disadvantage on inflammation is key in elucidating biological mechanisms underlying socioeconomic disparities. Here we explore the relatio...

journal_title：Nature communications

authors： Berger E,Castagné R,Chadeau-Hyam M,Bochud M,d'Errico A,Gandini M,Karimi M,Kivimäki M,Krogh V,Marmot M,Panico S,Preisig M,Ricceri F,Sacerdote C,Steptoe A,Stringhini S,Tumino R,Vineis P,Delpierre C,Kelly-Irving M

更新日期：2019-02-15 00:00:00

abstract：:The Spitzenkörper (SPK) constitutes a collection of secretory vesicles and polarity-related proteins intimately associated with polarized growth of fungal hyphae. Many SPK-localized proteins are known, but their assembly and dynamics remain poorly understood. Here, we identify protein-protein interaction cascades lead...

journal_title：Nature communications

authors： Zheng P,Nguyen TA,Wong JY,Lee M,Nguyen TA,Fan JS,Yang D,Jedd G

更新日期：2020-06-05 00:00:00

abstract：:A reliable method for recording evoked synaptic events in identified neurons in Caenorhabditis elegans would greatly accelerate our understanding of its nervous system at the molecular, cellular and network levels. Here we describe a method for recording synaptic currents and potentials from identified neurons in near...

journal_title：Nature communications

authors： Lindsay TH,Thiele TR,Lockery SR

更新日期：2011-01-01 00:00:00

abstract：:Understanding how evolution of antimicrobial resistance increases resistance to other drugs is a challenge of profound importance. By combining experimental evolution and genome sequencing of 63 laboratory-evolved lines, we charted a map of cross-resistance interactions between antibiotics in Escherichia coli, and exp...

journal_title：Nature communications

authors： Lázár V,Nagy I,Spohn R,Csörgő B,Györkei Á,Nyerges Á,Horváth B,Vörös A,Busa-Fekete R,Hrtyan M,Bogos B,Méhi O,Fekete G,Szappanos B,Kégl B,Papp B,Pál C

更新日期：2014-07-08 00:00:00

abstract：:Collisions between the DNA replication machinery and co-transcriptional R-loops can impede DNA synthesis and are a major source of genomic instability in cancer cells. How cancer cells deal with R-loops to proliferate is poorly understood. Here we show that the ATP-dependent chromatin remodelling INO80 complex promote...

journal_title：Nature communications

authors： Prendergast L,McClurg UL,Hristova R,Berlinguer-Palmini R,Greener S,Veitch K,Hernandez I,Pasero P,Rico D,Higgins JMG,Gospodinov A,Papamichos-Chronakis M

更新日期：2020-09-10 00:00:00

abstract：:The exceptional interest in improving the limitations of data storage, molecular electronics and optoelectronics has promoted the development of an ever increasing number of techniques used to pattern polymers at micro and nanoscale. Most of them rely on atomic force microscopy to thermally or electrostatically induce...

journal_title：Nature communications

authors： Farina M,Ye T,Lanzani G,di Donato A,Venanzoni G,Mencarelli D,Pietrangelo T,Morini A,Keivanidis PE

更新日期：2013-01-01 00:00:00

abstract：:Diatoms, a major group of photosynthetic microalgae, have a high biotechnological potential that has not been fully exploited because of the paucity of available genetic tools. Here we demonstrate targeted and stable modifications of the genome of the marine diatom Phaeodactylum tricornutum, using both meganucleases a...

journal_title：Nature communications

authors： Daboussi F,Leduc S,Maréchal A,Dubois G,Guyot V,Perez-Michaut C,Amato A,Falciatore A,Juillerat A,Beurdeley M,Voytas DF,Cavarec L,Duchateau P

更新日期：2014-05-29 00:00:00

abstract：:Carbon-carbon bond forming reactions are essential transformations in natural product biosynthesis. During de novo fatty acid and polyketide biosynthesis, β-ketoacyl-acyl carrier protein (ACP) synthases (KS), catalyze this process via a decarboxylative Claisen-like condensation reaction. KSs must recognize multiple ch...

journal_title：Nature communications

authors： Mindrebo JT,Patel A,Kim WE,Davis TD,Chen A,Bartholow TG,La Clair JJ,McCammon JA,Noel JP,Burkart MD

更新日期：2020-04-07 00:00:00

abstract：:Insect vectors are required for the transmission of many species of parasitic nematodes, but the mechanisms by which the vectors and nematodes coordinate their life cycles are poorly understood. Here, we report that ascarosides, an evolutionarily conserved family of nematode pheromones, are produced not only by a plan...

journal_title：Nature communications

authors： Zhao L,Zhang X,Wei Y,Zhou J,Zhang W,Qin P,Chinta S,Kong X,Liu Y,Yu H,Hu S,Zou Z,Butcher RA,Sun J

更新日期：2016-08-01 00:00:00

abstract：:Cell fate determination requires the cooperation between extrinsic signals and intrinsic molecules including transcription factors as well as epigenetic regulators. Nevertheless, how neural fate commitment is regulated by epigenetic modifications remains largely unclear. Here we show that transient histone deacetylati...

journal_title：Nature communications

authors： Liu P,Dou X,Liu C,Wang L,Xing C,Peng G,Chen J,Yu F,Qiao Y,Song L,Wu Y,Yue C,Li J,Han JD,Tang K,Jing N

更新日期：2015-04-23 00:00:00

abstract：:Individual cells in clonal populations often respond differently to environmental changes; for binary phenotypes, such as cell death, this can be measured as a fractional response. These types of responses have been attributed to cell-intrinsic stochastic processes and variable abundances of biochemical constituents, ...

journal_title：Nature communications

authors： Santos LC,Vogel R,Chipuk JE,Birtwistle MR,Stolovitzky G,Meyer P

更新日期：2019-03-21 00:00:00

abstract：:In the original version of this Article, the sixth sentence of the abstract incorrectly read 'Most of the genes upregulated and with hypermethylated CGIs in the Alb-R26Met HCC model undergo the same change.', and should have read 'Most of the genes upregulated and with hypermethylated CGIs in the Alb-R26Met HCC model ...

journal_title：Nature communications

authors： Arechederra M,Daian F,Yim A,Bazai SK,Richelme S,Dono R,Saurin AJ,Habermann BH,Maina F

更新日期：2018-09-25 00:00:00

abstract：:The stratospheric Arctic vortex (SAV) plays a critical role in forecasting cold winters in northern mid-latitudes. Its influence on the tropospheric mid- and high-latitudes has attracted growing attention in recent years. However, the trend in the SAV during the recent two decades is still unknown. Here, using three r...

journal_title：Nature communications

authors： Hu D,Guan Z,Tian W,Ren R

更新日期：2018-04-27 00:00:00

abstract：:Plasmacytoid dendritic cells (pDC) are type I interferon-producing cells with critical functions in a number of human illnesses; however, their molecular regulation is incompletely understood. Here we show the role of Src family kinases (SFK) in mouse and human pDCs. pDCs express Fyn and Lyn and their activating resid...

journal_title：Nature communications

authors： Dallari S,Macal M,Loureiro ME,Jo Y,Swanson L,Hesser C,Ghosh P,Zuniga EI

更新日期：2017-04-03 00:00:00

abstract：:There has been much research on renewable energy-harvesting techniques. However, owing to increasing energy demands, significant energy-related issues remain to be solved. Efforts aimed at reducing the amount of energy loss in electric/electronic systems are essential for reducing energy consumption and protecting the...

journal_title：Nature communications

authors： Kim T,Yong H,Kim B,Kim D,Choi D,Park YT,Lee S

更新日期：2018-04-12 00:00:00