Disinhibition of olfactory bulb granule cells accelerates odour discrimination in mice.

abstract：:Modern computation relies crucially on modular architectures, breaking a complex algorithm into self-contained subroutines. A client can then call upon a remote server to implement parts of the computation independently via an application programming interface (API). Present APIs relay only classical information. Here...

journal_title：Nature communications

authors： Zhang K,Thompson J,Zhang X,Shen Y,Lu Y,Zhang S,Ma J,Vedral V,Gu M,Kim K

更新日期：2019-10-16 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Wang ZH,Gong K,Liu X,Zhang Z,Sun X,Wei ZZ,Yu SP,Manfredsson FP,Sandoval IM,Johnson PF,Jia J,Wang JZ,Ye K

更新日期：2019-11-26 00:00:00

abstract：:Mantle plumes are thought to play a key role in transferring heat from the core-mantle boundary to the lithosphere, where it can significantly influence plate tectonics. On impinging on the lithosphere at spreading ridges or in intra-plate settings, mantle plumes may generate hotspots, large igneous provinces and henc...

journal_title：Nature communications

authors： Chang SJ,Ferreira AM,Faccenda M

更新日期：2016-02-29 00:00:00

abstract：:Engineering lattice thermal conductivity requires to control the heat carried by atomic vibration waves, the phonons. The key parameter for quantifying it is the phonon lifetime, limiting the travelling distance, whose determination is however at the limits of instrumental capabilities. Here, we show the achievement o...

journal_title：Nature communications

authors： Lory PF,Pailhès S,Giordano VM,Euchner H,Nguyen HD,Ramlau R,Borrmann H,Schmidt M,Baitinger M,Ikeda M,Tomeš P,Mihalkovič M,Allio C,Johnson MR,Schober H,Sidis Y,Bourdarot F,Regnault LP,Ollivier J,Paschen S,Grin Y,d

更新日期：2017-09-08 00:00:00

abstract：:Methane cold seep systems typically exhibit extensive buildups of authigenic carbonate minerals, resulting from local increases in alkalinity driven by methane oxidation. Here, we demonstrate that modern seep authigenic carbonates exhibit anomalously low clumped isotope values (Δ47), as much as ∼0.2‰ lower than expect...

journal_title：Nature communications

authors： Loyd SJ,Sample J,Tripati RE,Defliese WF,Brooks K,Hovland M,Torres M,Marlow J,Hancock LG,Martin R,Lyons T,Tripati AE

更新日期：2016-07-22 00:00:00

abstract：:The analysis of whole-genome sequencing studies is challenging due to the large number of noncoding rare variants, our limited understanding of their functional effects, and the lack of natural units for testing. Here we propose a scan statistic framework, WGScan, to simultaneously detect the existence, and estimate t...

journal_title：Nature communications

authors： He Z,Xu B,Buxbaum J,Ionita-Laza I

更新日期：2019-07-09 00:00:00

abstract：:Lipidic cubic phase (LCP) crystallization has proven successful for high-resolution structure determination of challenging membrane proteins. Here we present a technique for extruding gel-like LCP with embedded membrane protein microcrystals, providing a continuously renewed source of material for serial femtosecond c...

journal_title：Nature communications

authors： Weierstall U,James D,Wang C,White TA,Wang D,Liu W,Spence JC,Bruce Doak R,Nelson G,Fromme P,Fromme R,Grotjohann I,Kupitz C,Zatsepin NA,Liu H,Basu S,Wacker D,Han GW,Katritch V,Boutet S,Messerschmidt M,Williams GJ

更新日期：2014-01-01 00:00:00

abstract：:Understanding the fundamental alterations in brain functioning that lead to psychotic disorders remains a major challenge in clinical neuroscience. In particular, it is unknown whether any state-independent biomarkers can potentially predict the onset of psychosis and distinguish patients from healthy controls, regard...

journal_title：Nature communications

authors： Cao H,Chén OY,Chung Y,Forsyth JK,McEwen SC,Gee DG,Bearden CE,Addington J,Goodyear B,Cadenhead KS,Mirzakhanian H,Cornblatt BA,Carrión RE,Mathalon DH,McGlashan TH,Perkins DO,Belger A,Seidman LJ,Thermenos H,Tsuang MT,

更新日期：2018-09-21 00:00:00

abstract：:Device applications of graphene such as ultrafast transistors and photodetectors benefit from the combination of both high-quality p- and n-doped components prepared in a large-scale manner with spatial control and seamless connection. Here we develop a well-controlled chemical vapour deposition process for direct gro...

journal_title：Nature communications

authors： Yan K,Wu D,Peng H,Jin L,Fu Q,Bao X,Liu Z

更新日期：2012-01-01 00:00:00

abstract：:Soil microorganisms dominate terrestrial biogeochemical cycles; however, we know very little about their spatial distribution and how changes in the distributions of specific groups of microbes translate into landscape and global patterns of biogeochemical processes. In this paper, we use a nested sampling scheme at s...

journal_title：Nature communications

authors： King AJ,Freeman KR,McCormick KF,Lynch RC,Lozupone C,Knight R,Schmidt SK

更新日期：2010-08-10 00:00:00

abstract：:Soft particulate media include a wide range of systems involving athermal dissipative particles both in non-living and biological materials. Characterization of flows of particulate media is of great practical and theoretical importance. A fascinating feature of these systems is the existence of a critical rigidity tr...

journal_title：Nature communications

authors： Rahbari SHE,Saberi AA,Park H,Vollmer J

更新日期：2017-04-10 00:00:00

abstract：:The appearance of detritus shed from mountain ranges along the northern margin of the Tibetan Plateau heralds the Cenozoic development of high topography. Current estimates of the age of the basal conglomerate in the Qaidam basin place this event in Paleocene-Eocene. Here we present new magnetostratigraphy and mammali...

journal_title：Nature communications

authors： Wang W,Zheng W,Zhang P,Li Q,Kirby E,Yuan D,Zheng D,Liu C,Wang Z,Zhang H,Pang J

更新日期：2017-06-21 00:00:00

abstract：:Cellular events that occur across the seminiferous epithelium in the mammalian testis during spermatogenesis are tightly coordinated by biologically active peptides released from laminin chains. Laminin-γ3 domain IV is released at the apical ectoplasmic specialization during spermiation and mediates restructuring of t...

journal_title：Nature communications

authors： Su L,Mruk DD,Lie PP,Silvestrini B,Cheng CY

更新日期：2012-01-01 00:00:00

abstract：:The interaction of lipids and proteins plays an important role in plasma membrane bioactivity, and much can be learned from their diffusion characteristics. Here we present the combination of super-resolution STED microscopy with scanning fluorescence correlation spectroscopy (scanning STED-FCS, sSTED-FCS) to characte...

journal_title：Nature communications

authors： Honigmann A,Mueller V,Ta H,Schoenle A,Sezgin E,Hell SW,Eggeling C

更新日期：2014-11-20 00:00:00

abstract：:Choroidal neovascularization (CNV) is a major cause of visual impairment in patients suffering from wet age-related macular degeneration (AMD), particularly when refractory to intraocular anti-VEGF injections. Here we report that treatment with the oral mineralocorticoid receptor (MR) antagonist spironolactone reduces...

journal_title：Nature communications

authors： Zhao M,Mantel I,Gelize E,Li X,Xie X,Arboleda A,Seminel M,Levy-Boukris R,Dernigoghossian M,Prunotto A,Andrieu-Soler C,Rivolta C,Canonica J,Naud MC,Lechner S,Farman N,Bravo-Osuna I,Herrero-Vanrell R,Jaisser F,Behar-Co

更新日期：2019-01-21 00:00:00

abstract：:Secret communication over public channels is one of the central pillars of a modern information society. Using quantum key distribution this is achieved without relying on the hardness of mathematical problems, which might be compromised by improved algorithms or by future quantum computers. State-of-the-art quantum k...

journal_title：Nature communications

authors： Gehring T,Händchen V,Duhme J,Furrer F,Franz T,Pacher C,Werner RF,Schnabel R

更新日期：2015-10-30 00:00:00

abstract：:Connection of tubules into larger networks is the key process for the development of circulatory systems. In Drosophila development, tip cells of the tracheal system lead the migration of each branch and connect tubules by adhering to each other and simultaneously changing into a torus-shape. We show that as adhesion ...

journal_title：Nature communications

authors： Kato K,Dong B,Wada H,Tanaka-Matakatsu M,Yagi Y,Hayashi S

更新日期：2016-04-12 00:00:00

abstract：:Endogenous opioid peptides and prescription opioid drugs modulate pain, anxiety and stress by activating opioid receptors, currently classified into four subtypes. Here we demonstrate that ACKR3/CXCR7, hitherto known as an atypical scavenger receptor for chemokines, is a broad-spectrum scavenger of opioid peptides. Ph...

journal_title：Nature communications

authors： Meyrath M,Szpakowska M,Zeiner J,Massotte L,Merz MP,Benkel T,Simon K,Ohnmacht J,Turner JD,Krüger R,Seutin V,Ollert M,Kostenis E,Chevigné A

更新日期：2020-06-19 00:00:00

abstract：:Random numbers are commonly used in many different fields, ranging from simulations in fundamental science to security applications. In some critical cases, as Bell's tests and cryptography, the random numbers are required to be both private and to be provided at an ultra-fast rate. However, practical generators are u...

journal_title：Nature communications

authors： Avesani M,Marangon DG,Vallone G,Villoresi P

更新日期：2018-12-18 00:00:00

abstract：:Sensory perception modulates health and aging across taxa. Understanding the nature of relevant cues and the mechanisms underlying their action may lead to novel interventions that improve the length and quality of life. We found that in the vinegar fly, Drosophila melanogaster, exposure to dead conspecifics in the en...

journal_title：Nature communications

authors： Chakraborty TS,Gendron CM,Lyu Y,Munneke AS,DeMarco MN,Hoisington ZW,Pletcher SD

更新日期：2019-05-30 00:00:00

abstract：:In the human hematopoietic system, rare self-renewing multipotent long-term hematopoietic stem cells (LT-HSCs) are responsible for the lifelong production of mature blood cells and are the rational target for clinical regenerative therapies. However, the heterogeneity in the hematopoietic stem cell compartment and var...

journal_title：Nature communications

authors： Wagenblast E,Azkanaz M,Smith SA,Shakib L,McLeod JL,Krivdova G,Araújo J,Shultz LD,Gan OI,Dick JE,Lechman ER

更新日期：2019-10-18 00:00:00

abstract：:While erythropoietin (EPO) constitutes the major treatment for anemia, a range of anemic disorders remain resistant to EPO treatment. The need for alternative therapeutic strategies requires the identification of mechanisms that physiologically restrain erythropoiesis. Here we show that P38α restrains erythropoiesis i...

journal_title：Nature communications

authors： Hu P,Nebreda AR,Hanenberg H,Kinnebrew GH,Ivan M,Yoder MC,Filippi MD,Broxmeyer HE,Kapur R

更新日期：2018-08-29 00:00:00

abstract：:The diploid nature of the human genome is neglected in many analyses done today, where a genome is perceived as a set of unphased variants with respect to a reference genome. This lack of haplotype-level analyses can be explained by a lack of methods that can produce dense and accurate chromosome-length haplotypes at ...

journal_title：Nature communications

authors： Porubsky D,Garg S,Sanders AD,Korbel JO,Guryev V,Lansdorp PM,Marschall T

更新日期：2017-11-03 00:00:00

abstract：:Knowledge of the RNA three-dimensional structure, either in isolation or as part of RNP complexes, is fundamental to understand the mechanism of numerous cellular processes. Because of its flexibility, RNA represents a challenge for crystallization, while the large size of cellular complexes brings solution-state NMR ...

journal_title：Nature communications

authors： Marchanka A,Simon B,Althoff-Ospelt G,Carlomagno T

更新日期：2015-05-11 00:00:00

abstract：:Variants associated with blood lipid levels may be population-specific. To identify low-frequency variants associated with this phenotype, population-specific reference panels may be used. Here we impute nine large Dutch biobanks (~35,000 samples) with the population-specific reference panel created by the Genome of T...

journal_title：Nature communications

authors： van Leeuwen EM,Karssen LC,Deelen J,Isaacs A,Medina-Gomez C,Mbarek H,Kanterakis A,Trompet S,Postmus I,Verweij N,van Enckevort DJ,Huffman JE,White CC,Feitosa MF,Bartz TM,Manichaikul A,Joshi PK,Peloso GM,Deelen P,van D

更新日期：2015-03-09 00:00:00

abstract：:Although a hydrophobic microtexture at a solid surface most often reflects rain owing to the presence of entrapped air within the texture, it is much more challenging to repel hot water. As it contacts a colder material, hot water generates condensation within the cavities at the solid surface, which eventually builds...

journal_title：Nature communications

authors： Mouterde T,Lecointre P,Lehoucq G,Checco A,Clanet C,Quéré D

更新日期：2019-03-29 00:00:00

abstract：:Topological insulators represent a new quantum state of matter that are insulating in the bulk but metallic on the edge or surface. In the Dirac surface state, it is well-established that the electron spin is locked with the crystal momentum. Here we report a new phenomenon of the spin texture locking with the orbital...

journal_title：Nature communications

authors： Xie Z,He S,Chen C,Feng Y,Yi H,Liang A,Zhao L,Mou D,He J,Peng Y,Liu X,Liu Y,Liu G,Dong X,Yu L,Zhang J,Zhang S,Wang Z,Zhang F,Yang F,Peng Q,Wang X,Chen C,Xu Z,Zhou XJ

更新日期：2014-02-28 00:00:00

abstract：:A primary function of the midbrain stimulus selection network is to compute the highest-priority location for attention and gaze. Here we report the contribution of a specific cholinergic circuit to this computation. We functionally disconnected the tegmental cholinergic nucleus isthmi pars parvocellularis (Ipc) from ...

journal_title：Nature communications

authors： Asadollahi A,Knudsen EI

更新日期：2016-11-17 00:00:00

abstract：:Variation in body iron is associated with or causes diseases, including anaemia and iron overload. Here, we analyse genetic association data on biochemical markers of iron status from 11 European-population studies, with replication in eight additional cohorts (total up to 48,972 subjects). We find 11 genome-wide-sign...

journal_title：Nature communications

authors： Benyamin B,Esko T,Ried JS,Radhakrishnan A,Vermeulen SH,Traglia M,Gögele M,Anderson D,Broer L,Podmore C,Luan J,Kutalik Z,Sanna S,van der Meer P,Tanaka T,Wang F,Westra HJ,Franke L,Mihailov E,Milani L,Hälldin J,Win

更新日期：2014-10-29 00:00:00

abstract：:The photon-like behavior of electrons in graphene causes unusual confinement properties that depend strongly on the geometry and strength of the surrounding potential. We report bottom-up synthesis of atomically-precise one-dimensional (1D) arrays of point charges on graphene that allow exploration of a new type of su...

journal_title：Nature communications

authors： Lu J,Tsai HZ,Tatan AN,Wickenburg S,Omrani AA,Wong D,Riss A,Piatti E,Watanabe K,Taniguchi T,Zettl A,Pereira VM,Crommie MF

更新日期：2019-01-29 00:00:00