Abstract：
:Sensory perception modulates health and aging across taxa. Understanding the nature of relevant cues and the mechanisms underlying their action may lead to novel interventions that improve the length and quality of life. We found that in the vinegar fly, Drosophila melanogaster, exposure to dead conspecifics in the environment induced cues that were aversive to other flies, modulated physiology, and impaired longevity. The effects of exposure to dead conspecifics on aversiveness and lifespan required visual and olfactory function in the exposed flies. Furthermore, the sight of dead flies was sufficient to produce aversive cues and to induce changes in the head metabolome. Genetic and pharmacologic attenuation of serotonergic signaling eliminated the effects of exposure on aversiveness and lifespan. Our results indicate that Drosophila have an ability to perceive dead conspecifics in their environment and suggest conserved mechanistic links between neural state, health, and aging; the roots of which might be unearthed using invertebrate model systems.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Chakraborty TS,Gendron CM,Lyu Y,Munneke AS,DeMarco MN,Hoisington ZW,Pletcher SDdoi
10.1038/s41467-019-10285-ysubject
Has Abstractpub_date
2019-05-30 00:00:00pages
2365issue
1issn
2041-1723pii
10.1038/s41467-019-10285-yjournal_volume
10pub_type
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