Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity.

abstract：:Here, to overcome many limitations accompanying current available methods to detect protein-protein interactions (PPIs), we develop a live cell method called Split Intein-Mediated Protein Ligation (SIMPL). In this approach, bait and prey proteins are respectively fused to an intein N-terminal fragment (IN) and C-termi...

journal_title：Nature communications

authors： Yao Z,Aboualizadeh F,Kroll J,Akula I,Snider J,Lyakisheva A,Tang P,Kotlyar M,Jurisica I,Boxem M,Stagljar I

更新日期：2020-05-15 00:00:00

abstract：:Evolution of supramolecular chirality from self-assembly of achiral compounds and control over its handedness is closely related to the evolution of life and development of supramolecular materials with desired handedness. Here we report a system where the entire process of induction, control and locking of supramolec...

journal_title：Nature communications

authors： Kim J,Lee J,Kim WY,Kim H,Lee S,Lee HC,Lee YS,Seo M,Kim SY

更新日期：2015-04-23 00:00:00

abstract：:Understanding nanoscale thermal transport is of substantial importance for designing contemporary semiconductor technologies. Heat removal from small sources is well established to be severely impeded compared to diffusive predictions due to the ballistic nature of the dominant heat carriers. Experimental observations...

journal_title：Nature communications

authors： Ziabari A,Torres P,Vermeersch B,Xuan Y,Cartoixà X,Torelló A,Bahk JH,Koh YR,Parsa M,Ye PD,Alvarez FX,Shakouri A

更新日期：2018-01-17 00:00:00

abstract：:Bismuth chalcogenides and lead telluride/selenide alloys exhibit exceptional thermoelectric properties that could be harnessed for power generation and device applications. Since phonons play a significant role in achieving these desired properties, quantifying the interaction between phonons and electrons, which is e...

journal_title：Nature communications

authors： Zeljkovic I,Scipioni KL,Walkup D,Okada Y,Zhou W,Sankar R,Chang G,Wang YJ,Lin H,Bansil A,Chou F,Wang Z,Madhavan V

更新日期：2015-03-27 00:00:00

abstract：:Polymers bearing dynamic covalent bonds may exhibit dynamic properties, such as self-healing, shape memory and environmental adaptation. However, most dynamic covalent chemistries developed so far require either catalyst or change of environmental conditions to facilitate bond reversion and dynamic property change in ...

journal_title：Nature communications

authors： Ying H,Zhang Y,Cheng J

更新日期：2014-01-01 00:00:00

abstract：:Microbial symbiosis is integral to plant growth and reproduction, but its contribution to global patterns of plant distribution is unknown. Legumes (Fabaceae) are a diverse and widely distributed plant family largely dependent on symbiosis with nitrogen-fixing rhizobia, which are acquired from soil after germination. ...

journal_title：Nature communications

authors： Simonsen AK,Dinnage R,Barrett LG,Prober SM,Thrall PH

更新日期：2017-04-07 00:00:00

abstract：:The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of the minute quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy req...

journal_title：Nature communications

authors： Rothe S,Andreyev AN,Antalic S,Borschevsky A,Capponi L,Cocolios TE,De Witte H,Eliav E,Fedorov DV,Fedosseev VN,Fink DA,Fritzsche S,Ghys L,Huyse M,Imai N,Kaldor U,Kudryavtsev Y,Köster U,Lane JF,Lassen J,Liberati V,

更新日期：2013-01-01 00:00:00

abstract：:Acute otitis media (AOM) is among the most common pediatric diseases, and the most frequent reason for antibiotic treatment in children. Risk of AOM is dependent on environmental and host factors, as well as a significant genetic component. We identify genome-wide significance at a locus on 6q25.3 (rs2932989, Pmeta=2....

journal_title：Nature communications

authors： van Ingen G,Li J,Goedegebure A,Pandey R,Li YR,March ME,Jaddoe VW,Bakay M,Mentch FD,Thomas K,Wei Z,Chang X,Hain HS,Uitterlinden AG,Moll HA,van Duijn CM,Rivadeneira F,Raat H,Baatenburg de Jong RJ,Sleiman PM,van der

更新日期：2016-09-28 00:00:00

abstract：:The spatial organization of chromosomes has key functional roles, yet how chromosomes fold remains poorly understood at the single-molecule level. Here, we employ models of polymer physics to investigate DNA loci in human HCT116 and IMR90 wild-type and cohesin depleted cells. Model predictions on single-molecule struc...

journal_title：Nature communications

authors： Conte M,Fiorillo L,Bianco S,Chiariello AM,Esposito A,Nicodemi M

更新日期：2020-07-03 00:00:00

abstract：:In patients with damage to the primary visual cortex (V1), residual vision can guide goal-directed movements to targets in the blind field without awareness. This phenomenon has been termed blindsight, and its neural mechanisms are controversial. There should be visual pathways to the higher visual cortices bypassing ...

journal_title：Nature communications

authors： Kinoshita M,Kato R,Isa K,Kobayashi K,Kobayashi K,Onoe H,Isa T

更新日期：2019-01-11 00:00:00

abstract：:Among the perovskite oxide family, KTaO3 (KTO) has recently attracted considerable interest as a possible system for the realization of the Rashba effect. In this work, we report a novel conducting interface by placing KTO with another insulator, LaVO3 (LVO) and report planar Hall effect (PHE) and anisotropic magnetor...

journal_title：Nature communications

authors： Wadehra N,Tomar R,Varma RM,Gopal RK,Singh Y,Dattagupta S,Chakraverty S

更新日期：2020-02-13 00:00:00

abstract：:Aberrant splicing is frequently found in cancer, yet the biological consequences of such alterations are mostly undefined. Here we report that the Hippo-YAP signalling, a key pathway that regulates cell proliferation and organ size, is under control of a splicing switch. We show that TEAD4, the transcription factor th...

journal_title：Nature communications

authors： Qi Y,Yu J,Han W,Fan X,Qian H,Wei H,Tsai YH,Zhao J,Zhang W,Liu Q,Meng S,Wang Y,Wang Z

更新日期：2016-06-13 00:00:00

abstract：:Whilst demonstrated extensively in vitro, the control of cell behaviour via modulation of substrate compliance in live tissues has not been accomplished to date. Here we propose that stem cells can be regulated solely through in situ modulation of tissue biomechanics. By first establishing, via high-resolution Brillou...

journal_title：Nature communications

authors： Gouveia RM,Lepert G,Gupta S,Mohan RR,Paterson C,Connon CJ

更新日期：2019-04-03 00:00:00

abstract：:The functional role of adult neurogenesis in the hippocampus remains the subject of intense speculation. One recent hypothesis is that adult-born neurons contribute to the endocrine and behavioural outputs of the stress response. Here we show a genetic model system to ablate neurogenesis by inducibly deleting Tbr2 gen...

journal_title：Nature communications

authors： Tsai CY,Tsai CY,Arnold SJ,Huang GJ

更新日期：2015-09-29 00:00:00

abstract：:EpCAM (epithelial cell adhesion molecule), a stem and carcinoma cell marker, is a cell surface protein involved in homotypic cell-cell adhesion via intercellular oligomerization and proliferative signalling via proteolytic cleavage. Despite its use as a diagnostic marker and being a drug target, structural details of ...

journal_title：Nature communications

authors： Pavšič M,Gunčar G,Djinović-Carugo K,Lenarčič B

更新日期：2014-08-28 00:00:00

abstract：:The diversity of life and its organization in networks of interacting species has been a long-standing theoretical puzzle for ecologists. Ever since May's provocative paper challenging whether 'large complex systems [are] stable' various hypotheses have been proposed to explain when stability should be the rule, not t...

journal_title：Nature communications

authors： Gravel D,Massol F,Leibold MA

更新日期：2016-08-24 00:00:00

abstract：:Alcohol oxidation reactions are widely used for the preparation of aldehydes and ketones. The electrolysis of alcohols to carbonyl compounds have been underutilized owing to low efficiency. Herein, we report an electrochemical oxidation of various alcohols in a continuous-flow reactor without external oxidants, base o...

journal_title：Nature communications

authors： Wang D,Wang P,Wang S,Chen YH,Zhang H,Lei A

更新日期：2019-06-26 00:00:00

abstract：:Advanced-stage epithelial ovarian cancers are amongst the most difficult to treat tumors and have proven to be refractory to most cytotoxic, molecularly targeted, or immunotherapeutic approaches. Here, we report that nanoparticle-drug conjugates (NDCs) of monomethyl auristatin E (MMAE) significantly increase loading o...

journal_title：Nature communications

authors： Qi R,Wang Y,Bruno PM,Xiao H,Yu Y,Li T,Lauffer S,Wei W,Chen Q,Kang X,Song H,Yang X,Huang X,Detappe A,Matulonis U,Pepin D,Hemann MT,Birrer MJ,Ghoroghchian PP

更新日期：2017-12-18 00:00:00

abstract：:The sudden deterioration of patients with novel coronavirus disease 2019 (COVID-19) into critical illness is of major concern. It is imperative to identify these patients early. We show that a deep learning-based survival model can predict the risk of COVID-19 patients developing critical illness based on clinical cha...

journal_title：Nature communications

authors： Liang W,Yao J,Chen A,Lv Q,Zanin M,Liu J,Wong S,Li Y,Lu J,Liang H,Chen G,Guo H,Guo J,Zhou R,Ou L,Zhou N,Chen H,Yang F,Han X,Huan W,Tang W,Guan W,Chen Z,Zhao Y,Sang L,Xu Y,Wang W,Li S,Lu L,Zhang N

更新日期：2020-07-15 00:00:00

abstract：:Metal oxides with a tunnelled structure are attractive as charge storage materials for rechargeable batteries and supercapacitors, since the tunnels enable fast reversible insertion/extraction of charge carriers (for example, lithium ions). Common synthesis methods can introduce large cations such as potassium, barium...

journal_title：Nature communications

authors： Yuan Y,Zhan C,He K,Chen H,Yao W,Sharifi-Asl S,Song B,Yang Z,Nie A,Luo X,Wang H,Wood SM,Amine K,Islam MS,Lu J,Shahbazian-Yassar R

更新日期：2016-11-21 00:00:00

abstract：:How mixtures of immune cells associate with cancer cell phenotype and affect pathogenesis is still unclear. In 15 breast cancer gene expression datasets, we invariably identify three clusters of patients with gradual levels of immune infiltration. The intermediate immune infiltration cluster (Cluster B) is associated ...

journal_title：Nature communications

authors： Tekpli X,Lien T,Røssevold AH,Nebdal D,Borgen E,Ohnstad HO,Kyte JA,Vallon-Christersson J,Fongaard M,Due EU,Svartdal LG,Sveli MAT,Garred Ø,OSBREAC.,Frigessi A,Sahlberg KK,Sørlie T,Russnes HG,Naume B,Kristensen VN

更新日期：2019-12-03 00:00:00

abstract：:In the original version of this Article, the four structural depictions of orbital distributions were inadvertently omitted from Figure 5. This has now been corrected in both the HTML and PDF versions of the Article. ...

journal_title：Nature communications

authors： Zhao J,Peng Q,Wang Z,Xu W,Xiao H,Wu Q,Sun HL,Ma F,Zhao J,Sun CJ,Zhao J,Li J

更新日期：2019-06-21 00:00:00

abstract：:There has been much research on renewable energy-harvesting techniques. However, owing to increasing energy demands, significant energy-related issues remain to be solved. Efforts aimed at reducing the amount of energy loss in electric/electronic systems are essential for reducing energy consumption and protecting the...

journal_title：Nature communications

authors： Kim T,Yong H,Kim B,Kim D,Choi D,Park YT,Lee S

更新日期：2018-04-12 00:00:00

abstract：:Polymorphism is a remarkable concept in chemistry, materials science, computer science, and biology. Whether it is the ability of a material to exist in two or more crystal structures, a single interface connecting to two different entities, or alternative phenotypes of an organism, polymorphism determines function an...

journal_title：Nature communications

authors： Li L,Salamończyk M,Shadpour S,Zhu C,Jákli A,Hegmann T

更新日期：2018-02-19 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Panhans M,Hutsch S,Benduhn J,Schellhammer KS,Nikolis VC,Vangerven T,Vandewal K,Ortmann F

更新日期：2020-04-22 00:00:00

abstract：:A planar slab of negative-index material works as a superlens with sub-diffraction-limited resolution, as propagating waves are focused and, moreover, evanescent waves are reconstructed in the image plane. Here we demonstrate a superlens for electric evanescent fields with low losses using perovskites in the mid-infra...

journal_title：Nature communications

authors： Kehr SC,Liu YM,Martin LW,Yu P,Gajek M,Yang SY,Yang CH,Wenzel MT,Jacob R,von Ribbeck HG,Helm M,Zhang X,Eng LM,Ramesh R

更新日期：2011-01-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Weinert LA,Chaudhuri RR,Wang J,Peters SE,Corander J,Jombart T,Baig A,Howell KJ,Vehkala M,Välimäki N,Harris D,Chieu TTB,Van Vinh Chau N,Campbell J,Schultsz C,Parkhill J,Bentley SD,Langford PR,Rycroft AN,Wren BW,Far

更新日期：2019-11-22 00:00:00

abstract：:In carrier multiplication, the absorption of a single photon results in two or more electron-hole pairs. Quantum dots are promising materials for implementing carrier multiplication principles in real-life technologies. So far, however, most of research in this area has focused on optical studies of solution samples w...

journal_title：Nature communications

authors： Gao J,Fidler AF,Klimov VI

更新日期：2015-09-08 00:00:00

abstract：:Understanding how cellular functions emerge from the underlying molecular mechanisms is a key challenge in biology. This will require computational models, whose predictive power is expected to increase with coverage and precision of formulation. Genome-scale models revolutionised the metabolic field and made the firs...

journal_title：Nature communications

authors： Münzner U,Klipp E,Krantz M

更新日期：2019-03-21 00:00:00

abstract：:The mitochondrial respiratory chain is essential for oxidative phosphorylation and comprises multiple complexes, including cytochrome c oxidase, assembled in macromolecular supercomplexes. Little is known about factors that contribute to supercomplex organization. Here we identify COX7RP as a factor that promotes supe...

journal_title：Nature communications

authors： Ikeda K,Shiba S,Horie-Inoue K,Shimokata K,Inoue S

更新日期：2013-01-01 00:00:00