Local and thalamic origins of correlated ongoing and sensory-evoked cortical activities.

abstract：:Progranulin (GRN) loss-of-function mutations leading to progranulin protein (PGRN) haploinsufficiency are prevalent genetic causes of frontotemporal dementia. Reports also indicated PGRN-mediated neuroprotection in models of Alzheimer's and Parkinson's disease; thus, increasing PGRN levels is a promising therapeutic f...

journal_title：Nature communications

authors： Nicholson AM,Finch NA,Almeida M,Perkerson RB,van Blitterswijk M,Wojtas A,Cenik B,Rotondo S,Inskeep V,Almasy L,Dyer T,Peralta J,Jun G,Wood AR,Frayling TM,Fuchsberger C,Fowler S,Teslovich TM,Manning AK,Kumar S,Curra

更新日期：2016-06-30 00:00:00

abstract：:The gyrotropic rotation around the equilibrium position constitutes the fundamental excitation of magnetic vortices in nanostructures. The frequency of this mode varies with material and sample geometry, but is independent of the vortex handedness and its core direction. Here, we demonstrate that this degeneracy is li...

journal_title：Nature communications

authors： Sluka V,Kákay A,Deac AM,Bürgler DE,Schneider CM,Hertel R

更新日期：2015-03-03 00:00:00

abstract：:The possibility of measuring binding of small-molecule drugs to desired targets in live cells could provide a better understanding of drug action. However, current approaches mostly yield static data, require lysis or rely on indirect assays and thus often provide an incomplete understanding of drug action. Here, we p...

journal_title：Nature communications

authors： Dubach JM,Vinegoni C,Mazitschek R,Fumene Feruglio P,Cameron LA,Weissleder R

更新日期：2014-05-28 00:00:00

abstract：:Range expansions are central to two ecological issues reshaping patterns of global biodiversity: biological invasions and climate change. Traditional theory considers range expansion as the outcome of the demographic processes of birth, death and dispersal, while ignoring the evolutionary implications of such processe...

journal_title：Nature communications

authors： Weiss-Lehman C,Hufbauer RA,Melbourne BA

更新日期：2017-01-27 00:00:00

abstract：:Nanoscale dimensions in materials lead to unique electronic and structural properties with applications ranging from site-specific drug delivery to anodes for lithium-ion batteries. These functional properties often involve large-amplitude strains and structural modifications, and thus require an understanding of the ...

journal_title：Nature communications

authors： Szilagyi E,Wittenberg JS,Miller TA,Lutker K,Quirin F,Lemke H,Zhu D,Chollet M,Robinson J,Wen H,Sokolowski-Tinten K,Lindenberg AM

更新日期：2015-03-12 00:00:00

abstract：:Rapid and accurate clinical diagnosis remains challenging. A component of diagnosis tool development is the design of effective classification models with Mass spectrometry (MS) data. Some Machine Learning approaches have been investigated but these models require time-consuming preprocessing steps to remove artifacts...

journal_title：Nature communications

authors： Seddiki K,Saudemont P,Precioso F,Ogrinc N,Wisztorski M,Salzet M,Fournier I,Droit A

更新日期：2020-11-05 00:00:00

abstract：:CD11b(+)Gr-1(+) myeloid-derived suppressor cells (MDSCs) expand in the spleen during cancer and promote progression through suppression of cytotoxic T cells. An anti-inflammatory reflex arc involving the vagus nerve and memory T cells is necessary for resolution of acute inflammation. Failure of this neural circuit co...

journal_title：Nature communications

authors： Dubeykovskaya Z,Si Y,Chen X,Worthley DL,Renz BW,Urbanska AM,Hayakawa Y,Xu T,Westphalen CB,Dubeykovskiy A,Chen D,Friedman RA,Asfaha S,Nagar K,Tailor Y,Muthupalani S,Fox JG,Kitajewski J,Wang TC

更新日期：2016-02-04 00:00:00

abstract：:The serotonin transporter (SERT), a member of the neurotransmitter:sodium symporter family, is responsible for termination of serotonergic signaling by re-uptake of serotonin (5-HT) into the presynaptic neuron. Its key role in synaptic transmission makes it a major drug target, e.g. for the treatment of depression, an...

journal_title：Nature communications

authors： Möller IR,Slivacka M,Nielsen AK,Rasmussen SGF,Gether U,Loland CJ,Rand KD

更新日期：2019-04-11 00:00:00

abstract：:SIRT1, the founding member of the mammalian family of seven NAD(+)-dependent sirtuins, is composed of 747 amino acids forming a catalytic domain and extended N- and C-terminal regions. We report the design and characterization of an engineered human SIRT1 construct (mini-hSIRT1) containing the minimal structural eleme...

journal_title：Nature communications

authors： Dai H,Case AW,Riera TV,Considine T,Lee JE,Hamuro Y,Zhao H,Jiang Y,Sweitzer SM,Pietrak B,Schwartz B,Blum CA,Disch JS,Caldwell R,Szczepankiewicz B,Oalmann C,Yee Ng P,White BH,Casaubon R,Narayan R,Koppetsch K,Bourb

更新日期：2015-07-02 00:00:00

abstract：:Polyborylated organic compounds have been emerging as versatile building blocks in chemical synthesis. Here we report a selective cobalt-catalyzed deoxygenative 1,1,3-triborylation reaction of allylic ethers with pinacolborane to prepare 1,1,3-triborylalkane compounds. With naturally abundant and/or synthetic cinnamic...

journal_title：Nature communications

authors： Teo WJ,Yang X,Poon YY,Ge S

更新日期：2020-10-15 00:00:00

abstract：:Nitrogen fixation by cyanobacteria supplies critical bioavailable nitrogen to marine ecosystems worldwide; however, field and lab data have demonstrated it to be limited by iron, phosphorus and/or CO2. To address unknown future interactions among these factors, we grew the nitrogen-fixing cyanobacterium Trichodesmium ...

journal_title：Nature communications

authors： Walworth NG,Fu FX,Webb EA,Saito MA,Moran D,Mcllvin MR,Lee MD,Hutchins DA

更新日期：2016-06-27 00:00:00

abstract：:Naturally-occurring thermal materials usually possess specific thermal conductivity (κ), forming a digital set of κ values. Emerging thermal metamaterials have been deployed to realize effective thermal conductivities unattainable in natural materials. However, the effective thermal conductivities of such mixing-based...

journal_title：Nature communications

authors： Xu G,Dong K,Li Y,Li H,Liu K,Li L,Wu J,Qiu CW

更新日期：2020-11-27 00:00:00

abstract：:One key route for controlling reaction selectivity in heterogeneous catalysis is to prepare catalysts that exhibit only specific types of sites required for desired product formation. Here we show that alkanethiolate self-assembled monolayers with varying surface densities can be used to tune selectivity to desired hy...

journal_title：Nature communications

authors： Pang SH,Schoenbaum CA,Schwartz DK,Medlin JW

更新日期：2013-01-01 00:00:00

abstract：:Myelodysplastic syndromes (MDS) are uncommon in children and have a poor prognosis. In contrast to adult MDS, little is known about the genomic landscape of pediatric MDS. Here, we describe the somatic and germline changes of pediatric MDS using whole exome sequencing, targeted amplicon sequencing, and/or RNA-sequenci...

journal_title：Nature communications

authors： Schwartz JR,Ma J,Lamprecht T,Walsh M,Wang S,Bryant V,Song G,Wu G,Easton J,Kesserwan C,Nichols KE,Mullighan CG,Ribeiro RC,Klco JM

更新日期：2017-11-16 00:00:00

abstract：:The competition between bimolecular nucleophilic substitution and base-induced elimination is of fundamental importance for the synthesis of pure samples in organic chemistry. Many factors that influence this competition have been identified over the years, but the underlying atomistic dynamics have remained difficult...

journal_title：Nature communications

authors： Carrascosa E,Meyer J,Zhang J,Stei M,Michaelsen T,Hase WL,Yang L,Wester R

更新日期：2017-06-21 00:00:00

abstract：:Histone acetylation is known to affect the speed of seed germination, but the molecular regulatory basis of this remains ambiguous. Here we report that loss of function of two histone deacetylase-binding factors, SWI-INDEPENDENT3 (SIN3)-LIKE1 (SNL1) and SNL2, results in accelerated radicle protrusion and growth during...

journal_title：Nature communications

authors： Wang Z,Chen F,Li X,Cao H,Ding M,Zhang C,Zuo J,Xu C,Xu J,Deng X,Xiang Y,Soppe WJ,Liu Y

更新日期：2016-11-11 00:00:00

abstract：:A cloak that can hide living creatures from sight is a common feature of mythology but still remains unrealized as a practical device. To preserve the wave phase, the previous cloaking solution proposed by Pendry and colleagues required transformation of the electromagnetic space around the hidden object in such a way...

journal_title：Nature communications

authors： Chen H,Zheng B,Shen L,Wang H,Zhang X,Zheludev NI,Zhang B

更新日期：2013-01-01 00:00:00

abstract：:To expand the toolbox of imaging in living cells, we have engineered a single-chain variable fragment binding the linear HA epitope with high affinity and specificity in vivo. The resulting probe, called the HA frankenbody, can light up in multiple colors HA-tagged nuclear, cytoplasmic, membrane, and mitochondrial pro...

journal_title：Nature communications

authors： Zhao N,Kamijo K,Fox PD,Oda H,Morisaki T,Sato Y,Kimura H,Stasevich TJ

更新日期：2019-07-03 00:00:00

abstract：:For many stochastic processes, the probability [Formula: see text] of not-having reached a target in unbounded space up to time [Formula: see text] follows a slow algebraic decay at long times, [Formula: see text]. This is typically the case of symmetric compact (i.e. recurrent) random walks. While the persistence exp...

journal_title：Nature communications

authors： Levernier N,Dolgushev M,Bénichou O,Voituriez R,Guérin T

更新日期：2019-07-05 00:00:00

abstract：:Memory consolidation requires a timely controlled interplay between the hippocampus, a brain region important for memory formation, and the cortex, a region recruited for memory storage. Here we show that memory consolidation is associated with specific epigenetic modifications on histone proteins that have a distinct...

journal_title：Nature communications

authors： Gräff J,Woldemichael BT,Berchtold D,Dewarrat G,Mansuy IM

更新日期：2012-01-01 00:00:00

abstract：:Despite highly promising characteristics of three-dimensionally (3D) nanostructured catalysts for the oxygen evolution reaction (OER) in polymer electrolyte membrane water electrolyzers (PEMWEs), universal design rules for maximizing their performance have not been explored. Here we show that woodpile (WP)-structured ...

journal_title：Nature communications

authors： Kim YJ,Lim A,Kim JM,Lim D,Chae KH,Cho EN,Han HJ,Jeon KU,Kim M,Lee GH,Lee GR,Ahn HS,Park HS,Kim H,Kim JY,Jung YS

更新日期：2020-10-01 00:00:00

abstract：:CRISPR-Cas9 has emerged as a powerful technology that relies on Cas9/sgRNA ribonucleoprotein complexes (RNPs) to target and edit DNA. However, many therapeutic targets cannot currently be accessed due to the lack of carriers that can deliver RNPs systemically. Here, we report a generalizable methodology that allows en...

journal_title：Nature communications

authors： Wei T,Cheng Q,Min YL,Olson EN,Siegwart DJ

更新日期：2020-06-26 00:00:00

abstract：:Droplet interactions with compliant materials are familiar, but surprisingly complex processes of importance to the manufacturing, chemical, and garment industries. Despite progress-previous research indicates that mesoscopic substrate deformations can enhance droplet drying or slow down spreading dynamics-our underst...

journal_title：Nature communications

authors： Gerber J,Lendenmann T,Eghlidi H,Schutzius TM,Poulikakos D

更新日期：2019-10-21 00:00:00

abstract：:Modulation of epigenetic patterns has promising efficacy for treating cancer. 5-Hydroxymethylated cytosine (5-hmC) is an epigenetic mark potentially important in cancer. Here we report that 5-hmC is an epigenetic hallmark of prostate cancer (PCa) progression. A member of the ten-eleven translocation (TET) proteins, wh...

journal_title：Nature communications

authors： Takayama K,Misawa A,Suzuki T,Takagi K,Hayashizaki Y,Fujimura T,Homma Y,Takahashi S,Urano T,Inoue S

更新日期：2015-09-25 00:00:00

abstract：:Magnetic resonance imaging is an important technique for identifying different types of tissues in a body or spatial information about composite materials. Because temperature is a fundamental parameter reflecting the biological status of the body and individual tissues, it would be helpful to have temperature maps su...

journal_title：Nature communications

authors： Hankiewicz JH,Celinski Z,Stupic KF,Anderson NR,Camley RE

更新日期：2016-08-09 00:00:00

abstract：:Cancer persister cells tolerate anticancer drugs and serve as the founders of acquired resistance and cancer relapse. Here we show that a subpopulation of BRAFV600 mutant melanoma cells that tolerates exposure to BRAF and MEK inhibitors undergoes a reversible remodelling of mRNA translation that evolves in parallel wi...

journal_title：Nature communications

authors： Shen S,Faouzi S,Bastide A,Martineau S,Malka-Mahieu H,Fu Y,Sun X,Mateus C,Routier E,Roy S,Desaubry L,André F,Eggermont A,David A,Scoazec JY,Vagner S,Robert C

更新日期：2019-12-16 00:00:00

abstract：:Transforming growth factor-β (TGF-β) signaling and microRNAs (miRNAs) are important gene regulatory components in cancer. Usually in advanced malignant stages, TGF-β signaling is elevated but global miRNA expression is suppressed. Such a gene expression signature is well illustrated in a fibrosis (or mesenchymal) subt...

journal_title：Nature communications

authors： Ahn JH,Lee HS,Lee JS,Lee YS,Park JL,Kim SY,Hwang JA,Kunkeaw N,Jung SY,Kim TJ,Lee KS,Jeon SH,Lee I,Johnson BH,Choi JH,Lee YS

更新日期：2018-03-21 00:00:00

abstract：:Bone mineral density is known to be a heritable, polygenic trait whereas genetic variants contributing to lean mass variation remain largely unknown. We estimated the shared SNP heritability and performed a bivariate GWAS meta-analysis of total-body lean mass (TB-LM) and total-body less head bone mineral density (TBLH...

journal_title：Nature communications

authors： Medina-Gomez C,Kemp JP,Dimou NL,Kreiner E,Chesi A,Zemel BS,Bønnelykke K,Boer CG,Ahluwalia TS,Bisgaard H,Evangelou E,Heppe DHM,Bonewald LF,Gorski JP,Ghanbari M,Demissie S,Duque G,Maurano MT,Kiel DP,Hsu YH,C J van d

更新日期：2017-07-25 00:00:00

abstract：:Exciton dynamics can be strongly affected by lattice vibrations through electron-phonon coupling. This is rarely explored in two-dimensional magnetic semiconductors. Focusing on bilayer CrI3, we first show the presence of strong electron-phonon coupling through temperature-dependent photoluminescence and absorption sp...

journal_title：Nature communications

authors： Jin W,Kim HH,Ye Z,Ye G,Rojas L,Luo X,Yang B,Yin F,Horng JSA,Tian S,Fu Y,Xu G,Deng H,Lei H,Tsen AW,Sun K,He R,Zhao L

更新日期：2020-09-22 00:00:00

abstract：:Because maintenance of non-scalable cellular components--membranes and chromosomes--requires an increasing fraction of energy as cell size decreases, miniaturization comes at a considerable energetic cost for a phytoplanktonic cell. Consequently, if eukaryotes can use their superior energetic resources to acquire nutr...

journal_title：Nature communications

authors： Zubkov MV

更新日期：2014-04-29 00:00:00