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Imaging dynamic fingerprints of competing E2 and SN2 reactions.

Abstract：

:The competition between bimolecular nucleophilic substitution and base-induced elimination is of fundamental importance for the synthesis of pure samples in organic chemistry. Many factors that influence this competition have been identified over the years, but the underlying atomistic dynamics have remained difficult to observe. We present product velocity distributions for a series of reactive collisions of the type X- + RY with X and Y denoting the halogen atoms fluorine, chlorine and iodine. By increasing the size of the residue R from methyl to tert-butyl in several steps, we find that the dynamics drastically change from backward to dominant forward scattering of the leaving ion relative to the reactant RY velocity. This characteristic fingerprint is also confirmed by direct dynamics simulations for ethyl as residue and attributed to the dynamics of elimination reactions. This work opens the door to a detailed atomistic understanding of transformation reactions in even larger systems.The competition between chemical reactions critically affects our natural environment and the synthesis of new materials. Here, the authors present an approach to directly image distinct fingerprints of essential organic reactions and monitor their competition as a function of steric substitution.

journal_name

Nat Commun

journal_title

Nature communications

authors

Carrascosa E,Meyer J,Zhang J,Stei M,Michaelsen T,Hase WL,Yang L,Wester R

doi

10.1038/s41467-017-00065-x

subject

Has Abstract

pub_date

2017-06-21 00:00:00

pages

25

issue

1

issn

2041-1723

pii

10.1038/s41467-017-00065-x

journal_volume

8

pub_type

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