当前位置： SCI文献检索 > Nature Communications期刊下所有文献 > LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function.

LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function.

Abstract：

:Autophagy perturbation represents an emerging therapeutic strategy in cancer. Although LATS1 and LATS2 kinases, core components of the mammalian Hippo pathway, have been shown to exert tumor suppressive activities, here we report a pro-survival role of LATS1 but not LATS2 in hepatocellular carcinoma (HCC) cells. Specifically, LATS1 restricts lethal autophagy in HCC cells induced by sorafenib, the standard of care for advanced HCC patients. Notably, autophagy regulation by LATS1 is independent of its kinase activity. Instead, LATS1 stabilizes the autophagy core-machinery component Beclin-1 by promoting K27-linked ubiquitination at lysine residues K32 and K263 on Beclin-1. Consequently, ubiquitination of Beclin-1 negatively regulates autophagy by promoting inactive dimer formation of Beclin-1. Our study highlights a functional diversity between LATS1 and LATS2, and uncovers a scaffolding role of LATS1 in mediating a cross-talk between the Hippo signaling pathway and autophagy.

journal_name

Nat Commun

journal_title

Nature communications

authors

Tang F,Gao R,Jeevan-Raj B,Wyss CB,Kalathur RKR,Piscuoglio S,Ng CKY,Hindupur SK,Nuciforo S,Dazert E,Bock T,Song S,Buechel D,Morini MF,Hergovich A,Matthias P,Lim DS,Terracciano LM,Heim MH,Hall MN,Christofori G

doi

10.1038/s41467-019-13591-7

subject

Has Abstract

pub_date

2019-12-17 00:00:00

pages

5755

issue

1

issn

2041-1723

pii

10.1038/s41467-019-13591-7

journal_volume

10

pub_type

杂志文章

相关文献

Nature Communications文献大全
  • DOT1L cooperates with the c-Myc-p300 complex to epigenetically derepress CDH1 transcription factors in breast cancer progression.

    abstract：:DOT1L has emerged as an anticancer target for MLL-associated leukaemias; however, its functional role in solid tumours is largely unknown. Here we identify that DOT1L cooperates with c-Myc and p300 acetyltransferase to epigenetically activate epithelial-mesenchymal transition (EMT) regulators in breast cancer progress...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms8821

    authors： Cho MH,Park JH,Choi HJ,Park MK,Won HY,Park YJ,Lee CH,Oh SH,Song YS,Kim HS,Oh YH,Lee JY,Kong G

    更新日期：2015-07-22 00:00:00

  • Ultrasmall targeted nanoparticles with engineered antibody fragments for imaging detection of HER2-overexpressing breast cancer.

    abstract：:Controlling the biodistribution of nanoparticles upon intravenous injection is the key to achieving target specificity. One of the impediments in nanoparticle-based tumor targeting is the inability to limit the trafficking of nanoparticles to liver and other organs leading to smaller accumulated amounts in tumor tissu...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-06271-5

    authors： Chen F,Ma K,Madajewski B,Zhuang L,Zhang L,Rickert K,Marelli M,Yoo B,Turker MZ,Overholtzer M,Quinn TP,Gonen M,Zanzonico P,Tuesca A,Bowen MA,Norton L,Subramony JA,Wiesner U,Bradbury MS

    更新日期：2018-10-08 00:00:00

  • Oscillatory surface rheotaxis of swimming E. coli bacteria.

    abstract：:Bacterial contamination of biological channels, catheters or water resources is a major threat to public health, which can be amplified by the ability of bacteria to swim upstream. The mechanisms of this 'rheotaxis', the reorientation with respect to flow gradients, are still poorly understood. Here, we follow individ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-11360-0

    authors： Mathijssen AJTM,Figueroa-Morales N,Junot G,Clément É,Lindner A,Zöttl A

    更新日期：2019-07-31 00:00:00

  • Exploiting the tunability of stimulated emission depletion microscopy for super-resolution imaging of nuclear structures.

    abstract：:Imaging of nuclear structures within intact eukaryotic nuclei is imperative to understand the effect of chromatin folding on genome function. Recent developments of super-resolution fluorescence microscopy techniques combine high specificity, sensitivity, and less-invasive sample preparation procedures with the sub-di...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-05963-2

    authors： Sarmento MJ,Oneto M,Pelicci S,Pesce L,Scipioni L,Faretta M,Furia L,Dellino GI,Pelicci PG,Bianchini P,Diaspro A,Lanzanò L

    更新日期：2018-08-24 00:00:00

  • The shift of phosphorus transfers in global fisheries and aquaculture.

    abstract：:Global fish production (capture and aquaculture) has increased quickly, which has altered global flows of phosphorus (P). Here we show that in 2016, [Formula: see text] Tg P yr-1 (mean and interquartile range) was applied in aquaculture to increase fish production; while [Formula: see text] Tg P yr-1 was removed from ...

    journal_title：Nature communications

    pub_type： 历史文章,杂志文章

    doi：10.1038/s41467-019-14242-7

    authors： Huang Y,Ciais P,Goll DS,Sardans J,Peñuelas J,Cresto-Aleina F,Zhang H

    更新日期：2020-01-17 00:00:00

  • Neurons in the primate dorsal striatum signal the uncertainty of object-reward associations.

    abstract：:To learn, obtain reward and survive, humans and other animals must monitor, approach and act on objects that are associated with variable or unknown rewards. However, the neuronal mechanisms that mediate behaviours aimed at uncertain objects are poorly understood. Here we demonstrate that a set of neurons in an intern...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms12735

    authors： White JK,Monosov IE

    更新日期：2016-09-14 00:00:00

  • Suppression of a broad spectrum of liver autoimmune pathologies by single peptide-MHC-based nanomedicines.

    abstract：:Peptide-major histocompatibility complex class II (pMHCII)-based nanomedicines displaying tissue-specific autoantigenic epitopes can blunt specific autoimmune conditions by re-programming cognate antigen-experienced CD4+ T-cells into disease-suppressing T-regulatory type 1 (TR1) cells. Here, we show that single pMHCII...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-09893-5

    authors： Umeshappa CS,Singha S,Blanco J,Shao K,Nanjundappa RH,Yamanouchi J,Parés A,Serra P,Yang Y,Santamaria P

    更新日期：2019-05-14 00:00:00

  • A tied Fermi liquid to Luttinger liquid model for nonlinear transport in conducting polymers.

    abstract：:Organic conjugated polymers demonstrate great potential in transistors, solar cells and light-emitting diodes, whose performances are fundamentally governed by charge transport. However, the morphology-property relationships and the underpinning charge transport mechanisms remain unclear. Particularly, whether the non...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-20238-5

    authors： Wang J,Niu J,Shao B,Yang G,Lu C,Li M,Zhou Z,Chuai X,Chen J,Lu N,Huang B,Wang Y,Li L,Liu M

    更新日期：2021-01-04 00:00:00

  • KSRP specifies monocytic and granulocytic differentiation through regulating miR-129 biogenesis and RUNX1 expression.

    abstract：:RNA-binding proteins (RBPs) integrate the processing of RNAs into post-transcriptional gene regulation, but the direct contribution of them to myeloid cell specification is poorly understood. Here, we report the first global RBP transcriptomic analysis of myeloid differentiation by combining RNA-seq analysis with myel...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-01425-3

    authors： Zhao H,Wang X,Yi P,Si Y,Tan P,He J,Yu S,Ren Y,Ma Y,Zhang J,Wang D,Wang F,Yu J

    更新日期：2017-11-10 00:00:00

  • Telomerase reverse transcriptase promoter mutations in primary cutaneous melanoma.

    abstract：:We previously reported a disease segregating causal germline mutation in a melanoma family and recurrent somatic mutations in metastasized tumours from unrelated patients in the core promoter region of the telomerase reverse transcriptase (TERT) gene. Here we show that the TERT promoter mutations, besides causing an i...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms4401

    authors： Heidenreich B,Nagore E,Rachakonda PS,Garcia-Casado Z,Requena C,Traves V,Becker J,Soufir N,Hemminki K,Kumar R

    更新日期：2014-02-26 00:00:00

  • An autonomous DNA nanomachine maps spatiotemporal pH changes in a multicellular living organism.

    abstract：:Structural DNA nanotechnology seeks to build synthetic molecular machinery from DNA. DNA nanomachines are artificially designed assemblies that switch between defined conformations in response to an external cue. Though it has proved possible to create DNA machines and rudimentary walkers, the function of such autonom...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms1340

    authors： Surana S,Bhat JM,Koushika SP,Krishnan Y

    更新日期：2011-06-07 00:00:00

  • Somatodendritic consistency check for temporal feature segmentation.

    abstract：:The brain identifies potentially salient features within continuous information streams to process hierarchical temporal events. This requires the compression of information streams, for which effective computational principles are yet to be explored. Backpropagating action potentials can induce synaptic plasticity in...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-15367-w

    authors： Asabuki T,Fukai T

    更新日期：2020-03-25 00:00:00

  • High-energy-density dual-ion battery for stationary storage of electricity using concentrated potassium fluorosulfonylimide.

    abstract：:Graphite dual-ion batteries represent a potential battery concept for large-scale stationary storage of electricity, especially when constructed free of lithium and other chemical elements with limited natural reserves. Owing to their non-rocking-chair operation mechanism, however, the practical deployment of graphite...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-06923-6

    authors： Kravchyk KV,Bhauriyal P,Piveteau L,Guntlin CP,Pathak B,Kovalenko MV

    更新日期：2018-10-26 00:00:00

  • Opposing effects of target overexpression reveal drug mechanisms.

    abstract：:Overexpression of a drug's molecular target often increases drug resistance, offering a pathway for adaptive evolution and a tool for target identification. It is unclear though why this phenomenon applies to some drugs but not others. Here we gradually overexpressed antibiotic targets in Escherichia coli and found th...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms5296

    authors： Palmer AC,Kishony R

    更新日期：2014-07-01 00:00:00

  • Temporal control of gene expression by the pioneer factor Zelda through transient interactions in hubs.

    abstract：:Pioneer transcription factors can engage nucleosomal DNA, which leads to local chromatin remodeling and to the establishment of transcriptional competence. However, the impact of enhancer priming by pioneer factors on the temporal control of gene expression and on mitotic memory remains unclear. Here we employ quantit...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-07613-z

    authors： Dufourt J,Trullo A,Hunter J,Fernandez C,Lazaro J,Dejean M,Morales L,Nait-Amer S,Schulz KN,Harrison MM,Favard C,Radulescu O,Lagha M

    更新日期：2018-12-05 00:00:00

  • Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity.

    abstract：:Transthyretin (TTR) is a plasma homotetrameric protein implicated in fatal systemic amyloidoses. TTR tetramer dissociation precedes pathological TTR aggregation. Native state stabilizers are promising drugs to treat TTR amyloidoses. Here we repurpose tolcapone, an FDA-approved molecule for Parkinson's disease, as a po...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms10787

    authors： Sant'Anna R,Gallego P,Robinson LZ,Pereira-Henriques A,Ferreira N,Pinheiro F,Esperante S,Pallares I,Huertas O,Almeida MR,Reixach N,Insa R,Velazquez-Campoy A,Reverter D,Reig N,Ventura S

    更新日期：2016-02-23 00:00:00

  • Cascaded spintronic logic with low-dimensional carbon.

    abstract：:Remarkable breakthroughs have established the functionality of graphene and carbon nanotube transistors as replacements to silicon in conventional computing structures, and numerous spintronic logic gates have been presented. However, an efficient cascaded logic structure that exploits electron spin has not yet been d...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms15635

    authors： Friedman JS,Girdhar A,Gelfand RM,Memik G,Mohseni H,Taflove A,Wessels BW,Leburton JP,Sahakian AV

    更新日期：2017-06-05 00:00:00

  • Regional variation in health is predominantly driven by lifestyle rather than genetics.

    abstract：:Regional differences in health-related phenotypes have been detected between and within countries. In Scotland, regions differ for a variety of health-related traits and display differences in mean lifespan of up to 7.5 years. Both genetics and lifestyle differences are potential causes of this variation. Using data o...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-00497-5

    authors： Amador C,Xia C,Nagy R,Campbell A,Porteous D,Smith BH,Hastie N,Vitart V,Hayward C,Navarro P,Haley CS

    更新日期：2017-10-06 00:00:00

  • TREX exposes the RNA-binding domain of Nxf1 to enable mRNA export.

    abstract：:The metazoan TREX complex is recruited to mRNA during nuclear RNA processing and functions in exporting mRNA to the cytoplasm. Nxf1 is an mRNA export receptor, which binds processed mRNA and transports it through the nuclear pore complex. At present, the relationship between TREX and Nxf1 is not understood. Here we sh...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms2005

    authors： Viphakone N,Hautbergue GM,Walsh M,Chang CT,Holland A,Folco EG,Reed R,Wilson SA

    更新日期：2012-01-01 00:00:00

  • Publisher Correction: A square-root topological insulator with non-quantized indices realized with photonic Aharonov-Bohm cages.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Nature communications

    pub_type： 已发布勘误

    doi：10.1038/s41467-020-15252-6

    authors： Kremer M,Petrides I,Meyer E,Heinrich M,Zilberberg O,Szameit A

    更新日期：2020-04-08 00:00:00

  • Origin and structure of polar domains in doped molecular crystals.

    abstract：:Doping is a primary tool for the modification of the properties of materials. Occlusion of guest molecules in crystals generally reduces their symmetry by the creation of polar domains, which engender polarization and pyroelectricity in the doped crystals. Here we describe a molecular-level determination of the struct...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms13351

    authors： Meirzadeh E,Azuri I,Qi Y,Ehre D,Rappe AM,Lahav M,Kronik L,Lubomirsky I

    更新日期：2016-11-08 00:00:00

  • Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics.

    abstract：:Scalable, integrative methods to understand mechanisms that link genetic variants with phenotypes are needed. Here we derive a mathematical expression to compute PrediXcan (a gene mapping approach) results using summary data (S-PrediXcan) and show its accuracy and general robustness to misspecified reference sets. We ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-03621-1

    authors： Barbeira AN,Dickinson SP,Bonazzola R,Zheng J,Wheeler HE,Torres JM,Torstenson ES,Shah KP,Garcia T,Edwards TL,Stahl EA,Huckins LM,GTEx Consortium.,Nicolae DL,Cox NJ,Im HK

    更新日期：2018-05-08 00:00:00

  • The Glanville fritillary genome retains an ancient karyotype and reveals selective chromosomal fusions in Lepidoptera.

    abstract：:Previous studies have reported that chromosome synteny in Lepidoptera has been well conserved, yet the number of haploid chromosomes varies widely from 5 to 223. Here we report the genome (393 Mb) of the Glanville fritillary butterfly (Melitaea cinxia; Nymphalidae), a widely recognized model species in metapopulation ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms5737

    authors： Ahola V,Lehtonen R,Somervuo P,Salmela L,Koskinen P,Rastas P,Välimäki N,Paulin L,Kvist J,Wahlberg N,Tanskanen J,Hornett EA,Ferguson LC,Luo S,Cao Z,de Jong MA,Duplouy A,Smolander OP,Vogel H,McCoy RC,Qian K,Chong W

    更新日期：2014-09-05 00:00:00

  • Mechanisms of drug interactions between translation-inhibiting antibiotics.

    abstract：:Antibiotics that interfere with translation, when combined, interact in diverse and difficult-to-predict ways. Here, we explain these interactions by "translation bottlenecks": points in the translation cycle where antibiotics block ribosomal progression. To elucidate the underlying mechanisms of drug interactions bet...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-17734-z

    authors： Kavčič B,Tkačik G,Bollenbach T

    更新日期：2020-08-11 00:00:00

  • Validation of climate model-inferred regional temperature change for late-glacial Europe.

    abstract：:Comparisons of climate model hindcasts with independent proxy data are essential for assessing model performance in non-analogue situations. However, standardized palaeoclimate data sets for assessing the spatial pattern of past climatic change across continents are lacking for some of the most dynamic episodes of Ear...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms5914

    authors： Heiri O,Brooks SJ,Renssen H,Bedford A,Hazekamp M,Ilyashuk B,Jeffers ES,Lang B,Kirilova E,Kuiper S,Millet L,Samartin S,Toth M,Verbruggen F,Watson JE,van Asch N,Lammertsma E,Amon L,Birks HH,Birks HJ,Mortensen MF,H

    更新日期：2014-09-11 00:00:00

  • The plant-specific histone residue Phe41 is important for genome-wide H3.1 distribution.

    abstract：:The dynamic incorporation of histone variants influences chromatin structure and many biological processes. In Arabidopsis, the canonical variant H3.1 differs from H3.3 in four residues, one of which (H3.1Phe41) is unique and conserved in plants. However, its evolutionary significance remains unclear. Here, we show th...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-02976-9

    authors： Lu L,Chen X,Qian S,Zhong X

    更新日期：2018-02-12 00:00:00

  • High-order elastic multipoles as colloidal atoms.

    abstract：:Achieving and exceeding diversity of colloidal analogs of chemical elements and molecules as building blocks of matter has been the central goal and challenge of colloidal science ever since Einstein introduced the colloidal atom paradigm. Recent advances in colloids assembly have been achieved by exploiting the machi...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-09777-8

    authors： Senyuk B,Aplinc J,Ravnik M,Smalyukh II

    更新日期：2019-04-23 00:00:00

  • Elimination of HIV-1-infected cells by broadly neutralizing antibodies.

    abstract：:The Fc region of HIV-1 Env-specific broadly neutralizing antibodies (bNAbs) is required for suppressing viraemia, through mechanisms which remain poorly understood. Here, we identify bNAbs that exert antibody-dependent cellular cytotoxicity (ADCC) in cell culture and kill HIV-1-infected lymphocytes through natural kil...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms10844

    authors： Bruel T,Guivel-Benhassine F,Amraoui S,Malbec M,Richard L,Bourdic K,Donahue DA,Lorin V,Casartelli N,Noël N,Lambotte O,Mouquet H,Schwartz O

    更新日期：2016-03-03 00:00:00

  • Pink-beam serial crystallography.

    abstract：:Serial X-ray crystallography allows macromolecular structure determination at both X-ray free electron lasers (XFELs) and, more recently, synchrotron sources. The time resolution for serial synchrotron crystallography experiments has been limited to millisecond timescales with monochromatic beams. The polychromatic, "...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-01417-3

    authors： Meents A,Wiedorn MO,Srajer V,Henning R,Sarrou I,Bergtholdt J,Barthelmess M,Reinke PYA,Dierksmeyer D,Tolstikova A,Schaible S,Messerschmidt M,Ogata CM,Kissick DJ,Taft MH,Manstein DJ,Lieske J,Oberthuer D,Fischetti RF,C

    更新日期：2017-11-03 00:00:00

  • Small molecule regulated sgRNAs enable control of genome editing in E. coli by Cas9.

    abstract：:CRISPR-Cas9 has led to great advances in gene editing for a broad spectrum of applications. To further the utility of Cas9 there have been efforts to achieve temporal control over its nuclease activity. While different approaches have focused on regulation of CRISPR interference or editing in mammalian cells, none of ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-15226-8

    authors： Iwasaki RS,Ozdilek BA,Garst AD,Choudhury A,Batey RT

    更新日期：2020-03-13 00:00:00