TREX exposes the RNA-binding domain of Nxf1 to enable mRNA export.

abstract：:Martensitic transition is a solid-state phase transition involving cooperative movement of atoms, mostly studied in metallurgy. The main characteristics are low transition barrier, ultrafast kinetics, and structural reversibility. They are rarely observed in molecular crystals, and hence the origin and mechanism are l...

journal_title：Nature communications

authors： Chung H,Dudenko D,Zhang F,D'Avino G,Ruzié C,Richard A,Schweicher G,Cornil J,Beljonne D,Geerts Y,Diao Y

更新日期：2018-01-18 00:00:00

abstract：:Little is known about how our brains dynamically adapt for efficient functioning. Most previous work has focused on analyzing changes in co-fluctuations between a set of brain regions over several temporal segments of the data. We argue that by collapsing data in space or time, we stand to lose useful information abou...

journal_title：Nature communications

authors： Saggar M,Sporns O,Gonzalez-Castillo J,Bandettini PA,Carlsson G,Glover G,Reiss AL

更新日期：2018-04-11 00:00:00

abstract：:Quantum technologies promise a variety of exciting applications. Even though impressive progress has been achieved recently, a major bottleneck currently is the lack of practical certification techniques. The challenge consists of ensuring that classically intractable quantum devices perform as expected. Here we prese...

journal_title：Nature communications

authors： Aolita L,Gogolin C,Kliesch M,Eisert J

更新日期：2015-11-18 00:00:00

abstract：:Synthetic DNA-based data storage systems have received significant attention due to the promise of ultrahigh storage density and long-term stability. However, all known platforms suffer from high cost, read-write latency and error-rates that render them noncompetitive with modern storage devices. One means to avoid th...

journal_title：Nature communications

authors： Tabatabaei SK,Wang B,Athreya NBM,Enghiad B,Hernandez AG,Fields CJ,Leburton JP,Soloveichik D,Zhao H,Milenkovic O

更新日期：2020-04-08 00:00:00

abstract：:Modern science has developed well-defined and versatile sets of chemicals to perform many specific tasks, yet the diversity of these reagents is so large that it can be impractical for any one lab to stock everything they might need. At the same time, isssues of stability or limited supply mean these chemicals can be ...

journal_title：Nature communications

authors： Zalesskiy SS,Kitson PJ,Frei P,Bubliauskas A,Cronin L

更新日期：2019-12-02 00:00:00

abstract：:Magnetic skyrmion, a topologically stable spin-swirling object, can host emergent electromagnetism, as exemplified by the topological Hall effect and electric-current-driven skyrmion motion. To achieve efficient manipulation of nano-sized functional spin textures, it is imperative to exploit the resonant motion of sky...

journal_title：Nature communications

authors： Okamura Y,Kagawa F,Mochizuki M,Kubota M,Seki S,Ishiwata S,Kawasaki M,Onose Y,Tokura Y

更新日期：2013-01-01 00:00:00

abstract：:Translocating proteins across the double membrane of Gram-negative bacteria, type III secretion systems (T3SS) occur in two evolutionarily related forms: injectisomes, delivering virulence factors into host cells, and the flagellar system, secreting the polymeric filament used for motility. While both systems share re...

journal_title：Nature communications

authors： Notti RQ,Bhattacharya S,Lilic M,Stebbins CE

更新日期：2015-05-21 00:00:00

abstract：:Alteration of the gut microbiota has been associated with different gastrointestinal disorders. Normobiosis restoration by faecal microbiota transplantation (FMT) is considered a promising therapeutic approach, even if the mechanisms underlying its efficacy are at present largely unknown. Here we sought to elucidate t...

journal_title：Nature communications

authors： Burrello C,Garavaglia F,Cribiù FM,Ercoli G,Lopez G,Troisi J,Colucci A,Guglietta S,Carloni S,Guglielmetti S,Taverniti V,Nizzoli G,Bosari S,Caprioli F,Rescigno M,Facciotti F

更新日期：2018-12-05 00:00:00

abstract：:The Great Hungarian Plain was a crossroads of cultural transformations that have shaped European prehistory. Here we analyse a 5,000-year transect of human genomes, sampled from petrous bones giving consistently excellent endogenous DNA yields, from 13 Hungarian Neolithic, Copper, Bronze and Iron Age burials including...

journal_title：Nature communications

authors： Gamba C,Jones ER,Teasdale MD,McLaughlin RL,Gonzalez-Fortes G,Mattiangeli V,Domboróczki L,Kővári I,Pap I,Anders A,Whittle A,Dani J,Raczky P,Higham TF,Hofreiter M,Bradley DG,Pinhasi R

更新日期：2014-10-21 00:00:00

abstract：:Understanding how cellular functions emerge from the underlying molecular mechanisms is a key challenge in biology. This will require computational models, whose predictive power is expected to increase with coverage and precision of formulation. Genome-scale models revolutionised the metabolic field and made the firs...

journal_title：Nature communications

authors： Münzner U,Klipp E,Krantz M

更新日期：2019-03-21 00:00:00

abstract：:Ribosomes are essential intracellular machines composed of proteins and RNA molecules. The DNA sequences (rDNA) encoding ribosomal RNAs (rRNAs) are tandemly repeated and give origin to the nucleolus. Here we develop a computational method for estimating rDNA dosage (copy number) and mitochondrial DNA abundance using w...

journal_title：Nature communications

authors： Gibbons JG,Branco AT,Yu S,Lemos B

更新日期：2014-09-11 00:00:00

abstract：:D-Glucosamine (GlcN) is a freely available and commonly used dietary supplement potentially promoting cartilage health in humans, which also acts as an inhibitor of glycolysis. Here we show that GlcN, independent of the hexosamine pathway, extends Caenorhabditis elegans life span by impairing glucose metabolism that a...

journal_title：Nature communications

authors： Weimer S,Priebs J,Kuhlow D,Groth M,Priebe S,Mansfeld J,Merry TL,Dubuis S,Laube B,Pfeiffer AF,Schulz TJ,Guthke R,Platzer M,Zamboni N,Zarse K,Ristow M

更新日期：2014-04-08 00:00:00

abstract：:Heterozygous germline mutations in BRCA2 predispose to breast and ovarian cancer. Contrary to non-cancerous cells, where BRCA2 deletion causes cell cycle arrest or cell death, tumors carrying BRCA2 inactivation continue to proliferate. Here we set out to investigate adaptation to loss of BRCA2 focusing on genome-wide ...

journal_title：Nature communications

authors： Reisländer T,Lombardi EP,Groelly FJ,Miar A,Porru M,Di Vito S,Wright B,Lockstone H,Biroccio A,Harris A,Londoño-Vallejo A,Tarsounas M

更新日期：2019-07-17 00:00:00

abstract：:The development of transistors with high gain is essential for applications ranging from switching elements and drivers to transducers for chemical and biological sensing. Organic transistors have become well-established based on their distinct advantages, including ease of fabrication, synthetic freedom for chemical ...

journal_title：Nature communications

authors： Khodagholy D,Rivnay J,Sessolo M,Gurfinkel M,Leleux P,Jimison LH,Stavrinidou E,Herve T,Sanaur S,Owens RM,Malliaras GG

更新日期：2013-01-01 00:00:00

abstract：:A synthetic biology method based on heterologous biosynthesis coupled with genome mining is a promising approach for increasing the opportunities to rationally access natural product with novel structures and biological activities through total biosynthesis and combinatorial biosynthesis. Here, we demonstrate the adva...

journal_title：Nature communications

authors： Tsukada K,Shinki S,Kaneko A,Murakami K,Irie K,Murai M,Miyoshi H,Dan S,Kawaji K,Hayashi H,Kodama EN,Hori A,Salim E,Kuraishi T,Hirata N,Kanda Y,Asai T

更新日期：2020-04-14 00:00:00

abstract：:Identifying a bona fide population of cardiac stem cells (CSCs) is a critical step for developing cell-based therapies for heart failure patients. Previously, cardiac c-kit(+) cells were reported to be CSCs with a potential to become myocardial, endothelial and smooth muscle cells in vitro and after cardiac injury. He...

journal_title：Nature communications

authors： Sultana N,Zhang L,Yan J,Chen J,Cai W,Razzaque S,Jeong D,Sheng W,Bu L,Xu M,Huang GY,Hajjar RJ,Zhou B,Moon A,Cai CL

更新日期：2015-10-30 00:00:00

abstract：:In nature, protein subunits on the capsids of many icosahedral viruses form rotational patterns, and mathematicians also incorporate asymmetric patterns into faces of polyhedra. Chemists have constructed molecular polyhedra with vacant or highly symmetric faces, but very little is known about constructing polyhedra wi...

journal_title：Nature communications

authors： Wang X,Wang Y,Yang H,Fang H,Chen R,Sun Y,Zheng N,Tan K,Lu X,Tian Z,Cao X

更新日期：2016-08-24 00:00:00

abstract：:The indisputable role of epigenetics in cancer and the fact that epigenetic alterations can be reversed have favoured development of epigenetic drugs. In this study, we design and synthesize potent novel, selective and reversible chemical probes that simultaneously inhibit the G9a and DNMTs methyltransferase activity....

journal_title：Nature communications

authors： San José-Enériz E,Agirre X,Rabal O,Vilas-Zornoza A,Sanchez-Arias JA,Miranda E,Ugarte A,Roa S,Paiva B,Estella-Hermoso de Mendoza A,Alvarez RM,Casares N,Segura V,Martín-Subero JI,Ogi FX,Soule P,Santiveri CM,Campos-Olivas

更新日期：2017-05-26 00:00:00

abstract：:The development of drug resistance, the prime cause of failure in cancer therapy, is commonly explained by the selection of resistant mutant cancer cells. However, dynamic non-genetic heterogeneity of clonal cell populations continuously produces metastable phenotypic variants (persisters), some of which represent ste...

journal_title：Nature communications

authors： Pisco AO,Brock A,Zhou J,Moor A,Mojtahedi M,Jackson D,Huang S

更新日期：2013-01-01 00:00:00

abstract：:Macrophages play a pivotal role in tissue fibrogenesis, which underlies the pathogenesis of many end-stage chronic inflammatory diseases. MicroRNAs are key regulators of immune cell functions, but their roles in macrophage's fibrogenesis have not been characterized. Here we show that IL-4 and IL-13 induce miR-142-5p a...

journal_title：Nature communications

authors： Su S,Zhao Q,He C,Huang D,Liu J,Chen F,Chen J,Liao JY,Cui X,Zeng Y,Yao H,Su F,Liu Q,Jiang S,Song E

更新日期：2015-10-05 00:00:00

abstract：:Cell-to-cell variability (noise) is an important feature of gene expression that impacts cell fitness and development. The regulatory mechanism of this variability is not fully understood. Here we investigate the effect on gene expression noise in divergent gene pairs (DGPs). We generated reporters driven by divergent...

journal_title：Nature communications

authors： Yan C,Wu S,Pocetti C,Bai L

更新日期：2016-03-24 00:00:00

abstract：:Under pathophysiological conditions in adults, endothelial cells (ECs) sprout from pre-existing blood vessels to form new ones by a process termed angiogenesis. During embryonic development, Apelin (APLN) is robustly expressed in vascular ECs. In adult mice, however, APLN expression in the vasculature is significantly...

journal_title：Nature communications

authors： Liu Q,Hu T,He L,Huang X,Tian X,Zhang H,He L,Pu W,Zhang L,Sun H,Fang J,Yu Y,Duan S,Hu C,Hui L,Zhang H,Quertermous T,Xu Q,Red-Horse K,Wythe JD,Zhou B

更新日期：2015-01-19 00:00:00

abstract：:Samarium hexaboride is a classic three-dimensional mixed valence system with a high-temperature metallic phase that evolves into a paramagnetic charge insulator below 40 K. A number of recent experiments have suggested the possibility that the low-temperature insulating bulk hosts electrically neutral gapless fermioni...

journal_title：Nature communications

authors： Chowdhury D,Sodemann I,Senthil T

更新日期：2018-05-02 00:00:00

abstract：:Gamma-ray 'glows' are long duration (seconds to tens of minutes) X-ray and gamma-ray emission coming from thunderclouds. Measurements suggest the presence of relativistic runaway electron avalanches (RREA), the same process underlying terrestrial gamma-ray flashes. Here we demonstrate that glows are relatively a commo...

journal_title：Nature communications

authors： Kelley NA,Smith DM,Dwyer JR,Splitt M,Lazarus S,Martinez-McKinney F,Hazelton B,Grefenstette B,Lowell A,Rassoul HK

更新日期：2015-08-12 00:00:00

abstract：:Constitutive activation of Wnt/β-catenin inhibits oligodendrocyte myelination. Tcf7l2/Tcf4, a β-catenin transcriptional partner, is required for oligodendrocyte differentiation. How Tcf7l2 modifies β-catenin signalling and controls myelination remains elusive. Here we define a stage-specific Tcf7l2-regulated transcrip...

journal_title：Nature communications

authors： Zhao C,Deng Y,Liu L,Yu K,Zhang L,Wang H,He X,Wang J,Lu C,Wu LN,Weng Q,Mao M,Li J,van Es JH,Xin M,Parry L,Goldman SA,Clevers H,Lu QR

更新日期：2016-03-09 00:00:00

abstract：:High-angle grain boundaries are always the preferential fatigue cracking sites, while the intrinsic fatigue cracking mechanism of coherent twin boundary remains elusive. Here we systematically investigate the fatigue cracking behaviours of copper bicrystals with a coherent twin boundary as their sole internal boundary...

journal_title：Nature communications

authors： Li LL,Zhang ZJ,Zhang P,Wang ZG,Zhang ZF

更新日期：2014-03-26 00:00:00

abstract：:Ufuk Günesdogan was incorrectly associated with Center for Genetic Analysis of Behaviour, National Institute for Physiological Sciences, 5-1 Higashiyama Myodaiji, Okazaki, Aichi 444-8787, Japan and Toshihiro Kobayashi was incorrectly associated with Department of Developmental Biology, University of Göttingen, Götting...

journal_title：Nature communications

authors： Hackett JA,Huang Y,Günesdogan U,Gretarsson KA,Kobayashi T,Surani MA

更新日期：2018-12-11 00:00:00

abstract：:Due to the surge of natural gas production, feedstocks for chemicals shift towards lighter hydrocarbons, particularly methane. The success of a Gas-to-Chemicals process via synthesis gas (CO and H2) depends on the ability of catalysts to suppress methane and carbon dioxide formation. We designed a Co/Mn/Na/S catalyst,...

journal_title：Nature communications

authors： Xie J,Paalanen PP,van Deelen TW,Weckhuysen BM,Louwerse MJ,de Jong KP

更新日期：2019-01-11 00:00:00

abstract：:While many tools exist for identifying and quantifying individual cell types, few methods are available to assess the relationships between cell types in organs and tissues and how these relationships change during aging or disease states. We present a quantitative method for evaluating cellular organization, using th...

journal_title：Nature communications

authors： Sornborger A,Li J,Timmons C,Lupu F,Eggenschwiler J,Takahama Y,Manley NR

更新日期：2017-05-30 00:00:00

abstract：:Density functional theory (DFT) is the standard formalism to study the electronic structure of matter at the atomic scale. In Kohn-Sham DFT simulations, the balance between accuracy and computational cost depends on the choice of exchange and correlation functional, which only exists in approximate form. Here, we prop...

journal_title：Nature communications

authors： Dick S,Fernandez-Serra M

更新日期：2020-07-14 00:00:00