当前位置： SCI文献检索 > Nature Communications期刊下所有文献 > miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia.

miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia.

Abstract：

:HOXA9 and MEIS1 have essential oncogenic roles in mixed lineage leukaemia (MLL)-rearranged leukaemia. Here we show that they are direct targets of miRNA-196b, a microRNA (miRNA) located adjacent to and co-expressed with HOXA9, in MLL-rearranged leukaemic cells. Forced expression of miR-196b significantly delays MLL-fusion-mediated leukemogenesis in primary bone marrow transplantation through suppressing Hoxa9/Meis1 expression. However, ectopic expression of miR-196b results in more aggressive leukaemic phenotypes and causes much faster leukemogenesis in secondary transplantation than MLL fusion alone, likely through the further repression of Fas expression, a proapoptotic gene downregulated in MLL-rearranged leukaemia. Overexpression of FAS significantly inhibits leukemogenesis and reverses miR-196b-mediated phenotypes. Targeting Hoxa9/Meis1 and Fas by miR-196b is probably also important for normal haematopoiesis. Thus, our results uncover a previously unappreciated miRNA-regulation mechanism by which a single miRNA may target both oncogenes and tumour suppressors, simultaneously, or, sequentially, in tumourigenesis and normal development per cell differentiation, indicating that miRNA regulation is much more complex than previously thought.

journal_name

Nat Commun

journal_title

Nature communications

authors

Li Z,Huang H,Chen P,He M,Li Y,Arnovitz S,Jiang X,He C,Hyjek E,Zhang J,Zhang Z,Elkahloun A,Cao D,Shen C,Wunderlich M,Wang Y,Neilly MB,Jin J,Wei M,Lu J,Valk PJM,Delwel R,Lowenberg B,Le Beau MM,Vardiman J,M

doi

10.1038/ncomms1681

subject

Has Abstract

pub_date

2012-02-21 00:00:00

pages

688

issn

2041-1723

pii

10.1038/ncomms1681

journal_volume

3

pub_type

杂志文章

相关文献

Nature Communications文献大全
  • Information recovery from low coverage whole-genome bisulfite sequencing.

    abstract：:The cost of whole-genome bisulfite sequencing (WGBS) remains a bottleneck for many studies and it is therefore imperative to extract as much information as possible from a given dataset. This is particularly important because even at the recommend 30X coverage for reference methylomes, up to 50% of high-resolution fea...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms11306

    authors： Libertini E,Heath SC,Hamoudi RA,Gut M,Ziller MJ,Czyz A,Ruotti V,Stunnenberg HG,Frontini M,Ouwehand WH,Meissner A,Gut IG,Beck S

    更新日期：2016-06-27 00:00:00

  • Overcoming evanescent field decay using 3D-tapered nanocavities for on-chip targeted molecular analysis.

    abstract：:Enhancement of optical emission on plasmonic nanostructures is intrinsically limited by the distance between the emitter and nanostructure surface, owing to a tightly-confined and exponentially-decaying electromagnetic field. This fundamental limitation prevents efficient application of plasmonic fluorescence enhancem...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-16813-5

    authors： Kumar S,Park H,Cho H,Siddique RH,Narasimhan V,Yang D,Choo H

    更新日期：2020-06-10 00:00:00

  • Iron minerals within specific microfossil morphospecies of the 1.88 Ga Gunflint Formation.

    abstract：:Problematic microfossils dominate the palaeontological record between the Great Oxidation Event 2.4 billion years ago (Ga) and the last Palaeoproterozoic iron formations, deposited 500-600 million years later. These fossils are often associated with iron-rich sedimentary rocks, but their affinities, metabolism, and, h...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms14890

    authors： Lepot K,Addad A,Knoll AH,Wang J,Troadec D,Béché A,Javaux EJ

    更新日期：2017-03-23 00:00:00

  • Low frequency transcranial electrical stimulation does not entrain sleep rhythms measured by human intracranial recordings.

    abstract：:Transcranial electrical stimulation has widespread clinical and research applications, yet its effect on ongoing neural activity in humans is not well established. Previous reports argue that transcranial alternating current stimulation (tACS) can entrain and enhance neural rhythms related to memory, but the evidence ...

    journal_title：Nature communications

    pub_type： 临床试验,杂志文章

    doi：10.1038/s41467-017-01045-x

    authors： Lafon B,Henin S,Huang Y,Friedman D,Melloni L,Thesen T,Doyle W,Buzsáki G,Devinsky O,Parra LC,A Liu A

    更新日期：2017-10-31 00:00:00

  • 2N+4-rule and an atlas of bulk optical resonances of zigzag graphene nanoribbons.

    abstract：:Development of on-chip integrated carbon-based optoelectronic nanocircuits requires fast and non-invasive structural characterization of their building blocks. Recent advances in synthesis of single wall carbon nanotubes and graphene nanoribbons allow for their use as atomically precise building blocks. However, while...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-13728-8

    authors： Payod RB,Grassano D,Santos GNC,Levshov DI,Pulci O,Saroka VA

    更新日期：2020-01-03 00:00:00

  • Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma.

    abstract：:Diffuse Intrinsic Pontine Gliomas (DIPGs) are deadly paediatric brain tumours where needle biopsies help guide diagnosis and targeted therapies. To address spatial heterogeneity, here we analyse 134 specimens from various neuroanatomical structures of whole autopsy brains from nine DIPG patients. Evolutionary reconstr...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms11185

    authors： Nikbakht H,Panditharatna E,Mikael LG,Li R,Gayden T,Osmond M,Ho CY,Kambhampati M,Hwang EI,Faury D,Siu A,Papillon-Cavanagh S,Bechet D,Ligon KL,Ellezam B,Ingram WJ,Stinson C,Moore AS,Warren KE,Karamchandani J,Packer

    更新日期：2016-04-06 00:00:00

  • Ecscr regulates insulin sensitivity and predisposition to obesity by modulating endothelial cell functions.

    abstract：:Insulin resistance is closely associated with obesity and is one of the earliest symptoms of type-2 diabetes. Endothelial cells are involved in the pathogenesis of insulin resistance through their role in insulin delivery and adipose tissue angiogenesis. Here we show that Ecscr (endothelial cell surface expressed chem...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms3389

    authors： Akakabe Y,Koide M,Kitamura Y,Matsuo K,Ueyama T,Matoba S,Yamada H,Miyata K,Oike Y,Ikeda K

    更新日期：2013-01-01 00:00:00

  • Proteomic maps of breast cancer subtypes.

    abstract：:Systems-wide profiling of breast cancer has almost always entailed RNA and DNA analysis by microarray and sequencing techniques. Marked developments in proteomic technologies now enable very deep profiling of clinical samples, with high identification and quantification accuracy. We analysed 40 oestrogen receptor posi...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms10259

    authors： Tyanova S,Albrechtsen R,Kronqvist P,Cox J,Mann M,Geiger T

    更新日期：2016-01-04 00:00:00

  • SNHG5 promotes colorectal cancer cell survival by counteracting STAU1-mediated mRNA destabilization.

    abstract：:We currently have limited knowledge of the involvement of long non-coding RNAs (lncRNAs) in normal cellular processes and pathologies. Here, we identify and characterize SNHG5 as a stable cytoplasmic lncRNA with up-regulated expression in colorectal cancer. Depletion of SNHG5 induces cell cycle arrest and apoptosis in...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms13875

    authors： Damas ND,Marcatti M,Côme C,Christensen LL,Nielsen MM,Baumgartner R,Gylling HM,Maglieri G,Rundsten CF,Seemann SE,Rapin N,Thézenas S,Vang S,Ørntoft T,Andersen CL,Pedersen JS,Lund AH

    更新日期：2016-12-22 00:00:00

  • Haemodynamically dependent valvulogenesis of zebrafish heart is mediated by flow-dependent expression of miR-21.

    abstract：:Heartbeat is required for normal development of the heart, and perturbation of intracardiac flow leads to morphological defects resembling congenital heart diseases. These observations implicate intracardiac haemodynamics in cardiogenesis, but the signalling cascades connecting physical forces, gene expression and mor...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms2978

    authors： Banjo T,Grajcarek J,Yoshino D,Osada H,Miyasaka KY,Kida YS,Ueki Y,Nagayama K,Kawakami K,Matsumoto T,Sato M,Ogura T

    更新日期：2013-01-01 00:00:00

  • MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment.

    abstract：:Rather than targeting tumour cells directly, elements of the tumour microenvironment can be modulated to sensitize tumours to the effects of therapy. Here we report a unique mechanism by which ectopic microRNA-103 can manipulate tumour-associated endothelial cells to enhance tumour cell death. Using gain-and-loss of f...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms13597

    authors： Wilson R,Espinosa-Diez C,Kanner N,Chatterjee N,Ruhl R,Hipfinger C,Advani SJ,Li J,Khan OF,Franovic A,Weis SM,Kumar S,Coussens LM,Anderson DG,Chen CC,Cheresh DA,Anand S

    更新日期：2016-11-25 00:00:00

  • Identification of epilepsy-associated neuronal subtypes and gene expression underlying epileptogenesis.

    abstract：:Epilepsy is one of the most common neurological disorders, yet its pathophysiology is poorly understood due to the high complexity of affected neuronal circuits. To identify dysfunctional neuronal subtypes underlying seizure activity in the human brain, we have performed single-nucleus transcriptomics analysis of >110...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-18752-7

    authors： Pfisterer U,Petukhov V,Demharter S,Meichsner J,Thompson JJ,Batiuk MY,Asenjo-Martinez A,Vasistha NA,Thakur A,Mikkelsen J,Adorjan I,Pinborg LH,Pers TH,von Engelhardt J,Kharchenko PV,Khodosevich K

    更新日期：2020-10-07 00:00:00

  • A programmable epidermal microfluidic valving system for wearable biofluid management and contextual biomarker analysis.

    abstract：:Active biofluid management is central to the realization of wearable bioanalytical platforms that are poised to autonomously provide frequent, real-time, and accurate measures of biomarkers in epidermally-retrievable biofluids (e.g., sweat). Accordingly, here, a programmable epidermal microfluidic valving system is de...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-18238-6

    authors： Lin H,Tan J,Zhu J,Lin S,Zhao Y,Yu W,Hojaiji H,Wang B,Yang S,Cheng X,Wang Z,Tang E,Yeung C,Emaminejad S

    更新日期：2020-09-02 00:00:00

  • Structure and mechanism of an intramembrane liponucleotide synthetase central for phospholipid biosynthesis.

    abstract：:Phospholipids are elemental building-block molecules for biological membranes. Biosynthesis of phosphatidylinositol, phosphatidylglycerol and phosphatidylserine requires a central liponucleotide intermediate named cytidine-diphosphate diacylglycerol (CDP-DAG). The CDP-DAG synthetase (Cds) is an integral membrane enzym...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms5244

    authors： Liu X,Yin Y,Wu J,Liu Z

    更新日期：2014-06-27 00:00:00

  • Discovery of cationic nonribosomal peptides as Gram-negative antibiotics through global genome mining.

    abstract：:The worldwide prevalence of infections caused by antibiotic-resistant Gram-negative bacteria poses a serious threat to public health due to the limited therapeutic alternatives. Cationic peptides represent a large family of antibiotics and have attracted interest due to their diverse chemical structures and potential ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-05781-6

    authors： Li YX,Zhong Z,Zhang WP,Qian PY

    更新日期：2018-08-16 00:00:00

  • eEF2 and Ras-GAP SH3 domain-binding protein (G3BP1) modulate stress granule assembly during HIV-1 infection.

    abstract：:Stress granules (SG) are translationally silent sites of RNA triage induced by environmental stresses including viral infection. Here we show that HIV-1 Gag blocks SG assembly irrespective of eIF2α phosphorylation and even when SG assembly is forced by overexpression of Ras-GAP SH3 domain-binding protein (G3BP1) or TI...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms5819

    authors： Valiente-Echeverría F,Melnychuk L,Vyboh K,Ajamian L,Gallouzi IE,Bernard N,Mouland AJ

    更新日期：2014-09-17 00:00:00

  • Author Correction: P53 and mTOR signalling determine fitness selection through cell competition during early mouse embryonic development.

    abstract：:The original version of this article contained an error in the spelling of Juan Pedro Martinez-Barbera, which was incorrectly given as Juan Pedro Martinez Barbera. This error has now been corrected in both the PDF and HTML versions of the Article. ...

    journal_title：Nature communications

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/s41467-018-05718-z

    authors： Bowling S,Di Gregorio A,Sancho M,Pozzi S,Aarts M,Signore M,Schneider MD,Martinez-Barbera JP,Gil J,Rodríguez TA

    更新日期：2018-08-02 00:00:00

  • Overpumping leads to California groundwater arsenic threat.

    abstract：:Water resources are being challenged to meet domestic, agricultural, and industrial needs. To complement finite surface water supplies that are being stressed by changes in precipitation and increased demand, groundwater is increasingly being used. Sustaining groundwater use requires considering both water quantity an...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-04475-3

    authors： Smith R,Knight R,Fendorf S

    更新日期：2018-06-05 00:00:00

  • Telomerase reverse transcriptase promoter mutations in primary cutaneous melanoma.

    abstract：:We previously reported a disease segregating causal germline mutation in a melanoma family and recurrent somatic mutations in metastasized tumours from unrelated patients in the core promoter region of the telomerase reverse transcriptase (TERT) gene. Here we show that the TERT promoter mutations, besides causing an i...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms4401

    authors： Heidenreich B,Nagore E,Rachakonda PS,Garcia-Casado Z,Requena C,Traves V,Becker J,Soufir N,Hemminki K,Kumar R

    更新日期：2014-02-26 00:00:00

  • Full randomness from arbitrarily deterministic events.

    abstract：:Do completely unpredictable events exist? Classical physics excludes fundamental randomness. Although quantum theory makes probabilistic predictions, this does not imply that nature is random, as randomness should be certified without relying on the complete structure of the theory being used. Bell tests approach the ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms3654

    authors： Gallego R,Masanes L,De La Torre G,Dhara C,Aolita L,Acín A

    更新日期：2013-01-01 00:00:00

  • High-pressure synthesis of a polyethylene/zeolite nano-composite material.

    abstract：:Meso/micro-porous solids, such as zeolites, are complex materials used in an impressive range of applications. Here we photo-polymerized ethylene using non-catalytic high-pressure techniques at 0.5-1.5 GPa under ultraviolet (351-364 nm) irradiation on a sub-nanometre scale in the channels of a pure SiO2 zeolite, silic...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms2564

    authors： Santoro M,Gorelli FA,Bini R,Haines J,van der Lee A

    更新日期：2013-01-01 00:00:00

  • Generation of neutral and high-density electron-positron pair plasmas in the laboratory.

    abstract：:Electron-positron pair plasmas represent a unique state of matter, whereby there exists an intrinsic and complete symmetry between negatively charged (matter) and positively charged (antimatter) particles. These plasmas play a fundamental role in the dynamics of ultra-massive astrophysical objects and are believed to ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms7747

    authors： Sarri G,Poder K,Cole JM,Schumaker W,Di Piazza A,Reville B,Dzelzainis T,Doria D,Gizzi LA,Grittani G,Kar S,Keitel CH,Krushelnick K,Kuschel S,Mangles SP,Najmudin Z,Shukla N,Silva LO,Symes D,Thomas AG,Vargas M,Vieir

    更新日期：2015-04-23 00:00:00

  • High-energy-density dual-ion battery for stationary storage of electricity using concentrated potassium fluorosulfonylimide.

    abstract：:Graphite dual-ion batteries represent a potential battery concept for large-scale stationary storage of electricity, especially when constructed free of lithium and other chemical elements with limited natural reserves. Owing to their non-rocking-chair operation mechanism, however, the practical deployment of graphite...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-06923-6

    authors： Kravchyk KV,Bhauriyal P,Piveteau L,Guntlin CP,Pathak B,Kovalenko MV

    更新日期：2018-10-26 00:00:00

  • Dynamical trade-offs arise from antagonistic coevolution and decrease intraspecific diversity.

    abstract：:Trade-offs play an important role in evolution. Without trade-offs, evolution would maximize fitness of all traits leading to a "master of all traits". The shape of trade-offs has been shown to determine evolutionary trajectories and is often assumed to be static and independent of the actual evolutionary process. Her...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-01957-8

    authors： Huang W,Traulsen A,Werner B,Hiltunen T,Becks L

    更新日期：2017-12-12 00:00:00

  • Hemocyanin facilitates lignocellulose digestion by wood-boring marine crustaceans.

    abstract：:Woody (lignocellulosic) plant biomass is an abundant renewable feedstock, rich in polysaccharides that are bound into an insoluble fiber composite with lignin. Marine crustacean woodborers of the genus Limnoria are among the few animals that can survive on a diet of this recalcitrant material without relying on gut re...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-07575-2

    authors： Besser K,Malyon GP,Eborall WS,Paro da Cunha G,Filgueiras JG,Dowle A,Cruz Garcia L,Page SJ,Dupree R,Kern M,Gomez LD,Li Y,Elias L,Sabbadin F,Mohamad SE,Pesante G,Steele-King C,Ribeiro de Azevedo E,Polikarpov I,Dupree

    更新日期：2018-12-03 00:00:00

  • Hidden topological constellations and polyvalent charges in chiral nematic droplets.

    abstract：:Topology has an increasingly important role in the physics of condensed matter, quantum systems, material science, photonics and biology, with spectacular realizations of topological concepts in liquid crystals. Here we report on long-lived hidden topological states in thermally quenched, chiral nematic droplets, form...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms14594

    authors： Posnjak G,Čopar S,Muševič I

    更新日期：2017-02-21 00:00:00

  • Kinetic asymmetry allows macromolecular catalysts to drive an information ratchet.

    abstract：:Molecular machines carry out their function by equilibrium mechanical motions in environments that are far from thermodynamic equilibrium. The mechanically equilibrated character of the trajectories of the macromolecule has allowed development of a powerful theoretical description, reminiscent of Onsager's trajectory ...

    journal_title：Nature communications

    pub_type： 杂志文章,评审

    doi：10.1038/s41467-019-11402-7

    authors： Astumian RD

    更新日期：2019-08-23 00:00:00

  • Theoretical description and experimental simulation of quantum entanglement near open time-like curves via pseudo-density operators.

    abstract：:Closed timelike curves are striking predictions of general relativity allowing for time-travel. They are afflicted by notorious causality issues (e.g. grandfather's paradox). Quantum models where a qubit travels back in time solve these problems, at the cost of violating quantum theory's linearity-leading e.g. to univ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-08100-1

    authors： Marletto C,Vedral V,Virzì S,Rebufello E,Avella A,Piacentini F,Gramegna M,Degiovanni IP,Genovese M

    更新日期：2019-01-14 00:00:00

  • Distinct populations of cortical pyramidal neurons mediate drug reward and aversion.

    abstract：:Processing within the anterior cingulate cortex (ACC) is crucial for the patterning of appropriate behavior, and ACC dysfunction following chronic drug use is thought to play a major role in drug addiction. However, cortical pyramidal projection neurons can be subdivided into two major types (intratelencephalic (IT) a...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-20526-0

    authors： Garcia AF,Crummy EA,Webb IG,Nooney MN,Ferguson SM

    更新日期：2021-01-08 00:00:00

  • Genome engineering empowers the diatom Phaeodactylum tricornutum for biotechnology.

    abstract：:Diatoms, a major group of photosynthetic microalgae, have a high biotechnological potential that has not been fully exploited because of the paucity of available genetic tools. Here we demonstrate targeted and stable modifications of the genome of the marine diatom Phaeodactylum tricornutum, using both meganucleases a...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms4831

    authors： Daboussi F,Leduc S,Maréchal A,Dubois G,Guyot V,Perez-Michaut C,Amato A,Falciatore A,Juillerat A,Beurdeley M,Voytas DF,Cavarec L,Duchateau P

    更新日期：2014-05-29 00:00:00