Long livestock farming history and human landscape shaping revealed by lake sediment DNA.

abstract：:Knots are natural topologies of chains. Yet, little is known about spontaneous knot formation in a polypeptide chain-an event that can potentially impair its folding-and about the effect of a knot on the stability and folding kinetics of a protein. Here we used optical tweezers to show that the free energy cost to for...

journal_title：Nature communications

authors： Bustamante A,Sotelo-Campos J,Guerra DG,Floor M,Wilson CAM,Bustamante C,Báez M

更新日期：2017-11-17 00:00:00

abstract：:Biogenic furans are currently discussed as highly attractive alternative feedstock in a post-fossil society; thus, also the creation of sustainable furan valorization pathways appears of great importance. Here an artificial Achmatowicz monooxygenase activity for the aerobic ring expansion of furans is achieved by the ...

journal_title：Nature communications

authors： Thiel D,Doknić D,Deska J

更新日期：2014-10-22 00:00:00

abstract：:While molecular water-oxidation catalysts are remarkably rapid, oxidative and hydrolytic processes in water can convert their active transition metals to colloidal metal oxides or hydroxides that, while quite reactive, are insoluble or susceptible to precipitation. In response, we propose using oxidatively-inert ligan...

journal_title：Nature communications

authors： Chakraborty B,Gan-Or G,Raula M,Gadot E,Weinstock IA

更新日期：2018-11-20 00:00:00

abstract：:Hepatitis B virus causes chronic infections in 250 million people worldwide. Chronic hepatitis B virus carriers are at risk of developing fibrosis, cirrhosis, and hepatocellular carcinoma. A prophylactic vaccine exists and currently available antivirals can suppress but rarely cure chronic infections. The study of hep...

journal_title：Nature communications

authors： Winer BY,Huang TS,Pludwinski E,Heller B,Wojcik F,Lipkowitz GE,Parekh A,Cho C,Shrirao A,Muir TW,Novik E,Ploss A

更新日期：2017-07-25 00:00:00

abstract：:Poly-(ADP-ribose) polymerase inhibitors (PARPi) selectively kill breast and ovarian cancers with defects in homologous recombination (HR) caused by BRCA1/2 mutations. There is also clinical evidence for the utility of PARPi in breast and ovarian cancers without BRCA mutations, but the underlying mechanism is not clear...

journal_title：Nature communications

authors： Peng Y,Liao Q,Tan W,Peng C,Hu Z,Chen Y,Li Z,Li J,Zhen B,Zhu W,Li X,Yao Y,Song Q,Liu C,Qi X,He F,Pei H

更新日期：2019-03-15 00:00:00

abstract：:Most chemical vapor deposition methods for transition metal dichalcogenides use an extremely small amount of precursor to render large single-crystal flakes, which usually causes low coverage of the materials on the substrate. In this study, a self-capping vapor-liquid-solid reaction is proposed to fabricate large-gra...

journal_title：Nature communications

authors： Chang MC,Ho PH,Tseng MF,Lin FY,Hou CH,Lin IK,Wang H,Huang PP,Chiang CH,Yang YC,Wang IT,Du HY,Wen CY,Shyue JJ,Chen CW,Chen KH,Chiu PW,Chen LC

更新日期：2020-07-23 00:00:00

abstract：:In quantizing magnetic fields, graphene superlattices exhibit a complex fractal spectrum often referred to as the Hofstadter butterfly. It can be viewed as a collection of Landau levels that arise from quantization of Brown-Zak minibands recurring at rational (p/q) fractions of the magnetic flux quantum per superlatti...

journal_title：Nature communications

authors： Barrier J,Kumaravadivel P,Krishna Kumar R,Ponomarenko LA,Xin N,Holwill M,Mullan C,Kim M,Gorbachev RV,Thompson MD,Prance JR,Taniguchi T,Watanabe K,Grigorieva IV,Novoselov KS,Mishchenko A,Fal'ko VI,Geim AK,Berdyugin AI

更新日期：2020-11-13 00:00:00

abstract：:In all of the diverse areas of science where waves play an important role, one of the most fundamental solutions of the corresponding wave equation is a stationary wave with constant intensity. The most familiar example is that of a plane wave propagating in free space. In the presence of any Hermitian potential, a wa...

journal_title：Nature communications

authors： Makris KG,Musslimani ZH,Christodoulides DN,Rotter S

更新日期：2015-07-08 00:00:00

abstract：:Human immunoglobulin G (IgG) agonistic antibodies targeting costimulatory immunoreceptors represent promising cancer immunotherapies yet to be developed. Whether, and how, human IgG hinge and Fc impact on their agonistic functions have been disputed. Here, we show that different natural human IgGs confer divergent ago...

journal_title：Nature communications

authors： Liu X,Zhao Y,Shi H,Zhang Y,Yin X,Liu M,Zhang H,He Y,Lu B,Jin T,Li F

更新日期：2019-09-27 00:00:00

abstract：:Under climate warming, migratory birds should align reproduction dates with advancing plant and arthropod phenology. To arrive on the breeding grounds earlier, migrants may speed up spring migration by curtailing the time spent en route, possibly at the cost of decreased survival rates. Based on a decades-long series ...

journal_title：Nature communications

authors： Rakhimberdiev E,Duijns S,Karagicheva J,Camphuysen CJ,VRS Castricum.,Dekinga A,Dekker R,Gavrilov A,Ten Horn J,Jukema J,Saveliev A,Soloviev M,Tibbitts TL,van Gils JA,Piersma T

更新日期：2018-10-15 00:00:00

abstract：:Leads are a key feature of the Arctic ice pack during the winter owing to their substantial contribution to the surface energy balance. According to the present understanding, enhanced heat and moisture fluxes from high lead concentrations tend to produce more boundary layer clouds. However, described here in our comp...

journal_title：Nature communications

authors： Li X,Krueger SK,Strong C,Mace GG,Benson S

更新日期：2020-01-10 00:00:00

abstract：:Receptor families of the innate immune response engage in 'cross-talk' to tailor optimal immune responses against invading pathogens. However, these responses are subject to multiple levels of regulation to keep in check aberrant inflammatory signals. Here, we describe a role for the orphan receptor interleukin-17 rec...

journal_title：Nature communications

authors： Mellett M,Atzei P,Bergin R,Horgan A,Floss T,Wurst W,Callanan JJ,Moynagh PN

更新日期：2015-03-26 00:00:00

abstract：:Atmospheric iron affects the global carbon cycle by modulating ocean biogeochemistry through the deposition of soluble iron to the ocean. Iron emitted by anthropogenic (fossil fuel) combustion is a source of soluble iron that is currently considered less important than other soluble iron sources, such as mineral dust ...

journal_title：Nature communications

authors： Matsui H,Mahowald NM,Moteki N,Hamilton DS,Ohata S,Yoshida A,Koike M,Scanza RA,Flanner MG

更新日期：2018-04-23 00:00:00

abstract：:Monitoring the Earth's stress state plays a role in our understanding of an earthquake's mechanism and in the distribution of hazards. Crustal deformation due to the July 2019 earthquake sequence in Ridgecrest (California) that culminated in a preceding quake of magnitude (M) 6.4 and a subsequent M7.1 quake caused str...

journal_title：Nature communications

authors： Nanjo KZ

更新日期：2020-06-17 00:00:00

abstract：:Human activities are transforming grassland biomass via changing climate, elemental nutrients, and herbivory. Theory predicts that food-limited herbivores will consume any additional biomass stimulated by nutrient inputs ('consumer-controlled'). Alternatively, nutrient supply is predicted to increase biomass where her...

journal_title：Nature communications

authors： Borer ET,Harpole WS,Adler PB,Arnillas CA,Bugalho MN,Cadotte MW,Caldeira MC,Campana S,Dickman CR,Dickson TL,Donohue I,Eskelinen A,Firn JL,Graff P,Gruner DS,Heckman RW,Koltz AM,Komatsu KJ,Lannes LS,MacDougall AS,Mar

更新日期：2020-11-27 00:00:00

abstract：:In many dynamical systems and complex networks time delays appear naturally in feedback loops or coupling connections of individual elements. Moreover, in a whole class of systems, these delay times can depend on the state of the system. Nevertheless, so far the understanding of the impact of such state-dependent dela...

journal_title：Nature communications

authors： Martínez-Llinàs J,Porte X,Soriano MC,Colet P,Fischer I

更新日期：2015-06-17 00:00:00

abstract：:Central insulin is thought to act at the neural interface between metabolic and hedonic drives to eat. Here, using pharmacological fMRI, we show that intranasal insulin (INI) changes the value of food cues through modulation of mesolimbic pathways. Overnight fasted participants rated the palatability of food pictures ...

journal_title：Nature communications

authors： Tiedemann LJ,Schmid SM,Hettel J,Giesen K,Francke P,Büchel C,Brassen S

更新日期：2017-07-18 00:00:00

abstract：:Alkenes are fundamental functionalities in nature and highly useful intermediates in organic synthesis, medicinal chemistry and material sciences. Transition-metal-catalyzed Heck couplings with organic halides as electrophiles have been established as a powerful protocol for the synthesis of this valuable building blo...

journal_title：Nature communications

authors： Lv L,Zhu D,Li CJ

更新日期：2019-02-12 00:00:00

abstract：:High-dose ionizing radiation induces severe DNA damage in the epithelial stem cells in small intestinal crypts and causes gastrointestinal syndrome (GIS). Although the tumour suppressor p53 is a primary factor inducing death of crypt cells with DNA damage, its essential role in maintaining genome stability means inhib...

journal_title：Nature communications

authors： Takemura N,Kawasaki T,Kunisawa J,Sato S,Lamichhane A,Kobiyama K,Aoshi T,Ito J,Mizuguchi K,Karuppuchamy T,Matsunaga K,Miyatake S,Mori N,Tsujimura T,Satoh T,Kumagai Y,Kawai T,Standley DM,Ishii KJ,Kiyono H,Akira S,

更新日期：2014-03-18 00:00:00

abstract：:Canonical Wnt signaling is crucial for vascularization of the central nervous system and blood-brain barrier (BBB) formation. BBB formation and modulation are not only important for development, but also relevant for vascular and neurodegenerative diseases. However, there is little understanding of how Wnt signaling c...

journal_title：Nature communications

authors： Hübner K,Cabochette P,Diéguez-Hurtado R,Wiesner C,Wakayama Y,Grassme KS,Hubert M,Guenther S,Belting HG,Affolter M,Adams RH,Vanhollebeke B,Herzog W

更新日期：2018-11-19 00:00:00

abstract：:Modern ultrafast metrology relies on the postulate that the pulse to be measured is fully coherent, that is, that it can be completely described by its spectrum and spectral phase. However, synthesizing fully coherent pulses is not always possible in practice, especially in the domain of emerging ultrashort X-ray sour...

journal_title：Nature communications

authors： Bourassin-Bouchet C,Couprie ME

更新日期：2015-03-06 00:00:00

abstract：:A recent review concluded that earthworm presence increases CO₂ emissions by 33% but does not affect soil organic carbon stocks. However, the findings are controversial and raise new questions. Here we hypothesize that neither an increase in CO₂ emission nor in stabilized carbon would entirely reflect the earthworms' ...

journal_title：Nature communications

authors： Zhang W,Hendrix PF,Dame LE,Burke RA,Wu J,Neher DA,Li J,Shao Y,Fu S

更新日期：2013-01-01 00:00:00

abstract：:Foxp3+ regulatory T (Treg) cells are essential for maintaining peripheral tolerance and preventing autoimmunity. While genetic factors may predispose for autoimmunity, additional environmental triggers, such as viral infections, are usually required to initiate the onset of disease. Here, we show that viral infection ...

journal_title：Nature communications

authors： Schorer M,Lambert K,Rakebrandt N,Rost F,Kao KC,Yermanos A,Spörri R,Oderbolz J,Raeber ME,Keller CW,Lünemann JD,Rogler G,Boyman O,Oxenius A,Joller N

更新日期：2020-03-23 00:00:00

abstract：:Creating micro/nanostructures on fibers is beneficial for extending the application range of fiber-based devices. To achieve this using thermal fiber drawing is particularly important for the mass production of longitudinally uniform fibers up to tens of kilometers. However, the current thermal fiber drawing technique...

journal_title：Nature communications

authors： Wang Z,Wu T,Wang Z,Zhang T,Chen M,Zhang J,Liu L,Qi M,Zhang Q,Yang J,Liu W,Chen H,Luo Y,Wei L

更新日期：2020-07-31 00:00:00

abstract：:Enantioenriched 1,4-dienes are versatile building blocks in asymmetric synthesis, therefore their efficient synthesis directly from chemical feedstock is highly sought after. Here, we show an enantioselective cross-hydroalkenylation of cyclic 1,3-diene and hetero-substituted terminal olefin by using a chiral [NHC-Ni(a...

journal_title：Nature communications

authors： Chen Y,Dang L,Ho CY

更新日期：2020-05-08 00:00:00

abstract：:Replication-Factor-C (RFC) and RFC-like complexes (RLCs) mediate chromatin engagement of the proliferating cell nuclear antigen (PCNA). It remains controversial how RFC and RLCs cooperate to regulate PCNA loading and unloading. Here, we show the distinct PCNA loading or unloading activity of each clamp loader. ATAD5-R...

journal_title：Nature communications

authors： Kang MS,Ryu E,Lee SW,Park J,Ha NY,Ra JS,Kim YJ,Kim J,Abdel-Rahman M,Park SH,Lee KY,Kim H,Kang S,Myung K

更新日期：2019-06-03 00:00:00

abstract：:Nano-sized metal particles are attracting much interest in industrial and biomedical applications due to the recent progress and development of nanotechnology, and the surface-modifications by appropriate polymers are key techniques to stably express their characteristics. Herein, we applied cyclic poly(ethylene glyco...

journal_title：Nature communications

authors： Wang Y,Quinsaat JEQ,Ono T,Maeki M,Tokeshi M,Isono T,Tajima K,Satoh T,Sato SI,Miura Y,Yamamoto T

更新日期：2020-11-30 00:00:00

abstract：:The same odorant can induce attractive or repulsive responses depending on its concentration in various animals including humans. However, little is understood about the neuronal basis of this behavioural phenomenon. Here we show that Caenorhabditis elegans avoids high concentrations of odorants that are attractive at...

journal_title：Nature communications

authors： Yoshida K,Hirotsu T,Tagawa T,Oda S,Wakabayashi T,Iino Y,Ishihara T

更新日期：2012-03-13 00:00:00

abstract：:Electric fields can transform materials with respect to their structure and properties, enabling various applications ranging from batteries to spintronics. Recently electrolytic gating, which can generate large electric fields and voltage-driven ion transfer, has been identified as a powerful means to achieve electri...

journal_title：Nature communications

authors： Yi D,Wang Y,van ʼt Erve OMJ,Xu L,Yuan H,Veit MJ,Balakrishnan PP,Choi Y,N'Diaye AT,Shafer P,Arenholz E,Grutter A,Xu H,Yu P,Jonker BT,Suzuki Y

更新日期：2020-02-14 00:00:00

abstract：:Tuning the thermodynamic state of a material has a tremendous impact on its performance. In the case of polymers placed in proximity of a solid wall, this is possible by annealing above the glass transition temperature, Tg, which induces the formation of an adsorbed layer. Whether heating to higher temperatures would ...

journal_title：Nature communications

authors： Monnier X,Napolitano S,Cangialosi D

更新日期：2020-08-28 00:00:00