Abstract:
:Transforming growth factor-β (TGF-β) signaling and microRNAs (miRNAs) are important gene regulatory components in cancer. Usually in advanced malignant stages, TGF-β signaling is elevated but global miRNA expression is suppressed. Such a gene expression signature is well illustrated in a fibrosis (or mesenchymal) subtype of ovarian cancer (OC) that is of poor prognosis. However, the interplay between the two pathways in the OC subtype has not yet been elucidated. nc886 is a recently identified non-coding RNA implicated in several malignancies. The high expression of nc886 is associated with poor prognosis in 285 OC patients. Herein, we find that in OC nc886 expression is induced by TGF-β and that nc886 binds to Dicer to inhibit miRNA maturation. By preventing the miRNA pathway, nc886 emulates TGF-β in gene expression patterns and potentiates cell adhesion, migration, invasion, and drug resistance. Here we report nc886 to be a molecular link between the TGF-β and miRNA pathways.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Ahn JH,Lee HS,Lee JS,Lee YS,Park JL,Kim SY,Hwang JA,Kunkeaw N,Jung SY,Kim TJ,Lee KS,Jeon SH,Lee I,Johnson BH,Choi JH,Lee YSdoi
10.1038/s41467-018-03556-7subject
Has Abstractpub_date
2018-03-21 00:00:00pages
1166issue
1issn
2041-1723pii
10.1038/s41467-018-03556-7journal_volume
9pub_type
杂志文章abstract::The Tie receptors with their Angiopoietin ligands act as regulators of angiogenesis and vessel maturation. Tie2 exerts its functions through its supposed endothelial-specific expression. Yet, Tie2 is also expressed at lower levels by pericytes and it has not been unravelled through which mechanisms pericyte Angiopoiet...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms16106
更新日期:2017-07-18 00:00:00
abstract::The application of nanoparticle drug formulations, such as nanoliposomal doxorubicin (Doxil), is increasingly integrated in clinical cancer care. Despite nanomedicine's remarkable potential and growth over the last three decades, its clinical benefits for cancer patients vary. Here we report a non-invasive quantitativ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11838
更新日期:2016-06-20 00:00:00
abstract::Post-transcriptional regulation of cellular mRNA is essential for protein synthesis. Here we describe the importance of mRNA translational repression and mRNA subcellular location for protein expression during B lymphocyte activation and the DNA damage response. Cytoplasmic RNA granules are formed upon cell activation...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00454-2
更新日期:2017-09-13 00:00:00
abstract::Here, to overcome many limitations accompanying current available methods to detect protein-protein interactions (PPIs), we develop a live cell method called Split Intein-Mediated Protein Ligation (SIMPL). In this approach, bait and prey proteins are respectively fused to an intein N-terminal fragment (IN) and C-termi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16299-1
更新日期:2020-05-15 00:00:00
abstract::One-fourth of Plasmodium falciparum proteins have asparagine repeats that increase the propensity for aggregation, especially at elevated temperatures that occur routinely in malaria-infected patients. Here we report that a Plasmodium Asn repeat-containing protein (PFI1155w) formed aggregates in mammalian cells at feb...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2306
更新日期:2012-01-01 00:00:00
abstract::Nucleoplasmin (Npm) is a highly conserved histone chaperone responsible for the maternal storage and zygotic release of histones H2A/H2B. Npm contains a pentameric N-terminal core domain and an intrinsically disordered C-terminal tail domain. Though intrinsically disordered regions are common among histone chaperones,...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02308-3
更新日期:2017-12-20 00:00:00
abstract::We present Biomedisa, a free and easy-to-use open-source online platform developed for semi-automatic segmentation of large volumetric images. The segmentation is based on a smart interpolation of sparsely pre-segmented slices taking into account the complete underlying image data. Biomedisa is particularly valuable w...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19303-w
更新日期:2020-11-04 00:00:00
abstract::Conventional rigid electronic systems use a number of metallization layers to route all necessary connections to and from isolated surface mount devices using well-established printed circuit board technology. In contrast, present solutions to prepare stretchable electronic systems are typically confined to a single s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12870-7
更新日期:2019-10-28 00:00:00
abstract::Gastrin-releasing peptide (GRP) functions as a neurotransmitter for non-histaminergic itch, but its site of action (sensory neurons vs spinal cord) remains controversial. To determine the role of GRP in sensory neurons, we generated a floxed Grp mouse line. We found that conditional knockout of Grp in sensory neurons ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15230-y
更新日期:2020-03-13 00:00:00
abstract::The exocyst is an essential component of the secretory pathway required for delivery of basolateral proteins to the plasma membranes of epithelial cells. Delivery occurs adjacent to tight junctions (TJ), suggesting that it recognizes a receptor at this location. However, no such receptor has been identified. The Par3 ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14867
更新日期:2017-03-30 00:00:00
abstract::The European steppes and their biota have been hypothesized to be either young remnants of the Pleistocene steppe belt or, alternatively, to represent relicts of long-term persisting populations; both scenarios directly bear on nature conservation priorities. Here, we evaluate the conservation value of threatened disj...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15620-2
更新日期:2020-04-23 00:00:00
abstract::Anion-π interactions occur on the surface of π-acidic aromatic planes with positive quadrupole moments. Their ability to contribute to the binding and transport of anions has been demonstrated recently. However, their ability to stabilize anionic reactive intermediates and transition states remains essentially unexplo...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4911
更新日期:2014-05-21 00:00:00
abstract::Hox genes have been shown to be essential in vertebrate neural circuit formation and their depletion has resulted in homeotic transformations with neuron loss and miswiring. Here we quantifiy four eye movements in the zebrafish mutant valentino and hox3 knockdowns, and find that contrary to the classical model, oculom...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5221
更新日期:2014-06-25 00:00:00
abstract::Nacre-mimetics hold great promise as mechanical high-performance and functional materials. Here we demonstrate large progress of mechanical and functional properties of self-assembled polymer/nanoclay nacre-mimetics by using synthetic nanoclays with aspect ratios covering three orders in magnitude (25-3,500). We estab...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6967
更新日期:2015-01-20 00:00:00
abstract::Nanocarrier administration has primarily been restricted to intermittent bolus injections with limited available options for sustained delivery in vivo. Here, we demonstrate that cylinder-to-sphere transitions of self-assembled filomicelle (FM) scaffolds can be employed for sustained delivery of monodisperse micellar ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03001-9
更新日期:2018-02-12 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 已发布勘误
doi:10.1038/s41467-019-11801-w
更新日期:2019-08-19 00:00:00
abstract::Acute kidney injury (AKI) is considered largely reversible based on the capacity of surviving tubular cells to dedifferentiate and replace lost cells via cell division. Here we show by tracking individual tubular cells in conditional Pax8/Confetti mice that kidney function is recovered after AKI despite substantial t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03753-4
更新日期:2018-04-09 00:00:00
abstract::Topological insulators do not allow conduction in the bulk, yet they support edge modes that travel along the boundary only in one direction, determined by the carried electron spin, with inherent robustness to defects and disorder. Topological insulators have inspired analogues in photonics and optics, in which one-w...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9260
更新日期:2015-10-06 00:00:00
abstract::To function, biomolecules require sufficient specificity of interaction as well as stability to live in the cell while still being able to move. Thermodynamic stability of only a limited number of specific structures is important so as to prevent promiscuous interactions. The individual interactions in proteins, there...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19560-9
更新日期:2020-11-23 00:00:00
abstract::Considerable interest has been devoted to converting mechanical energy into electricity using polymer nanofibres. In particular, piezoelectric nanofibres produced by electrospinning have shown remarkable mechanical energy-to-electricity conversion ability. However, there is little data for the acoustic-to-electric con...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11108
更新日期:2016-03-23 00:00:00
abstract::Neutrophilic granulocytes are able to release their own DNA as neutrophil extracellular traps (NETs) to capture and eliminate pathogens. DNA expulsion (NETosis) has also been documented for other cells and organisms, thus highlighting the evolutionary conservation of this process. Moreover, dysregulated NETosis has be...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06263-5
更新日期:2018-09-14 00:00:00
abstract::Monomeric near-infrared (NIR) fluorescent proteins (FPs) are in high demand as protein tags and components of biosensors for deep-tissue imaging and multicolour microscopy. We report three bright and spectrally distinct monomeric NIR FPs, termed miRFPs, engineered from bacterial phytochrome, which can be used as easil...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12405
更新日期:2016-08-19 00:00:00
abstract::Insulin resistance is closely associated with obesity and is one of the earliest symptoms of type-2 diabetes. Endothelial cells are involved in the pathogenesis of insulin resistance through their role in insulin delivery and adipose tissue angiogenesis. Here we show that Ecscr (endothelial cell surface expressed chem...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3389
更新日期:2013-01-01 00:00:00
abstract::Human land use may detrimentally affect biodiversity, yet long-term stability of species communities is vital for maintaining ecosystem functioning. Community stability can be achieved by higher species diversity (portfolio effect), higher asynchrony across species (insurance hypothesis) and higher abundance of popula...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10697
更新日期:2016-02-12 00:00:00
abstract::Strain engineering is widely used in material science to tune the (opto-)electronic properties of materials and enhance the performance of devices. Two-dimensional atomic crystals are a versatile playground to study the influence of strain, as they can sustain very large deformations without breaking. Various optical ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-02830-y
更新日期:2018-02-06 00:00:00
abstract::Processive chitinase is a linear molecular motor which moves on the surface of crystalline chitin driven by processive hydrolysis of single chitin chain. Here, we analyse the mechanism underlying unidirectional movement of Serratia marcescens chitinase A (SmChiA) using high-precision single-molecule imaging, X-ray cry...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06362-3
更新日期:2018-09-19 00:00:00
abstract::Microfluidics by soft lithography has proven to be of key importance for biophysics and life science research. While being based on replicating structures of a master mold using benchtop devices, design modifications are time consuming and require sophisticated cleanroom equipment. Here, we introduce virtual fluidic c...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15813-9
更新日期:2020-05-04 00:00:00
abstract::Building a population-specific catalogue of single nucleotide variants (SNVs), indels and structural variants (SVs) with frequencies, termed a national pan-genome, is critical for further advancing clinical and public health genetics in large cohorts. Here we report a Danish pan-genome obtained from sequencing 10 trio...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6969
更新日期:2015-01-19 00:00:00
abstract::Engineering catalytic sites at the atomic level provides an opportunity to understand the catalyst's active sites, which is vital to the development of improved catalysts. Here we show a reliable and tunable polyoxometalate template-based synthetic strategy to atomically engineer metal doping sites onto metallic 1T-Mo...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08877-9
更新日期:2019-02-28 00:00:00
abstract::Iminium catalysis, involving the transformation of iminium ions to enamines, has been extensively studied in the context of a number of organic processes. However, the reverse of this process involving conversion of enamines to iminium species has not been realized. Here, we describe a new transformation-'oxidative en...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1214
更新日期:2011-01-01 00:00:00