当前位置： SCI文献检索 > Nature Communications期刊下所有文献 > Ecscr regulates insulin sensitivity and predisposition to obesity by modulating endothelial cell functions.

Ecscr regulates insulin sensitivity and predisposition to obesity by modulating endothelial cell functions.

Abstract：

:Insulin resistance is closely associated with obesity and is one of the earliest symptoms of type-2 diabetes. Endothelial cells are involved in the pathogenesis of insulin resistance through their role in insulin delivery and adipose tissue angiogenesis. Here we show that Ecscr (endothelial cell surface expressed chemotaxis and apoptosis regulator; also known as ARIA), the transmembrane protein that regulates endothelial cell signalling, is highly expressed in white and brown adipose tissues, and regulates energy metabolism and glucose homeostasis by modulating endothelial cell functions. Ecscr-deficient mice fed a normal chow show improved glucose tolerance and enhanced insulin sensitivity. We demonstrate that Ecscr deletion enhances the insulin-mediated Akt/endothelial nitric oxide synthase activation in endothelial cells, which increases insulin delivery into the skeletal muscle. Ecscr deletion also protects mice on a high-fat diet from obesity and obesity-related metabolic disorders by enhancing adipose tissue angiogenesis. Conversely, targeted activation of Ecscr in endothelial cells impairs glucose tolerance and predisposes mice to diet-induced obesity. Our results suggest that the inactivation of Ecscr enhances insulin sensitivity and may represent a new therapeutic strategy for treating metabolic syndrome.

journal_name

Nat Commun

journal_title

Nature communications

authors

Akakabe Y,Koide M,Kitamura Y,Matsuo K,Ueyama T,Matoba S,Yamada H,Miyata K,Oike Y,Ikeda K

doi

10.1038/ncomms3389

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

2389

issn

2041-1723

pii

ncomms3389

journal_volume

4

pub_type

杂志文章

相关文献

Nature Communications文献大全
  • Ultra-low carrier concentration and surface-dominant transport in antimony-doped Bi₂Se₃ topological insulator nanoribbons.

    abstract：:A topological insulator is the state of quantum matter possessing gapless spin-locking surface states across the bulk band gap, which has created new opportunities from novel electronics to energy conversion. However, the large concentration of bulk residual carriers has been a major challenge for revealing the proper...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms1771

    authors： Hong SS,Cha JJ,Kong D,Cui Y

    更新日期：2012-03-27 00:00:00

  • Resolving Dirac electrons with broadband high-resolution NMR.

    abstract：:Detecting the metallic Dirac electronic states on the surface of Topological Insulators (TIs) is critical for the study of important surface quantum properties (SQPs), such as Majorana zero modes, where simultaneous probing of the bulk and edge electron states is required. However, there is a particular shortage of ex...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-14838-4

    authors： Papawassiliou W,Jaworski A,Pell AJ,Jang JH,Kim Y,Lee SC,Kim HJ,Alwahedi Y,Alhassan S,Subrati A,Fardis M,Karagianni M,Panopoulos N,Dolinšek J,Papavassiliou G

    更新日期：2020-03-09 00:00:00

  • miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia.

    abstract：:HOXA9 and MEIS1 have essential oncogenic roles in mixed lineage leukaemia (MLL)-rearranged leukaemia. Here we show that they are direct targets of miRNA-196b, a microRNA (miRNA) located adjacent to and co-expressed with HOXA9, in MLL-rearranged leukaemic cells. Forced expression of miR-196b significantly delays MLL-fu...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms1681

    authors： Li Z,Huang H,Chen P,He M,Li Y,Arnovitz S,Jiang X,He C,Hyjek E,Zhang J,Zhang Z,Elkahloun A,Cao D,Shen C,Wunderlich M,Wang Y,Neilly MB,Jin J,Wei M,Lu J,Valk PJM,Delwel R,Lowenberg B,Le Beau MM,Vardiman J,M

    更新日期：2012-02-21 00:00:00

  • The neuropeptide NLP-22 regulates a sleep-like state in Caenorhabditis elegans.

    abstract：:Neuropeptides have central roles in the regulation of homoeostatic behaviours such as sleep and feeding. Caenorhabditis elegans displays sleep-like quiescence of locomotion and feeding during a larval transition stage called lethargus and feeds during active larval and adult stages. Here we show that the neuropeptide ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms3846

    authors： Nelson MD,Trojanowski NF,George-Raizen JB,Smith CJ,Yu CC,Fang-Yen C,Raizen DM

    更新日期：2013-01-01 00:00:00

  • Ultralong UV/mechano-excited room temperature phosphorescence from purely organic cluster excitons.

    abstract：:Purely organic room temperature phosphorescence (RTP) has attracted wide attention recently due to its various application potentials. However, ultralong RTP (URTP) with high efficiency is still rarely achieved. Herein, by dissolving 1,8-naphthalic anhydride in certain organic solid hosts, URTP with a lifetime of over...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-13048-x

    authors： Zhang X,Du L,Zhao W,Zhao Z,Xiong Y,He X,Gao PF,Alam P,Wang C,Li Z,Leng J,Liu J,Zhou C,Lam JWY,Phillips DL,Zhang G,Tang BZ

    更新日期：2019-11-14 00:00:00

  • Optical gating and streaking of free electrons with sub-optical cycle precision.

    abstract：:The temporal resolution of ultrafast electron diffraction and microscopy experiments is currently limited by the available experimental techniques for the generation and characterization of electron bunches with single femtosecond or attosecond durations. Here, we present proof of principle experiments of an optical g...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms14342

    authors： Kozák M,McNeur J,Leedle KJ,Deng H,Schönenberger N,Ruehl A,Hartl I,Harris JS,Byer RL,Hommelhoff P

    更新日期：2017-01-25 00:00:00

  • MUC1-C regulates lineage plasticity driving progression to neuroendocrine prostate cancer.

    abstract：:Neuroendocrine prostate cancer (NEPC) is an aggressive malignancy with no effective targeted therapies. The oncogenic MUC1-C protein is overexpressed in castration-resistant prostate cancer (CRPC) and NEPC, but its specific role is unknown. Here, we demonstrate that upregulation of MUC1-C in androgen-dependent PC cell...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-14219-6

    authors： Yasumizu Y,Rajabi H,Jin C,Hata T,Pitroda S,Long MD,Hagiwara M,Li W,Hu Q,Liu S,Yamashita N,Fushimi A,Kui L,Samur M,Yamamoto M,Zhang Y,Zhang N,Hong D,Maeda T,Kosaka T,Wong KK,Oya M,Kufe D

    更新日期：2020-01-17 00:00:00

  • Dynamic changes of muscle insulin sensitivity after metabolic surgery.

    abstract：:The mechanisms underlying improved insulin sensitivity after surgically-induced weight loss are still unclear. We monitored skeletal muscle metabolism in obese individuals before and over 52 weeks after metabolic surgery. Initial weight loss occurs in parallel with a decrease in muscle oxidative capacity and respirato...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-12081-0

    authors： Gancheva S,Ouni M,Jelenik T,Koliaki C,Szendroedi J,Toledo FGS,Markgraf DF,Pesta DH,Mastrototaro L,De Filippo E,Herder C,Jähnert M,Weiss J,Strassburger K,Schlensak M,Schürmann A,Roden M

    更新日期：2019-09-13 00:00:00

  • Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin.

    abstract：:Synaptic vesicle (SV) exocytosis is mediated by SNARE proteins. Reconstituted SNAREs are constitutively active, so a major focus has been to identify fusion clamps that regulate their activity in synapses: the primary candidates are synaptotagmin (syt) 1 and complexin I/II. Syt1 is a Ca2+ sensor for SV release that bi...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-12015-w

    authors： Courtney NA,Bao H,Briguglio JS,Chapman ER

    更新日期：2019-09-09 00:00:00

  • Collective dynamics of strain-coupled nanomechanical pillar resonators.

    abstract：:Semiconductur nano- and micropillars represent a promising platform for hybrid nanodevices. Their ability to couple to a broad variety of nanomechanical, acoustic, charge, spin, excitonic, polaritonic, or electromagnetic excitations is utilized in fields as diverse as force sensing or optoelectronics. In order to full...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-13309-9

    authors： Doster J,Hoenl S,Lorenz H,Paulitschke P,Weig EM

    更新日期：2019-11-20 00:00:00

  • RNA structure determination by solid-state NMR spectroscopy.

    abstract：:Knowledge of the RNA three-dimensional structure, either in isolation or as part of RNP complexes, is fundamental to understand the mechanism of numerous cellular processes. Because of its flexibility, RNA represents a challenge for crystallization, while the large size of cellular complexes brings solution-state NMR ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms8024

    authors： Marchanka A,Simon B,Althoff-Ospelt G,Carlomagno T

    更新日期：2015-05-11 00:00:00

  • Direct RNA sequencing reveals m6A modifications on adenovirus RNA are necessary for efficient splicing.

    abstract：:Adenovirus is a nuclear replicating DNA virus reliant on host RNA processing machinery. Processing and metabolism of cellular RNAs can be regulated by METTL3, which catalyzes the addition of N6-methyladenosine (m6A) to mRNAs. While m6A-modified adenoviral RNAs have been previously detected, the location and function o...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-19787-6

    authors： Price AM,Hayer KE,McIntyre ABR,Gokhale NS,Abebe JS,Della Fera AN,Mason CE,Horner SM,Wilson AC,Depledge DP,Weitzman MD

    更新日期：2020-11-26 00:00:00

  • MreB polymers and curvature localization are enhanced by RodZ and predict E. coli's cylindrical uniformity.

    abstract：:The actin-like protein MreB has been proposed to coordinate the synthesis of the cell wall to determine cell shape in bacteria. MreB is preferentially localized to areas of the cell with specific curved geometries, avoiding the cell poles. It remains unclear whether MreB's curvature preference is regulated by addition...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-05186-5

    authors： Bratton BP,Shaevitz JW,Gitai Z,Morgenstein RM

    更新日期：2018-07-18 00:00:00

  • CREB controls cortical circuit plasticity and functional recovery after stroke.

    abstract：:Treatments that stimulate neuronal excitability enhance motor performance after stroke. cAMP-response-element binding protein (CREB) is a transcription factor that plays a key role in neuronal excitability. Increasing the levels of CREB with a viral vector in a small pool of motor neurons enhances motor recovery after...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-04445-9

    authors： Caracciolo L,Marosi M,Mazzitelli J,Latifi S,Sano Y,Galvan L,Kawaguchi R,Holley S,Levine MS,Coppola G,Portera-Cailliau C,Silva AJ,Carmichael ST

    更新日期：2018-06-08 00:00:00

  • A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats.

    abstract：:We previously demonstrated that beta II protein kinase C (βIIPKC) activity is elevated in failing hearts and contributes to this pathology. Here we report that βIIPKC accumulates on the mitochondrial outer membrane and phosphorylates mitofusin 1 (Mfn1) at serine 86. Mfn1 phosphorylation results in partial loss of its ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-08276-6

    authors： Ferreira JCB,Campos JC,Qvit N,Qi X,Bozi LHM,Bechara LRG,Lima VM,Queliconi BB,Disatnik MH,Dourado PMM,Kowaltowski AJ,Mochly-Rosen D

    更新日期：2019-01-18 00:00:00

  • Zero-bias mid-infrared graphene photodetectors with bulk photoresponse and calibration-free polarization detection.

    abstract：:Bulk photovoltaic effect (BPVE), featuring polarization-dependent uniform photoresponse at zero external bias, holds potential for exceeding the Shockley-Queisser limit in the efficiency of existing opto-electronic devices. However, the implementation of BPVE has been limited to the naturally existing materials with b...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-20115-1

    authors： Wei J,Li Y,Wang L,Liao W,Dong B,Xu C,Zhu C,Ang KW,Qiu CW,Lee C

    更新日期：2020-12-17 00:00:00

  • Anomalous circular bulk photovoltaic effect in BiFeO3 thin films with stripe-domain pattern.

    abstract：:Multiferroic bismuth ferrite, BiFeO3, offers a vast landscape to study the interplay between different ferrroic orders. Another aspect which is equally exciting, and yet underutilized, is the possibility of large-scale ordering of domains. Along with symmetry-driven bulk photovoltaic effect, BiFeO3 presents opportunit...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-20446-z

    authors： Knoche DS,Steimecke M,Yun Y,Mühlenbein L,Bhatnagar A

    更新日期：2021-01-12 00:00:00

  • Purging of highly deleterious mutations through severe bottlenecks in Alpine ibex.

    abstract：:Human activity has caused dramatic population declines in many wild species. The resulting bottlenecks have a profound impact on the genetic makeup of a species with unknown consequences for health. A key genetic factor for species survival is the evolution of deleterious mutation load, but how bottleneck strength and...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-14803-1

    authors： Grossen C,Guillaume F,Keller LF,Croll D

    更新日期：2020-02-21 00:00:00

  • Reduced exposure to extreme precipitation from 0.5 °C less warming in global land monsoon regions.

    abstract：:The Paris Agreement set a goal to keep global warming well below 2 °C and pursue efforts to limit it to 1.5 °C. Understanding how 0.5 °C less warming reduces impacts and risks is key for climate policies. Here, we show that both areal and population exposures to dangerous extreme precipitation events (e.g., once in 10...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-05633-3

    authors： Zhang W,Zhou T,Zou L,Zhang L,Chen X

    更新日期：2018-08-08 00:00:00

  • Publisher Correction: Tracing the transitions from pluripotency to germ cell fate with CRISPR screening.

    abstract：:Ufuk Günesdogan was incorrectly associated with Center for Genetic Analysis of Behaviour, National Institute for Physiological Sciences, 5-1 Higashiyama Myodaiji, Okazaki, Aichi 444-8787, Japan and Toshihiro Kobayashi was incorrectly associated with Department of Developmental Biology, University of Göttingen, Götting...

    journal_title：Nature communications

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/s41467-018-07765-y

    authors： Hackett JA,Huang Y,Günesdogan U,Gretarsson KA,Kobayashi T,Surani MA

    更新日期：2018-12-11 00:00:00

  • Biochemical mechanisms determine the functional compatibility of heterologous genes.

    abstract：:Elucidating the factors governing the functional compatibility of horizontally transferred genes is important to understand bacterial evolution, including the emergence and spread of antibiotic resistance, and to successfully engineer biological systems. In silico efforts and work using single-gene libraries have sugg...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-02944-3

    authors： Porse A,Schou TS,Munck C,Ellabaan MMH,Sommer MOA

    更新日期：2018-02-06 00:00:00

  • Global chromatin conformation differences in the Drosophila dosage compensated chromosome X.

    abstract：:In Drosophila melanogaster the single male chromosome X undergoes an average twofold transcriptional upregulation for balancing the transcriptional output between sexes. Previous literature hypothesised that a global change in chromosome structure may accompany this process. However, recent studies based on Hi-C faile...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-13350-8

    authors： Pal K,Forcato M,Jost D,Sexton T,Vaillant C,Salviato E,Mazza EMC,Lugli E,Cavalli G,Ferrari F

    更新日期：2019-11-25 00:00:00

  • Redox reactions and weak buffering capacity lead to acidification in the Chesapeake Bay.

    abstract：:The combined effects of anthropogenic and biological CO2 inputs may lead to more rapid acidification in coastal waters compared to the open ocean. It is less clear, however, how redox reactions would contribute to acidification. Here we report estuarine acidification dynamics based on oxygen, hydrogen sulfide (H2S), p...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-00417-7

    authors： Cai WJ,Huang WJ,Luther GW 3rd,Pierrot D,Li M,Testa J,Xue M,Joesoef A,Mann R,Brodeur J,Xu YY,Chen B,Hussain N,Waldbusser GG,Cornwell J,Kemp WM

    更新日期：2017-08-28 00:00:00

  • Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity.

    abstract：:Transthyretin (TTR) is a plasma homotetrameric protein implicated in fatal systemic amyloidoses. TTR tetramer dissociation precedes pathological TTR aggregation. Native state stabilizers are promising drugs to treat TTR amyloidoses. Here we repurpose tolcapone, an FDA-approved molecule for Parkinson's disease, as a po...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms10787

    authors： Sant'Anna R,Gallego P,Robinson LZ,Pereira-Henriques A,Ferreira N,Pinheiro F,Esperante S,Pallares I,Huertas O,Almeida MR,Reixach N,Insa R,Velazquez-Campoy A,Reverter D,Reig N,Ventura S

    更新日期：2016-02-23 00:00:00

  • Accessibility of the histone H3 tail in the nucleosome for binding of paired readers.

    abstract：:Combinatorial polyvalent contacts of histone-binding domains or readers commonly mediate localization and activities of chromatin-associated proteins. A pair of readers, the PHD fingers of the protein CHD4, has been shown to bivalently recognize histone H3 tails. Here we describe a mechanism by which these linked but ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-01598-x

    authors： Gatchalian J,Wang X,Ikebe J,Cox KL,Tencer AH,Zhang Y,Burge NL,Di L,Gibson MD,Musselman CA,Poirier MG,Kono H,Hayes JJ,Kutateladze TG

    更新日期：2017-11-14 00:00:00

  • Scalable salt-templated synthesis of two-dimensional transition metal oxides.

    abstract：:Two-dimensional atomic crystals, such as two-dimensional oxides, have attracted much attention in energy storage because nearly all of the atoms can be exposed to the electrolyte and involved in redox reactions. However, current strategies are largely limited to intrinsically layered compounds. Here we report a genera...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms11296

    authors： Xiao X,Song H,Lin S,Zhou Y,Zhan X,Hu Z,Zhang Q,Sun J,Yang B,Li T,Jiao L,Zhou J,Tang J,Gogotsi Y

    更新日期：2016-04-22 00:00:00

  • Conformations and cryo-force spectroscopy of spray-deposited single-strand DNA on gold.

    abstract：:Cryo-electron microscopy can determine the structure of biological matter in vitrified liquids. However, structure alone is insufficient to understand the function of native and engineered biomolecules. So far, their mechanical properties have mainly been probed at room temperature using tens of pico-newton forces wit...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-08531-4

    authors： Pawlak R,Vilhena JG,Hinaut A,Meier T,Glatzel T,Baratoff A,Gnecco E,Pérez R,Meyer E

    更新日期：2019-02-08 00:00:00

  • Enabling unassisted solar water splitting by iron oxide and silicon.

    abstract：:Photoelectrochemical (PEC) water splitting promises a solution to the problem of large-scale solar energy storage. However, its development has been impeded by the poor performance of photoanodes, particularly in their capability for photovoltage generation. Many examples employing photovoltaic modules to correct the ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms8447

    authors： Jang JW,Du C,Ye Y,Lin Y,Yao X,Thorne J,Liu E,McMahon G,Zhu J,Javey A,Guo J,Wang D

    更新日期：2015-06-16 00:00:00

  • Solution nuclear magnetic resonance spectroscopy on a nanostructured diamond chip.

    abstract：:Sensors using nitrogen-vacancy centers in diamond are a promising tool for small-volume nuclear magnetic resonance (NMR) spectroscopy, but the limited sensitivity remains a challenge. Here we show nearly two orders of magnitude improvement in concentration sensitivity over previous nitrogen-vacancy and picoliter NMR s...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-00266-4

    authors： Kehayias P,Jarmola A,Mosavian N,Fescenko I,Benito FM,Laraoui A,Smits J,Bougas L,Budker D,Neumann A,Brueck SRJ,Acosta VM

    更新日期：2017-08-04 00:00:00

  • Store-independent modulation of Ca(2+) entry through Orai by Septin 7.

    abstract：:Orai channels are required for store-operated Ca(2+) entry (SOCE) in multiple cell types. Septins are a class of GTP-binding proteins that function as diffusion barriers in cells. Here we show that Septin 7 acts as a 'molecular brake' on activation of Orai channels in Drosophila neurons. Lowering Septin 7 levels resul...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms11751

    authors： Deb BK,Pathak T,Hasan G

    更新日期：2016-05-26 00:00:00