Global chromatin conformation differences in the Drosophila dosage compensated chromosome X.

Abstract:

:In Drosophila melanogaster the single male chromosome X undergoes an average twofold transcriptional upregulation for balancing the transcriptional output between sexes. Previous literature hypothesised that a global change in chromosome structure may accompany this process. However, recent studies based on Hi-C failed to detect these differences. Here we show that global conformational differences are specifically present in the male chromosome X and detectable using Hi-C data on sex-sorted embryos, as well as male and female cell lines, by leveraging custom data analysis solutions. We find the male chromosome X has more mid-/long-range interactions. We also identify differences at structural domain boundaries containing BEAF-32 in conjunction with CP190 or Chromator. Weakening of these domain boundaries in male chromosome X co-localizes with the binding of the dosage compensation complex and its co-factor CLAMP, reported to enhance chromatin accessibility. Together, our data strongly indicate that chromosome X dosage compensation affects global chromosome structure.

journal_name

Nat Commun

journal_title

Nature communications

authors

Pal K,Forcato M,Jost D,Sexton T,Vaillant C,Salviato E,Mazza EMC,Lugli E,Cavalli G,Ferrari F

doi

10.1038/s41467-019-13350-8

subject

Has Abstract

pub_date

2019-11-25 00:00:00

pages

5355

issue

1

issn

2041-1723

pii

10.1038/s41467-019-13350-8

journal_volume

10

pub_type

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