The neuropeptide NLP-22 regulates a sleep-like state in Caenorhabditis elegans.

abstract：:High-harmonic generation (HHG) in gases has been the main enabling technology of attosecond science since its discovery. Recently, HHG from solids has been demonstrated, opening a lively area of research. In contrast, harmonic generation from liquids has so far remained restricted to low harmonics in the visible regim...

journal_title：Nature communications

authors： Luu TT,Yin Z,Jain A,Gaumnitz T,Pertot Y,Ma J,Wörner HJ

更新日期：2018-09-13 00:00:00

abstract：:Novelty-seeking tendencies in adolescents may promote innovation as well as problematic impulsive behaviour, including drug abuse. Previous research has not clarified whether neural hyper- or hypo-responsiveness to anticipated rewards promotes vulnerability in these individuals. Here we use a longitudinal design to tr...

journal_title：Nature communications

authors： Büchel C,Peters J,Banaschewski T,Bokde AL,Bromberg U,Conrod PJ,Flor H,Papadopoulos D,Garavan H,Gowland P,Heinz A,Walter H,Ittermann B,Mann K,Martinot JL,Paillère-Martinot ML,Nees F,Paus T,Pausova Z,Poustka L,Riets

更新日期：2017-02-21 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Temko D,Tomlinson IPM,Severini S,Schuster-Böckler B,Graham TA

更新日期：2020-04-20 00:00:00

abstract：:A number of marine organisms use muscle-controlled surface structures to achieve rapid changes in colour and transparency with outstanding reversibility. Inspired by these display tactics, we develop analogous deformation-controlled surface-engineering approaches via strain-dependent cracks and folds to realize the fo...

journal_title：Nature communications

authors： Zeng S,Zhang D,Huang W,Wang Z,Freire SG,Yu X,Smith AT,Huang EY,Nguon H,Sun L

更新日期：2016-07-08 00:00:00

abstract：:Perisomatic inhibition of pyramidal neurons is established by fast-spiking, parvalbumin-expressing interneurons (PV cells). Failure to assemble adequate perisomatic inhibition is thought to underlie the aetiology of neurological dysfunction in seizures, autism spectrum disorders and schizophrenia. Here we show that in...

journal_title：Nature communications

authors： Baohan A,Ikrar T,Tring E,Xu X,Trachtenberg JT

更新日期：2016-09-09 00:00:00

abstract：:The growth of atomically dispersed metal catalysts (ADMCs) remains a great challenge owing to the thermodynamically driven atom aggregation. Here we report a surface-limited electrodeposition technique that uses site-specific substrates for the rapid and room-temperature synthesis of ADMCs. We obtained ADMCs by the un...

journal_title：Nature communications

authors： Shi Y,Huang WM,Li J,Zhou Y,Li ZQ,Yin YC,Xia XH

更新日期：2020-09-11 00:00:00

abstract：:RNA silencing inhibits mRNA translation. While mRNA translation accounts for the majority of cellular energy expenditure, it is unclear if RNA silencing regulates energy homeostasis. Here, we report that hepatic Argonaute 2 (Ago2)-mediated RNA silencing regulates both intrinsic energy production and consumption and di...

journal_title：Nature communications

authors： Zhang C,Seo J,Murakami K,Salem ESB,Bernhard E,Borra VJ,Choi K,Yuan CL,Chan CC,Chen X,Huang T,Weirauch MT,Divanovic S,Qi NR,Thomas HE,Mercer CA,Siomi H,Nakamura T

更新日期：2018-09-10 00:00:00

abstract：:We establish a powerful poly(4-styrenesulfonate) (PSS)-treated strategy for sulfur vacancy healing in monolayer MoS2 to precisely and steadily tune its electronic state. The self-healing mechanism, in which the sulfur vacancies are healed spontaneously by the sulfur adatom clusters on the MoS2 surface through a PSS-in...

journal_title：Nature communications

authors： Zhang X,Liao Q,Liu S,Kang Z,Zhang Z,Du J,Li F,Zhang S,Xiao J,Liu B,Ou Y,Liu X,Gu L,Zhang Y

更新日期：2017-06-22 00:00:00

abstract：:A primary function of the midbrain stimulus selection network is to compute the highest-priority location for attention and gaze. Here we report the contribution of a specific cholinergic circuit to this computation. We functionally disconnected the tegmental cholinergic nucleus isthmi pars parvocellularis (Ipc) from ...

journal_title：Nature communications

authors： Asadollahi A,Knudsen EI

更新日期：2016-11-17 00:00:00

abstract：:Heartbeat is required for normal development of the heart, and perturbation of intracardiac flow leads to morphological defects resembling congenital heart diseases. These observations implicate intracardiac haemodynamics in cardiogenesis, but the signalling cascades connecting physical forces, gene expression and mor...

journal_title：Nature communications

authors： Banjo T,Grajcarek J,Yoshino D,Osada H,Miyasaka KY,Kida YS,Ueki Y,Nagayama K,Kawakami K,Matsumoto T,Sato M,Ogura T

更新日期：2013-01-01 00:00:00

abstract：:Standard units of measurement are required for the quantitative description of nature; however, few standard units have been established for genomics to date. Here, we have developed a synthetic DNA ladder that defines a quantitative standard unit that can measure DNA sequence abundance within a next-generation sequen...

journal_title：Nature communications

authors： Reis ALM,Deveson IW,Wong T,Madala BS,Barker C,Blackburn J,Marcellin E,Mercer TR

更新日期：2020-07-17 00:00:00

abstract：:The phase diagram of BaPb(1-x)Bi(x)O3 exhibits a superconducting dome in the proximity of a charge density wave phase. For the superconducting compositions, the material coexists as two structural polymorphs. Here we show, via high-resolution transmission electron microscopy, that the structural dimorphism is accommod...

journal_title：Nature communications

authors： Giraldo-Gallo P,Zhang Y,Parra C,Manoharan HC,Beasley MR,Geballe TH,Kramer MJ,Fisher IR

更新日期：2015-09-16 00:00:00

abstract：:High electron mobility is one of graphene's key properties, exploited for applications and fundamental research alike. Highest mobility values are found in heterostructures of graphene and hexagonal boron nitride, which consequently are widely used. However, surprisingly little is known about the interaction between t...

journal_title：Nature communications

authors： Jobst J,van der Torren AJH,Krasovskii EE,Balgley J,Dean CR,Tromp RM,van der Molen SJ

更新日期：2016-11-29 00:00:00

abstract：:Understanding the fundamental alterations in brain functioning that lead to psychotic disorders remains a major challenge in clinical neuroscience. In particular, it is unknown whether any state-independent biomarkers can potentially predict the onset of psychosis and distinguish patients from healthy controls, regard...

journal_title：Nature communications

authors： Cao H,Chén OY,Chung Y,Forsyth JK,McEwen SC,Gee DG,Bearden CE,Addington J,Goodyear B,Cadenhead KS,Mirzakhanian H,Cornblatt BA,Carrión RE,Mathalon DH,McGlashan TH,Perkins DO,Belger A,Seidman LJ,Thermenos H,Tsuang MT,

更新日期：2018-09-21 00:00:00

abstract：:Genetic screens are powerful tools to identify the genes required for a given biological process. However, for technical reasons, comprehensive screens have been restricted to very few model organisms. Therefore, although deep sequencing is revealing the genes of ever more insect species, the functional studies predom...

journal_title：Nature communications

authors： Schmitt-Engel C,Schultheis D,Schwirz J,Ströhlein N,Troelenberg N,Majumdar U,Dao VA,Grossmann D,Richter T,Tech M,Dönitz J,Gerischer L,Theis M,Schild I,Trauner J,Koniszewski ND,Küster E,Kittelmann S,Hu Y,Lehmann S,S

更新日期：2015-07-28 00:00:00

abstract：:Fusion proteins containing blue-light-activable protein domains possess great potential as molecular switches in cell signalling. This has recently been impressively demonstrated by connecting the light oxygen voltage LOV2-Jα-protein domain of A. sativa (AsLOV2-Jα) with the Rac1-GTPase, responsible for regulating the ...

journal_title：Nature communications

authors： Peter E,Dick B,Baeurle SA

更新日期：2010-11-16 00:00:00

abstract：:Although soluble inhibitors are frequently used to block cell binding to the extracellular matrix (ECM), mechanical stretching of a protein fibre alone can physically destroy a cell-binding site. Here, we show using binding assays and steered molecular dynamics that mechanical tension along fibronectin (Fn) fibres cau...

journal_title：Nature communications

authors： Chabria M,Hertig S,Smith ML,Vogel V

更新日期：2010-01-01 00:00:00

abstract：:Many regulatory and signaling proteins have multiple modification sites. In bacterial chemotaxis, each chemoreceptor has multiple methylation sites that are responsible for adaptation. However, whether the ordering of the multisite methylation process affects adaptation remains unclear. Furthermore, the benefit of hav...

journal_title：Nature communications

authors： Mello BA,Beserra AB,Tu Y

更新日期：2020-06-08 00:00:00

abstract：:Marine low clouds play an important role in the climate system, and their properties are sensitive to cloud condensation nuclei concentrations. While new particle formation represents a major source of cloud condensation nuclei globally, the prevailing view is that new particle formation rarely occurs in remote marine...

journal_title：Nature communications

authors： Zheng G,Wang Y,Wood R,Jensen MP,Kuang C,McCoy IL,Matthews A,Mei F,Tomlinson JM,Shilling JE,Zawadowicz MA,Crosbie E,Moore R,Ziemba L,Andreae MO,Wang J

更新日期：2021-01-22 00:00:00

abstract：:Southern Africa is characterised by unusually elevated topography and abnormal heat flow. This can be explained by thermal perturbation of the mantle, but the origin of this is unclear. Geophysics has not detected a thermal anomaly in the upper mantle and there is no geochemical evidence of an asthenosphere mantle con...

journal_title：Nature communications

authors： Gilfillan SMV,Györe D,Flude S,Johnson G,Bond CE,Hicks N,Lister R,Jones DG,Kremer Y,Haszeldine RS,Stuart FM

更新日期：2019-11-05 00:00:00

abstract：:MicroRNAs (miRNAs) associated with Argonaute proteins (AGOs) regulate gene expression in mammals. miRNA 3' ends are subject to frequent sequence modifications, which have been proposed to affect miRNA stability. However, the underlying mechanism is not well understood. Here, by genetic and biochemical studies as well ...

journal_title：Nature communications

authors： Yang A,Shao TJ,Bofill-De Ros X,Lian C,Villanueva P,Dai L,Gu S

更新日期：2020-06-02 00:00:00

abstract：:Suppressor of Fused (SuFu), a tumour suppressor mutated in medulloblastoma, is a central player of Hh signalling, a pathway crucial for development and deregulated in cancer. Although the control of Gli transcription factors by SuFu is critical in Hh signalling, our understanding of the mechanism regulating this key e...

journal_title：Nature communications

authors： Infante P,Faedda R,Bernardi F,Bufalieri F,Lospinoso Severini L,Alfonsi R,Mazzà D,Siler M,Coni S,Po A,Petroni M,Ferretti E,Mori M,De Smaele E,Canettieri G,Capalbo C,Maroder M,Screpanti I,Kool M,Pfister SM,Guardavac

更新日期：2018-03-07 00:00:00

abstract：:MicroRNAs (miRNAs) are critical to somatic cell reprogramming into induced pluripotent stem cells (iPSCs), however, exactly how miRNA expression changes support the transition to pluripotency requires further investigation. Here we use a murine secondary reprogramming system to sample cellular trajectories towards iPS...

journal_title：Nature communications

authors： Clancy JL,Patel HR,Hussein SM,Tonge PD,Cloonan N,Corso AJ,Li M,Lee DS,Shin JY,Wong JJ,Bailey CG,Benevento M,Munoz J,Chuah A,Wood D,Rasko JE,Heck AJ,Grimmond SM,Rogers IM,Seo JS,Wells CA,Puri MC,Nagy A,Preiss

更新日期：2014-12-10 00:00:00

abstract：:Untethered small actuators have various applications in multiple fields. However, existing small-scale actuators are very limited in their intractability with their surroundings, respond to only a single type of stimulus and are unable to achieve programmable structural changes under different stimuli. Here, we presen...

journal_title：Nature communications

authors： Dong Y,Wang J,Guo X,Yang S,Ozen MO,Chen P,Liu X,Du W,Xiao F,Demirci U,Liu BF

更新日期：2019-09-09 00:00:00

abstract：:Single-celled eukaryotes (protists) are critical players in global biogeochemical cycling of nutrients and energy in the oceans. While their roles as primary producers and grazers are well appreciated, other aspects of their life histories remain obscure due to challenges in culturing and sequencing their natural dive...

journal_title：Nature communications

authors： Seeleuthner Y,Mondy S,Lombard V,Carradec Q,Pelletier E,Wessner M,Leconte J,Mangot JF,Poulain J,Labadie K,Logares R,Sunagawa S,de Berardinis V,Salanoubat M,Dimier C,Kandels-Lewis S,Picheral M,Searson S,Tara Oceans Coor

更新日期：2018-01-22 00:00:00

abstract：:β-Diguetoxin-Dc1a (Dc1a) is a toxin from the desert bush spider Diguetia canities that incapacitates insects at concentrations that are non-toxic to mammals. Dc1a promotes opening of German cockroach voltage-gated sodium (Nav) channels (BgNav1), whereas human Nav channels are insensitive. Here, by transplanting common...

journal_title：Nature communications

authors： Bende NS,Dziemborowicz S,Mobli M,Herzig V,Gilchrist J,Wagner J,Nicholson GM,King GF,Bosmans F

更新日期：2014-07-11 00:00:00

abstract：:The ter region of the bacterial chromosome, where replication terminates, is the last to be segregated before cell division in Escherichia coli. Delayed segregation is controlled by the MatP protein, which binds to specific sites (matS) within ter, and interacts with other proteins such as ZapB. Here, we investigate t...

journal_title：Nature communications

authors： Crozat E,Tardin C,Salhi M,Rousseau P,Lablaine A,Bertoni T,Holcman D,Sclavi B,Cicuta P,Cornet F

更新日期：2020-07-30 00:00:00

abstract：:In conventional computers, wiring between transistors is required to enable the execution of Boolean logic functions. This has resulted in processors in which billions of transistors are physically interconnected, which limits integration densities, gives rise to huge power consumption and restricts processing speeds....

journal_title：Nature communications

authors： Mahboob I,Flurin E,Nishiguchi K,Fujiwara A,Yamaguchi H

更新日期：2011-02-15 00:00:00

abstract：:Although environmental selection and spatial separation have been shown to shape the distribution and abundance of marine microorganisms, the effects of advection (physical transport) have not been directly tested. Here we examine 25 samples covering all major water masses of the Southern Ocean to determine the effect...

journal_title：Nature communications

authors： Wilkins D,van Sebille E,Rintoul SR,Lauro FM,Cavicchioli R

更新日期：2013-01-01 00:00:00

abstract：:Pseudomonas aeruginosa, an opportunistic pathogen of humans, uses quorum sensing (QS) to regulate the production of extracellular products that can benefit all members of the population. P. aeruginosa can police QS-deficient cheaters by producing hydrogen cyanide, which is also QS regulated; however, the mechanism by ...

journal_title：Nature communications

authors： Yan H,Asfahl KL,Li N,Sun F,Xiao J,Shen D,Dandekar AA,Wang M

更新日期：2019-11-01 00:00:00