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Stretching fibronectin fibres disrupts binding of bacterial adhesins by physically destroying an epitope.

Abstract：

:Although soluble inhibitors are frequently used to block cell binding to the extracellular matrix (ECM), mechanical stretching of a protein fibre alone can physically destroy a cell-binding site. Here, we show using binding assays and steered molecular dynamics that mechanical tension along fibronectin (Fn) fibres causes a structural mismatch between Fn-binding proteins from Streptococcus dysgalactiae and Staphylococcus aureus. Both adhesins target a multimodular site on Fn that is switched to low affinity by stretching the intermodular distances on Fn. Heparin reduces binding but does not eliminate mechanosensitivity. These adhesins might thus preferentially bind to sites at which ECM fibres are cleaved, such as wounds or inflamed tissues. The mechanical switch described here operates differently from the catch bond mechanism that Escherichia coli uses to adhere to surfaces under fluid flow. Demonstrating the existence of a mechanosensitive cell-binding site provides a new perspective on how the mechanobiology of ECM might regulate bacterial and cell-binding events, virulence and the course of infection.

journal_name

Nat Commun

journal_title

Nature communications

authors

Chabria M,Hertig S,Smith ML,Vogel V

doi

10.1038/ncomms1135

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

135

issn

2041-1723

pii

ncomms1135

journal_volume

1

pub_type

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