Abstract:
:Quantum technology promises revolutionizing applications in information processing, communications, sensing and modelling. However, efficient on-demand cooling of the functional quantum degrees of freedom remains challenging in many solid-state implementations, such as superconducting circuits. Here we demonstrate direct cooling of a superconducting resonator mode using voltage-controllable electron tunnelling in a nanoscale refrigerator. This result is revealed by a decreased electron temperature at a resonator-coupled probe resistor, even for an elevated electron temperature at the refrigerator. Our conclusions are verified by control experiments and by a good quantitative agreement between theory and experimental observations at various operation voltages and bath temperatures. In the future, we aim to remove spurious dissipation introduced by our refrigerator and to decrease the operational temperature. Such an ideal quantum-circuit refrigerator has potential applications in the initialization of quantum electric devices. In the superconducting quantum computer, for example, fast and accurate reset of the quantum memory is needed.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Tan KY,Partanen M,Lake RE,Govenius J,Masuda S,Möttönen Mdoi
10.1038/ncomms15189subject
Has Abstractpub_date
2017-05-08 00:00:00pages
15189issn
2041-1723pii
ncomms15189journal_volume
8pub_type
杂志文章abstract::Bcl9 and Pygo are Wnt enhanceosome components that effect β-catenin-dependent transcription. Whether they mediate β-catenin-dependent neoplasia is unclear. Here we assess their roles in intestinal tumourigenesis initiated by Apc loss-of-function (ApcMin), or by Apc1322T encoding a partially-functional Apc truncation c...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-08164-z
更新日期:2019-02-13 00:00:00
abstract::A Weyl semimetal possesses spin-polarized band-crossings, called Weyl nodes, connected by topological surface arcs. The low-energy excitations near the crossing points behave the same as massless Weyl fermions, leading to exotic properties like chiral anomaly. To have the transport properties dominated by Weyl fermion...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11006
更新日期:2016-03-17 00:00:00
abstract::Intermolecular halogen bonds are ideally suited for designing new molecular assemblies because of their strong directionality and the possibility of tuning the interactions by using different types of halogens or molecular moieties. Due to these unique properties of the halogen bonds, numerous areas of application hav...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19379-4
更新日期:2020-11-06 00:00:00
abstract::We show how the kinetics of a fast and irreversible chemical reaction in a nanocrystalline material at high temperature can be studied using nanosecond electron pulses in an electron microscope. Infrared laser pulses first heat a nanocrystalline oxide layer on a carbon film, then single nanosecond electron pulses allo...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11669-w
更新日期:2019-08-13 00:00:00
abstract::Genomic evidence is increasingly underpinning that hybridization between taxa is commonplace, challenging our views on the mechanisms that maintain their boundaries. Here, we focus on seven catadromous eel species (genus Anguilla) and use genome-wide sequence data from more than 450 individuals sampled across the trop...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15099-x
更新日期:2020-03-18 00:00:00
abstract::Random numbers are commonly used in many different fields, ranging from simulations in fundamental science to security applications. In some critical cases, as Bell's tests and cryptography, the random numbers are required to be both private and to be provided at an ultra-fast rate. However, practical generators are u...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07585-0
更新日期:2018-12-18 00:00:00
abstract::The nasal cellular epigenome may serve as biomarker of airway disease and environmental response. Here we collect nasal swabs from the anterior nares of 547 children (mean-age 12.9 y), and measure DNA methylation (DNAm) with the Infinium MethylationEPIC BeadChip. We perform nasal Epigenome-Wide Association analyses (E...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11058-3
更新日期:2019-07-12 00:00:00
abstract::Myelin, rather than being a static insulator of axons, is emerging as an active participant in circuit plasticity. This requires precise regulation of oligodendrocyte numbers and myelination patterns. Here, by devising a laser ablation approach of single oligodendrocytes, followed by in vivo imaging and correlated ult...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18632-0
更新日期:2020-09-29 00:00:00
abstract::Liver cancer stem cells (CSCs) may contribute to the high rate of recurrence and heterogeneity of hepatocellular carcinoma (HCC). However, the biology of hepatic CSCs remains largely undefined. Through analysis of transcriptome microarray data, we identify a long noncoding RNA (lncRNA) called lncBRM, which is highly e...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13608
更新日期:2016-12-01 00:00:00
abstract::Mutant p53s (mutp53) increase cancer invasiveness by upregulating Rab-coupling protein (RCP) and diacylglycerol kinase-α (DGKα)-dependent endosomal recycling. Here we report that mutp53-expressing tumour cells produce exosomes that mediate intercellular transfer of mutp53's invasive/migratory gain-of-function by incre...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07339-y
更新日期:2018-11-29 00:00:00
abstract::Spectrally-selective monitoring of ultraviolet radiations (UVR) is of paramount importance across diverse fields, including effective monitoring of excessive solar exposure. Current UV sensors cannot differentiate between UVA, B, and C, each of which has a remarkably different impact on human health. Here we show spec...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06273-3
更新日期:2018-09-25 00:00:00
abstract::Fatty acids (FAs) are not only essential components of cellular energy storage and structure, but play crucial roles in signalling. Here we present a toolkit of photoswitchable FA analogues (FAAzos) that incorporate an azobenzene photoswitch along the FA chain. By modifying the FAAzos to resemble capsaicin, we prepare...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8118
更新日期:2015-05-22 00:00:00
abstract::The molecular mechanisms that couple glycolysis to cancer drug resistance remain unclear. Here we identify an ATP-binding motif within the NADPH oxidase isoform, NOX4, and show that ATP directly binds and negatively regulates NOX4 activity. We find that NOX4 localizes to the inner mitochondria membrane and that subcel...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01106-1
更新日期:2017-10-19 00:00:00
abstract::Most cancer vaccines are unsuccessful in eliciting clinically relevant effects. Without using exogenous antigens and adoptive cells, we show a concept of utilizing biologically reprogrammed cytomembranes of the fused cells (FCs) derived from dendritic cells (DCs) and cancer cells as tumor vaccines. The fusion of immun...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11157-1
更新日期:2019-07-19 00:00:00
abstract::Tunable metasurfaces enable dynamical control of the key constitutive properties of light at a subwavelength scale. To date, electrically tunable metasurfaces at near-infrared wavelengths have been realized using free carrier modulation, and switching of thermo-optical, liquid crystal and phase change media. However, ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11598-8
更新日期:2019-08-13 00:00:00
abstract::Pancreatic cancer is the fourth leading cause of cancer-related deaths in Japan. To identify risk loci, we perform a meta-analysis of three genome-wide association studies comprising 2,039 pancreatic cancer patients and 32,592 controls in the Japanese population. Here, we identify 3 (13q12.2, 13q22.1, and 16p12.3) gen...
journal_title:Nature communications
pub_type: 杂志文章,meta分析
doi:10.1038/s41467-020-16711-w
更新日期:2020-06-24 00:00:00
abstract::AML1-ETO (AE) is a fusion transcription factor, generated by the t(8;21) translocation, that functions as a leukemia promoting oncogene. Here, we demonstrate that TATA-Box Binding Protein Associated Factor 1 (TAF1) associates with K43 acetylated AE and this association plays a pivotal role in the proliferation of AE-e...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12735-z
更新日期:2019-10-29 00:00:00
abstract::Many glasses exhibit fractional power law (FPL) between the mean atomic volume va and the first diffraction peak position q1, i.e. [Formula: see text] with d ≃ 2.5 deviating from the space dimension D = 3, under compression or composition change. What structural change causes such FPL and whether the FPL and d are uni...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15583-4
更新日期:2020-04-24 00:00:00
abstract::Type I interferon (IFN) is a key driver of immunity to infections and cancer. Plasmacytoid dendritic cells (pDCs) are uniquely equipped to produce large quantities of type I IFN but the mechanisms that control this process are poorly understood. Here we report on a droplet-based microfluidic platform to investigate ty...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05784-3
更新日期:2018-08-20 00:00:00
abstract::In the original version of this Article, an incorrect sample size was provided for the number of relict species (443 instead of 442) and the number of relict forests (423 instead of 422). These errors have been corrected in both the PDF and HTML versions of the Article. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-018-07727-4
更新日期:2018-12-04 00:00:00
abstract::We have sequenced 463 presenting cases of myeloma entered into the UK Myeloma XI study using whole exome sequencing. Here we identify mutations induced as a consequence of misdirected AID in the partner oncogenes of IGH translocations, which are activating and associated with impaired clinical outcome. An APOBEC mutat...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7997
更新日期:2015-04-23 00:00:00
abstract::Plasma wakefield accelerators have been used to accelerate electron and positron particle beams with gradients that are orders of magnitude larger than those achieved in conventional accelerators. In addition to being accelerated by the plasma wakefield, the beam particles also experience strong transverse forces that...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11785
更新日期:2016-06-02 00:00:00
abstract::It is known that transient receptor potential ankyrin 1 (TRPA1) channels, expressed by nociceptors, contribute to neuropathic pain. Here we show that TRPA1 is also expressed in Schwann cells. We found that in mice with partial sciatic nerve ligation, TRPA1 silencing in nociceptors attenuated mechanical allodynia, with...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01739-2
更新日期:2017-12-01 00:00:00
abstract::Triacylglycerols are among the most attractive alternative raw materials for biofuel development. Current oil plant-based technologies are limited in terms of triacylglycerol production capacity and rate. These limitations may be circumvented by biotransformation of carbohydrates into lipids; however, our understandin...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2112
更新日期:2012-01-01 00:00:00
abstract::Inspired by biological neural systems, neuromorphic devices may open up new computing paradigms to explore cognition, learning and limits of parallel computation. Here we report the demonstration of a synaptic transistor with SmNiO₃, a correlated electron system with insulator-metal transition temperature at 130°C in ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3676
更新日期:2013-01-01 00:00:00
abstract::Identifying regions important for spreading and mediating perturbations is crucial to assess the susceptibilities of spatio-temporal complex systems such as the Earth's climate to volcanic eruptions, extreme events or geoengineering. Here a data-driven approach is introduced based on a dimension reduction, causal reco...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9502
更新日期:2015-10-07 00:00:00
abstract::When pressure is applied, the molecules inside a crystal undergo significant changes of their stereoelectronic properties. The most interesting are those enhancing the reactivity of systems that would be otherwise rather inert at ambient conditions. Before a reaction can occur, however, a molecule must be activated, w...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10901
更新日期:2016-03-16 00:00:00
abstract::The coupled translocation of transfer RNA and messenger RNA through the ribosome entails large-scale structural rearrangements, including step-wise movements of the tRNAs. Recent structural work has visualized intermediates of translocation induced by elongation factor G (EF-G) with tRNAs trapped in chimeric states wi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8442
更新日期:2015-06-15 00:00:00
abstract::Th9 cells protect hosts against helminthic infection but also mediate allergic disease. Here we show that nitric oxide (NO) promotes Th9 cell polarization of murine and human CD4(+) T cells. NO de-represses the tumour suppressor gene p53 via nitrosylation of Mdm2. NO also increases p53-mediated IL-2 production, STAT5 ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5575
更新日期:2014-08-07 00:00:00
abstract::In the original version of this Article, the title of the legend to Fig. 7 incorrectly read 'Knockdown of B55α increases breast cancer metastasis' instead of 'Knockdown of B55α decreases breast cancer metastasis'. This has now been corrected in both the PDF and HTML versions of the Article. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-018-06265-3
更新日期:2018-09-17 00:00:00