MyD88 promotes myoblast fusion in a cell-autonomous manner.

abstract：:Several CRISPR-Cas9 orthologues have been used for genome editing. Here, we present the smallest Cas9 orthologue characterized to date, derived from Campylobacter jejuni (CjCas9), for efficient genome editing in vivo. After determining protospacer-adjacent motif (PAM) sequences and optimizing single-guide RNA (sgRNA) ...

journal_title：Nature communications

authors： Kim E,Koo T,Park SW,Kim D,Kim K,Cho HY,Song DW,Lee KJ,Jung MH,Kim S,Kim JH,Kim JH,Kim JS

更新日期：2017-02-21 00:00:00

abstract：:The ubiquitous SAR11 and Prochlorococcus bacteria manage to maintain a sufficient supply of phosphate in phosphate-poor surface waters of the North Atlantic subtropical gyre. Furthermore, it seems that their phosphate uptake may counter-intuitively be lower in more productive tropical waters, as if their cellular dema...

journal_title：Nature communications

authors： Zubkov MV,Martin AP,Hartmann M,Grob C,Scanlan DJ

更新日期：2015-07-22 00:00:00

abstract：:Extracellular vesicles have an important function in cellular communication. Here, we show that human and mouse monocytes release TGF-β1-transporting vesicles in response to the pathogenic fungus Candida albicans. Soluble β-glucan from C. albicans binds to complement receptor 3 (CR3, also known as CD11b/CD18) on monoc...

journal_title：Nature communications

authors： Halder LD,Jo EAH,Hasan MZ,Ferreira-Gomes M,Krüger T,Westermann M,Palme DI,Rambach G,Beyersdorf N,Speth C,Jacobsen ID,Kniemeyer O,Jungnickel B,Zipfel PF,Skerka C

更新日期：2020-05-11 00:00:00

abstract：:The size of the membrane-bound nucleus scales with cell size in a wide range of cell types but the mechanisms determining overall nuclear size remain largely unknown. Here we investigate the role of fission yeast inner nuclear membrane proteins in determining nuclear size, and propose that the Lap2-Emerin-Man1 domain ...

journal_title：Nature communications

authors： Kume K,Cantwell H,Burrell A,Nurse P

更新日期：2019-04-23 00:00:00

abstract：:Laser powder bed fusion additive manufacturing is an emerging 3D printing technique for the fabrication of advanced metal components. Widespread adoption of it and similar additive technologies is hampered by poor understanding of laser-metal interactions under such extreme thermal regimes. Here, we elucidate the mech...

journal_title：Nature communications

authors： Martin AA,Calta NP,Khairallah SA,Wang J,Depond PJ,Fong AY,Thampy V,Guss GM,Kiss AM,Stone KH,Tassone CJ,Nelson Weker J,Toney MF,van Buuren T,Matthews MJ

更新日期：2019-04-30 00:00:00

abstract：:Many physical phenomena can be understood by single-particle physics; that is, treating particles as non-interacting entities. When this fails, many-body interactions lead to spontaneous symmetry breaking and phenomena such as fundamental particles' mass generation, superconductivity and magnetism. Competition between...

journal_title：Nature communications

authors： Lee Y,Tran D,Myhro K,Velasco J,Gillgren N,Lau CN,Barlas Y,Poumirol JM,Smirnov D,Guinea F

更新日期：2014-12-12 00:00:00

abstract：:Both anti-PD1/PD-L1 therapy and oncolytic virotherapy have demonstrated promise, yet have exhibited efficacy in only a small fraction of cancer patients. Here we hypothesized that an oncolytic poxvirus would attract T cells into the tumour, and induce PD-L1 expression in cancer and immune cells, leading to more suscep...

journal_title：Nature communications

authors： Liu Z,Ravindranathan R,Kalinski P,Guo ZS,Bartlett DL

更新日期：2017-03-27 00:00:00

abstract：:Topological insulators represent a new quantum state of matter that are insulating in the bulk but metallic on the edge or surface. In the Dirac surface state, it is well-established that the electron spin is locked with the crystal momentum. Here we report a new phenomenon of the spin texture locking with the orbital...

journal_title：Nature communications

authors： Xie Z,He S,Chen C,Feng Y,Yi H,Liang A,Zhao L,Mou D,He J,Peng Y,Liu X,Liu Y,Liu G,Dong X,Yu L,Zhang J,Zhang S,Wang Z,Zhang F,Yang F,Peng Q,Wang X,Chen C,Xu Z,Zhou XJ

更新日期：2014-02-28 00:00:00

abstract：:Idiopathic scoliosis (IS) is a common paediatric musculoskeletal disease that displays a strong female bias. By performing a genome-wide association study (GWAS) of 3,102 individuals, we identify significant associations with 20p11.22 SNPs for females (P=6.89 × 10(-9)) but not males (P=0.71). This association with IS ...

journal_title：Nature communications

authors： Sharma S,Londono D,Eckalbar WL,Gao X,Zhang D,Mauldin K,Kou I,Takahashi A,Matsumoto M,Kamiya N,Murphy KK,Cornelia R,TSRHC Scoliosis Clinical Group.,Japan Scoliosis Clinical Research Group.,Herring JA,Burns D,Ahituv N,Ike

更新日期：2015-03-18 00:00:00

abstract：:Cancer cells often display altered cell-surface glycans compared to their nontransformed counterparts. However, functional contributions of glycans to cancer initiation and progression remain poorly understood. Here, from expression-based analyses across cancer lineages, we found that melanomas exhibit significant tra...

journal_title：Nature communications

authors： Sweeney JG,Liang J,Antonopoulos A,Giovannone N,Kang S,Mondala TS,Head SR,King SL,Tani Y,Brackett D,Dell A,Murphy GF,Haslam SM,Widlund HR,Dimitroff CJ

更新日期：2018-08-22 00:00:00

abstract：:Horizontal gene transfer is a major contributor to the evolution of bacterial genomes and can facilitate the dissemination of antibiotic resistance genes between environmental reservoirs and potential pathogens. Wastewater treatment plants (WWTPs) are believed to play a central role in the dissemination of antibiotic ...

journal_title：Nature communications

authors： Munck C,Albertsen M,Telke A,Ellabaan M,Nielsen PH,Sommer MOA

更新日期：2015-09-30 00:00:00

abstract：:We report color-selective photodetection from intermediate, monolayered, quantum dots buried in between amorphous-oxide semiconductors. The proposed active channel in phototransistors is a hybrid configuration of oxide-quantum dot-oxide layers, where the gate-tunable electrical property of silicon-doped, indium-zinc-o...

journal_title：Nature communications

authors： Cho KS,Heo K,Baik CW,Choi JY,Jeong H,Hwang S,Lee SY

更新日期：2017-10-10 00:00:00

abstract：:Pladienolide, herboxidiene and spliceostatin have been identified as splicing modulators that target SF3B1 in the SF3b subcomplex. Here we report that PHF5A, another component of this subcomplex, is also targeted by these compounds. Mutations in PHF5A-Y36, SF3B1-K1071, SF3B1-R1074 and SF3B1-V1078 confer resistance to ...

journal_title：Nature communications

authors： Teng T,Tsai JH,Puyang X,Seiler M,Peng S,Prajapati S,Aird D,Buonamici S,Caleb B,Chan B,Corson L,Feala J,Fekkes P,Gerard B,Karr C,Korpal M,Liu X,T Lowe J,Mizui Y,Palacino J,Park E,Smith PG,Subramanian V,Wu ZJ

更新日期：2017-05-25 00:00:00

abstract：:Gene deletion-induced autophagy deficiency leads to neural tube defects (NTDs), similar to those in diabetic pregnancy. Here we report the key autophagy regulators modulated by diabetes in the murine developing neuroepithelium. Diabetes predominantly leads to exencephaly, induces neuroepithelial cell apoptosis and sup...

journal_title：Nature communications

authors： Wang F,Xu C,Reece EA,Li X,Wu Y,Harman C,Yu J,Dong D,Wang C,Yang P,Zhong J,Yang P

更新日期：2017-05-05 00:00:00

abstract：:Kevin J. Cao and Richard H. Kramer, who developed extended release with beta cyclodextrin, were inadvertently omitted from the author list and author contributions section of this Article. These errors have now been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Berry MH,Holt A,Levitz J,Broichhagen J,Gaub BM,Visel M,Stanley C,Aghi K,Kim YJ,Cao K,Kramer RH,Trauner D,Flannery J,Isacoff EY

更新日期：2018-03-13 00:00:00

abstract：:Semiconductor-based surface-enhanced Raman spectroscopy (SERS) substrates represent a new frontier in the field of SERS. However, the application of semiconductor materials as SERS substrates is still seriously impeded by their low SERS enhancement and inferior detection sensitivity, especially for non-metal-oxide sem...

journal_title：Nature communications

authors： Zheng Z,Cong S,Gong W,Xuan J,Li G,Lu W,Geng F,Zhao Z

更新日期：2017-12-08 00:00:00

abstract：:Polyelectrolyte gel diodes that are double layers of two oppositely charged polyelectrolyte gels, sandwiched by two symmetric electrodes, are emergent ionic devices. These diodes are designed to rectify ion currents with a physical mechanism that is analogous to conventional semiconductor diodes-the asymmetry in the p...

journal_title：Nature communications

authors： Yamamoto T,Doi M

更新日期：2014-06-17 00:00:00

abstract：:Improved measurement techniques are central to technological development and foundational scientific exploration. Quantum physics relies on detectors sensitive to non-classical features of systems, enabling precise tests of physical laws and quantum-enhanced technologies including precision measurement and secure comm...

journal_title：Nature communications

authors： Cooper M,Karpiński M,Smith BJ

更新日期：2014-07-14 00:00:00

abstract：:A collective order of spin and charge degrees of freedom into stripes has been predicted to be a possible ground state of hole-doped CuO(2) planes, which are the building blocks of high-temperature superconductors. In fact, stripe-like spin and charge order has been observed in various layered cuprate systems. For the...

journal_title：Nature communications

authors： Wu HH,Buchholz M,Trabant C,Chang CF,Komarek AC,Heigl F,Zimmermann MV,Cwik M,Nakamura F,Braden M,Schüßler-Langeheine C

更新日期：2012-01-01 00:00:00

abstract：:Staphylococcal pathogens adhere to their human targets with exceptional resilience to mechanical stress, some propagating force to the bacterium via small, Ig-like folds called B domains. We examine the mechanical stability of these folds using atomic force microscopy-based single-molecule force spectroscopy. The forc...

journal_title：Nature communications

authors： Milles LF,Unterauer EM,Nicolaus T,Gaub HE

更新日期：2018-11-12 00:00:00

abstract：:Mountain glaciers are known to be strongly affected by global climate change. Here we compute temporally consistent changes in glacier area, surface elevation and ice mass over the entire European Alps between 2000 and 2014. We apply remote sensing techniques on an extensive database of optical and radar imagery cover...

journal_title：Nature communications

authors： Sommer C,Malz P,Seehaus TC,Lippl S,Zemp M,Braun MH

更新日期：2020-06-25 00:00:00

abstract：:To function, biomolecules require sufficient specificity of interaction as well as stability to live in the cell while still being able to move. Thermodynamic stability of only a limited number of specific structures is important so as to prevent promiscuous interactions. The individual interactions in proteins, there...

journal_title：Nature communications

authors： Chen M,Chen X,Schafer NP,Clementi C,Komives EA,Ferreiro DU,Wolynes PG

更新日期：2020-11-23 00:00:00

abstract：:Exercise induces expression of the myokine irisin, which is known to promote browning of white adipose tissue and has been shown to mediate beneficial effects following exercise. Here we show that irisin induces expression of a number of pro-myogenic and exercise response genes in myotubes. Irisin increases myogenic d...

journal_title：Nature communications

authors： Reza MM,Subramaniyam N,Sim CM,Ge X,Sathiakumar D,McFarlane C,Sharma M,Kambadur R

更新日期：2017-10-24 00:00:00

abstract：:The Tie receptors with their Angiopoietin ligands act as regulators of angiogenesis and vessel maturation. Tie2 exerts its functions through its supposed endothelial-specific expression. Yet, Tie2 is also expressed at lower levels by pericytes and it has not been unravelled through which mechanisms pericyte Angiopoiet...

journal_title：Nature communications

authors： Teichert M,Milde L,Holm A,Stanicek L,Gengenbacher N,Savant S,Ruckdeschel T,Hasanov Z,Srivastava K,Hu J,Hertel S,Bartol A,Schlereth K,Augustin HG

更新日期：2017-07-18 00:00:00

abstract：:Multidrug resistance (MDR) represents a global threat to health. Here, we used whole genome sequencing to characterise Pseudomonas aeruginosa MDR clinical isolates from a hospital in Thailand. Using long-read sequence data we obtained complete sequences of two closely related megaplasmids (>420 kb) carrying large arra...

journal_title：Nature communications

authors： Cazares A,Moore MP,Hall JPJ,Wright LL,Grimes M,Emond-Rhéault JG,Pongchaikul P,Santanirand P,Levesque RC,Fothergill JL,Winstanley C

更新日期：2020-03-13 00:00:00

abstract：:Distal appendages (DAPs) are nanoscale, pinwheel-like structures protruding from the distal end of the centriole that mediate membrane docking during ciliogenesis, marking the cilia base around the ciliary gate. Here we determine a super-resolved multiplex of 16 centriole-distal-end components. Surprisingly, rather th...

journal_title：Nature communications

authors： Yang TT,Chong WM,Wang WJ,Mazo G,Tanos B,Chen Z,Tran TMN,Chen YD,Weng RR,Huang CE,Jane WN,Tsou MB,Liao JC

更新日期：2018-05-22 00:00:00

abstract：:Radiotherapy induces and promotes innate and adaptive immunity in which host STING plays an important role. However, radioresistance in irradiated tumors can also develop, resulting in relapse. Here we report a mechanism by which extrinsic resistance develops after local ablative radiation that relies on the immunosup...

journal_title：Nature communications

authors： Liang H,Deng L,Hou Y,Meng X,Huang X,Rao E,Zheng W,Mauceri H,Mack M,Xu M,Fu YX,Weichselbaum RR

更新日期：2017-11-23 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Michaelis KA,Norgard MA,Zhu X,Levasseur PR,Sivagnanam S,Liudahl SM,Burfeind KG,Olson B,Pelz KR,Ramos DMA,Maurer HC,Olive KP,Coussens LM,Morgan TK,Marks DL

更新日期：2019-11-15 00:00:00

abstract：:Subglacial lakes are widespread beneath the Antarctic Ice Sheet but their control on ice-sheet dynamics and their ability to harbour life remain poorly characterized. Here we present evidence for a palaeo-subglacial lake on the Antarctic continental shelf. A distinct sediment facies recovered from a bedrock basin in P...

journal_title：Nature communications

authors： Kuhn G,Hillenbrand CD,Kasten S,Smith JA,Nitsche FO,Frederichs T,Wiers S,Ehrmann W,Klages JP,Mogollón JM

更新日期：2017-06-01 00:00:00

abstract：:In the lead-up to the Cretaceous/Paleogene mass extinction, dinosaur diversity is argued to have been either in long-term decline, or thriving until their sudden demise. The latest Cretaceous (Campanian-Maastrichtian [83-66 Ma]) of North America provides the best record to address this debate, but even here diversity ...

journal_title：Nature communications

authors： Chiarenza AA,Mannion PD,Lunt DJ,Farnsworth A,Jones LA,Kelland SJ,Allison PA

更新日期：2019-03-06 00:00:00