当前位置： SCI文献检索 > Nature Communications期刊下所有文献 > Protein kinase C-alpha suppresses autophagy and induces neural tube defects via miR-129-2 in diabetic pregnancy.

Protein kinase C-alpha suppresses autophagy and induces neural tube defects via miR-129-2 in diabetic pregnancy.

Abstract：

:Gene deletion-induced autophagy deficiency leads to neural tube defects (NTDs), similar to those in diabetic pregnancy. Here we report the key autophagy regulators modulated by diabetes in the murine developing neuroepithelium. Diabetes predominantly leads to exencephaly, induces neuroepithelial cell apoptosis and suppresses autophagy in the forebrain and midbrain of NTD embryos. Deleting the Prkca gene, which encodes PKCα, reverses diabetes-induced autophagy impairment, cellular organelle stress and apoptosis, leading to an NTD reduction. PKCα increases the expression of miR-129-2, which is a negative regulator of autophagy. miR-129-2 represses autophagy by directly targeting PGC-1α, a positive regulator for mitochondrial function, which is disturbed by maternal diabetes. PGC-1α supports neurulation by stimulating autophagy in neuroepithelial cells. These findings identify two negative autophagy regulators, PKCα and miR-129-2, which mediate the teratogenicity of hyperglycaemia leading to NTDs. We also reveal a function for PGC-1α in embryonic development through promoting autophagy and ameliorating hyperglycaemia-induced NTDs.

journal_name

Nat Commun

journal_title

Nature communications

authors

Wang F,Xu C,Reece EA,Li X,Wu Y,Harman C,Yu J,Dong D,Wang C,Yang P,Zhong J,Yang P

doi

10.1038/ncomms15182

subject

Has Abstract

pub_date

2017-05-05 00:00:00

pages

15182

issn

2041-1723

pii

ncomms15182

journal_volume

8

pub_type

杂志文章

相关文献

Nature Communications文献大全
  • Surface cooling caused by rare but intense near-inertial wave induced mixing in the tropical Atlantic.

    abstract：:The direct response of the tropical mixed layer to near-inertial waves (NIWs) has only rarely been observed. Here, we present upper-ocean turbulence data that provide evidence for a strongly elevated vertical diffusive heat flux across the base of the mixed layer in the presence of a NIW, thereby cooling the mixed lay...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-17601-x

    authors： Hummels R,Dengler M,Rath W,Foltz GR,Schütte F,Fischer T,Brandt P

    更新日期：2020-07-31 00:00:00

  • Layer-by-layer assembly of vertically conducting graphene devices.

    abstract：:Graphene has various potential applications owing to its unique electronic, optical, mechanical and chemical properties, which are primarily based on its two-dimensional nature. Graphene-based vertical devices can extend the investigations and potential applications range to three dimensions, while interfacial propert...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms2935

    authors： Chen JJ,Meng J,Zhou YB,Wu HC,Bie YQ,Liao ZM,Yu DP

    更新日期：2013-01-01 00:00:00

  • Confinement-deconfinement transition due to spontaneous symmetry breaking in quantum Hall bilayers.

    abstract：:Band-inverted electron-hole bilayers support quantum spin Hall insulator and exciton condensate phases. Interest in quantum spin Hall effect in these systems has recently put them in the spotlight. We investigate such a bilayer in an external magnetic field. We show that the interlayer correlations lead to formation o...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms10462

    authors： Pikulin DI,Silvestrov PG,Hyart T

    更新日期：2016-01-25 00:00:00

  • The evolution of the temporal program of genome replication.

    abstract：:Genome replication is highly regulated in time and space, but the rules governing the remodeling of these programs during evolution remain largely unknown. We generated genome-wide replication timing profiles for ten Lachancea yeasts, covering a continuous evolutionary range from closely related to more divergent spec...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-04628-4

    authors： Agier N,Delmas S,Zhang Q,Fleiss A,Jaszczyszyn Y,van Dijk E,Thermes C,Weigt M,Cosentino-Lagomarsino M,Fischer G

    更新日期：2018-06-06 00:00:00

  • Olfactory bulb acetylcholine release dishabituates odor responses and reinstates odor investigation.

    abstract：:Habituation and dishabituation modulate the neural resources and behavioral significance allocated to incoming stimuli across the sensory systems. We characterize these processes in the mouse olfactory bulb (OB) and uncover a role for OB acetylcholine (ACh) in physiological and behavioral olfactory dishabituation. We ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-04371-w

    authors： Ogg MC,Ross JM,Bendahmane M,Fletcher ML

    更新日期：2018-05-14 00:00:00

  • Efficient non-Markovian quantum dynamics using time-evolving matrix product operators.

    abstract：:In order to model realistic quantum devices it is necessary to simulate quantum systems strongly coupled to their environment. To date, most understanding of open quantum systems is restricted either to weak system-bath couplings or to special cases where specific numerical techniques become effective. Here we present...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-05617-3

    authors： Strathearn A,Kirton P,Kilda D,Keeling J,Lovett BW

    更新日期：2018-08-20 00:00:00

  • Cryo-EM structures of the eukaryotic replicative helicase bound to a translocation substrate.

    abstract：:The Cdc45-MCM-GINS (CMG) helicase unwinds DNA during the elongation step of eukaryotic genome duplication and this process depends on the MCM ATPase function. Whether CMG translocation occurs on single- or double-stranded DNA and how ATP hydrolysis drives DNA unwinding remain open questions. Here we use cryo-electron ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms10708

    authors： Abid Ali F,Renault L,Gannon J,Gahlon HL,Kotecha A,Zhou JC,Rueda D,Costa A

    更新日期：2016-02-18 00:00:00

  • STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters.

    abstract：:Emergence of SARS-CoV-2 causing COVID-19 has resulted in hundreds of thousands of deaths. In search for key targets of effective therapeutics, robust animal models mimicking COVID-19 in humans are urgently needed. Here, we show that Syrian hamsters, in contrast to mice, are highly permissive to SARS-CoV-2 and develop ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-19684-y

    authors： Boudewijns R,Thibaut HJ,Kaptein SJF,Li R,Vergote V,Seldeslachts L,Van Weyenbergh J,De Keyzer C,Bervoets L,Sharma S,Liesenborghs L,Ma J,Jansen S,Van Looveren D,Vercruysse T,Wang X,Jochmans D,Martens E,Roose K,De Vlie

    更新日期：2020-11-17 00:00:00

  • ER-mitochondria contacts promote mtDNA nucleoids active transportation via mitochondrial dynamic tubulation.

    abstract：:A human cell contains hundreds to thousands of mitochondrial DNA (mtDNA) packaged into nucleoids. Currently, the segregation and allocation of nucleoids are thought to be passively determined by mitochondrial fusion and division. Here we provide evidence, using live-cell super-resolution imaging, that nucleoids can be...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-18202-4

    authors： Qin J,Guo Y,Xue B,Shi P,Chen Y,Su QP,Hao H,Zhao S,Wu C,Yu L,Li D,Sun Y

    更新日期：2020-09-08 00:00:00

  • A rapid cosmic-ray increase in BC 3372-3371 from ancient buried tree rings in China.

    abstract：:Cosmic rays interact with the Earth's atmosphere to produce 14C, which can be absorbed by trees. Therefore, rapid increases of 14C in tree rings can be used to probe previous cosmic-ray events. By this method, three 14C rapidly increasing events have been found. Plausible causes of these events include large solar pro...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-01698-8

    authors： Wang FY,Yu H,Zou YC,Dai ZG,Cheng KS

    更新日期：2017-11-14 00:00:00

  • Two sequential cleavage reactions on cruciform DNA structures cause palindrome-mediated chromosomal translocations.

    abstract：:Gross chromosomal rearrangements (GCRs), such as translocations, deletions or inversions, are often generated by illegitimate repair between two DNA breakages at regions with nucleotide sequences that might potentially adopt a non-B DNA conformation. We previously established a plasmid-based model system that recapitu...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms2595

    authors： Inagaki H,Ohye T,Kogo H,Tsutsumi M,Kato T,Tong M,Emanuel BS,Kurahashi H

    更新日期：2013-01-01 00:00:00

  • In situ conversion of defective Treg into SuperTreg cells to treat advanced IPEX-like disorders in mice.

    abstract：:Mutations disrupting regulatory T (Treg) cell function can cause IPEX and IPEX-related disorders, but whether established disease can be reversed by correcting these mutations is unclear. Treg-specific deletion of the chromatin remodeling factor Brg1 impairs Treg cell activation and causes fatal autoimmunity in mice. ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-15836-2

    authors： Li Y,Chen Y,Mao S,Kaundal R,Jing Z,Chen Q,Wang X,Xia J,Liu D,Sun J,Wang H,Chi T

    更新日期：2020-06-03 00:00:00

  • Elevated levels of TRF2 induce telomeric ultrafine anaphase bridges and rapid telomere deletions.

    abstract：:The shelterin protein TRF2 is essential for chromosome-end protection. Depletion of TRF2 causes chromosome end-to-end fusions, initiating genomic instability that can be cancer promoting. Paradoxically, significant increased levels of TRF2 are observed in a subset of human cancers. Experimental overexpression of TRF2 ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms10132

    authors： Nera B,Huang HS,Lai T,Xu L

    更新日期：2015-12-07 00:00:00

  • Longshot enables accurate variant calling in diploid genomes from single-molecule long read sequencing.

    abstract：:Whole-genome sequencing using sequencing technologies such as Illumina enables the accurate detection of small-scale variants but provides limited information about haplotypes and variants in repetitive regions of the human genome. Single-molecule sequencing (SMS) technologies such as Pacific Biosciences and Oxford Na...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-12493-y

    authors： Edge P,Bansal V

    更新日期：2019-10-11 00:00:00

  • Low potential enzymatic hydride transfer via highly cooperative and inversely functionalized flavin cofactors.

    abstract：:Hydride transfers play a crucial role in a multitude of biological redox reactions and are mediated by flavin, deazaflavin or nicotinamide adenine dinucleotide cofactors at standard redox potentials ranging from 0 to -340 mV. 2-Naphthoyl-CoA reductase, a key enzyme of oxygen-independent bacterial naphthalene degradati...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-10078-3

    authors： Willistein M,Bechtel DF,Müller CS,Demmer U,Heimann L,Kayastha K,Schünemann V,Pierik AJ,Ullmann GM,Ermler U,Boll M

    更新日期：2019-05-06 00:00:00

  • A moiré deflectometer for antimatter.

    abstract：:The precise measurement of forces is one way to obtain deep insight into the fundamental interactions present in nature. In the context of neutral antimatter, the gravitational interaction is of high interest, potentially revealing new forces that violate the weak equivalence principle. Here we report on a successful ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms5538

    authors： Aghion S,Ahlén O,Amsler C,Ariga A,Ariga T,Belov AS,Berggren K,Bonomi G,Bräunig P,Bremer J,Brusa RS,Cabaret L,Canali C,Caravita R,Castelli F,Cerchiari G,Cialdi S,Comparat D,Consolati G,Derking H,Di Domizio S,Di N

    更新日期：2014-07-28 00:00:00

  • Tailoring the hydrophobicity of graphene for its use as nanopores for DNA translocation.

    abstract：:Graphene nanopores are potential successors to biological and silicon-based nanopores. For sensing applications, it is however crucial to understand and block the strong nonspecific hydrophobic interactions between DNA and graphene. Here we demonstrate a novel scheme to prevent DNA-graphene interactions, based on a ta...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms3619

    authors： Schneider GF,Xu Q,Hage S,Luik S,Spoor JN,Malladi S,Zandbergen H,Dekker C

    更新日期：2013-01-01 00:00:00

  • Highly multiplexed imaging of single cells using a high-throughput cyclic immunofluorescence method.

    abstract：:Single-cell analysis reveals aspects of cellular physiology not evident from population-based studies, particularly in the case of highly multiplexed methods such as mass cytometry (CyTOF) able to correlate the levels of multiple signalling, differentiation and cell fate markers. Immunofluorescence (IF) microscopy add...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms9390

    authors： Lin JR,Fallahi-Sichani M,Sorger PK

    更新日期：2015-09-24 00:00:00

  • Author Correction: Structural determinants and functional consequences of protein affinity for membrane rafts.

    abstract：:In the originally published version of this Article, financial support was not fully acknowledged. The PDF and HTML versions of the Article have now been corrected to include support from National Institute of General Medical Sciences, National Institutes of Health grant R01GM124072. ...

    journal_title：Nature communications

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/s41467-018-04164-1

    authors： Lorent JH,Diaz-Rohrer B,Lin X,Spring K,Gorfe AA,Levental KR,Levental I

    更新日期：2018-05-01 00:00:00

  • Bottom-up growth of homogeneous Moiré superlattices in bismuth oxychloride spiral nanosheets.

    abstract：:Moiré superlattices (MSLs) are modulated structures produced from homogeneous or heterogeneous 2D layers stacked with a twist angle and/or lattice mismatch. Expanding the range of available materials, methods for fabricating MSL, and realization of unique emergent properties are key challenges. Here we report a facile...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-12347-7

    authors： Liu L,Sun Y,Cui X,Qi K,He X,Bao Q,Ma W,Lu J,Fang H,Zhang P,Zheng L,Yu L,Singh DJ,Xiong Q,Zhang L,Zheng W

    更新日期：2019-10-02 00:00:00

  • Confidence controls perceptual evidence accumulation.

    abstract：:Perceptual decisions are accompanied by feelings of confidence that reflect the likelihood that the decision was correct. Here we aim to clarify the relationship between perception and confidence by studying the same perceptual task across three different confidence contexts. Human observers were asked to categorize t...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-15561-w

    authors： Balsdon T,Wyart V,Mamassian P

    更新日期：2020-04-09 00:00:00

  • Central insulin modulates food valuation via mesolimbic pathways.

    abstract：:Central insulin is thought to act at the neural interface between metabolic and hedonic drives to eat. Here, using pharmacological fMRI, we show that intranasal insulin (INI) changes the value of food cues through modulation of mesolimbic pathways. Overnight fasted participants rated the palatability of food pictures ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms16052

    authors： Tiedemann LJ,Schmid SM,Hettel J,Giesen K,Francke P,Büchel C,Brassen S

    更新日期：2017-07-18 00:00:00

  • Evidence for ACTN3 as a genetic modifier of Duchenne muscular dystrophy.

    abstract：:Duchenne muscular dystrophy (DMD) is characterized by muscle degeneration and progressive weakness. There is considerable inter-patient variability in disease onset and progression, which can confound the results of clinical trials. Here we show that a common null polymorphism (R577X) in ACTN3 results in significantly...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms14143

    authors： Hogarth MW,Houweling PJ,Thomas KC,Gordish-Dressman H,Bello L,Cooperative International Neuromuscular Research Group (CINRG).,Pegoraro E,Hoffman EP,Head SI,North KN

    更新日期：2017-01-31 00:00:00

  • A rare functional cardioprotective APOC3 variant has risen in frequency in distinct population isolates.

    abstract：:Isolated populations can empower the identification of rare variation associated with complex traits through next generation association studies, but the generalizability of such findings remains unknown. Here we genotype 1,267 individuals from a Greek population isolate on the Illumina HumanExome Beadchip, in search ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms3872

    authors： Tachmazidou I,Dedoussis G,Southam L,Farmaki AE,Ritchie GR,Xifara DK,Matchan A,Hatzikotoulas K,Rayner NW,Chen Y,Pollin TI,O'Connell JR,Yerges-Armstrong LM,Kiagiadaki C,Panoutsopoulou K,Schwartzentruber J,Moutsianas L,UK1

    更新日期：2013-01-01 00:00:00

  • Receptor-binding loops in alphacoronavirus adaptation and evolution.

    abstract：:RNA viruses are characterized by a high mutation rate, a buffer against environmental change. Nevertheless, the means by which random mutation improves viral fitness is not well characterized. Here we report the X-ray crystal structure of the receptor-binding domain (RBD) of the human coronavirus, HCoV-229E, in comple...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-01706-x

    authors： Wong AHM,Tomlinson ACA,Zhou D,Satkunarajah M,Chen K,Sharon C,Desforges M,Talbot PJ,Rini JM

    更新日期：2017-11-23 00:00:00

  • Spatially inhomogeneous competition between superconductivity and the charge density wave in YBa2Cu3O6.67.

    abstract：:The charge density wave in the high-temperature superconductor YBa2Cu3O7-x (YBCO) has two different ordering tendencies differentiated by their c-axis correlations. These correspond to ferro- (F-CDW) and antiferro- (AF-CDW) couplings between CDWs in neighbouring CuO2 bilayers. This discovery has prompted several funda...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-14536-1

    authors： Choi J,Ivashko O,Blackburn E,Liang R,Bonn DA,Hardy WN,Holmes AT,Christensen NB,Hücker M,Gerber S,Gutowski O,Rütt U,Zimmermann MV,Forgan EM,Hayden SM,Chang J

    更新日期：2020-02-20 00:00:00

  • Genetic suppression reveals DNA repair-independent antagonism between BRCA1 and COBRA1 in mammary gland development.

    abstract：:The breast cancer susceptibility gene BRCA1 is well known for its function in double-strand break (DSB) DNA repair. While BRCA1 is also implicated in transcriptional regulation, the physiological significance remains unclear. COBRA1 (also known as NELF-B) is a BRCA1-binding protein that regulates RNA polymerase II (RN...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms10913

    authors： Nair SJ,Zhang X,Chiang HC,Jahid MJ,Wang Y,Garza P,April C,Salathia N,Banerjee T,Alenazi FS,Ruan J,Fan JB,Parvin JD,Jin VX,Hu Y,Li R

    更新日期：2016-03-04 00:00:00

  • Towards full-colour tunability of inorganic electrochromic devices using ultracompact fabry-perot nanocavities.

    abstract：:Intercalation-based inorganic materials that change their colours upon ion insertion/extraction lay an important foundation for existing electrochromic technology. However, using only such inorganic electrochromic materials, it is very difficult to achieve the utmost goal of full-colour tunability for future electroch...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-14194-y

    authors： Wang Z,Wang X,Cong S,Chen J,Sun H,Chen Z,Song G,Geng F,Chen Q,Zhao Z

    更新日期：2020-01-16 00:00:00

  • Tespa1 regulates T cell receptor-induced calcium signals by recruiting inositol 1,4,5-trisphosphate receptors.

    abstract：:Thymocyte-expressed, positive selection-associated 1 (Tespa1) is important in T cell receptor (TCR)-driven thymocyte development. Downstream of the TCR, Tespa1 is a crucial component of the linker for activation of T cells (LAT) signalosome, facilitating calcium signalling and subsequent MAPK activation. However, it i...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms15732

    authors： Liang J,Lyu J,Zhao M,Li D,Zheng M,Fang Y,Zhao F,Lou J,Guo C,Wang L,Wang D,Liu W,Lu L

    更新日期：2017-06-09 00:00:00

  • The complex structure of GRL0617 and SARS-CoV-2 PLpro reveals a hot spot for antiviral drug discovery.

    abstract：:SARS-CoV-2 is the pathogen responsible for the COVID-19 pandemic. The SARS-CoV-2 papain-like cysteine protease (PLpro) has been implicated in playing important roles in virus maturation, dysregulation of host inflammation, and antiviral immune responses. The multiple functions of PLpro render it a promising drug targe...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-20718-8

    authors： Fu Z,Huang B,Tang J,Liu S,Liu M,Ye Y,Liu Z,Xiong Y,Zhu W,Cao D,Li J,Niu X,Zhou H,Zhao YJ,Zhang G,Huang H

    更新日期：2021-01-20 00:00:00