Dominant oceanic bacteria secure phosphate using a large extracellular buffer.

abstract：:Insulin regulates glycaemia, lipogenesis and increases mRNA translation. Cells with reduced eukaryotic initiation factor 6 (eIF6) do not increase translation in response to insulin. The role of insulin-regulated translation is unknown. Here we show that reduction of insulin-regulated translation in mice heterozygous f...

journal_title：Nature communications

authors： Brina D,Miluzio A,Ricciardi S,Clarke K,Davidsen PK,Viero G,Tebaldi T,Offenhäuser N,Rozman J,Rathkolb B,Neschen S,Klingenspor M,Wolf E,Gailus-Durner V,Fuchs H,Hrabe de Angelis M,Quattrone A,Falciani F,Biffo S

更新日期：2015-09-18 00:00:00

abstract：:Zinc finger E-box binding homeobox 1 (Zeb1) has been demonstrated to participate in the acquisition of the properties of cancer stem cells (CSCs). However, it is largely unknown how signals from the tumor microenvironment (TME) contribute to aberrant Zeb1 expression. Here, we show that Zeb1 depletion suppresses stemne...

journal_title：Nature communications

authors： Jiang H,Zhou C,Zhang Z,Wang Q,Wei H,Shi W,Li J,Wang Z,Ou Y,Wang W,Wang H,Zhang Q,Sun W,Sun P,Yang S

更新日期：2020-10-12 00:00:00

abstract：:Regulatory T (Treg) cells derived from the thymus (tTreg) and periphery (pTreg) have central and distinct functions in immunosuppression, but mechanisms for the generation and activation of Treg subsets in vivo are unclear. Here, we show that mechanistic target of rapamycin (mTOR) unexpectedly supports the homeostasis...

journal_title：Nature communications

authors： Chapman NM,Zeng H,Nguyen TM,Wang Y,Vogel P,Dhungana Y,Liu X,Neale G,Locasale JW,Chi H

更新日期：2018-05-29 00:00:00

abstract：:Transition metal dichalcogenides have attracted research interest over the last few decades due to their interesting structural chemistry, unusual electronic properties, rich intercalation chemistry and wide spectrum of potential applications. Despite the fact that the majority of related research focuses on semicondu...

journal_title：Nature communications

authors： Qi Y,Naumov PG,Ali MN,Rajamathi CR,Schnelle W,Barkalov O,Hanfland M,Wu SC,Shekhar C,Sun Y,Süß V,Schmidt M,Schwarz U,Pippel E,Werner P,Hillebrand R,Förster T,Kampert E,Parkin S,Cava RJ,Felser C,Yan B,Medvedev S

更新日期：2016-03-14 00:00:00

abstract：:Synthesis of ethanol from non-petroleum carbon resources via syngas (a mixture of H2 and CO) is an important but challenging research target. The current conversion of syngas to ethanol suffers from low selectivity or multiple processes with high energy consumption. Here, we report a high-selective conversion of synga...

journal_title：Nature communications

authors： Kang J,He S,Zhou W,Shen Z,Li Y,Chen M,Zhang Q,Wang Y

更新日期：2020-02-11 00:00:00

abstract：:Secret communication over public channels is one of the central pillars of a modern information society. Using quantum key distribution this is achieved without relying on the hardness of mathematical problems, which might be compromised by improved algorithms or by future quantum computers. State-of-the-art quantum k...

journal_title：Nature communications

authors： Gehring T,Händchen V,Duhme J,Furrer F,Franz T,Pacher C,Werner RF,Schnabel R

更新日期：2015-10-30 00:00:00

abstract：:The shift from maternal to embryonic control is a critical developmental milestone in preimplantation development. Widespread transcriptomic and epigenetic remodeling facilitate this transition from terminally differentiated gametes to totipotent blastomeres, but the identity of transcription factors (TF) and genomic ...

journal_title：Nature communications

authors： Halstead MM,Ma X,Zhou C,Schultz RM,Ross PJ

更新日期：2020-09-17 00:00:00

abstract：:The xeroderma pigmentosum C (XPC) complex initiates nucleotide excision repair by recognizing DNA lesions before recruiting downstream factors. How XPC detects structurally diverse lesions embedded within normal DNA is unknown. Here we present a crystal structure that captures the yeast XPC orthologue (Rad4) on a sing...

journal_title：Nature communications

authors： Chen X,Velmurugu Y,Zheng G,Park B,Shim Y,Kim Y,Liu L,Van Houten B,He C,Ansari A,Min JH

更新日期：2015-01-06 00:00:00

abstract：:Activation of innate immunity by membrane-localized receptors is conserved across eukaryotes. Plant genomes contain hundreds of such receptor-like genes and those encoding proteins with an extracellular leucine-rich repeat (LRR) domain represent the largest family. Here, we develop a high-throughput approach to study ...

journal_title：Nature communications

authors： Wang Y,Xu Y,Sun Y,Wang H,Qi J,Wan B,Ye W,Lin Y,Shao Y,Dong S,Tyler BM,Wang Y

更新日期：2018-02-09 00:00:00

abstract：:The quantum spin Hall (QSH) phase is an exotic phenomena in condensed-matter physics. Here we show that a minimal basis of three orbitals (s, px, py) is required to produce a QSH phase via nearest-neighbour hopping in a two-dimensional trigonal lattice. Tight-binding model analyses and calculations show that the QSH p...

journal_title：Nature communications

authors： Wang ZF,Jin KH,Liu F

更新日期：2016-09-07 00:00:00

abstract：:Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, we identify 45 brainstem-associated genetic loci, including the first linked to midbrain, pon...

journal_title：Nature communications

authors： Elvsåshagen T,Bahrami S,van der Meer D,Agartz I,Alnæs D,Barch DM,Baur-Streubel R,Bertolino A,Beyer MK,Blasi G,Borgwardt S,Boye B,Buitelaar J,Bøen E,Celius EG,Cervenka S,Conzelmann A,Coynel D,Di Carlo P,Djurovic S,

更新日期：2020-08-11 00:00:00

abstract：:D-Glucosamine (GlcN) is a freely available and commonly used dietary supplement potentially promoting cartilage health in humans, which also acts as an inhibitor of glycolysis. Here we show that GlcN, independent of the hexosamine pathway, extends Caenorhabditis elegans life span by impairing glucose metabolism that a...

journal_title：Nature communications

authors： Weimer S,Priebs J,Kuhlow D,Groth M,Priebe S,Mansfeld J,Merry TL,Dubuis S,Laube B,Pfeiffer AF,Schulz TJ,Guthke R,Platzer M,Zamboni N,Zarse K,Ristow M

更新日期：2014-04-08 00:00:00

abstract：:The liver integrates multiple metabolic pathways to warrant systemic energy homeostasis. An excessive lipogenic flux due to chronic dietary stimulation contributes to the development of hepatic steatosis, dyslipidemia and hyperglycemia. Here we show that the oxidoreductase retinol saturase (RetSat) is involved in the ...

journal_title：Nature communications

authors： Heidenreich S,Witte N,Weber P,Goehring I,Tolkachov A,von Loeffelholz C,Döcke S,Bauer M,Stockmann M,Pfeiffer AFH,Birkenfeld AL,Pietzke M,Kempa S,Muenzner M,Schupp M

更新日期：2017-08-30 00:00:00

abstract：:In 1927, J.B.S. Haldane reasoned that the probability of fixation of new beneficial alleles is twice their fitness effect. This result, later generalized by M. Kimura, has since become the cornerstone of modern population genetics. There is no experimental test of Haldane's insight that new beneficial alleles are lost...

journal_title：Nature communications

authors： Chelo IM,Nédli J,Gordo I,Teotónio H

更新日期：2013-01-01 00:00:00

abstract：:FAM46C is one of the most frequently mutated genes in multiple myeloma. Here, using a combination of in vitro and in vivo approaches, we demonstrate that FAM46C encodes an active non-canonical poly(A) polymerase which enhances mRNA stability and gene expression. Reintroduction of active FAM46C into multiple myeloma ce...

journal_title：Nature communications

authors： Mroczek S,Chlebowska J,Kuliński TM,Gewartowska O,Gruchota J,Cysewski D,Liudkovska V,Borsuk E,Nowis D,Dziembowski A

更新日期：2017-09-20 00:00:00

abstract：:The bio-integrated electronics industry is booming and becoming more integrated with biological tissues. To successfully integrate with the soft tissues of the body (eg. skin), the material must possess many of the same properties including compliance, toughness, elasticity, and tear resistance. In this work, we prepa...

journal_title：Nature communications

authors： Chen S,Sun L,Zhou X,Guo Y,Song J,Qian S,Liu Z,Guan Q,Meade Jeffries E,Liu W,Wang Y,He C,You Z

更新日期：2020-02-27 00:00:00

abstract：:Ultra-small, magic-sized metal nanoclusters represent an important new class of materials with properties between molecules and particles. However, their small size challenges the conventional methods for structure characterization. Here we present the structure of ultra-stable Au144(SR)60 magic-sized nanoclusters obt...

journal_title：Nature communications

authors： Jensen KM,Juhas P,Tofanelli MA,Heinecke CL,Vaughan G,Ackerson CJ,Billinge SJ

更新日期：2016-06-14 00:00:00

abstract：:Layer-by-layer-stacked chemical vapour deposition (CVD) graphene films find applications as transparent and conductive electrodes in solar cells, organic light-emitting diodes and touch panels. Common to lamellar-type systems with anisotropic electron delocalization, the plane-to-plane (vertical) conductivity in such ...

journal_title：Nature communications

authors： Liu Y,Yuan L,Yang M,Zheng Y,Li L,Gao L,Nerngchamnong N,Nai CT,Sangeeth CS,Feng YP,Nijhuis CA,Loh KP

更新日期：2014-11-20 00:00:00

abstract：:The amniote middle ear is a classical example of the evolutionary novelty. Although paleontological evidence supports the view that mammals and diapsids (modern reptiles and birds) independently acquired the middle ear after divergence from their common ancestor, the developmental bases of these transformations remain...

journal_title：Nature communications

authors： Kitazawa T,Takechi M,Hirasawa T,Adachi N,Narboux-Nême N,Kume H,Maeda K,Hirai T,Miyagawa-Tomita S,Kurihara Y,Hitomi J,Levi G,Kuratani S,Kurihara H

更新日期：2015-04-22 00:00:00

abstract：:Interferon gamma (IFNγ)-producing CD8(+) T cells (Tc1) play important roles in immunological disease. We now report that CD3/CD28-mediated stimulation of CD8(+) T cells to generate Tc1 cells, not only increases IFNγ production but also boosts the generation of reactive oxygen species (ROS) and augments expression of C...

journal_title：Nature communications

authors： Bai A,Moss A,Rothweiler S,Serena Longhi M,Wu Y,Junger WG,Robson SC

更新日期：2015-11-09 00:00:00

abstract：:The reversible modification of cysteine residues by thioester formation with palmitate (S-palmitoylation) is an abundant lipid post-translational modification (PTM) in mammalian systems. S-palmitoylation has been observed on mitochondrial proteins, providing an intriguing potential connection between metabolic lipids ...

journal_title：Nature communications

authors： Kathayat RS,Cao Y,Elvira PD,Sandoz PA,Zaballa ME,Springer MZ,Drake LE,Macleod KF,van der Goot FG,Dickinson BC

更新日期：2018-01-23 00:00:00

abstract：:When pressure is applied, the molecules inside a crystal undergo significant changes of their stereoelectronic properties. The most interesting are those enhancing the reactivity of systems that would be otherwise rather inert at ambient conditions. Before a reaction can occur, however, a molecule must be activated, w...

journal_title：Nature communications

authors： Casati N,Kleppe A,Jephcoat AP,Macchi P

更新日期：2016-03-16 00:00:00

abstract：:The potential of the folic acid biosynthesis pathway as a target for the development of antibiotics has been clinically validated. However, many pathogens have developed resistance to these antibiotics, prompting a re-evaluation of potential drug targets within the pathway. The ydaH gene of Alcanivorax borkumensis enc...

journal_title：Nature communications

authors： Bolla JR,Su CC,Delmar JA,Radhakrishnan A,Kumar N,Chou TH,Long F,Rajashankar KR,Yu EW

更新日期：2015-04-20 00:00:00

abstract：:Low-damping magnetic materials have been widely used in microwave and spintronic applications because of their low energy loss and high sensitivity. While the Gilbert damping constant can reach 10-4 to 10-5 in some insulating ferromagnets, metallic ferromagnets generally have larger damping due to magnon scattering by...

journal_title：Nature communications

authors： Lee AJ,Brangham JT,Cheng Y,White SP,Ruane WT,Esser BD,McComb DW,Hammel PC,Yang F

更新日期：2017-08-10 00:00:00

abstract：:High-altitude pulmonary hypertension (HAPH) has heritable features and is a major cause of death in cattle in the Rocky Mountains, USA. Although multiple genes are likely involved in the genesis of HAPH, to date no major gene variant has been identified. Using whole-exome sequencing, we report the high association of ...

journal_title：Nature communications

authors： Newman JH,Holt TN,Cogan JD,Womack B,Phillips JA 3rd,Li C,Kendall Z,Stenmark KR,Thomas MG,Brown RD,Riddle SR,West JD,Hamid R

更新日期：2015-04-15 00:00:00

abstract：:CRISPR-Cas9 has led to great advances in gene editing for a broad spectrum of applications. To further the utility of Cas9 there have been efforts to achieve temporal control over its nuclease activity. While different approaches have focused on regulation of CRISPR interference or editing in mammalian cells, none of ...

journal_title：Nature communications

authors： Iwasaki RS,Ozdilek BA,Garst AD,Choudhury A,Batey RT

更新日期：2020-03-13 00:00:00

abstract：:Acute myeloid leukaemia (AML) affects children and adults of all ages. AML remains one of the major causes of death in children with cancer and for children with AML relapse is the most common cause of death. Here, by modelling AML in vivo we demonstrate that AML is discriminated by the age of the cell of origin. Youn...

journal_title：Nature communications

authors： Chaudhury S,O'Connor C,Cañete A,Bittencourt-Silvestre J,Sarrou E,Prendergast Á,Choi J,Johnston P,Wells CA,Gibson B,Keeshan K

更新日期：2018-12-11 00:00:00

abstract：:Prostate development depends on balanced cell proliferation and differentiation, and acetylated KLF5 is known to alter epithelial proliferation. It remains elusive whether post-translational modifications of transcription factors can differentially determine adult stem/progenitor cell fate. Here we report that, in hum...

journal_title：Nature communications

authors： Zhang B,Ci X,Tao R,Ni JJ,Xuan X,King JL,Xia S,Li Y,Frierson HF,Lee DK,Xu J,Osunkoya AO,Dong JT

更新日期：2020-02-21 00:00:00

abstract：:Advanced-stage epithelial ovarian cancers are amongst the most difficult to treat tumors and have proven to be refractory to most cytotoxic, molecularly targeted, or immunotherapeutic approaches. Here, we report that nanoparticle-drug conjugates (NDCs) of monomethyl auristatin E (MMAE) significantly increase loading o...

journal_title：Nature communications

authors： Qi R,Wang Y,Bruno PM,Xiao H,Yu Y,Li T,Lauffer S,Wei W,Chen Q,Kang X,Song H,Yang X,Huang X,Detappe A,Matulonis U,Pepin D,Hemann MT,Birrer MJ,Ghoroghchian PP

更新日期：2017-12-18 00:00:00

abstract：:Bone mineral density is known to be a heritable, polygenic trait whereas genetic variants contributing to lean mass variation remain largely unknown. We estimated the shared SNP heritability and performed a bivariate GWAS meta-analysis of total-body lean mass (TB-LM) and total-body less head bone mineral density (TBLH...

journal_title：Nature communications

authors： Medina-Gomez C,Kemp JP,Dimou NL,Kreiner E,Chesi A,Zemel BS,Bønnelykke K,Boer CG,Ahluwalia TS,Bisgaard H,Evangelou E,Heppe DHM,Bonewald LF,Gorski JP,Ghanbari M,Demissie S,Duque G,Maurano MT,Kiel DP,Hsu YH,C J van d

更新日期：2017-07-25 00:00:00