Publisher Correction: The TLR7/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer.

abstract：:Influenza virus can escape most antibodies with single mutations. However, rare antibodies broadly neutralize many viral strains. It is unclear how easily influenza virus might escape such antibodies if there was strong pressure to do so. Here, we map all single amino-acid mutations that increase resistance to broad a...

journal_title：Nature communications

authors： Doud MB,Lee JM,Bloom JD

更新日期：2018-04-11 00:00:00

abstract：:Netrins, a family of laminin-related molecules, have been proposed to act as guidance cues either during nervous system development or the establishment of the vascular system. This was clearly demonstrated for netrin-1 via its interaction with the receptors DCC and UNC5s. However, mainly based on shared homologies wi...

journal_title：Nature communications

authors： Reuten R,Patel TR,McDougall M,Rama N,Nikodemus D,Gibert B,Delcros JG,Prein C,Meier M,Metzger S,Zhou Z,Kaltenberg J,McKee KK,Bald T,Tüting T,Zigrino P,Djonov V,Bloch W,Clausen-Schaumann H,Poschl E,Yurchenco PD,Eh

更新日期：2016-11-30 00:00:00

abstract：:The high incidence of aneuploidy in the embryo is considered the principal cause for low human fecundity. However, the prevalence of aneuploidy dramatically declines as pregnancy progresses, with the steepest drop occurring as the embryo completes implantation. Despite the fact that the plasticity of the embryo in dea...

journal_title：Nature communications

authors： Singla S,Iwamoto-Stohl LK,Zhu M,Zernicka-Goetz M

更新日期：2020-06-11 00:00:00

abstract：:Discharge from sliding outlet glaciers controls uncertainty in projections for future sea level. Remarkably, over 90% of glacial area is subject to gravitational driving stresses below 150 kPa (median ∼70 kPa). Longstanding explanations that appeal to the shear-thinning rheology of ice tend to overpredict driving stre...

journal_title：Nature communications

authors： Meyer CR,Downey AS,Rempel AW

更新日期：2018-08-13 00:00:00

abstract：:Interfacial water constitutes a formidable barrier to strong surface bonding, hampering the development of water-resistant synthetic adhesives. Notwithstanding this obstacle, the Asian green mussel Perna viridis attaches firmly to underwater surfaces via a proteinaceous secretion (byssus). Extending beyond the current...

journal_title：Nature communications

authors： Petrone L,Kumar A,Sutanto CN,Patil NJ,Kannan S,Palaniappan A,Amini S,Zappone B,Verma C,Miserez A

更新日期：2015-10-28 00:00:00

abstract：:Recent years have seen great advances in the development of synthetic self-assembling molecular systems. Designing out-of-equilibrium architectures, however, requires a more subtle control over the thermodynamics and kinetics of reactions. We propose a mechanism for enhancing the thermodynamic drive of DNA strand-disp...

journal_title：Nature communications

authors： Haley NEC,Ouldridge TE,Mullor Ruiz I,Geraldini A,Louis AA,Bath J,Turberfield AJ

更新日期：2020-05-22 00:00:00

abstract：:A synthetic biology method based on heterologous biosynthesis coupled with genome mining is a promising approach for increasing the opportunities to rationally access natural product with novel structures and biological activities through total biosynthesis and combinatorial biosynthesis. Here, we demonstrate the adva...

journal_title：Nature communications

authors： Tsukada K,Shinki S,Kaneko A,Murakami K,Irie K,Murai M,Miyoshi H,Dan S,Kawaji K,Hayashi H,Kodama EN,Hori A,Salim E,Kuraishi T,Hirata N,Kanda Y,Asai T

更新日期：2020-04-14 00:00:00

abstract：:Small-molecule inhibitor of apoptosis (IAP) antagonists, called Smac mimetic compounds (SMCs), sensitize tumours to TNF-α-induced killing while simultaneously blocking TNF-α growth-promoting activities. SMCs also regulate several immunomodulatory properties within immune cells. We report that SMCs synergize with innat...

journal_title：Nature communications

authors： Beug ST,Beauregard CE,Healy C,Sanda T,St-Jean M,Chabot J,Walker DE,Mohan A,Earl N,Lun X,Senger DL,Robbins SM,Staeheli P,Forsyth PA,Alain T,LaCasse EC,Korneluk RG

更新日期：2017-02-15 00:00:00

abstract：:Replicating biological patterns is promising for designing materials with multifaceted properties. Twisted cholesteric liquid crystal patterns are found in the iridescent tessellated cuticles of many insects and a few fruits. Their accurate replication is extremely difficult since discontinuous patterns and colors mus...

journal_title：Nature communications

authors： Scarangella A,Soldan V,Mitov M

更新日期：2020-08-14 00:00:00

abstract：:Many crystals, such as those of metals, can transform from one symmetry into another having lower free energy via a diffusionless transformation. Here we create binary colloidal crystals consisting of polymer microspheres, pulled together by DNA bridges, that induce specific, reversible attractions between two species...

journal_title：Nature communications

authors： Casey MT,Scarlett RT,Rogers WB,Jenkins I,Sinno T,Crocker JC

更新日期：2012-01-01 00:00:00

abstract：:Bcl9 and Pygo are Wnt enhanceosome components that effect β-catenin-dependent transcription. Whether they mediate β-catenin-dependent neoplasia is unclear. Here we assess their roles in intestinal tumourigenesis initiated by Apc loss-of-function (ApcMin), or by Apc1322T encoding a partially-functional Apc truncation c...

journal_title：Nature communications

authors： Mieszczanek J,van Tienen LM,Ibrahim AEK,Winton DJ,Bienz M

更新日期：2019-02-13 00:00:00

abstract：:Loss of appetite or anorexia associated with inflammation impairs quality of life and increases morbidity in many diseases. However, the exact neural mechanism that mediates inflammation-associated anorexia is still poorly understood. Here we identified a population of neurons, marked by the expression of protein kina...

journal_title：Nature communications

authors： Wang Y,Kim J,Schmit MB,Cho TS,Fang C,Cai H

更新日期：2019-06-24 00:00:00

abstract：:Matter-wave interferometry performed with massive objects elucidates their wave nature and thus tests the quantum superposition principle at large scales. Whereas standard quantum theory places no limit on particle size, alternative, yet untested theories--conceived to explain the apparent quantum to classical transit...

journal_title：Nature communications

authors： Bateman J,Nimmrichter S,Hornberger K,Ulbricht H

更新日期：2014-09-02 00:00:00

abstract：:The hierarchical relationships between various stem and progenitor cell subpopulations driving mammary gland morphogenesis and homoeostasis are poorly understood. Conditional inactivation experiments previously demonstrated that expression of the zinc finger transcriptional repressor Blimp1/PRDM1 is essential for the ...

journal_title：Nature communications

authors： Elias S,Morgan MA,Bikoff EK,Robertson EJ

更新日期：2017-11-20 00:00:00

abstract：:Profound global loss of DNA methylation is a hallmark of many cancers. One potential consequence of this is the reactivation of transposable elements (TEs) which could stimulate the immune system via cell-intrinsic antiviral responses. Here, we develop REdiscoverTE, a computational method for quantifying genome-wide T...

journal_title：Nature communications

authors： Kong Y,Rose CM,Cass AA,Williams AG,Darwish M,Lianoglou S,Haverty PM,Tong AJ,Blanchette C,Albert ML,Mellman I,Bourgon R,Greally J,Jhunjhunwala S,Chen-Harris H

更新日期：2019-11-19 00:00:00

abstract：:The ability to understand and control the electronic properties of individual molecules in a device environment is crucial for developing future technologies at the nanometre scale and below. Achieving this, however, requires the creation of three-terminal devices that allow single molecules to be both gated and image...

journal_title：Nature communications

authors： Wickenburg S,Lu J,Lischner J,Tsai HZ,Omrani AA,Riss A,Karrasch C,Bradley A,Jung HS,Khajeh R,Wong D,Watanabe K,Taniguchi T,Zettl A,Neto AHC,Louie SG,Crommie MF

更新日期：2016-11-25 00:00:00

abstract：:Breaking time-reversal symmetry enables the realization of non-reciprocal devices, such as isolators and circulators, of fundamental importance in microwave and photonic communication systems. This effect is almost exclusively achieved today through magneto-optical phenomena, which are incompatible with integrated tec...

journal_title：Nature communications

authors： Sounas DL,Caloz C,Alù A

更新日期：2013-01-01 00:00:00

abstract：:Puberty is regulated by epigenetic mechanisms and is highly sensitive to metabolic and nutritional cues. However, the epigenetic pathways mediating the effects of nutrition and obesity on pubertal timing are unknown. Here, we identify Sirtuin 1 (SIRT1), a fuel-sensing deacetylase, as a molecule that restrains female p...

journal_title：Nature communications

authors： Vazquez MJ,Toro CA,Castellano JM,Ruiz-Pino F,Roa J,Beiroa D,Heras V,Velasco I,Dieguez C,Pinilla L,Gaytan F,Nogueiras R,Bosch MA,Rønnekleiv OK,Lomniczi A,Ojeda SR,Tena-Sempere M

更新日期：2018-10-10 00:00:00

abstract：:The sigma-2 receptor, whose gene remains to be cloned, has been validated as a biomarker for tumour cell proliferation. Here we report the use of a novel photoaffinity probe, WC-21, to identify the sigma-2 receptor-binding site. WC-21, a sigma-2 ligand containing both a photoactive azide moiety and a fluorescein isoth...

journal_title：Nature communications

authors： Xu J,Zeng C,Chu W,Pan F,Rothfuss JM,Zhang F,Tu Z,Zhou D,Zeng D,Vangveravong S,Johnston F,Spitzer D,Chang KC,Hotchkiss RS,Hawkins WG,Wheeler KT,Mach RH

更新日期：2011-07-05 00:00:00

abstract：:Auditory cortex neurons nonlinearly integrate synaptic inputs from the thalamus and cortex, and generate spiking outputs for simple and complex sounds. Directly comparing synaptic and spiking activity can determine whether this input-output transformation is stimulus-dependent. We employ in vivo whole-cell recordings ...

journal_title：Nature communications

authors： Kim KX,Atencio CA,Schreiner CE

更新日期：2020-02-27 00:00:00

abstract：:Droplet interactions with compliant materials are familiar, but surprisingly complex processes of importance to the manufacturing, chemical, and garment industries. Despite progress-previous research indicates that mesoscopic substrate deformations can enhance droplet drying or slow down spreading dynamics-our underst...

journal_title：Nature communications

authors： Gerber J,Lendenmann T,Eghlidi H,Schutzius TM,Poulikakos D

更新日期：2019-10-21 00:00:00

abstract：:Problematic microfossils dominate the palaeontological record between the Great Oxidation Event 2.4 billion years ago (Ga) and the last Palaeoproterozoic iron formations, deposited 500-600 million years later. These fossils are often associated with iron-rich sedimentary rocks, but their affinities, metabolism, and, h...

journal_title：Nature communications

authors： Lepot K,Addad A,Knoll AH,Wang J,Troadec D,Béché A,Javaux EJ

更新日期：2017-03-23 00:00:00

abstract：:A gene is considered essential if loss of function results in loss of viability, fitness or in disease. This concept is well established for coding genes; however, non-coding regions are thought less likely to be determinants of critical functions. Here we train a machine learning model using functional, mutational an...

journal_title：Nature communications

authors： Wells A,Heckerman D,Torkamani A,Yin L,Sebat J,Ren B,Telenti A,di Iulio J

更新日期：2019-11-20 00:00:00

abstract：:The electron deficiency and strong bonding capacity of boron have led to a vast variety of molecular structures in chemistry and materials science. Here we report the observation of highly symmetric cobalt-centered boron drum-like structures of CoB16(-), characterized by photoelectron spectroscopy and ab initio calcul...

journal_title：Nature communications

authors： Popov IA,Jian T,Lopez GV,Boldyrev AI,Wang LS

更新日期：2015-10-12 00:00:00

abstract：:The CCCTC-binding zinc-finger protein (CTCF)-mediated network of long-range chromatin interactions is important for genome organization and function. Although this network has been considered largely invariant, we find that it exhibits extensive cell-type-specific interactions that contribute to cell identity. Here, w...

journal_title：Nature communications

authors： Kai Y,Andricovich J,Zeng Z,Zhu J,Tzatsos A,Peng W

更新日期：2018-10-11 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： López-Barneo J,Simon MC

更新日期：2020-02-25 00:00:00

abstract：:The social intelligence hypothesis (SIH) posits that within-group interactions drive cognitive evolution, but it has received equivocal support. We argue the SIH overlooks a major component of social life: interactions with conspecific outsiders. Competition for vital resources means conspecific outsiders present myri...

journal_title：Nature communications

authors： Ashton BJ,Kennedy P,Radford AN

更新日期：2020-10-06 00:00:00

abstract：:Epitaxial films may be released from growth substrates and transferred to structurally and chemically incompatible substrates, but epitaxial films of transition metal perovskite oxides have not been transferred to electroactive substrates for voltage control of their myriad functional properties. Here we demonstrate g...

journal_title：Nature communications

authors： Pesquera D,Khestanova E,Ghidini M,Zhang S,Rooney AP,Maccherozzi F,Riego P,Farokhipoor S,Kim J,Moya X,Vickers ME,Stelmashenko NA,Haigh SJ,Dhesi SS,Mathur ND

更新日期：2020-06-24 00:00:00

abstract：:A number of modes of oscillations of particles and fields can exist in space plasmas. Since the early 1970s, space missions have observed noise-like plasma waves near the geomagnetic equator known as 'equatorial noise'. Several theories were suggested, but clear observational evidence supported by realistic modelling ...

journal_title：Nature communications

authors： Balikhin MA,Shprits YY,Walker SN,Chen L,Cornilleau-Wehrlin N,Dandouras I,Santolik O,Carr C,Yearby KH,Weiss B

更新日期：2015-07-14 00:00:00

abstract：:The exceptional interest in improving the limitations of data storage, molecular electronics and optoelectronics has promoted the development of an ever increasing number of techniques used to pattern polymers at micro and nanoscale. Most of them rely on atomic force microscopy to thermally or electrostatically induce...

journal_title：Nature communications

authors： Farina M,Ye T,Lanzani G,di Donato A,Venanzoni G,Mencarelli D,Pietrangelo T,Morini A,Keivanidis PE

更新日期：2013-01-01 00:00:00