Mussel adhesion is dictated by time-regulated secretion and molecular conformation of mussel adhesive proteins.


:Interfacial water constitutes a formidable barrier to strong surface bonding, hampering the development of water-resistant synthetic adhesives. Notwithstanding this obstacle, the Asian green mussel Perna viridis attaches firmly to underwater surfaces via a proteinaceous secretion (byssus). Extending beyond the currently known design principles of mussel adhesion, here we elucidate the precise time-regulated secretion of P. viridis mussel adhesive proteins. The vanguard 3,4-dihydroxy-L-phenylalanine (Dopa)-rich protein Pvfp-5 acts as an adhesive primer, overcoming repulsive hydration forces by displacing surface-bound water and generating strong surface adhesion. Using homology modelling and molecular dynamics simulations, we find that all mussel adhesive proteins are largely unordered, with Pvfp-5 adopting a disordered structure and elongated conformation whereby all Dopa residues reside on the protein surface. Time-regulated secretion and structural disorder of mussel adhesive proteins appear essential for optimizing extended nonspecific surface interactions and byssus' assembly. Our findings reveal molecular-scale principles to help the development of wet-resistant adhesives.


Nat Commun


Nature communications


Petrone L,Kumar A,Sutanto CN,Patil NJ,Kannan S,Palaniappan A,Amini S,Zappone B,Verma C,Miserez A




Has Abstract


2015-10-28 00:00:00










  • Single-molecule chemical reaction reveals molecular reaction kinetics and dynamics.

    abstract::Understanding the microscopic elementary process of chemical reactions, especially in condensed phase, is highly desirable for improvement of efficiencies in industrial chemical processes. Here we show an approach to gaining new insights into elementary reactions in condensed phase by combining quantum chemical calcul...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Zhang Y,Song P,Fu Q,Ruan M,Xu W

    更新日期:2014-06-25 00:00:00

  • Tau local structure shields an amyloid-forming motif and controls aggregation propensity.

    abstract::Tauopathies are neurodegenerative diseases characterized by intracellular amyloid deposits of tau protein. Missense mutations in the tau gene (MAPT) correlate with aggregation propensity and cause dominantly inherited tauopathies, but their biophysical mechanism driving amyloid formation is poorly understood. Many dis...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Chen D,Drombosky KW,Hou Z,Sari L,Kashmer OM,Ryder BD,Perez VA,Woodard DR,Lin MM,Diamond MI,Joachimiak LA

    更新日期:2019-06-07 00:00:00

  • Two recipes for repelling hot water.

    abstract::Although a hydrophobic microtexture at a solid surface most often reflects rain owing to the presence of entrapped air within the texture, it is much more challenging to repel hot water. As it contacts a colder material, hot water generates condensation within the cavities at the solid surface, which eventually builds...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Mouterde T,Lecointre P,Lehoucq G,Checco A,Clanet C,Quéré D

    更新日期:2019-03-29 00:00:00

  • Vastly extended drug release from poly(pro-17β-estradiol) materials facilitates in vitro neurotrophism and neuroprotection.

    abstract::Central nervous system (CNS) injuries persist for years, and currently there are no therapeutics that can address the complex injury cascade that develops over this time-scale. 17β-estradiol (E2) has broad tropism within the CNS, targeting and inducing beneficial phenotypic changes in myriad cells following injury. To...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: D'Amato AR,Puhl DL,Ellman SAT,Balouch B,Gilbert RJ,Palermo EF

    更新日期:2019-10-23 00:00:00

  • Rapid regional perturbations to the recent global geomagnetic decay revealed by a new Hawaiian record.

    abstract::The dominant dipolar component of the Earth's magnetic field has been steadily weakening for at least the last 170 years. Prior to these direct measurements, archaeomagnetic records show short periods of significantly elevated geomagnetic intensity. These striking phenomena are not captured by current field models and...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: de Groot LV,Biggin AJ,Dekkers MJ,Langereis CG,Herrero-Bervera E

    更新日期:2013-01-01 00:00:00

  • Long-term isolation of European steppe outposts boosts the biome's conservation value.

    abstract::The European steppes and their biota have been hypothesized to be either young remnants of the Pleistocene steppe belt or, alternatively, to represent relicts of long-term persisting populations; both scenarios directly bear on nature conservation priorities. Here, we evaluate the conservation value of threatened disj...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Kirschner P,Záveská E,Gamisch A,Hilpold A,Trucchi E,Paun O,Sanmartín I,Schlick-Steiner BC,Frajman B,Arthofer W,STEPPE Consortium.,Steiner FM,Schönswetter P

    更新日期:2020-04-23 00:00:00

  • Efficient non-Markovian quantum dynamics using time-evolving matrix product operators.

    abstract::In order to model realistic quantum devices it is necessary to simulate quantum systems strongly coupled to their environment. To date, most understanding of open quantum systems is restricted either to weak system-bath couplings or to special cases where specific numerical techniques become effective. Here we present...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Strathearn A,Kirton P,Kilda D,Keeling J,Lovett BW

    更新日期:2018-08-20 00:00:00

  • Shuttling a single charge across a one-dimensional array of silicon quantum dots.

    abstract::Significant advances have been made towards fault-tolerant operation of silicon spin qubits, with single qubit fidelities exceeding 99.9%, several demonstrations of two-qubit gates based on exchange coupling, and the achievement of coherent single spin-photon coupling. Coupling arbitrary pairs of spatially separated q...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Mills AR,Zajac DM,Gullans MJ,Schupp FJ,Hazard TM,Petta JR

    更新日期:2019-03-05 00:00:00

  • Mutations in the HPV16 genome induced by APOBEC3 are associated with viral clearance.

    abstract::HPV16 causes half of cervical cancers worldwide; for unknown reasons, most infections resolve within two years. Here, we analyze the viral genomes of 5,328 HPV16-positive case-control samples to investigate mutational signatures and the role of human APOBEC3-induced mutations in viral clearance and cervical carcinogen...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Zhu B,Xiao Y,Yeager M,Clifford G,Wentzensen N,Cullen M,Boland JF,Bass S,Steinberg MK,Raine-Bennett T,Lee D,Burk RD,Pinheiro M,Song L,Dean M,Nelson CW,Burdett L,Yu K,Roberson D,Lorey T,Franceschi S,Castle PE,Wa

    更新日期:2020-02-14 00:00:00

  • The immunoreceptor NKG2D promotes tumour growth in a model of hepatocellular carcinoma.

    abstract::Inflammation is recognized as one of the drivers of cancer. Yet, the individual immune components that possess pro- and anti-tumorigenic functions in individual cancers remain largely unknown. NKG2D is a potent activating immunoreceptor that has emerged as an important player in inflammatory disorders besides its well...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Sheppard S,Guedes J,Mroz A,Zavitsanou AM,Kudo H,Rothery SM,Angelopoulos P,Goldin R,Guerra N

    更新日期:2017-01-27 00:00:00

  • Correct determination of charge transfer state energy from luminescence spectra in organic solar cells.

    abstract::Generation and recombination of electrons and holes in organic solar cells occurs via charge transfer states located at the donor/acceptor interface. The energy of these charge transfer states is a crucial factor for the attainable open-circuit voltage and its correct determination is thus of utmost importance for a d...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: List M,Sarkar T,Perkhun P,Ackermann J,Luo C,Würfel U

    更新日期:2018-09-07 00:00:00

  • Size-dependent strong metal-support interaction in TiO2 supported Au nanocatalysts.

    abstract::The strong metal-support interaction (SMSI) has long been studied in heterogonous catalysis on account of its importance in stabilizing active metals and tuning catalytic performance. As a dynamic process taking place at the metal-support interface, the SMSI is closely related to the metal surface properties which are...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Du X,Huang Y,Pan X,Han B,Su Y,Jiang Q,Li M,Tang H,Li G,Qiao B

    更新日期:2020-11-16 00:00:00

  • Myelin replacement triggered by single-cell demyelination in mouse cortex.

    abstract::Myelin, rather than being a static insulator of axons, is emerging as an active participant in circuit plasticity. This requires precise regulation of oligodendrocyte numbers and myelination patterns. Here, by devising a laser ablation approach of single oligodendrocytes, followed by in vivo imaging and correlated ult...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Snaidero N,Schifferer M,Mezydlo A,Zalc B,Kerschensteiner M,Misgeld T

    更新日期:2020-09-29 00:00:00

  • Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma.

    abstract::Notch1 transactivates Notch3 to drive terminal differentiation in stratified squamous epithelia. Notch1 and other Notch receptor paralogs cooperate to act as a tumor suppressor in squamous cell carcinomas (SCCs). However, Notch1 can be stochastically activated to promote carcinogenesis in murine models of SCC. Activat...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Natsuizaka M,Whelan KA,Kagawa S,Tanaka K,Giroux V,Chandramouleeswaran PM,Long A,Sahu V,Darling DS,Que J,Yang Y,Katz JP,Wileyto EP,Basu D,Kita Y,Natsugoe S,Naganuma S,Klein-Szanto AJ,Diehl JA,Bass AJ,Wong KK,Rust

    更新日期:2017-11-24 00:00:00

  • De novo compartment deconvolution and weight estimation of tumor samples using DECODER.

    abstract::Tumors are mixtures of different compartments. While global gene expression analysis profiles the average expression of all compartments in a sample, identifying the specific contribution of each compartment remains a challenge. With the increasing recognition of the importance of non-neoplastic components, the abilit...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Peng XL,Moffitt RA,Torphy RJ,Volmar KE,Yeh JJ

    更新日期:2019-10-18 00:00:00

  • Functional genomic analysis identifies miRNA repertoire regulating C. elegans oocyte development.

    abstract::Oocyte-specific miRNA function remains unclear in mice and worms because loss of Dgcr8 and Dicer from mouse and worm oocytes, respectively, does not yield oogenic defects. These data lead to several models: (a) miRNAs are not generated in oocytes; (b) miRNAs are generated but do not perform an oogenic function; (c) fu...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Minogue AL,Tackett MR,Atabakhsh E,Tejada G,Arur S

    更新日期:2018-12-14 00:00:00

  • CRISPR/Cas9-mediated gene targeting in Arabidopsis using sequential transformation.

    abstract::Homologous recombination-based gene targeting is a powerful tool for precise genome modification and has been widely used in organisms ranging from yeast to higher organisms such as Drosophila and mouse. However, gene targeting in higher plants, including the most widely used model plant Arabidopsis thaliana, remains ...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Miki D,Zhang W,Zeng W,Feng Z,Zhu JK

    更新日期:2018-05-17 00:00:00

  • First direct observation of the Van Hove singularity in the tunnelling spectra of cuprates.

    abstract::In two-dimensional (2D) lattices, the electronic levels are unevenly spaced, and the density of states (DOS) displays a logarithmic divergence known as the Van Hove singularity (VHS). This is the case in particular for the layered cuprate superconductors. The scanning tunnelling microscope (STM) probes the DOS, and is...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Piriou A,Jenkins N,Berthod C,Maggio-Aprile I,Fischer O

    更新日期:2011-01-01 00:00:00

  • An unusual endo-selective C-H hydroarylationof norbornene by the Rh(I)-catalyzed reactionof benzamides.

    abstract::Hydroarylation is an environmentally attractive strategy which incorporates all of the atoms contained in the substrates into the desired products. Almost all the hydroarylations of norbornene reported to date involve an exo-selective reaction. Here we show the endo-selective hydroarylation of norbornene in the Rh(I)-...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Shibata K,Natsui S,Tobisu M,Fukumoto Y,Chatani N

    更新日期:2017-11-13 00:00:00

  • Probing the gating mechanism of the mechanosensitive channel Piezo1 with the small molecule Yoda1.

    abstract::Piezo proteins are transmembrane ion channels which transduce many forms of mechanical stimuli into electrochemical signals. Their pore, formed by the assembly of three identical subunits, opens by an unknown mechanism. Here, to probe this mechanism, we investigate the interaction of Piezo1 with the small molecule ago...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Lacroix JJ,Botello-Smith WM,Luo Y

    更新日期:2018-05-23 00:00:00

  • Divergent changes in the elevational gradient of vegetation activities over the last 30 years.

    abstract::The reported progressive change of vegetation activity along elevational gradients has important aesthetic and conservation values. With climate change, cooler locations are suggested to warm faster than warmer ones, raising concerns of a more homogenized landscape along the elevation. Here, we use global satellite da...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Gao M,Piao S,Chen A,Yang H,Liu Q,Fu YH,Janssens IA

    更新日期:2019-07-05 00:00:00

  • Continental shelves as a variable but increasing global sink for atmospheric carbon dioxide.

    abstract::It has been speculated that the partial pressure of carbon dioxide (pCO2) in shelf waters may lag the rise in atmospheric CO2. Here, we show that this is the case across many shelf regions, implying a tendency for enhanced shelf uptake of atmospheric CO2. This result is based on analysis of long-term trends in the air...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Laruelle GG,Cai WJ,Hu X,Gruber N,Mackenzie FT,Regnier P

    更新日期:2018-01-31 00:00:00

  • Nanoreporter PET predicts the efficacy of anti-cancer nanotherapy.

    abstract::The application of nanoparticle drug formulations, such as nanoliposomal doxorubicin (Doxil), is increasingly integrated in clinical cancer care. Despite nanomedicine's remarkable potential and growth over the last three decades, its clinical benefits for cancer patients vary. Here we report a non-invasive quantitativ...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Pérez-Medina C,Abdel-Atti D,Tang J,Zhao Y,Fayad ZA,Lewis JS,Mulder WJM,Reiner T

    更新日期:2016-06-20 00:00:00

  • Artificial morphogen-mediated differentiation in synthetic protocells.

    abstract::The design and assembly of artificial protocell consortia displaying dynamical behaviours and systems-based properties are emerging challenges in bottom-up synthetic biology. Cellular processes such as morphogenesis and differentiation rely in part on reaction-diffusion gradients, and the ability to mimic rudimentary ...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Tian L,Li M,Patil AJ,Drinkwater BW,Mann S

    更新日期:2019-07-25 00:00:00

  • A light-driven three-dimensional plasmonic nanosystem that translates molecular motion into reversible chiroptical function.

    abstract::Nature has developed striking light-powered proteins such as bacteriorhodopsin, which can convert light energy into conformational changes for biological functions. Such natural machines are a great source of inspiration for creation of their synthetic analogues. However, synthetic molecular machines typically operate...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Kuzyk A,Yang Y,Duan X,Stoll S,Govorov AO,Sugiyama H,Endo M,Liu N

    更新日期:2016-02-02 00:00:00

  • Mapping of H3N2 influenza antigenic evolution in China reveals a strategy for vaccine strain recommendation.

    abstract::One of the primary efforts in influenza vaccine strain recommendation is to monitor through gene sequencing the viral surface protein haemagglutinin (HA) variants that lead to viral antigenic changes. Here we have developed a computational method, denoted as PREDAC, to predict antigenic clusters of influenza A (H3N2) ...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Du X,Dong L,Lan Y,Peng Y,Wu A,Zhang Y,Huang W,Wang D,Wang M,Guo Y,Shu Y,Jiang T

    更新日期:2012-02-28 00:00:00

  • MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis.

    abstract::Mixed lineage kinase domain-like (MLKL) is the terminal protein in the pro-inflammatory necroptotic cell death program. RIPK3-mediated phosphorylation is thought to initiate MLKL oligomerization, membrane translocation and membrane disruption, although the precise choreography of events is incompletely understood. Her...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Samson AL,Zhang Y,Geoghegan ND,Gavin XJ,Davies KA,Mlodzianoski MJ,Whitehead LW,Frank D,Garnish SE,Fitzgibbon C,Hempel A,Young SN,Jacobsen AV,Cawthorne W,Petrie EJ,Faux MC,Shield-Artin K,Lalaoui N,Hildebrand JM,Silke

    更新日期:2020-06-19 00:00:00

  • Mobility transition from ballistic to diffusive transport in non-Hermitian lattices.

    abstract::Within all physical disciplines, it is accepted that wave transport is predetermined by the existence of disorder. In this vein, it is known that ballistic transport is possible only when a structure is ordered, and that disorder is crucial for diffusion or (Anderson-)localization to occur. As this commonly accepted p...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Eichelkraut T,Heilmann R,Weimann S,Stützer S,Dreisow F,Christodoulides DN,Nolte S,Szameit A

    更新日期:2013-01-01 00:00:00

  • Transneuronal delivery of hyper-interleukin-6 enables functional recovery after severe spinal cord injury in mice.

    abstract::Spinal cord injury (SCI) often causes severe and permanent disabilities due to the regenerative failure of severed axons. Here we report significant locomotor recovery of both hindlimbs after a complete spinal cord crush. This is achieved by the unilateral transduction of cortical motoneurons with an AAV expressing hy...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Leibinger M,Zeitler C,Gobrecht P,Andreadaki A,Gisselmann G,Fischer D

    更新日期:2021-01-15 00:00:00

  • Impaired β-arrestin recruitment and reduced desensitization by non-catechol agonists of the D1 dopamine receptor.

    abstract::Selective activation of dopamine D1 receptors (D1Rs) has been pursued for 40 years as a therapeutic strategy for neurologic and psychiatric diseases due to the fundamental role of D1Rs in motor function, reward processing, and cognition. All known D1R-selective agonists are catechols, which are rapidly metabolized and...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Gray DL,Allen JA,Mente S,O'Connor RE,DeMarco GJ,Efremov I,Tierney P,Volfson D,Davoren J,Guilmette E,Salafia M,Kozak R,Ehlers MD

    更新日期:2018-02-14 00:00:00