In vivo genome editing with a small Cas9 orthologue derived from Campylobacter jejuni.

abstract：:The use of graphene in electronic devices requires a band gap, which can be achieved by creating nanostructures such as graphene nanoribbons. A wide variety of atomically precise graphene nanoribbons can be prepared through on-surface synthesis, bringing the concept of graphene nanoribbon electronics closer to reality...

journal_title：Nature communications

authors： Jacobse PH,Kimouche A,Gebraad T,Ervasti MM,Thijssen JM,Liljeroth P,Swart I

更新日期：2017-07-25 00:00:00

abstract：:In areas where malaria epidemiology is spatially and temporally heterogeneous, human-mediated parasite importation can result in non-locally acquired clinical cases and outbreaks in low-transmission areas. Using mobility estimates derived from the mobile phone data and spatial malaria prevalence data, we identify trav...

journal_title：Nature communications

authors： Ihantamalala FA,Herbreteau V,Rakotoarimanana FMJ,Rakotondramanga JM,Cauchemez S,Rahoilijaona B,Pennober G,Buckee CO,Rogier C,Metcalf CJE,Wesolowski A

更新日期：2018-09-25 00:00:00

abstract：:Drought comprehensively affects different interlinked aspects of the terrestrial water cycle, which have so far been mostly investigated without direct comparison. Resolving the partitioning of water deficit during drought into blue-water runoff and green-water evapotranspiration fluxes is critical, as anomalies in th...

journal_title：Nature communications

authors： Orth R,Destouni G

更新日期：2018-09-06 00:00:00

abstract：:The only known compound of sodium and hydrogen is archetypal ionic NaH. Application of high pressure is known to promote states with higher atomic coordination, but extensive searches for polyhydrides with unusual stoichiometry have had only limited success in spite of several theoretical predictions. Here we report t...

journal_title：Nature communications

authors： Struzhkin VV,Kim DY,Stavrou E,Muramatsu T,Mao HK,Pickard CJ,Needs RJ,Prakapenka VB,Goncharov AF

更新日期：2016-07-28 00:00:00

abstract：:Supported atomic clusters with uniform metal sites and definite low-nuclearity are intermediate states between single-atom catalysts (SACs) and nanoparticles in size. Benefiting from the presence of metal-metal bonds, supported atomic clusters can trigger synergistic effects among every metal atom, which contributes t...

journal_title：Nature communications

authors： Rong H,Ji S,Zhang J,Wang D,Li Y

更新日期：2020-11-18 00:00:00

abstract：:Oxide-ion conductors have found applications in various electrochemical devices, such as solid-oxide fuel cells, gas sensors, and separation membranes. Dion-Jacobson phases are known for their rich magnetic and electrical properties; however, there have been no reports on oxide-ion conduction in this family of materia...

journal_title：Nature communications

authors： Zhang W,Fujii K,Niwa E,Hagihala M,Kamiyama T,Yashima M

更新日期：2020-03-06 00:00:00

abstract：:Identifying therapeutic targets in rare cancers remains challenging due to the paucity of established models to perform preclinical studies. As a proof-of-concept, we developed a patient-derived cancer cell line, CLF-PED-015-T, from a paediatric patient with a rare undifferentiated sarcoma. Here, we confirm that this ...

journal_title：Nature communications

authors： Hong AL,Tseng YY,Cowley GS,Jonas O,Cheah JH,Kynnap BD,Doshi MB,Oh C,Meyer SC,Church AJ,Gill S,Bielski CM,Keskula P,Imamovic A,Howell S,Kryukov GV,Clemons PA,Tsherniak A,Vazquez F,Crompton BD,Shamji AF,Rodriguez-

更新日期：2016-06-22 00:00:00

abstract：:Nematode neurons generally produce graded potentials instead of action potentials. It is unclear how the graded potentials control postsynaptic cells under physiological conditions. Here we show that postsynaptic currents frequently occur in bursts at the neuromuscular junction of Caenorhabditis elegans. Cholinergic b...

journal_title：Nature communications

authors： Liu P,Chen B,Wang ZW

更新日期：2013-01-01 00:00:00

abstract：:Heterostructured material systems devoid of ferroic components are presumed not to display ordering associated with ferroelectricity. In heterostructures composed of transition metal oxides, however, the disruption introduced by an interface can affect the balance of the competing interactions among electronic spins, ...

journal_title：Nature communications

authors： Rogdakis K,Seo JW,Viskadourakis Z,Wang Y,Qune LF,Choi E,Burton JD,Tsymbal EY,Lee J,Panagopoulos C

更新日期：2012-01-01 00:00:00

abstract：:Bipolaron states, in which two electrons or two holes occupy a single molecule or conjugated polymer segment, are typically considered to be negligible in organic semiconductor devices due to Coulomb repulsion between the two charges. Here we use charge modulation spectroscopy to reveal a bipolaron sheet density >1010...

journal_title：Nature communications

authors： Dhanker R,Gray CL,Mukhopadhyay S,Nunez S,Cheng CY,Sokolov AN,Giebink NC

更新日期：2017-12-21 00:00:00

abstract：:The nitrogen-vacancy (NV) centre in diamond is emerging as a promising platform for solid-state quantum information processing and nanoscale metrology. Of interest in these applications is the manipulation of the NV charge, which can be attained by optical excitation. Here, we use two-colour optical microscopy to inve...

journal_title：Nature communications

authors： Jayakumar H,Henshaw J,Dhomkar S,Pagliero D,Laraoui A,Manson NB,Albu R,Doherty MW,Meriles CA

更新日期：2016-08-30 00:00:00

abstract：:We previously reported children homozygous for two MC3R sequence variants (C17A+G241A) have greater fat mass than controls. Here we show, using homozygous knock-in mouse models in which we replace murine Mc3r with wild-type human (MC3R(hWT/hWT)) and double-mutant (C17A+G241A) human (MC3R(hDM/hDM)) MC3R, that MC3R(hDM/...

journal_title：Nature communications

authors： Lee B,Koo J,Yun Jun J,Gavrilova O,Lee Y,Seo AY,Taylor-Douglas DC,Adler-Wailes DC,Chen F,Gardner R,Koutzoumis D,Sherafat Kazemzadeh R,Roberson RB,Yanovski JA

更新日期：2016-01-28 00:00:00

abstract：:Perovskite quantum-dot-based light-emitting diodes (QLEDs) possess the features of wide gamut and real color expression, which have been considered as candidates for high-quality lightings and displays. However, massive defects are prone to be reproduced during the quantum dot (QD) film assembly, which would sorely af...

journal_title：Nature communications

authors： Xu L,Li J,Cai B,Song J,Zhang F,Fang T,Zeng H

更新日期：2020-08-06 00:00:00

abstract：:Processing of interleukin RNAs must be tightly controlled during the immune response. Here we report that a subnuclear body called the interleukin-6 and -10 splicing activating compartment (InSAC) is a nuclear site of cytokine RNA production and stability. Tat-activating regulatory DNA-binding protein-43 (TDP-43) acts...

journal_title：Nature communications

authors： Lee S,Lee TA,Lee E,Kang S,Park A,Kim SW,Park HJ,Yoon JH,Ha SJ,Park T,Lee JS,Cheon JH,Park B

更新日期：2015-01-05 00:00:00

abstract：:Regaining the function of an impaired limb is highly desirable in paralyzed individuals. One possible avenue to achieve this goal is to bridge the interrupted pathway between preserved neural structures and muscles using a brain-computer interface. Here, we demonstrate that monkeys with subcortical stroke were able to...

journal_title：Nature communications

authors： Kato K,Sawada M,Nishimura Y

更新日期：2019-10-16 00:00:00

abstract：:High-intensity lasers can be used to generate shockwaves, which have found applications in nuclear fusion, proton imaging, cancer therapies and materials science. Collisionless electrostatic shocks are one type of shockwave widely studied for applications involving ion acceleration. Here we show a novel mechanism for ...

journal_title：Nature communications

authors： Turrell AE,Sherlock M,Rose SJ

更新日期：2015-11-13 00:00:00

abstract：:A detailed understanding of the human infectious reservoir is essential for improving malaria transmission-reducing interventions. Here we report a multi-regional assessment of population-wide malaria transmission potential based on 1209 mosquito feeding assays in endemic areas of Burkina Faso and Kenya. Across both s...

journal_title：Nature communications

authors： Gonçalves BP,Kapulu MC,Sawa P,Guelbéogo WM,Tiono AB,Grignard L,Stone W,Hellewell J,Lanke K,Bastiaens GJH,Bradley J,Nébié I,Ngoi JM,Oriango R,Mkabili D,Nyaurah M,Midega J,Wirth DF,Marsh K,Churcher TS,Bejon P,Siri

更新日期：2017-10-26 00:00:00

abstract：:The potential of the folic acid biosynthesis pathway as a target for the development of antibiotics has been clinically validated. However, many pathogens have developed resistance to these antibiotics, prompting a re-evaluation of potential drug targets within the pathway. The ydaH gene of Alcanivorax borkumensis enc...

journal_title：Nature communications

authors： Bolla JR,Su CC,Delmar JA,Radhakrishnan A,Kumar N,Chou TH,Long F,Rajashankar KR,Yu EW

更新日期：2015-04-20 00:00:00

abstract：:Integrin αVβ8, which like αVβ6 functions to activate TGF-βs, is atypical. Its β8 subunit binds to a distinctive cytoskeleton adaptor and does not exhibit large changes in conformation upon binding to ligand. Here, crystal structures, hydrogen-deuterium exchange dynamics, and affinity measurements on mutants are used t...

journal_title：Nature communications

authors： Wang J,Su Y,Iacob RE,Engen JR,Springer TA

更新日期：2019-12-02 00:00:00

abstract：:The liver parenchyma is composed of hepatocytes and bile duct epithelial cells (BECs). Controversy exists regarding the cellular origin of human liver parenchymal tissue generation during embryonic development, homeostasis or repair. Here we report the existence of a hepatobiliary hybrid progenitor (HHyP) population i...

journal_title：Nature communications

authors： Segal JM,Kent D,Wesche DJ,Ng SS,Serra M,Oulès B,Kar G,Emerton G,Blackford SJI,Darmanis S,Miquel R,Luong TV,Yamamoto R,Bonham A,Jassem W,Heaton N,Vigilante A,King A,Sancho R,Teichmann S,Quake SR,Nakauchi H,Rash

更新日期：2019-07-26 00:00:00

abstract：:Interfacial water constitutes a formidable barrier to strong surface bonding, hampering the development of water-resistant synthetic adhesives. Notwithstanding this obstacle, the Asian green mussel Perna viridis attaches firmly to underwater surfaces via a proteinaceous secretion (byssus). Extending beyond the current...

journal_title：Nature communications

authors： Petrone L,Kumar A,Sutanto CN,Patil NJ,Kannan S,Palaniappan A,Amini S,Zappone B,Verma C,Miserez A

更新日期：2015-10-28 00:00:00

abstract：:The impact of liquid drops on solid surfaces is ubiquitous in nature, and of practical importance in many industrial processes. A drop hitting a flat surface retains a circular symmetry throughout the impact process. Here we show that a drop impinging on Echevaria leaves exhibits asymmetric bouncing dynamics with dist...

journal_title：Nature communications

authors： Liu Y,Andrew M,Li J,Yeomans JM,Wang Z

更新日期：2015-11-25 00:00:00

abstract：:Preterm birth places infants in an adverse environment that leads to abnormal brain development and cerebral injury through a poorly understood mechanism known to involve neuroinflammation. In this study, we integrate human and mouse molecular and neuroimaging data to investigate the role of microglia in preterm white...

journal_title：Nature communications

authors： Krishnan ML,Van Steenwinckel J,Schang AL,Yan J,Arnadottir J,Le Charpentier T,Csaba Z,Dournaud P,Cipriani S,Auvynet C,Titomanlio L,Pansiot J,Ball G,Boardman JP,Walley AJ,Saxena A,Mirza G,Fleiss B,Edwards AD,Petretto

更新日期：2017-09-05 00:00:00

abstract：:Anthropogenic CO2 emissions are causing ocean acidification, which can affect the physiology of marine organisms. Here we assess the possible effects of ocean acidification on the metabolic potential of sponge symbionts, inferred by metagenomic analyses of the microbiomes of two sponge species sampled at a shallow vol...

journal_title：Nature communications

authors： Botté ES,Nielsen S,Abdul Wahab MA,Webster J,Robbins S,Thomas T,Webster NS

更新日期：2019-09-12 00:00:00

abstract：:Engineering strong metal-support interactions (SMSI) is an effective strategy for tuning structures and performances of supported metal catalysts but induces poor exposure of active sites. Here, we demonstrate a strong metal-support interaction via a reverse route (SMSIR) by starting from the final morphology of SMSI ...

journal_title：Nature communications

authors： Wu P,Tan S,Moon J,Yan Z,Fung V,Li N,Yang SZ,Cheng Y,Abney CW,Wu Z,Savara A,Momen AM,Jiang DE,Su D,Li H,Zhu W,Dai S,Zhu H

更新日期：2020-06-16 00:00:00

abstract：:In genome editing with CRISPR-Cas9, transgene integration often remains challenging. Here, we present an approach for increasing the efficiency of transgene integration by homology-dependent repair (HDR). CtIP, a key protein in early steps of homologous recombination, is fused to Cas9 and stimulates transgene integrat...

journal_title：Nature communications

authors： Charpentier M,Khedher AHY,Menoret S,Brion A,Lamribet K,Dardillac E,Boix C,Perrouault L,Tesson L,Geny S,De Cian A,Itier JM,Anegon I,Lopez B,Giovannangeli C,Concordet JP

更新日期：2018-03-19 00:00:00

abstract：:Metal oxides with a tunnelled structure are attractive as charge storage materials for rechargeable batteries and supercapacitors, since the tunnels enable fast reversible insertion/extraction of charge carriers (for example, lithium ions). Common synthesis methods can introduce large cations such as potassium, barium...

journal_title：Nature communications

authors： Yuan Y,Zhan C,He K,Chen H,Yao W,Sharifi-Asl S,Song B,Yang Z,Nie A,Luo X,Wang H,Wood SM,Amine K,Islam MS,Lu J,Shahbazian-Yassar R

更新日期：2016-11-21 00:00:00

abstract：:Instant curing adhesives typically fall within three categories, being activated by either light (photocuring), heat (thermocuring) or chemical means. These curing strategies limit applications to specific substrates and can only be activated under certain conditions. Here we present the development of an instant curi...

journal_title：Nature communications

authors： Ping J,Gao F,Chen JL,Webster RD,Steele TW

更新日期：2015-08-18 00:00:00

abstract：:Synthetic genetic circuits allow us to modify the behavior of living cells. However, changes in environmental conditions and unforeseen interactions with the host cell can cause deviations from a desired function, resulting in the need for time-consuming reassembly to fix these issues. Here, we use a regulatory motif ...

journal_title：Nature communications

authors： Bartoli V,Meaker GA,di Bernardo M,Gorochowski TE

更新日期：2020-04-29 00:00:00

abstract：:Diffusion is the result of repeated random scattering. It governs a wide range of phenomena from Brownian motion, to heat flow through window panes, neutron flux in fuel rods, dispersion of light in human tissue, and electronic conduction. It is universally acknowledged that the diffusion approach to describing wave t...

journal_title：Nature communications

authors： Shi Z,Genack AZ

更新日期：2018-05-10 00:00:00