Abstract:
:Novelty-seeking tendencies in adolescents may promote innovation as well as problematic impulsive behaviour, including drug abuse. Previous research has not clarified whether neural hyper- or hypo-responsiveness to anticipated rewards promotes vulnerability in these individuals. Here we use a longitudinal design to track 144 novelty-seeking adolescents at age 14 and 16 to determine whether neural activity in response to anticipated rewards predicts problematic drug use. We find that diminished BOLD activity in mesolimbic (ventral striatal and midbrain) and prefrontal cortical (dorsolateral prefrontal cortex) regions during reward anticipation at age 14 predicts problematic drug use at age 16. Lower psychometric conscientiousness and steeper discounting of future rewards at age 14 also predicts problematic drug use at age 16, but the neural responses independently predict more variance than psychometric measures. Together, these findings suggest that diminished neural responses to anticipated rewards in novelty-seeking adolescents may increase vulnerability to future problematic drug use.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Büchel C,Peters J,Banaschewski T,Bokde AL,Bromberg U,Conrod PJ,Flor H,Papadopoulos D,Garavan H,Gowland P,Heinz A,Walter H,Ittermann B,Mann K,Martinot JL,Paillère-Martinot ML,Nees F,Paus T,Pausova Z,Poustka L,Rietsdoi
10.1038/ncomms14140subject
Has Abstractpub_date
2017-02-21 00:00:00pages
14140issn
2041-1723pii
ncomms14140journal_volume
8pub_type
杂志文章,多中心研究abstract::Large-scale genomic data highlight the complexity and diversity of the molecular changes that drive cancer progression. Statistical analysis of cancer data from different tissues can guide drug repositioning as well as the design of targeted treatments. Here, we develop an improved Bayesian network model for tumour mu...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06867-x
更新日期:2018-10-19 00:00:00
abstract::Early dissemination, metastasis and therapy resistance are central hallmarks of aggressive cancer types and the leading cause of cancer-associated deaths. The EMT-inducing transcriptional repressor ZEB1 is a crucial stimulator of these processes, particularly by coupling the activation of cellular motility with stemne...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10498
更新日期:2016-02-15 00:00:00
abstract::Quantum communication and computing offer many new opportunities for information processing in a connected world. Networks using quantum resources with tailor-made entanglement structures have been proposed for a variety of tasks, including distributing, sharing and processing information. Recently, a class of states ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6480
更新日期:2014-11-21 00:00:00
abstract::The competition between bimolecular nucleophilic substitution and base-induced elimination is of fundamental importance for the synthesis of pure samples in organic chemistry. Many factors that influence this competition have been identified over the years, but the underlying atomistic dynamics have remained difficult...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00065-x
更新日期:2017-06-21 00:00:00
abstract::The global urbanization rate is accelerating; however, data limitations have far prevented robust estimations of either global urban expansion or its effects on terrestrial net primary productivity (NPP). Here, using a high resolution dataset of global land use/cover (GlobeLand30), we show that global urban areas expa...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13462-1
更新日期:2019-12-05 00:00:00
abstract::MicroRNAs (miRNAs) loss-of-function phenotypes are mainly induced by chemically modified antisense oligonucleotides. Here we develop an alternative inhibitor for miRNAs, termed 'small RNA zipper'. It is designed to connect miRNA molecules end to end, forming a DNA-RNA duplex through a complementary interaction with hi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13964
更新日期:2017-01-03 00:00:00
abstract::Drugs of abuse, including alcohol, ablate the expression of specific forms of long-term synaptic depression (LTD) at glutamatergic synapses in dorsal striatum (DS), a brain region involved in goal-directed and habitual behaviors. This loss of LTD is associated with altered DS-dependent behavior. Given the role of the ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03683-1
更新日期:2018-04-03 00:00:00
abstract::Macrophages are a major immune cell type infiltrating tumors and promoting tumor growth and metastasis. To elucidate the mechanism of macrophage recruitment, we utilize an overgrowth tumor model ("undead" model) in larval Drosophila imaginal discs that are attached by numerous macrophages. Here we report that changes ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17399-8
更新日期:2020-07-20 00:00:00
abstract::Volcanoes are increasingly recognized as agents and recorders of global climate variability, although deciphering the linkages between planetary climate and volcanism is still in its infancy. The growth and emergence of subaqueous volcanoes produce passage zones, which are stratigraphic surfaces marking major transiti...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2829
更新日期:2013-01-01 00:00:00
abstract::Myopia can cause severe visual impairment. Here, we report a two-stage genome-wide association study for three myopia-related traits in 9,804 Japanese individuals, which was extended with trans-ethnic replication in 2,674 Chinese and 2,690 Caucasian individuals. We identify WNT7B as a novel susceptibility gene for axi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7689
更新日期:2015-03-31 00:00:00
abstract::A key mechanism of bacterial resistance to macrolide antibiotics is the dimethylation of a nucleotide in the large ribosomal subunit by erythromycin resistance methyltransferases. The majority of erm genes are expressed only when the antibiotic is present and the erythromycin resistance methyltransferase activity is c...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2984
更新日期:2013-01-01 00:00:00
abstract::Mitochondria and peroxisomes proliferate by division. During division, a part of their membrane is pinched off by constriction of the ring-shaped mitochondrial division (MD) and peroxisome-dividing (POD) machinery. This constriction is mediated by a dynamin-like GTPase Dnm1 that requires a large amount of GTP as an en...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07009-z
更新日期:2018-11-06 00:00:00
abstract::Interest in manipulating the magnetic order by ultrashort laser pulses has thrived since it was observed that such pulses can be used to alter the magnetization on a sub-picosecond timescale. Usually this involves demagnetization by laser heating or, in rare cases, a transient increase of magnetization. Here we demons...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7724
更新日期:2015-04-02 00:00:00
abstract::Mountains are plant biodiversity hotspots considered particularly vulnerable to multiple environmental changes. Here, we quantify population changes and range-shift dynamics along elevational gradients over the last three decades for c. two-thirds of the orchid species of the European Alps. Local extinctions were more...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19680-2
更新日期:2020-11-17 00:00:00
abstract::Global emergence of Gram-negative bacteria carrying the plasmid-borne resistance genes, blaMBL and mcr, raises a significant challenge to the treatment of life-threatening infections by the antibiotics, carbapenem and colistin (COL). Here, we identify an antirheumatic drug, auranofin (AUR) as a dual inhibitor of metal...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18939-y
更新日期:2020-10-16 00:00:00
abstract::Genetic noise together with genome duplication and volume changes during cell cycle are significant contributors to cell-to-cell heterogeneity. How can cells buffer the effects of these unavoidable epigenetic and genetic variations on phenotypes that are sensitive to such variations? Here we show that a simple network...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12959
更新日期:2016-10-03 00:00:00
abstract::Activation of autophagy and elevation of glutamine synthesis represent key adaptations to maintain amino acid balance during starvation. In this study, we investigate the role of autophagy and glutamine on the regulation of mTORC1, a critical kinase that regulates cell growth and proliferation. We report that suppleme...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00369-y
更新日期:2017-08-24 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-020-15800-0
更新日期:2020-04-20 00:00:00
abstract::Crystalline phase transitions caused by external stimuli have been used to detect physical changes in the solid-state properties. This study presents the mechanical switching of crystals of ferrocene-containing rotaxane controlled by focused laser light. The expansion and contraction of the crystals can be driven by t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13321
更新日期:2016-11-03 00:00:00
abstract::The plausibility of any model in science comes from the extent of its interconnections to other models that are grounded in different premises and reasoning. Focusing research on paradoxes in those models, logic whereby they appear to generate unacceptable conclusions from seemingly indisputable premises, helps find t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07274-y
更新日期:2018-12-12 00:00:00
abstract::The central phenomenon in the field of organic spintronics is the large magnetoresistance in thick organic spin valves. A prerequisite for understanding the magnetoresistance is a reliable description of the device resistance, or the I-V characteristics. Here I show that the observed I-V characteristics in the organic...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5842
更新日期:2014-09-09 00:00:00
abstract::A magnetic impurity coupled to a superconductor gives rise to a Yu-Shiba-Rusinov (YSR) state inside the superconducting energy gap. With increasing exchange coupling the excitation energy of this state eventually crosses zero and the system switches to a YSR ground state with bound quasiparticles screening the impurit...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04683-x
更新日期:2018-06-18 00:00:00
abstract::Understanding the fundamental alterations in brain functioning that lead to psychotic disorders remains a major challenge in clinical neuroscience. In particular, it is unknown whether any state-independent biomarkers can potentially predict the onset of psychosis and distinguish patients from healthy controls, regard...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06350-7
更新日期:2018-09-21 00:00:00
abstract::The prediction of implant behavior in vivo by the use of easy-to-perform in vitro methods is of great interest in biomaterials research. Simulated body fluids (SBFs) have been proposed and widely used to evaluate the bone-bonding ability of implant materials. In view of its limitations, we report here a rapid in vitro...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09673-1
更新日期:2019-05-02 00:00:00
abstract::Fatty acids (FAs) are not only essential components of cellular energy storage and structure, but play crucial roles in signalling. Here we present a toolkit of photoswitchable FA analogues (FAAzos) that incorporate an azobenzene photoswitch along the FA chain. By modifying the FAAzos to resemble capsaicin, we prepare...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8118
更新日期:2015-05-22 00:00:00
abstract::Genomic changes observed across treatment may result from either clonal evolution or geographically disparate sampling of heterogeneous tumors. Here we use computational modeling based on analysis of fifteen primary breast tumors and find that apparent clonal change between two tumor samples can frequently be explaine...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08593-4
更新日期:2019-02-08 00:00:00
abstract::Energy metabolism has been repeatedly linked to amyotrophic lateral sclerosis (ALS). Yet, motor neuron (MN) metabolism remains poorly studied and it is unknown if ALS MNs differ metabolically from healthy MNs. To address this question, we first performed a metabolic characterization of induced pluripotent stem cells (...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12099-4
更新日期:2019-09-12 00:00:00
abstract::Pentatricopeptide repeat (PPR) proteins control diverse aspects of RNA metabolism in eukaryotic cells. Although recent computational and structural studies have provided insights into RNA recognition by PPR proteins, their highly insoluble nature and inconsistencies between predicted and observed modes of RNA binding ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6729
更新日期:2014-12-17 00:00:00
abstract::Homozygosity mapping is a powerful method for identifying mutations in patients with recessive conditions, especially in consanguineous families or isolated populations. Historically, it has been used in conjunction with genotypes from highly polymorphic markers, such as DNA microsatellites or common SNPs. Traditional...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20584-4
更新日期:2021-01-22 00:00:00
abstract::Solution-processable perovskites show highly emissive and good charge transport, making them attractive for low-cost light-emitting diodes (LEDs) with high energy conversion efficiencies. Despite recent advances in device efficiency, the stability of perovskite LEDs is still a major obstacle. Here, we demonstrate stab...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11567-1
更新日期:2019-08-09 00:00:00