Abstract:
:Global emergence of Gram-negative bacteria carrying the plasmid-borne resistance genes, blaMBL and mcr, raises a significant challenge to the treatment of life-threatening infections by the antibiotics, carbapenem and colistin (COL). Here, we identify an antirheumatic drug, auranofin (AUR) as a dual inhibitor of metallo-β-lactamases (MBLs) and mobilized colistin resistance (MCRs), two resistance enzymes that have distinct structures and substrates. We demonstrate that AUR irreversibly abrogates both enzyme activity via the displacement of Zn(II) cofactors from their active sites. We further show that AUR synergizes with antibiotics on killing a broad spectrum of carbapenem and/or COL resistant bacterial strains, and slows down the development of β-lactam and COL resistance. Combination of AUR and COL rescues all mice infected by Escherichia coli co-expressing MCR-1 and New Delhi metallo-β-lactamase 5 (NDM-5). Our findings provide potential therapeutic strategy to combine AUR with antibiotics for combating superbugs co-producing MBLs and MCRs.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Sun H,Zhang Q,Wang R,Wang H,Wong YT,Wang M,Hao Q,Yan A,Kao RY,Ho PL,Li Hdoi
10.1038/s41467-020-18939-ysubject
Has Abstractpub_date
2020-10-16 00:00:00pages
5263issue
1issn
2041-1723pii
10.1038/s41467-020-18939-yjournal_volume
11pub_type
杂志文章abstract::Flexible, wearable sensing devices can yield important information about the underlying physiology of a human subject for applications in real-time health and fitness monitoring. Despite significant progress in the fabrication of flexible biosensors that naturally comply with the epidermis, most designs measure only a...
journal_title:Nature communications
pub_type: 临床试验,杂志文章
doi:10.1038/ncomms11650
更新日期:2016-05-23 00:00:00
abstract::Printed electronics offer a breakthrough in the penetration of information technology into everyday life. The possibility of printing electronic circuits will further promote the spread of the Internet of Things applications. Inks based on graphene have a chance to dominate this technology, as they potentially can be ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07632-w
更新日期:2018-12-05 00:00:00
abstract::Magmatic intrusions and volcanic eruptions are intimately related phenomena. Shallow magma intrusion builds subsurface reservoirs that are drained by volcanic eruptions. Thus, the long-held view is that intrusions must precede and feed eruptions. Here we show that explosive eruptions can also cause magma intrusion. We...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13585
更新日期:2016-11-23 00:00:00
abstract::The small ubiquitin-like modifier (SUMO) can form polymeric chains that are important signals in cellular processes such as meiosis, genome maintenance and stress response. The SUMO-targeted ubiquitin ligase RNF4 engages with SUMO chains on linked substrates and catalyses their ubiquitination, which targets substrates...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5217
更新日期:2014-06-27 00:00:00
abstract::Magnetic storage and logic devices based on magnetic domain wall motion rely on the precise and synchronous displacement of multiple domain walls. The conventional approach using magnetic fields does not allow for the synchronous motion of multiple domains. As an alternative method, synchronous current-induced domain ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4429
更新日期:2014-03-24 00:00:00
abstract::Osmoregulation is important for plant growth, development and response to environmental changes. SNF1-related protein kinase 2s (SnRK2s) are quickly activated by osmotic stress and are central components in osmotic stress and abscisic acid (ABA) signaling pathways; however, the upstream components required for SnRK2 a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14477-9
更新日期:2020-01-30 00:00:00
abstract::Rosemary extracts containing the phenolic diterpenes carnosic acid and its derivative carnosol are approved food additives used in an increasingly wide range of products to enhance shelf-life, thanks to their high anti-oxidant activity. We describe here the elucidation of the complete biosynthetic pathway of carnosic ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12942
更新日期:2016-10-05 00:00:00
abstract::Cleavage of transfer (t)RNA and ribosomal (r)RNA are critical and conserved steps of translational control for cells to overcome varied environmental stresses. However, enzymes that are responsible for this event have not been fully identified in high eukaryotes. Here, we report a mammalian tRNA/rRNA-targeting endorib...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03544-x
更新日期:2018-03-21 00:00:00
abstract::The shape-controlled synthesis of nanoparticles was established in single-phase solutions by controlling growth directions of crystalline facets on seed nanocrystals kinetically; however, it was difficult to rationally predict and design nanoparticle shapes. Here we introduce a methodology to fabricate nanoparticles i...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4870
更新日期:2014-05-14 00:00:00
abstract::Previous studies have revealed that nucleosomes impede elongation of RNA polymerase II (RNAPII). Recent observations suggest a role for ATP-dependent chromatin remodellers in modulating this process, but direct in vivo evidence for this is unknown. Here using fission yeast, we identify Fun30Fft3 as a chromatin remodel...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14527
更新日期:2017-02-20 00:00:00
abstract::Necroptosis is a type of programmed cell death with great significance in many pathological processes. Tumour necrosis factor-α(TNF), a proinflammatory cytokine, is a prototypic trigger of necroptosis. It is known that mitochondrial reactive oxygen species (ROS) promote necroptosis, and that kinase activity of recepto...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14329
更新日期:2017-02-08 00:00:00
abstract::Multidrug resistant Plasmodium falciparum in Southeast Asia endangers regional malaria elimination and threatens to spread to other malaria endemic areas. Understanding mechanisms of piperaquine (PPQ) resistance is crucial for tracking its emergence and spread, and to develop effective strategies for overcoming it. He...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04104-z
更新日期:2018-05-02 00:00:00
abstract::Complex materials often exhibit a hierarchical structure with an intriguing mechanism responsible for the 'propagation' of order from the molecular to the nano- or micro-scale level. In particular, the chirality of biological molecules such as nucleic acids and amino acids is responsible for the helical structure of D...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09862-y
更新日期:2019-04-23 00:00:00
abstract::The reversible modification of cysteine residues by thioester formation with palmitate (S-palmitoylation) is an abundant lipid post-translational modification (PTM) in mammalian systems. S-palmitoylation has been observed on mitochondrial proteins, providing an intriguing potential connection between metabolic lipids ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02655-1
更新日期:2018-01-23 00:00:00
abstract::Multiple hypotheses propose an ostensibly disparate array of drivers of food chain length (FCL), with contradictory support from natural settings. Here we posit that the magnitude of vertical energy flux in food webs underlies several drivers of FCL. We show that rising energy flux fuels top-heavy biomass pyramids, pr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02157-0
更新日期:2017-12-11 00:00:00
abstract::Superchiral light, generated by the interference of two counter-propagating circularly polarized light (CPL) with same frequency, opposite handedness and different intensity, exhibits enhanced dissymmetry in its interaction with chiral molecules, and has the potential for ultrasensitive detection and characterization ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07533-y
更新日期:2018-11-30 00:00:00
abstract::Though the concept of Berry force was proposed thirty years ago, little is known about the practical consequences of this force as far as chemical dynamics are concerned. Here, we report that when molecular dynamics pass near a conical intersection, a massive Berry force can appear as a result of even a small amount o...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20831-8
更新日期:2021-01-29 00:00:00
abstract::Rising demand for ruminant meat and dairy products in developing countries is expected to double anthropogenic greenhouse gas and ammonia emissions from livestock by 2050. Mitigation strategies are urgently needed to meet demand while minimizing environmental impacts. Here, we develop scenarios for mitigating emission...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06381-0
更新日期:2018-10-08 00:00:00
abstract::Organic-inorganic hybrid perovskites are promising candidates for the next-generation solar cells. Many efforts have been made to study their structures in the search for a better mechanistic understanding to guide the materials optimization. Here, we investigate the structure instability of the single-crystalline CH3...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07177-y
更新日期:2018-11-15 00:00:00
abstract::Humans typically make near-optimal sensorimotor judgements but show systematic biases when making more cognitive judgements. Here we test the hypothesis that, while humans are sensitive to the noise present during early sensory encoding, the "optimality gap" arises because they are blind to noise introduced by later c...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09330-7
更新日期:2019-04-12 00:00:00
abstract::Nanocarrier administration has primarily been restricted to intermittent bolus injections with limited available options for sustained delivery in vivo. Here, we demonstrate that cylinder-to-sphere transitions of self-assembled filomicelle (FM) scaffolds can be employed for sustained delivery of monodisperse micellar ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03001-9
更新日期:2018-02-12 00:00:00
abstract::The degraded, misfolded C terminus of TAR DNA-binding protein-43 is associated with a wide spectrum of neurodegenerative diseases, particularly frontotemporal lobar degeneration with ubiquitin-positive inclusions and amyotrophic lateral sclerosis. However, the precise mechanism of pathological cleavage of the TAR DNA-...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1766
更新日期:2012-04-03 00:00:00
abstract::Layered materials embrace rich intercalation reactions to accommodate high concentrations of foreign species within their structures, and find many applications spanning from energy storage, ion exchange to secondary batteries. Light alkali metals are generally most easily intercalated due to their light mass, high ch...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13809
更新日期:2016-12-14 00:00:00
abstract::Following the discovery of high-temperature superconductivity in the La-H system, we studied the formation of new chemical compounds in the barium-hydrogen system at pressures from 75 to 173 GPa. Using in situ generation of hydrogen from NH3BH3, we synthesized previously unknown superhydride BaH12 with a pseudocubic (...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20103-5
更新日期:2021-01-11 00:00:00
abstract::DNA-based nanopores are synthetic biomolecular membrane pores, whose geometry and chemical functionality can be tuned using the tools of DNA nanotechnology, making them promising molecular devices for applications in single-molecule biosensing and synthetic biology. Here we introduce a large DNA membrane channel with ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12787
更新日期:2016-09-23 00:00:00
abstract::The development of transistors with high gain is essential for applications ranging from switching elements and drivers to transducers for chemical and biological sensing. Organic transistors have become well-established based on their distinct advantages, including ease of fabrication, synthetic freedom for chemical ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3133
更新日期:2013-01-01 00:00:00
abstract::Dopamine regulates reward, cognition, and locomotor functions. By mediating rapid reuptake of extracellular dopamine, the dopamine transporter is critical for spatiotemporal control of dopaminergic neurotransmission. Here, we use super-resolution imaging to show that the dopamine transporter is dynamically sequestrate...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00790-3
更新日期:2017-09-29 00:00:00
abstract::To reconstruct the evolutionary origin of multicellular animals from their unicellular ancestors, the genome sequences of diverse unicellular relatives are essential. However, only the genome of the choanoflagellate Monosiga brevicollis has been reported to date. Here we completely sequence the genome of the filastere...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3325
更新日期:2013-01-01 00:00:00
abstract::Inner hair cells (IHCs) are the primary receptors for hearing. They are housed in the cochlea and convey sound information to the brain via synapses with the auditory nerve. IHCs have been thought to be electrically and metabolically independent from each other. We report that, upon developmental maturation, in mice 3...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17003-z
更新日期:2020-06-25 00:00:00
abstract::Owing to the significant difference in the numbers of simulated and experimentally feasible zeolite structures, several alternative strategies have been developed for zeolite synthesis. Despite their rationality and originality, most of these techniques are based on trial-and-error, which makes it difficult to predict...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12882-3
更新日期:2019-11-12 00:00:00