Noise reduction facilitated by dosage compensation in gene networks.

abstract：:SCRaMbLE (Synthetic Chromosome Rearrangement and Modification by LoxP-mediated Evolution) is a genome restructuring technique that can be used in synthetic genomes such as that of Sc2.0, the synthetic yeast genome, which contains hundreds to thousands of strategically positioned loxPsym sites. SCRaMbLE has been used t...

journal_title：Nature communications

authors： Shen MJ,Wu Y,Yang K,Li Y,Xu H,Zhang H,Li BZ,Li X,Xiao WH,Zhou X,Mitchell LA,Bader JS,Yuan Y,Boeke JD

更新日期：2018-05-22 00:00:00

abstract：:Amongst the rare-earth perovskite nickelates, LaNiO3 (LNO) is an exception. While the former have insulating and antiferromagnetic ground states, LNO remains metallic and non-magnetic down to the lowest temperatures. It is believed that LNO is a strange metal, on the verge of an antiferromagnetic instability. Our work...

journal_title：Nature communications

authors： Liu C,Humbert VFC,Bretz-Sullivan TM,Wang G,Hong D,Wrobel F,Zhang J,Hoffman JD,Pearson JE,Jiang JS,Chang C,Suslov A,Mason N,Norman MR,Bhattacharya A

更新日期：2020-03-16 00:00:00

abstract：:Many glasses exhibit fractional power law (FPL) between the mean atomic volume va and the first diffraction peak position q1, i.e. [Formula: see text] with d ≃ 2.5 deviating from the space dimension D = 3, under compression or composition change. What structural change causes such FPL and whether the FPL and d are uni...

journal_title：Nature communications

authors： Zhang H,Qiao K,Han Y

更新日期：2020-04-24 00:00:00

abstract：:In all known examples of metal-ligand (M-L) δ and φ bonds, the metal orbitals are aligned to the ligand orbitals in a "head-to-head" or "side-to-head" fashion. Here, we report two fundamentally new types of M-L δ and φ interactions; "head-to-side" δ and "side-to-side" φ back-bonding, found in complexes of metallacyclo...

journal_title：Nature communications

authors： Kelley MP,Popov IA,Jung J,Batista ER,Yang P

更新日期：2020-03-25 00:00:00

abstract：:The isolation of the two-dimensional semiconductor molybdenum disulphide introduced a new optically active material possessing a band gap that can be facilely tuned via elastic strain. As an atomically thin membrane with exceptional strength, monolayer molybdenum disulphide subjected to biaxial strain can embed wide b...

journal_title：Nature communications

authors： Li H,Contryman AW,Qian X,Ardakani SM,Gong Y,Wang X,Weisse JM,Lee CH,Zhao J,Ajayan PM,Li J,Manoharan HC,Zheng X

更新日期：2015-06-19 00:00:00

abstract：:Pentacyclic triterpenoids (PTs) constitute one of the biggest families of natural products, many with higher oxidation state at the D/E rings possess a wide spectrum of biological activties but are poorly accessible. Here we report a site-selective C-H hydroxylation at the D/E rings of PTs paving a way toward these im...

journal_title：Nature communications

authors： Mu T,Wei B,Zhu D,Yu B

更新日期：2020-09-01 00:00:00

abstract：:Cyclic GMP-AMP synthase (cGAS) is the primary sensor for aberrant intracellular dsDNA producing the cyclic dinucleotide cGAMP, a second messenger initiating cytokine production in subsets of myeloid lineage cell types. Therefore, inhibition of the enzyme cGAS may act anti-inflammatory. Here we report the discovery of ...

journal_title：Nature communications

authors： Lama L,Adura C,Xie W,Tomita D,Kamei T,Kuryavyi V,Gogakos T,Steinberg JI,Miller M,Ramos-Espiritu L,Asano Y,Hashizume S,Aida J,Imaeda T,Okamoto R,Jennings AJ,Michino M,Kuroita T,Stamford A,Gao P,Meinke P,Glickman

更新日期：2019-05-21 00:00:00

abstract：:Modelling of non-adiabatic dynamics in extended molecular systems and solids is a next frontier of atomistic electronic structure theory. The underlying numerical algorithms should operate only with a few quantities (that can be efficiently obtained from quantum chemistry), provide a controlled approximation (which ca...

journal_title：Nature communications

authors： Gorshkov VN,Tretiak S,Mozyrsky D

更新日期：2013-01-01 00:00:00

abstract：:Parallel single-cell sequencing protocols represent powerful methods for investigating regulatory relationships, including epigenome-transcriptome interactions. Here, we report a single-cell method for parallel chromatin accessibility, DNA methylation and transcriptome profiling. scNMT-seq (single-cell nucleosome, met...

journal_title：Nature communications

authors： Clark SJ,Argelaguet R,Kapourani CA,Stubbs TM,Lee HJ,Alda-Catalinas C,Krueger F,Sanguinetti G,Kelsey G,Marioni JC,Stegle O,Reik W

更新日期：2018-02-22 00:00:00

abstract：:Processing of interleukin RNAs must be tightly controlled during the immune response. Here we report that a subnuclear body called the interleukin-6 and -10 splicing activating compartment (InSAC) is a nuclear site of cytokine RNA production and stability. Tat-activating regulatory DNA-binding protein-43 (TDP-43) acts...

journal_title：Nature communications

authors： Lee S,Lee TA,Lee E,Kang S,Park A,Kim SW,Park HJ,Yoon JH,Ha SJ,Park T,Lee JS,Cheon JH,Park B

更新日期：2015-01-05 00:00:00

abstract：:Signal regulatory protein α (SIRPα), an immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptor, is an essential negative regulator of leukocyte inflammatory responses. Here we report that SIRPα cytoplasmic signalling ITIMs in neutrophils are cleaved during active inflammation and that the loss of SI...

journal_title：Nature communications

authors： Zen K,Guo Y,Bian Z,Lv Z,Zhu D,Ohnishi H,Matozaki T,Liu Y

更新日期：2013-01-01 00:00:00

abstract：:Recently, stretchable electronics combined with wireless technology have been crucial for realizing efficient human-machine interaction. Here, we demonstrate highly stretchable transparent wireless electronics composed of Ag nanofibers coils and functional electronic components for power transfer and information commu...

journal_title：Nature communications

authors： Zhang Y,Huo Z,Wang X,Han X,Wu W,Wan B,Wang H,Zhai J,Tao J,Pan C,Wang ZL

更新日期：2020-11-06 00:00:00

abstract：:The welding and sintering of nanomaterials is relevant, for example, to form electrical contacts between metallic particles in printed electronic devices. Usually the welding of nanoparticles is achieved at high temperatures. Here we find that merging of two different metals, silver and gold nanoparticles, occurs on c...

journal_title：Nature communications

authors： Grouchko M,Roitman P,Zhu X,Popov I,Kamyshny A,Su H,Magdassi S

更新日期：2014-01-01 00:00:00

abstract：:Intratumor heterogeneity (ITH) and tumor evolution have been well described for clear cell renal cell carcinomas (ccRCC), but they are less studied for other kidney cancer subtypes. Here we investigate ITH and clonal evolution of papillary renal cell carcinoma (pRCC) and rarer kidney cancer subtypes, integrating whole...

journal_title：Nature communications

authors： Zhu B,Poeta ML,Costantini M,Zhang T,Shi J,Sentinelli S,Zhao W,Pompeo V,Cardelli M,Alexandrov BS,Otlu B,Hua X,Jones K,Brodie S,Dabrowska ME,Toro JR,Yeager M,Wang M,Hicks B,Alexandrov LB,Brown KM,Wedge DC,Chanoc

更新日期：2020-06-18 00:00:00

abstract：:Stimuli-responsive hydrogel actuators have promising applications in various fields. However, the typical hydrogel actuation relies on the swelling and de-swelling process caused by osmotic-pressure changes, which is slow and normally requires the presence of water environment. Herein, we report a light-powered in-air...

journal_title：Nature communications

authors： Li M,Wang X,Dong B,Sitti M

更新日期：2020-08-10 00:00:00

abstract：:Angiogenesis is a dynamic process relying on endothelial cell rearrangements within vascular tubes, yet the underlying mechanisms and functional relevance are poorly understood. Here we show that PI3Kα regulates endothelial cell rearrangements using a combination of a PI3Kα-selective inhibitor and endothelial-specific...

journal_title：Nature communications

authors： Angulo-Urarte A,Casado P,Castillo SD,Kobialka P,Kotini MP,Figueiredo AM,Castel P,Rajeeve V,Milà-Guasch M,Millan J,Wiesner C,Serra H,Muixi L,Casanovas O,Viñals F,Affolter M,Gerhardt H,Huveneers S,Belting HG,Cutillas

更新日期：2018-11-16 00:00:00

abstract：:Quantum metrology bears a great promise in enhancing measurement precision, but is unlikely to become practical in the near future. Its concepts can nevertheless inspire classical or hybrid methods of immediate value. Here we demonstrate NOON-like photonic states of m quanta of angular momentum up to m=100, in a setup...

journal_title：Nature communications

authors： D'Ambrosio V,Spagnolo N,Del Re L,Slussarenko S,Li Y,Kwek LC,Marrucci L,Walborn SP,Aolita L,Sciarrino F

更新日期：2013-01-01 00:00:00

abstract：:Whole-genome sequencing using sequencing technologies such as Illumina enables the accurate detection of small-scale variants but provides limited information about haplotypes and variants in repetitive regions of the human genome. Single-molecule sequencing (SMS) technologies such as Pacific Biosciences and Oxford Na...

journal_title：Nature communications

authors： Edge P,Bansal V

更新日期：2019-10-11 00:00:00

abstract：:The brain identifies potentially salient features within continuous information streams to process hierarchical temporal events. This requires the compression of information streams, for which effective computational principles are yet to be explored. Backpropagating action potentials can induce synaptic plasticity in...

journal_title：Nature communications

authors： Asabuki T,Fukai T

更新日期：2020-03-25 00:00:00

abstract：:Optical tracking is often combined with conventional flat panel solar cells to maximize electrical power generation over the course of a day. However, conventional trackers are complex and often require costly and cumbersome structural components to support system weight. Here we use kirigami (the art of paper cutting...

journal_title：Nature communications

authors： Lamoureux A,Lee K,Shlian M,Forrest SR,Shtein M

更新日期：2015-09-08 00:00:00

abstract：:Planar spindle orientation in polarized epithelial cells depends on the precise localization of the dynein-dynactin motor protein complex at the lateral cortex. The contribution of cell adhesion molecules to the cortical localization of the dynein-dynactin complex is poorly understood. Here we find that junctional adh...

journal_title：Nature communications

authors： Tuncay H,Brinkmann BF,Steinbacher T,Schürmann A,Gerke V,Iden S,Ebnet K

更新日期：2015-08-26 00:00:00

abstract：:The ability to understand and control the electronic properties of individual molecules in a device environment is crucial for developing future technologies at the nanometre scale and below. Achieving this, however, requires the creation of three-terminal devices that allow single molecules to be both gated and image...

journal_title：Nature communications

authors： Wickenburg S,Lu J,Lischner J,Tsai HZ,Omrani AA,Riss A,Karrasch C,Bradley A,Jung HS,Khajeh R,Wong D,Watanabe K,Taniguchi T,Zettl A,Neto AHC,Louie SG,Crommie MF

更新日期：2016-11-25 00:00:00

abstract：:Τhe morphology, physiology and immunology, of solid tumors exhibit spatial heterogeneity which complicates our understanding of cancer progression and therapy response. Understanding spatial heterogeneity necessitates high resolution in vivo imaging of anatomical and pathophysiological tumor information. We introduce ...

journal_title：Nature communications

authors： Peters L,Weidenfeld I,Klemm U,Loeschcke A,Weihmann R,Jaeger KE,Drepper T,Ntziachristos V,Stiel AC

更新日期：2019-03-13 00:00:00

abstract：:Perovskite quantum-dot-based light-emitting diodes (QLEDs) possess the features of wide gamut and real color expression, which have been considered as candidates for high-quality lightings and displays. However, massive defects are prone to be reproduced during the quantum dot (QD) film assembly, which would sorely af...

journal_title：Nature communications

authors： Xu L,Li J,Cai B,Song J,Zhang F,Fang T,Zeng H

更新日期：2020-08-06 00:00:00

abstract：:Tumors are mixtures of different compartments. While global gene expression analysis profiles the average expression of all compartments in a sample, identifying the specific contribution of each compartment remains a challenge. With the increasing recognition of the importance of non-neoplastic components, the abilit...

journal_title：Nature communications

authors： Peng XL,Moffitt RA,Torphy RJ,Volmar KE,Yeh JJ

更新日期：2019-10-18 00:00:00

abstract：:Self-healing materials are highly desirable because they allow products to maintain their performance. Typical stimuli used for self-healing are heat and light, despite being unsuitable for materials used in certain products as heat can damage other components, and light cannot reach materials located within a product...

journal_title：Nature communications

authors： Miwa Y,Taira K,Kurachi J,Udagawa T,Kutsumizu S

更新日期：2019-04-23 00:00:00

abstract：:Inelastic collisions involving molecular species are key to energy transfer in gaseous environments. They are commonly governed by an energy gap law, which dictates that transitions are dominated by those between initial and final states with roughly the same ro-vibrational energy. Transitions involving rotational ine...

journal_title：Nature communications

authors： Yang D,Huang J,Hu X,Guo H,Xie D

更新日期：2019-10-11 00:00:00

abstract：:The efficiencies of green and red perovskite light-emitting diodes (PeLEDs) have been increased close to their theoretical upper limit, while the efficiency of blue PeLEDs is lagging far behind. Here we report enhancing the efficiency of sky-blue PeLEDs by overcoming a major hurdle of low photoluminescence quantum eff...

journal_title：Nature communications

authors： Wang Q,Wang X,Yang Z,Zhou N,Deng Y,Zhao J,Xiao X,Rudd P,Moran A,Yan Y,Huang J

更新日期：2019-12-10 00:00:00

abstract：:Although a hydrophobic microtexture at a solid surface most often reflects rain owing to the presence of entrapped air within the texture, it is much more challenging to repel hot water. As it contacts a colder material, hot water generates condensation within the cavities at the solid surface, which eventually builds...

journal_title：Nature communications

authors： Mouterde T,Lecointre P,Lehoucq G,Checco A,Clanet C,Quéré D

更新日期：2019-03-29 00:00:00

abstract：:Blood brain barrier (BBB) breakdown is not only a consequence of but also contributes to many neurological disorders, including stroke and Alzheimer's disease. How the basement membrane (BM) contributes to the normal functioning of the BBB remains elusive. Here we use conditional knockout mice and an acute adenovirus-...

journal_title：Nature communications

authors： Yao Y,Chen ZL,Norris EH,Strickland S

更新日期：2014-03-03 00:00:00